COX-2 inhibitors.

C J Hawkey

doi:10.1016/s0140-6736(98)12154-2

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PubMed · 9929039

COX-2 inhibitors.

C J Hawkey

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Abstract

In the past 100 years aspirin has demonstrated its value as an analgesic, anti-inflammatory, and antithrombotic agent. However, by 1938, it was clear that aspirin was gastrotoxic. Non-steroidal anti-inflammatory drugs (NSAIDs), developed since the 1960s, failed to achieve the goal of "a safer aspirin". The demonstration that inhibition of prostaglandin synthesis via a cyclo-oxygenase (COX) enzyme was central to both the therapeutic and toxic effects of aspirin and non-aspirin NSAIDs appeared to establish the principle of no gain without pain. This link may have been broken by drugs that selectively inhibit the inducible COX-2 enzyme. The COX enzyme is now a target of drug interventions against the inflammatory process. Might the "safe aspirin" be here at last?

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Anti-Inflammatory Agents, Non-Steroidal Aspirin Celecoxib Crystallography, X-Ray Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors Humans Isoenzymes Lactones Membrane Proteins Molecular Structure Prostaglandin-Endoperoxide Synthases Pyrazoles Sulfonamides Sulfones Journal Article Research Support, Non-U.S. Gov't

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C J Hawkey. 1999-01-23. COX-2 inhibitors.. https://doi.org/10.1016/s0140-6736(98)12154-2

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