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At least 181 records · Page 10Linked to original sources

A case of non-small cell lung cancer with false-positive staging by positron emission tomography.

A 70-year-old woman with right lung cancer was admitted to our hospital. Chest computed tomography (CT) revealed an approximate 2.5 cm sized mass in the right middle lobe, and enlarged hilar and mediastinal lymph nodes. The 2-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) showed high uptake in the right hilar and mediastinal nodes. Therefore we diagnosed N2 (mediastinal nodal involvement) disease. Microscopically, however, all dissected lymph nodes revealed anthracosilicosis and negative for malignancy. Although false-positive evaluation of mediastinal involvement by PET can occur in the setting of metabolically active inflammatory disease, this case did not have these active diseases. The FDG-PET result of this case was unusual.

Aged↗

[Cellular functional changes in the endocrine system of the rats upon exposure to coal rock dust and during exercise].

Exposure to coal rock dust in combination with exercise for 2 months was found to have a negative impact on cellular metabolism in the endocrine system. The early form of anthracosilicosis developed in this period. Cytomorphological study revealed cellular changes in the pituitary, thyroid, parathyroid, and pancreatic glands. The cells of the endocrine organs are functionally tense upon exposure to toxic and physical factors and they are most vulnerable in this period of an experiment.

Air Pollutants↗

[Experience with the roentgenodiagnosis of disturbances of respiratory function in coal miners].

The paper is concerned with the results of roentgenofunctional investigation of 293 miners, among them there were 63 patients with dust bronchitis and 230 patients with the main types of dust disease (anthracosis, silicosis and anthracosilicosis). Two-stage roentgenopneumopolygraphy (RPPG) with a chess grid and spiral pneumoroentgenography (SPRG) with a spiral grid were employed. Respiratory dysfunction in patients with pneumoconiosis depended on an x-ray and morphological type of fibrosis and stage of disease rather than on its type. The formation of zones of emphysematous inflation in the apical area, in the upper and middle regions of the lungs was revealed, however signs of basal emphysema were ++undetectable. Analysis of RPPG and SPRG findings has shown that unlike pneumoconiosis, dust bronchitis is characterized by earlier development of respiratory dysfunction of more noticeable type, particularly in early signs of disease.

Adult↗

[Technics for the exploration of pulmonary arteriovenous shunts in liver cirrhosis. Apropos of 2 cases].

Pulmonary arterio-venous shunts represent a rare cause of hypoxia in cirrhosis. We present two cases, the first was an alcoholic cirrhotic with anthracosilicosis. This patient rapidly developed a picture of significant hypoxaemia with a raised alveolar-arterial oxygen gradient. The presence of this shunt was confirmed by a scintigraphic analysis. A porto-pulmonary localisation was excluded by a changing angiographic picture. Death supervened after refractory hypoxaemia. Post mortem microangiographic studies confirmed the pulmonary nature of the shunt and its pre-capillary localisation. The second patient was alcoholic, with a compensated cirrhosis and developed severe hypoxaemia which progressed to death in less than two months, when he was being treated effectively with corticosteroids for a diffuse interstitial pulmonary fibrosis confirmed histologically. The pulmonary localisation of the shunt was confirmed by an analysis of the angioscintigraphs. The different techniques for the investigation of intra-pulmonary shunt are discussed, as well as the patho-physiological mechanisms involved. The hormone levels measured (sex hormones, serotonin, prostaglandins, intestinal hormones) remained normal. The therapeutic trials tried out (oestrogen, CPD Choline, indomethacin) were ineffective.

Humans↗

[Comparative morphological-statistical investigations in deaths with clinically known and unknown hepatocirrhosis (author's transl)].

352 hepatocirrhosis cases were among the 7139 autopsy cases of the years 1964--1973. It could be ascertained statistically: Together with the increasing scarred liver transformation the number of oesophageal piles and ascites increased. The greater the scarred transformation and cirrhosis activity the higher was the number of hepatocirrhoses known at lifetime. An increase of spleen weight due to scarred liver transformation could not be proved. The expected correlation between degree of fibrosis and liver weight could not be confirmed. According to expectation, hepatocirrhosis cases known at lifetime caused death more frequently than cases with unknown hepatocirrhosis. We want to point out, however, that 13 cases of death may be directly attributed to clinically unknown hepatocirrhosis. The medically unknown hepatocirrhosis cases in one group were frequently still "young" hepatocirrhosis cases without ascites and oesophageal piles, or the clinical features of advanced hepatocirrhosis were masked by other severe diseases (e.g., anthracosilicosis of the lung).

Aged↗

[Irregular heart rate correction among miners with early signs of pulmonary diseases by the method of alternative biocontrol of the heart contraction frequency].

The study covered 45 miners having anthracosilicosis and dust bronchitis. The registered signs were lower spectral intensity of high-frequency waves (oscillations period 3 to 36 s) and higher spectral intensity of low-frequency waves (oscillations period 36 s), asymmetry of blood pressure, higher systolic and diastolic BP before stress period of adaptation. Adequate therapy associated with biologic regulation of cardiac rhythm restores normal regulation.

Age Factors↗