A novel aromatase inhibitor, vorozole, shows antitumor activity and a decrease of tissue insulin-like growth factor-I level in 7, 12-dimethylbenz[a]anthracene-induced rat mammary tumors.

N Sugamata; Y Koibuchi; Y Iino; Y Morishita

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PubMed · 9917500

A novel aromatase inhibitor, vorozole, shows antitumor activity and a decrease of tissue insulin-like growth factor-I level in 7, 12-dimethylbenz[a]anthracene-induced rat mammary tumors.

N Sugamata·Y Koibuchi·Y Iino·Y Morishita

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Abstract

Effects of vorozole, a potent and specific non-steroidal aromatase inhibitor, were evaluated on female Sprague-Dawley (SD) rats with 7, 12-dimethylbenz[a]anthracene (DMBA)-induced mammary tumors. Vorozole at a dose of 0.25, 1.0 and 4.0 mg/kg was orally administered once a day for 28 consecutive days. A significant regression in tumor size was observed in each treated group at 1, 2, 3 and 4 weeks after the start of treatment compared with control group. Tissue insulin-like growth factor I (IGF-I) in the DMBA-induced tumors in each treated group significantly decreased in a dose-dependent fashion compared with control group. These results show the mechanism of vorozole in DMBA-induced rat mammary tumors.

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9,10-Dimethyl-1,2-benzanthracene Administration, Oral Animals Antineoplastic Agents Aromatase Inhibitors Enzyme Inhibitors Female Insulin-Like Growth Factor I Mammary Neoplasms, Experimental Rats Triazoles Journal Article

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N Sugamata, Y Koibuchi, Y Iino, Y Morishita. 1999. A novel aromatase inhibitor, vorozole, shows antitumor activity and a decrease of tissue insulin-like growth factor-I level in 7, 12-dimethylbenz[a]anthracene-induced rat mammary tumors.. https://pubmed.ncbi.nlm.nih.gov/9917500/

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