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The life long challenge of expertise.

The development and maintenance of expertise in any domain requires extensive, sustained practice of the necessary skills. However, the quantity of time spent is not the only factor in achieving expertise; the quality of this time is at least as important. The development and maintenance of expertise requires extensive time dedicated specifically to the improvement of skills, an activity termed deliberate practise. Unfortunately, determining how to engage in this deliberate practise is not obvious for tasks such as diagnosis, which involve high stakes and are predominantly cognitive nature. Reflection on and adaptation of one's cognitive processes is important; this could be supplanted by seeking out the opportunity to engage in trial and error in low risk environments such as simulators. Regardless, most individuals tend to favour well-entrenched activities and avoid practise. This may be due to lack of awareness of deficiencies in performance. However, it may also be due to the individual's conception of the nature of expertise. Although expertise requires experience, experience alone is insufficient. Rather, the development of expertise is critically dependent on the individual making the most of that experience. As a result, motivational factors are fundamental to the development of expertise. Overcoming deficiencies in self-monitoring is not a sufficient remedy. It is also necessary is that clinicians form an attitude toward work that includes continual re-investment in improvement.

Clinical Competence↗

High-frequency brain activity: its possible role in attention, perception and language processing.

Coherent high-frequency neuronal activity has been proposed as a physiological indicator of perceptual and higher cognitive processes. Some of these processes can only be investigated in humans and the use of non-invasive recording techniques appears to be a prerequisite for investigating their physiological substrate in the healthy human brain. After addressing methodological issues in the non-invasive recording of high-frequency responses, we summarize studies indicating co-occurrence of neuronal synchrony of single cells exhibiting rhythmic activity at high frequencies, oscillations in the local field potential and dynamics in high frequencies recorded using high-resolution electroencephalography (EEG) and magnetoencephalography (MEG). We then review EEG and MEG studies of attention, perception, and language processing in humans indicating that dynamics in the high-frequency range > 20 Hz reflect specific cognitive processes. Types of high-frequency (HF) activity can be distinguished according to their latency after stimulus onset, stimulus-locking, cortical topography and frequency. There appears to be a systematic relationship between specific cognitive processes and types of HF activity. The findings are related to recent theories about the generation of HF activity and their possible role in binding of stimulus features. Dynamics of HF cortical activity reflecting higher cognitive processes can be accounted for based on the assumption that the elements of cognitive processing, e.g. visual objects and words, are organized in the brain as distributed neuronal assemblies with defined cortical topographies generating well-timed spatio-temporal activity patterns.

Arousal↗

P300 latency reflects the degree of cognitive decline in dementing illness.

An auditory discrimination paradigm was employed to elicit the P3 component of the event-related brain potential (ERP) from 39 demented patients (mean age = 71 years). Component latency was longer in patients who were diagnosed as having primary degenerative dementia and other cognitive impairment disorders compared to age-matched controls. Neurologist ratings of cognitive impairment were significantly correlated with P3 latency values, although no differences in mean latency were obtained between the various categories of dementia. ERP measurement techniques and the interpretation of P3 latency as in index of dementing illness are discussed.

Aged↗

Individual differences in schizotypy as reflected in measures of cognitive inhibition.

Three experiments are reported using the 'negative priming' paradigm to investigate cognitive differences in normal schizotypal subjects. Lists of Stroop colour words were presented at different display times in a number of priming and non-priming conditions, in one of which the ignored colour name predicted the colour of the next target item. The increased RT latencies to the target normally found in this condition were reduced, or even reversed, in high schizotypal subjects selected on the basis of a new schizotypy scale (STA). This effect was confined to a very short presentation time (100 ms), suggesting that schizotypy is associated with weakened inhibition operating in the early (automatic) stages of information processing. The familiar Stroop (interference) effect was related overall to negative priming, but was not responsible for the schizotypy differences.

Adolescent↗

Cognitive and psychodynamic correlates of depressive symptomatology.

31 depressed, 26 nondepressed participants completed measures reflecting putative cognitive and psychodynamic characteristics of self-reported depression. Of the 16 variables 9 discriminated the groups in the expected direction. Ten characteristics correlated significantly with scores on the Beck Depression Inventory, 4 reflecting negative automatic thinking, two of which (Negative Self-concepts and Expectations, Low Self-esteem) were important predictors of severity of depression.

Adult↗

Perceived cognitive function is a major determinant of health related quality of life in a non-selected population of patients with coronary artery disease--a principal components analysis.

OBJECTIVE: To assess health related quality of life (HRQL) and explore its underlying structure in a non-selected population of patients with coronary artery disease (CAD). DESIGN, SETTING AND SUBJECTS: HRQL was estimated by the disease specific Cardiac Health Profile (CHP) questionnaire and the EuroQol-VAS (EQ) in 253 consecutive unselected CAD patients in Södertälje, Stockholm County, Sweden. Explorative factor analysis was used to identify independent dimensions of HRQL. Current angina was ranked according to Canadian Cardiovascular Society Classification (CCS). RESULTS: Four independent principal factors representing perceived cognitive, physical, social and emotional functions underlying the patients' HRQL were found. Identical factors were recognized with an alternate technique. The major factor--explaining 43 % of HRQL--was perceived cognitive function reflecting ability to concentrate, activity drive, memory and problem solving. Cognitive function correlated to EQ but not to CCS. Perceived physical function/general health explained 9% of HRQL and was as expected related both to EQ and CCS. Total CHP scores differed significantly to those of healthy controls. CONCLUSIONS: Perceived cognitive function seems to be a major determinant of HRQL in CAD patients. This, in addition to earlier reports of possible prognostic information of reduced cognitive function, would prompt us to propose that HRQL assessments should include questions aimed to assess cognitive function.

Aged↗

Rehabilitation of frontal/executive impairments in schizophrenia.

OBJECTIVE: A relatively high prevalence of deficits in cognitive flexibility, working memory and planning ability has been reported in schizophrenia patients. The objective was to develop a rehabilitation training program in an attempt to improve these specific cognitive functions. METHODS: The deficits in cognitive flexibility, working memory and planning ability were interpreted as reflecting executive cognitive processing impairments secondary to prefrontal neural system dysfunction. Following the 'process specific' approach, it was considered important to develop tasks that hypothesised the exercise of these cognitive abilities and the more molecular information processes thought to be fundamental to these abilities. Care was taken to ensure that all tasks involved the practice of processes thought to activate frontal/prefrontal neural systems. Attentional, visual, verbal, conceptual, motor and fine motor tasks were considered important for each process area in order to involve as many functional modalities as possible. RESULTS: A program comprising cognitive shift, working memory and planning modules was developed. Conducted over 11 weeks, four modules were of 2 weeks' duration, and the fifth of 3 weeks' duration. Four individual 1 hour training sessions were conducted each week. Core elements of the modules are described. CONCLUSION: Consisting predominantly of pencil and paper information processing exercises, all of the training exercises are presented in the volumes of the Frontal/Executive Program. The program appears to be user-friendly with therapists now successfully delivering the program, in its entirety, to schizophrenia patients. Should future studies replicate preliminary findings of improved neurocognitive performance following training with the program, such findings would have important implications for the treatment of schizophrenia.

Cognition Disorders↗

Effect of antiepileptic drugs on cognitive function in individuals with epilepsy: a comparative review of newer versus older agents.

Several 'new' antiepileptic drugs (AEDs), i.e. oxcarbazepine, vigabatrin, lamotrigine, zonisamide, gabapentin, tiagabine, topiramate and levetiracetam have been introduced into clinical practice within the last decade. Most of these new drugs are at least as effective as the 'old' AEDs [phenytoin, phenobarbital (phenobarbitone), valproic acid (sodium valproate) and carbamazepine] and, in general, they seem to be better tolerated than the old drugs. The new AEDs might have less influence on cognitive functions but the aspect has not been systematically studied. Neuropsychological testing has been the major method of objectively examining cognitive function related to the use of AEDs but a number of methodological problems blur the results. Alteration of cognition might reflect a chronic adverse effect of AEDs but the negative effects of the drugs are only one of several factors that may influence cognition. In addition, subjective complaints about cognitive deficits (e.g. memory problems or attention) may also reflect other aspects of adverse effects than those concerning specific cognitive functions (e.g. mood and anxiety). This review focuses on studies of the cognitive effects of the new AEDs, and in particular on studies that compare cognitive effects of the old and new drugs. In general, the new AEDs seem to display no or minor negative cognitive effects. In studies in which new AEDs have been compared with old AEDs, there was a tendency in favour of the new AEDs in some of the studies.

Adult↗

Relationship between testosterone supplementation and insulin-like growth factor-I levels and cognition in healthy older men.

BACKGROUND: Our laboratory has previously reported that testosterone (T) administration to older men significantly improves cognitive function. This study examined potential changes in insulin-like growth factor (IGF) IGF-I, IGF-II and IGF-related binding proteins in response to T administration in older men and their relationship to cognitive functioning. METHODS: Twenty-five healthy community dwelling volunteers, ranging in age from 50-80 years were randomized to receive weekly intra-muscular (i.m.) injections of either 100 mg T enanthate or placebo (saline) for 6 weeks. Serum hormone levels and cognitive functioning was assessed at baseline and twice during treatment. RESULTS: Significant positive associations between IGF-I and IGF-II and spatial memory, spatial reasoning, and verbal fluency were observed after 6 weeks of T administration. Increased serum T levels from treatment were positively associated with improvement in spatial reasoning performance, whereas estradiol was associated with a decline in divided attention performance. Serum IGF-I, IGF-II and IGFBPs did not change in response to T treatment. CONCLUSIONS: Our results suggest that T, estradiol and IGF-I may have independent and selective effects on cognitive functioning. Positive associations between T levels and cognition are consistent with an effect of androgen treatment, whereas positive associations between IGF-I levels and cognition are reflective of a relationship between endogenous IGF-I levels and cognition.

Aged↗

Passive long-latency event-related potentials in mental retardation.

Long-latency auditory event-related potentials (ERPs) were passively recorded in ten mental retardates and ten age-matched normal controls. Patients were mildly to moderately retarded and had epilepsy controlled with monotherapy, ERPs were recorded from CA-A1+A2, with 1000 and 3000 Hz tones in an "oddball" paradigm. Latency and amplitude of N1, N2, P2, and P3 components were compared in controls and retardates. All ten patients had reproducible AEPs, but these were attenuated in amplitude in four, although amplitudes did not differ significantly from controls. P3 was prolonged in latency in four patients, but patients and controls did not differ significantly. AEP latency and amplitude was not correlated with degree of retardation. These findings suggest that "cognitive" evoked potentials an be recorded passively in persons with impaired cognition, but are not correlated with intellectual ability and may not reflect specific cognitive functions.

Adult↗

Far generalization of visual analogies strategies by impulsive and reflective EMR students.

Cognitive style and its interaction with training effects in promoting the acquisition and far generalization of a visual analogies strategy by 22 male and 17 female EMR pupils was evaluated. Training was effective in producing acquisition and far generalization; cognitive style was not. We suggested that the lack of interaction between cognitive style and training was due to the fact that the training program modified the subjects' cognitive style, i.e., impulsives tended to perform more like reflectives.

Adolescent↗

Time-frequency analysis of single-sweep event-related potentials by means of fast wavelet transform.

A time-frequency decomposition was applied to the event-related potentials (ERPs) elicited in an auditory oddball condition to assess differences in cognitive information processing. Analysis in the time domain has revealed that cognitive processes are reflected by various ERP components such as N1, P2, N2, P300, and late positive complex. However, the heterogeneous nature of these components has been strongly emphasized due to simultaneously occurring processes. The wavelet transform (WT), which decomposes the signal onto the time-frequency plane, allows the time-dependent and frequency-related information in ERPs to be captured and precisely measured. A four-octave quadratic B-spline wavelet transform was applied to single-sweep ERPs recorded in an auditory oddball paradigm. Frequency components in delta, theta, and alpha ranges reflected specific aspects of cognitive information processing. Furthermore, the temporal position of these components was related to specific cognitive processes.

Adolescent↗

Demographically adjusted normative standards for new indices of performance on the Paced Auditory Serial Addition Task (PASAT).

The Paced Auditory Serial Addition Task (PASAT) is a complex cognitive test sensitive to neuropsychological disorders. Its traditional Total Correct score seemingly reflects multiple cognitive abilities, including attention, working memory, and processing speed. Snyder, Aniskiewicz, and Snyder (1993) modified scoring guidelines for the PASAT to give credit only for "dyads." This method emphasizes working memory operations and has been found superior to Total Correct scores at detecting cognitive impairments in several investigations. To date, normative standards are not available for the "dyad" scoring method, thus limiting its utility in clinical and research settings. The current investigation provides demographically adjusted normative data based on a sample of 500 healthy adults of varied age, education, sex, and race (African American and Caucasian) for various indices of performance on the PASAT, including "Total Dyads" obtained across the four PASAT trials. In addition, we describe and present normative data on four other indices designed to quantify various aspects of performance on the PASAT: invalid responding, effects of varied information processing speed demands, and tendency to omit responses and to make arithmetic errors.

Abstracting and Indexing↗

Content and predictors of the ethnic identity of Russian-speaking immigrant adolescents in Finland.

The content and predictors of the ethnic identity of Russian-speaking immigrant adolescents (N = 170) in Finland were investigated. The ethnic identity of immigrants was found to be composed of two dimensions, one reflecting the cognitive, evaluative and emotional components of their Russian identity and the other reflecting those of their Finnish identity. The ethnic and linguistic self-identifications of adolescents were strongly related to the extent of and the value given to the Russian and Finnish identity, but neither to the frequency of using nor to their proficiency in the respective languages. The immigrants' perceptions of the relationships with parents were strongly related to their Russian identity. This association was, however, very different for girls and boys. In addition, the Russian contact orientation and Russian language use were strong predictors of the adolescents' Russian identity, whereas their Finnish contact orientation and Finnish language use strongly predicted their Finnish identity.

Acculturation↗

Multiple neuronal networks mediate sustained attention.

Sustained attention deficits occur in several neuropsychiatric disorders. However, the underlying neurobiological mechanisms are still incompletely understood. To that end, functional MRI was used to investigate the neural substrates of sustained attention (vigilance) using the rapid visual information processing (RVIP) task in 25 healthy volunteers. In order to better understand the neural networks underlying attentional abilities, brain regions where task-induced activation correlated with task performance were identified. Performance of the RVIP task activated a network of frontal, parietal, occipital, thalamic, and cerebellar regions. Deactivation during task performance was seen in the anterior and posterior cingulate, insula, and the left temporal and parahippocampal gyrus. Good task performance, as defined by better detection of target stimuli, was correlated with enhanced activation in predominantly right fronto-parietal regions and with decreased activation in predominantly left temporo-limbic and cingulate areas. Factor analysis revealed that these performance-correlated regions were grouped into two separate networks comprised of positively activated and negatively activated intercorrelated regions. Poor performers failed to significantly activate or deactivate these networks, whereas good performers either activated the positive or deactivated the negative network, or did both. The fact that both increased activation of task-specific areas and increased deactivation of task-irrelevant areas mediate cognitive functions underlying good RVIP task performance suggests two independent circuits, presumably reflecting different cognitive strategies, can be recruited to perform this vigilance task.

Adolescent↗

P300 event-related potentials and cognitive function in social phobia.

The aim of the study was to investigate abnormalities of event-related potentials (ERPs) in social phobia patients indicating deficits in speed and amount of perceptual and cognitive resources as well as relationships between ERPs and cognitive functioning. ERPs were recorded from 19 EEG leads in a two-tone oddball paradigm in medication-free patients with DSM-IV social phobia (n=25) and in age- and sex-matched healthy controls (HC). Neuropsychological test performance was administered. Compared with the HC group, patients with social phobia showed reductions in N1 at temporal leads, N2 and P300 amplitudes, predominantly centroparietally, and longer P300 latencies. The observed P300 latency prolongation was associated with reduced Non-Verbal Learning Test (NVLT) but not the Wisconsin Card Sorting Test (WCST) scores. The reduction in N1 amplitude indicates an impairment in perceptual processing. The reduced P300 amplitudes may reflect reduced cognitive resources for the evaluation of relevant information. The increased P300 latency, indicating longer stimulus evaluation time, was correlated to deficits in learning processes as measured by the Non-Verbal Learning Test but not to executive function as measured by the Wisconsin Card Sorting Test. It may therefore be concluded that social phobia patients show deficits in cognitive information processing as reflected by ERPs.

Adult↗