Knockout mouse model and gametogenic failure.

J A Grootegoed; W M Baarends; H P Roest; J H Hoeijmakers

doi:10.1016/s0303-7207(98)00183-x

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Knockout mouse model and gametogenic failure.

J A Grootegoed·W M Baarends·H P Roest·J H Hoeijmakers

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Abstract

To evaluate the function of a defined gene in gametogenesis, exciting opportunities are offered by the introduction of techniques to generate knockout mice. In this short article, we briefly describe a few gene knockout mouse models, which show a phenotype that involves impairment of gametogenesis and/or fertility. The focus will be on the mHR6B gene knockout mouse, which shows male infertility. The mHR6B gene encodes an ubiquitin-conjugating enzyme, and the data point to an important role of the ubiquitin pathway in gametogenesis.

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Animals Female Gene Expression Infertility, Male Ligases Male Mice Mice, Knockout Oogenesis Phenotype Spermatogenesis Ubiquitin-Conjugating Enzymes Ubiquitins Journal Article Research Support, Non-U.S. Gov't Review

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J A Grootegoed, W M Baarends, H P Roest, J H Hoeijmakers. 1998-10-25. Knockout mouse model and gametogenic failure.. https://doi.org/10.1016/s0303-7207(98)00183-x

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