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PubMed · 9914829

The mitochondrial permeability transition.

P Bernardi·R Colonna·P Costantini·O Eriksson·E Fontaine·F Ichas·S Massari·A Nicolli·V Petronilli·L Scorrano
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Abstract

This review summarizes recent work on the regulation of the permeability transition pore, a cyclosporin A-sensitive mitochondrial channel that may play a role in intracellular calcium homeostasis and in a variety of forms of cell death. The basic bioenergetics aspects of pore modulation are discussed, with some emphasis on the links between oxidative stress and pore dysregulation as a potential cause of mitochondrial dysfunction that may be relevant to cell injury.

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AnimalsCalciumCell DeathCell Membrane PermeabilityHumansMitochondriaMitochondrial ADP, ATP TranslocasesOxidative StressJournal ArticleResearch Support, Non-U.S. Gov'tReview

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P Bernardi, R Colonna, P Costantini, O Eriksson, E Fontaine, F Ichas, S Massari, A Nicolli, V Petronilli, L Scorrano. 1998. The mitochondrial permeability transition.. https://doi.org/10.1002/biof.5520080315

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