Resequencing and mutational analysis using oligonucleotide microarrays.

J G Hacia

doi:10.1038/4469

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PubMed · 9915500

Resequencing and mutational analysis using oligonucleotide microarrays.

J G Hacia

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Abstract

Oligonucleotide microarray (DNA chip)-based hybridization analysis is a promising new technology which potentially allows rapid and cost-effective screens for all possible mutations and sequence variations in genomic DNA. Here, I review current strategies and uses for DNA chip-based resequencing and mutational analysis, the underlying principles of experimental designs, and future efforts to improve the sensitivity and specificity of chip-based assays.

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Animals DNA Mutational Analysis Genetic Variation Genome Humans Oligonucleotide Array Sequence Analysis Oligonucleotide Probes Sensitivity and Specificity Journal Article Review

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J G Hacia. 1999. Resequencing and mutational analysis using oligonucleotide microarrays.. https://doi.org/10.1038/4469

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