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Health problems after travel to developing countries.

Travelers to developing countries participated in a follow-up study of the health risks associated with short (less than three months) visits to these nations. Travelers to the Greek or Canary Islands served as a control cohort. Participants completed a questionnaire to elicit information regarding pretravel vaccinations, malaria prophylaxis, and health problems during and after their journey. Relevant infections were confirmed by the respondent's personal physician. The questionnaire was completed by 10,524 travelers; the answer rate was 73.8%. After a visit to developing countries, 15% of the travelers reported health problems, 8% consulted a doctor, and 3% were unable to work for an average of 15 days. The incidence of infection per month abroad was as follows: giardiasis, 7/1,000; amebiasis, 4/1,000; hepatitis, 4/1,000; gonorrhea, 3/1,000; and malaria, helminthiases, or syphilis, less than 1/1,000. There were no cases of typhoid fever or cholera.

Adult↗

The tobacco problem: commercial profit versus health--the conflict of interests in developing countries.

As smoking gradually decreases in developed countries, the tobacco epidemic is overtaking developing countries, where the legislative controls and other measures, which in industrialised countries succeed in limiting tobacco use, either do not exist or are, at best, inadequate. Of particular concern is the penetration of developing countries by the transnational tobacco companies, who with aggressive promotional campaigns and the use of political and commercial pressures, open up markets to promote foreign cigarettes. The number of smokers in developing countries will inevitably increase, due to the rise in population, increased smoking among youth and women, lack of awareness of the harmfulness of tobacco, shortage of funding for tobacco control measures, and difficulties in implementing legislation. An appalling increase is predicted in disease, disability, and death from tobacco in developing countries. Developing countries must exercise their own public health responsibility and implement measures to reduce the growing tobacco epidemic. Health concerns in Western countries can assist by bringing these issues to public and government attention in order to ensure that transnational tobacco companies, at minimum, adhere to the same standards of product, marketing, promotion, and sales in developing countries as are required in their country of origin; that these tobacco companies should desist from lobbying and pressuring the governments of developing countries to prevent the passing and implementing of antitobacco measures; that the United States and UK governments desist from helping their tobacco companies with export activities; and that Western expertise in countering the tobacco epidemic be shared with developing countries so that the West becomes an exporter of health rather than of tobacco-related diseases.

Adolescent↗

Perinatal HIV transmission: developing country considerations.

In many developing countries, because the prevalence of maternal HIV infection is high (more than 30% in some sub-Saharan African countries) and the resources commonly used to prevent transmission in developed countries are generally not available, transmission of HIV from mother to infant is a devastating problem. Countries already experiencing infant mortality rates 10- to 20-fold greater than those in developed countries can expect a doubling of infant and childhood mortality due to HIV. Those infants who escape infection themselves can expect to be orphaned in early childhood. Low-cost antiviral therapy can reduce transmission substantially, but many countries do not have the infrastructure to screen pregnant women for HIV and appropriately treat the mothers and infants. In developing countries, reduction in maternal-child transmission is feasible, but will require substantial additional resources and a well-functioning obstetric care system.

Anti-HIV Agents↗

HIV and infant feeding: issues in developed and developing countries.

Women in developed countries who are human immunodeficiency virus (HIV)-positive generally feed their infants formula to avoid virus transmission via breastfeeding. However, for most of the world's women who are HIV positive, the choice of infant feeding method is not so clear. Poor socioeconomic and living conditions place infants on breast milk substitutes at higher risk of non-HIV infectious diseases as compared with breastfed infants. Mothers in these settings who are HIV positive must weigh the risks and benefits of breastfeeding to choose the best infant feeding option.

Breast Feeding↗

Specific problems of the diabetic foot in developing countries.

As in many developed countries, diabetic foot disease is also resulting in major debilitating complications with severe morbidity and possible amputations in many developing countries. The developing countries, however, have certain specific cultural and social habits that may put a person with diabetes at a higher risk. The high prevalence of neuropathy promotes recurrence of foot infections and these are seldom treated adequately. Lack of facilities in nearby hospitals and unsatisfactory metabolic control are major contributory factors for foot problems. Regular inspection of the feet for signs of neuropathy and other risk factors would play a major role in the prevention of these complications. Patient education for foot care and early institution of preventive measures by the medical practitioners, particularly in view of the high prevalence of neuropathy, will help in reducing the morbidity and economic burden from diabetic foot.

Costs and Cost Analysis↗

The health transition in developing countries: a role for internists from the developed world.

Demographic and epidemiologic changes that have occurred in the past five decades in many developing countries provide new opportunities for internists from developed countries to contribute to improvements in international health. These changes, called the "health transition," are characterized by major growth in the number and proportion of middle-aged and elderly persons and in the frequency of the chronic diseases that occur in these age groups. The health transition is the result of concentrated national and international efforts to improve maternal and child health by emphasizing primary care and community-organized outreach services. In many developing countries, such efforts have been responsible for a decrease in the birth rate; reduced maternal mortality; improved preventive services; and a vigorous therapeutic approach to infantile diarrhea and respiratory infection, which, in turn, have resulted in the reduced infant mortality and the increased life expectancy that defines the health transition. These changes, often accompanied by increasing urbanization and industrialization, are creating health problems similar to those seen in the "developed" world but are occurring in countries that have far fewer resources. Internists interested in working in developing countries can therefore bring their skills, experience, and perspective to bear on these problems, primarily by working within well-structured programs, the aim of which is to strengthen the capacity of the organizations and institutions within these countries to cope with the rising tide of chronic adult diseases.

Delivery of Health Care↗

An open label evaluation of topotecan in patients with relapsed or refractory epithelial ovarian cancer - single institution experience in a developing country.

Investigators in developing countries rarely get an opportunity to participate in clinical drug trials in oncology. We recently participated in two clinical trials involving the use of topotecan in patients with advanced epithelial ovarian cancer who had failed initial platinum based chemotherapy. It provided us an opportunity to gain experience with the use of a rather highly myelosuppressive drug and also enabled us to compare our data with those reported from the western countries. Thirty-nine patients with good performance status and adequate bone marrow, liver, and renal functions were accrued. All patients had previously received at least one platin containing regimen of chemotherapy. The most common histologic sub type was serous adenocarcinoma. Almost half of the patients had platinum refractory disease. Mean number of cycles delivered was 7.5. Eleven patients (28%) achieved complete or partial remission. Time to progression was 4.6 months. Mean overall survival was 11.3 months. Toxicity was primarily hematologic and manageable. Performance status was the only variable predictive of response. Ability to obtain informed consent, data management, and availability of adequate radiologic and laboratory facilities were important limitations. Our results confirm the applicability of results obtained in the western countries to other patient groups and ability to conduct clinical trials in oncology in the developing countries.

Journal Article↗

Body size at birth and blood pressure among children in developing countries.

BACKGROUND: Studies in developed countries have shown that reduced fetal growth is related to raised blood pressure in childhood and adult life. Little is known about this association in developing countries, where fetal growth retardation is common. METHODS: In 1994-1995, we measured blood pressure in 1570 3-6-year-old children living in China, Guatemala, Chile, Nigeria and Sweden. We related their blood pressure to patterns of fetal growth, as measured by body proportions at birth. The children were all born after 37 weeks gestation and weighed more than 2.5 kg at birth. RESULTS: In each country, blood pressure was positively related to the child's current weight. After adjusting for this and gender, systolic pressure was inversely related to size at birth in all countries except Nigeria. In Chile, China and Guatemala, children who were proportionately small at birth had raised systolic pressure. For example, in Chile, systolic pressure adjusted for current weight increased by 4.9 mmHg (95% CI : 2.1, 7.7) for every kilogram decrease in birthweight, by 1 mmHg (95% CI : 0.4, 1.6) for every centimetre decrease in birth length, and by 1.3 mmHg (95% CI : 0.4, 2.2) for every centimetre decrease in head circumference at birth. In Sweden, systolic pressure was higher in children who were disproportionately small, that is thin, at birth. Systolic pressure increased by 0.3 mmHg (95% CI : 0.0, 0.6) for every unit (kg/m3) decrease in ponderal index at birth. These associations were independent of the duration of gestation. CONCLUSIONS: Raised blood pressure among children in three samples from China, Central and South America is related to proportionate reduction in body size at birth, which results from reduced growth throughout gestation. The relation between fetal growth and blood pressure may be different in African populations. Proportionately reduced fetal growth is the prevalent pattern of fetal growth retardation in developing countries, and is associated with chronic undernutrition among women. Improvement in the nutrition and health of girls and young women may be important in preventing cardiovascular disease in developing countries.

Birth Weight↗

Implementing electronic medical record systems in developing countries.

The developing world faces a series of health crises including HIV/AIDS and tuberculosis that threaten the lives of millions of people. Lack of infrastructure and trained, experienced staff are considered important barriers to scaling up treatment for these diseases. In this paper we explain why information systems are important in many healthcare projects in the developing world. We discuss pilot projects demonstrating that such systems are possible and can expand to manage hundreds of thousands of patients. We also pass on the most important practical lessons in design and implementation from our experience in doing this work. Finally, we discuss the importance of collaboration between projects in the development of electronic medical record systems rather than reinventing systems in isolation, and the use of open standards and open source software.

Computer Security↗

Water safety plans for small systems: a model for applying HACCP concepts for cost-effective monitoring in developing countries.

The development of water safety plans (WSPs) for small systems should be based on a thorough understanding of the relationships between risk factors and contamination events. This can be achieved through the use of well-designed assessments of water quality that provide better evidence to support the identification of control measures, performance limits, monitoring parameters and verification procedures. Training of community operators is critical to the success of the WSP and the understanding gained from the assessments provides a sound basis for addressing these needs. The WSP approach provides for more effective control of water quality and the use of targeted assessments is cost-effective in improving the design of WSPs.

Cost-Benefit Analysis↗

Food from developing countries: steps to improve compliance.

Developing countries seeking to expand their exports often turn to food exports and seek to market these products in developed countries such as the United States. To be successful, developing countries must overcome an array of obstacles, including the need to comply with the food safety and other requirements of the importing country. This article discusses how compliance with international food norms and national food laws benefits exporting and importing countries, what trends in food trade influence measures to deal with food problems, and what categories of controls are available to deal with good products offered for importation. The article concludes by outlining several suggested steps that can be taken to improve the likelihood of acceptability of food offered for importation. These steps include assessing the needs of the importing country and improving the physical, legal, and technical infrastructure in various ways. Technical assistance from developed countries and international organizations can assist developing countries, but such assistance needs to be carefully designed and coordinated.

Commerce↗

Socioeconomic disadvantage and adolescent women's sexual and reproductive behavior: the case of five developed countries.

CONTEXT: Differences among developed countries in teenagers' patterns of sexual and reproductive behavior may partly reflect differences in the extent of disadvantage. However, to date, this potential contribution has received little attention. METHODS: Researchers in Canada, France, Great Britain, Sweden and the United States used the most current survey and other data to study adolescent sexual and reproductive behavior. Comparisons were made within and across countries to assess the relationships between these behaviors and factors that may indicate disadvantage. RESULTS: Adolescent childbearing is more likely among women with low levels of income and education than among their better-off peers. Levels of childbearing are also strongly related to race, ethnicity and immigrant status, but these differences vary across countries. Early sexual activity has little association with income, but young women who have little education are more likely to initiate intercourse during adolescence than those who are better educated. Contraceptive use at first intercourse differs substantially according to socioeconomic status in some countries but not in others. Within countries, current contraceptive use does not differ greatly according to economic status, but at each economic level, use is higher in Great Britain than in the United States. Regardless of their socioeconomic status, U.S. women are the most likely to give birth as adolescents. In addition, larger proportions of adolescents are disadvantaged in the United States than in other developed countries. CONCLUSIONS: Comparatively widespread disadvantage in the United States helps explain why U.S. teenagers have higher birthrates andpregnancy rates than those in other developed countries. Improving U.S. teenagers' sexual and reproductive behavior requires strategies to reduce the numbers of young people growing up in disadvantaged conditions and to help those who are disadvantaged overcome the obstacles they face.

Adolescent↗

Metropolitan concentration in developing countries.

"We examine the economic, political and cultural determinants of urban concentration in developing countries using a sample of 53 countries. We find that as countries develop, urban concentration, measured as the largest city's share of the population, at first increases and then decreases. We also find that foreign investment influences concentration in a similar way since foreign investors tend to locate in the main city at low levels of development but are willing to locate outside the center in more developed countries. Political and cultural factors such as lack of democracy, government instability and religiously and [ethnically] homogeneous populations all contribute to high levels of urban concentration. For many developing countries these non-economic factors have led to primate cities whose size far exceeds what would be justified by economic considerations." (SUMMARY IN FRE AND GER)

Culture↗

A community approach to the prevention of dental disease in the children of developing countries.

Even in developed Western countries the ready availability of sophisticated restorative dentistry has been relatively unsuccessful in reducing the prevalence of dental disease. It is therefore totally wrong to seek to impose a similar structure of dental care in the developing countries with their shortages of wealth, communications and trained personnel. Instead, the emphasis must be on education and the application of preventive methods by relatively simply trained personnel working with the support and under the guidance of a few fully trained dentists. The establishment of a dental service in the developing countries must contain the following three elements. First, the undertaking of a nationwide survey of the prevalence of dental disease. Next the establishment of training schools in each ethnic area where dental surgeons, dental therapists and dental assistants can be recruited and trained. Lastly, the recruitment and training of local instructors in dental health to work in their own schools, villages and districts, concerned with the supervision of oral hygiene, fluoride mouthrinsing and diet. This scheme is based on the principle of self help through locally recruited and trained personnel and the encouragement of community pride in positive dental health.

Child↗

Medical technology and developing countries: the case of Brazil.

Developing countries, faced with severe resource limitations, are trying to develop modern health care services that deliver sensible medical technologies. Because of their lack of development, these countries must import much technology, while often lacking the expertise to make wise choices. In this article, the case of Brazil is examined. Brazil has shared many of the problems of other developing countries, including inadequate access of the population to health services, maldistribution and excessive use of technology, a relatively weak national industry for production of drugs and medical devices, a weak policy structure for dealing with medical technology, and little tradition of using research or policy analysis as a guide to action. Since the election in 1985 that returned Brazil to democratic rule, the government has taken active steps to address many of these problems. The example of Brazil is important for all of the developing world to examine and follow, where applicable. In addition, North American and European aid programs could play a much more constructive role in helping less developed countries develop their health care services. International organizations such as the World Health Organization must also be active in assisting such countries to improve their decisions concerning medical technology.

Brazil↗

Assessment of national family planning programs in developing countries.

Today, 34 developing countries have policies and programs to lower fertility, and an additional 32 countries provide family planning services for health and humanitarian reasons. Specific causal relationships and linkages between social and economic development, family planning programs, and fertility levels and changes remain mostly unclear at this point. Based on percent acceptors, percent users, and changes in fertility rates (the most commonly used measures to evaluate family planning program accomplishments), however, the performance of programs on the whole has been moderately encouraging.

Abortion, Legal↗

Efficacy and limitations of QBC acridine orange staining as a routine diagnostic technique for malaria in developing countries.

The recently developed QBC technique has been reported to be rapid, sensitive and specific for the detection of malaria infection. We evaluated this technique in comparison with thin and thick Giemsa stained blood films for the diagnosis of malaria in acute fever and PUO cases. The technique was slightly more sensitive than thin blood film but equal to thick blood film examination. Identification of species of malaria posed some difficulties. Due to its high cost and requirement for a fluorescent microscope this technique, in spite of its speed and sensitivity, may not have the potential to be a substitute for the conventional blood film examination for the diagnosis of malaria, especially in developing countries.

Acridine Orange↗