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Results for “Decamethonium Compounds”

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At least 181 records · Page 10Linked to original sources
PubMed1969

Effects of quaternary ammonium compounds on choline transport in red cells.

1. Neuromuscular blocking agents have been shown to be powerful inhibitors of choline transport in human erythrocytes. Ganglionic blocking agents were weaker inhibitors.2. The affinity of the choline transport site for alkyltrimethylammonium compounds was considerably higher than its affinity for alkyl-bis-(trimethylammonium) compounds of similar chain length. The affinity increases with increasing length of the alkyl chain in both series.3. Tetramethylammonium (TMA), ethyl- and propyltrimethylammonium appear to enter the cells on the choline carrier while the larger monoquaternary compounds, and the bisquaternary compounds, bind to the carrier but are unable to cross the cell membrane.4. Radioactively labelled carbachol, acetylcholine and decamethonium do not enter the cells on the choline carrier.5. Choline transport in erythrocytes from patients with myasthenia gravis is normal, suggesting that this disorder is not associated with a generalized defect of choline transport.

Acetylcholine↗
PubMed1962

Blocking action of decamethonium at different sites in the autonomic nervous system of the cat.

Doses of decamethonium sufficient to paralyse skeletal and respiratory muscles in the cat for 20 to 30 min can reversibly block transmission at several sites in the autonomic nervous system. The sympathetic vasodilator outflow to skeletal muscle was blocked at the post-ganglionic nerve endings, probably by preventing the release of acetylcholine. The effects of vagal stimulation on heart-rate and intestinal contraction were blocked in most experiments, possibly by an action on pre-ganglionic as well as post-ganglionic nerve endings. However, decamethonium did not block all cholinergic nerve endings-for example, it did not diminish either the effects of stimulation of the chorda tympani on the submandibular salivary gland or those of pelvic nerve stimulation on the bladder.

Acetylcholine↗
PubMed1992

[Resistance of hospital strains of microorganisms to antibiotics and antiseptics].

The development of resistance of collection and freshly isolated S. aureus and C. albicans strains to the antiseptic decamethoxim and an original diarylcyclohexane derivative was studied comparatively in vitro. It was shown that the rate of the resistance development was low. After 20 subcultures in the presence of increasing concentrations of decamethoxin, its sensitivity of S. aureus and C. albicans decreased 16-32 and 16-fold respectively. After 20 subcultures in the presence of increasing doses of the diarylcyclohexane derivative, its sensitivity S. aureus and C. albicans decreased 4- and 4-8-fold, respectively. It was found that in the hospital strains of S. aureus and C. albicans, the antibiotic resistance and sensitivity to decamethoxin and the diarylcyclohexane remained high, which indicated that there was no cross resistance to these compounds in the strains studied.

Anti-Infective Agents, Local↗