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At least 181 records · Page 10Linked to original sources
PubMed1989

Surgery of brain neoplasms using 32-P tumour marker.

In a series of 60 patients 62 intraoperative measurements with the 32-P (radiophosphorus) tumour marker were performed. Using miniature semiconductor probes a reliable discrimination between normal brain and neoplastic tissue was possible in nearly all brain tumours. The best results were found in meningiomas, where even small, visually hardly discernible tumour resides within the matrix zone could be reliably detected. Only in low-grade gliomas the application of the 32-P marker was impossible due to count rates similar to or below the basic rates of normal brain. This simple to use, non-invasive method proved its usefulness in all situations where a local radical tumour removal was important.

Adult↗
PubMedDate not supplied

[Use of the navigation system Stealth Station(TM) for removal of brain neoplasm].

The paper analyzes the authors' initial experience with the Stealth Station navigation system (Medtronic-Sofamor Danek, USA) during neurosurgery for intracranial tumors and outlines its techniques. Twenty eight patients with various brain tumors were operated on. Thirteen patients had tumors of the skull base (meningiomas, chordomas, paragangliomas, fibrous dysplasia). Twelve patients showed various intracerebral tumor-forming processes (gliomas, cavernous angiomas, and metastizing carcinomas). The navigation system ensured resection of these tumors. It was used in 2 other patients with gliomas and in 1 patient with cystic craniopharyngioma for their stereotactic puncture, biopsy, and drainage. The Stealth Station proved to be an effective tool for preoperative planning of cranial neurosurgical operations and their intraoperative guidance. Strict observance of the protocols of preoperative preparation ensures a high accuracy and facilitates search for and identification of anatomic guides. Only in 1 patient with surface glioma involving the central gyri, its resection was followed by hemiparesis that subsequently progressed. In the remaining 27 cases, the operation ran smoothly and caused no new neurological defect. The brain-shift phenomenon is the principal limitation of accuracy of the intraoperative system. This problem is less evident in skull-base surgery where the system was effectively used for critical structural location. Also, it can be safely employed for elimination of slight deep lesions to protect the brain and to minimize its injury via approach to a tumor through the brain parenchyma.

Brain Neoplasms↗
PubMed1995

Neurobehavioral presentations of brain neoplasms.

We studied 8 patients with frontal or temporolimbic neoplasms who had psychiatric presentations to clarify diagnostic criteria for distinguishing psychiatric disease from structural brain lesions and to examine brain-behavior relationships associated with cerebral neoplasms using modern neuroimaging techniques. Medical records were retrospectively reviewed for evidence of neurobehavioral and neurologic manifestations, tumor histologic features, and the results of treatment. Clinical presentations were correlated with tumor location as determined by computed tomography and magnetic resonance imaging. Patients with frontal lobe tumors presented with abulia, personality change, or depression, whereas those with temporolimbic tumors had auditory and visual hallucinations, mania, panic attacks, or amnesia. After treatment, neurobehavioral syndromes abated or resolved in 7 of 8 patients. We recommend that any patient 40 years of age or older with a change in mental state, cognitive or emotional, should have neuroimaging of the brain. Any patient with a psychiatric presentation who has specific neurobehavioral or neurologic findings or an unexpectedly poor response to psychopharmacologic treatment should also have brain imaging. These case reports extend and update observations on the importance of frontal and temporolimbic systems in the pathogenesis of neurobehavioral disorders.

Adult↗
PubMedDate not supplied

Embryonal brain neoplasms in the neonatal period and early infancy.

We report on two cases of congenital primitive neuroectodermal tumors located in the posterior cranial fossa. They were symptomatic at birth with occlusive internal hydrocephalus. Clinical investigations had failed to diagnose brain tumors and had led to the suggestion of maldevelopment syndromes. In one of these children a malignant rhabdoid tumor of the kidney was operated at the age of 4 1/2 months. Autopsy revealed medulloblastoma combined with a malignant rhabdoid tumor of the kidney in one case and ependymoblastoma in the other.

Brain Neoplasms↗
PubMed1976

[Comparative in vitro action of various antimitotic agents on cell lines established from human brain neoplasms].

The effects of six chemotherapeutic drugs currently used in human gliomas treatment were tested with an in vitro cytotoxicity test. Out of six, VM 26 proved to be the most potent against tumor cells along with a moderate cytotoxicity against normal brain or embryonnic human cells. This specificity did not seem to be related to differences in cellular growth rates.

Antineoplastic Agents↗
PubMed1992

[Use of a stereotaxic method in the diagnosis and treatment of brain neoplasms in children].

The paper presents the possibility of application of the stereotactic method in the diagnosis and treatment of pediatric brain tumours, based on the material of the Dept. of Stereotactic Neurosurgery of the University Clinic in Homburg-Saar (Germany). The basic theoretical principles and diagnostic potential of serial biopsy and intraoperative diagnosis are presented. Shown are new therapeutic possibilities created by interstitial brachytherapy. The results obtained in stereotactic treatment of brain tumours are deemed satisfactory, as the method enables a cause-oriented treatment in cases hitherto inoperable because of localisation and resistant to megavolt radiotherapy because of radiobiological characteristics of the given neoplasm.

Adolescent↗
PubMedDate not supplied

Classification of 1H MR spectra of human brain neoplasms: the influence of preprocessing and computerized consensus diagnosis on classification accuracy.

We study how classification accuracy can be improved when both different data preprocessing methods and computerized consensus diagnosis (CCD) are applied to 1H magnetic resonance (MR) spectra of astrocytomas, meningiomas, and epileptic brain tissue. The MR spectra (360 MHz, 37 degrees C) of tissue specimens (biopsies) from subjects with meningiomas (95; 26 cases), astrocytomas (74; 26 cases), and epilepsy (37; 8 cases) were preprocessed by several methods. Each data set was partitioned into training and validation sets. Robust classification was carried out via linear discriminant analysis (LDA), artificial neural nets (NN), and CCD, and the results were compared with histopathological diagnosis of the MR specimens. Normalization of the relevant spectral regions affects classification accuracy significantly. The spectra-based average three-class classification accuracies of LDA and NN increased from 81.7% (unnormalized data sets) to 89.9% (normalized). CCD increased the classification accuracy of the normalized sets to an average of 91.8%. CCD invariably decreases the fraction of unclassifiable spectra. The same trends prevail, with improved results, for case-based classification. Preprocessing the 1H MR spectra is essential for accurate and reliable classification of astrocytomas, meningiomas, and nontumorous epileptic brain tissue. CCD improves classification accuracy, with an attendant decrease in the fraction of unclassifiable spectra or cases.

Astrocytoma↗
PubMed1998

[Angiogenesis in brain neoplasms--biological and clinical aspects].

Solid tumors are dependent on angiogenesis for sustained growth, therefore anti-angiogenic treatment is a potential antineoplastic therapy. Glioblastoma multiforme has been considered a suitable candidate for such treatment. This review summarizes the fundamentals of angiogenic process in glioblastoma multiforme and in other types of brain tumors for which they represent a potential for anti-angiogenic therapy.

Animals↗
PubMed2006

Nontuberculous mycobacterial infection of a metastatic brain neoplasm in an immunocompromised patient.

BACKGROUND: Nontuberculous mycobacterial infections occur in immunocompromised patients but so rarely involve the central nervous system (CNS) that they may not be included in a differential diagnosis of CNS lesions in such patients. OBJECTIVE: To illustrate a putative mechanism for nontuberculous mycobacterial infection of the CNS via breakdown of the blood-brain barrier by metastatic neoplasm. RESULTS: A 56-year-old man who had undergone renal transplantation in February 2003 and was taking an immunosuppressive regimen of mycophenolate mofetil and cyclosporine was seen in the emergency department after a syncopal episode. Head computed tomography revealed a single focal occipital lesion with vasogenic edema. Hospital admission and further workup led to diagnosis of metastatic carcinoma infected with nontuberculous mycobacteria in the setting of a disseminated nontuberculous mycobacterial infection. CONCLUSION: This case illustrates that breakdown of the blood-brain barrier by metastatic neoplasm may provide a route of access for a pathogen that is not normally seen in the CNS.

Adenocarcinoma↗
PubMed2003

[Rare case of a malignant brain neoplasm in an 18-years old pregnant woman].

Authors presented rare case of anaplastic ependymoma diagnosed in the first trimester of pregnancy 18-years of age patient. Main symptoms of increased intracranial pressure and cerebral edema were vomits, severe headache and apathy. In the sixteen week of pregnancy performed craniotomy and evacuated malignant tumor of region IV ventricle trunk of the brain. Follow during pregnancy made brachytherapy (LDR). Cesarean section performed in the 30th week of pregnancy. Then indispensable radical radiotherapy was continued.

Adult↗