Thymic microenvironments, 3-D versus 2-D?

W van Ewijk; B Wang; G Hollander; H Kawamoto; E Spanopoulou; M Itoi; T Amagai; Y F Jiang; W T Germeraad; W F Chen; Y Katsura

doi:10.1006/smim.1998.0158

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PubMed · 9950752

Thymic microenvironments, 3-D versus 2-D?

W van Ewijk·B Wang·G Hollander·H Kawamoto·E Spanopoulou·M Itoi·T Amagai·Y F Jiang·W T Germeraad·W F Chen·Y Katsura

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Abstract

Lympho-stromal interactions in the thymus crucially de- termine the fate of developing T cells. Epithelial cells, inter- digitating reticular cells, macrophages and fibroblasts all play a role in the shaping of the T cell repertoire. Recently published evidence shows that lympho-stromal interaction acts bi-directional. Developing T cell themselves, at different stages of differentiation, control the microarchitecture of thymic microenvironments, a phenomenon designated as 'crosstalk'. This paper reviews experiments showing that developing T cells crosstalk to different thymic epithelial cells in a stepwise fashion. In this way, correctly organized thymic microenvironments guarantee normal thymopoiesis.

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Animals Cell Communication Cell Differentiation Humans Stromal Cells T-Lymphocytes Thymus Gland Journal Article Review

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W van Ewijk, B Wang, G Hollander, H Kawamoto, E Spanopoulou, M Itoi, T Amagai, Y F Jiang, W T Germeraad, W F Chen, Y Katsura. 1999. Thymic microenvironments, 3-D versus 2-D?. https://doi.org/10.1006/smim.1998.0158

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