Non-linear microscale alterations in membrane transport by electropermeabilization.

T R Gowrishankar; W Chen; R C Lee

doi:10.1111/j.1749-6632.1998.tb10154.x

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Non-linear microscale alterations in membrane transport by electropermeabilization.

T R Gowrishankar·W Chen·R C Lee

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Abstract

The purpose of this study was to quantify the changes in cell membrane conductance in response to electropermeabilization, which may elucidate the mechanisms of tissue injury resulting from high-voltage electrical shock. A high-speed, space-clamp and voltage-clamp experimental configuration was used. The pulse parameters of an imposed transmembrane potential that are instrumental in membrane properties alteration were precisely controlled. The dynamics of the non-linear electroporation response was characterized.

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Animals Cell Membrane Electric Conductivity Electroporation In Vitro Techniques Membrane Potentials Muscle Fibers, Fast-Twitch Muscle, Skeletal Patch-Clamp Techniques Rana temporaria Time Factors Journal Article Research Support, Non-U.S. Gov't

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T R Gowrishankar, W Chen, R C Lee. 1998-09-11. Non-linear microscale alterations in membrane transport by electropermeabilization.. https://doi.org/10.1111/j.1749-6632.1998.tb10154.x

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