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Recent progress in identifying genes regulating hematopoietic stem cell function and fate.

C T Jordan·G Van Zant
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Abstract

Significant advances in the use of genetic and molecular biology strategies have recently begun to identify genes that have a major impact on the determination, commitment and developmental potential of hematopoietic stem cells. Using a variety of experimental strategies, genes such as SCL, GATA-2, HoxB4, Flk-2, c-mpl, dlk, and others have been implicated as important regulators of stem cell growth. In addition, genetic mapping has identified several loci that correlate strongly with stem cell numbers and proliferation.

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AnimalsCell DifferentiationCell DivisionCell LineageGene Expression Regulation, DevelopmentalGenesHematopoietic Stem CellsHumansJournal ArticleReview

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C T Jordan, G Van Zant. 1998. Recent progress in identifying genes regulating hematopoietic stem cell function and fate.. https://doi.org/10.1016/s0955-0674(98)80112-9

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