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PubMed2001

The Virtual Cell: a software environment for computational cell biology.

The newly emerging field of computational cell biology requires software tools that address the needs of a broad community of scientists. Cell biological processes are controlled by an interacting set of biochemical and electrophysiological events that are distributed within complex cellular structures. Computational modeling is familiar to researchers in fields such as molecular structure, neurobiology and metabolic pathway engineering, and is rapidly emerging in the area of gene expression. Although some of these established modeling approaches can be adapted to address problems of interest to cell biologists, relatively few software development efforts have been directed at the field as a whole. The Virtual Cell is a computational environment designed for cell biologists as well as for mathematical biologists and bioengineers. It serves to aid the construction of cell biological models and the generation of simulations from them. The system enables the formulation of both compartmental and spatial models, the latter with either idealized or experimentally derived geometries of one, two or three dimensions.

Biology↗

PubMed2001

[The main health problems according to patients' opinion].

OBJECTIVE: To know the health problems or diseases that patients of 2 basic health areas (BHA) assess as the most important for Spanish population and for themselves; to know if any relation exists between these problems and their existence in the family or social patients' environment. DESIGN: An observational cross-sectional and descriptive study. SETTING: Four clinics of the BHA Sant Josep (L'Hospitalet de Llobregat) and 2 clinics of the BHA Sant Martí (Barcelonés).Patients. The sample consists of 360 patients aged above 26 years who attended clinics for some health problem. Participants were chosen by a randomised systematic sampling, from May to October 2000. MEASUREMENTS AND MAIN RESULTS: Data were gathered from a questionnaire of ten items. According with the participants, the main problems for Spanish population and for themselves were: cancer, cardiovascular diseases and AIDS. Cancer (58,61%; 95% CI, 53,53-63,69) and AIDS (15,27%; 95% CI, 11,56-18,98) are the problems pointed out as research priorities. The aparato locomotor (22,10%; 95% CI, 17,82-26,38), hypertension (14,74%; 95% CI, 11,08-18,40) and diabetes (13,14%, 95% CI, 9,66-16,62) are the main problems suffered by the surveyed. Cancer is the disease that more participants' relatives suffered. CONCLUSIONS: Cancer and cardiovascular diseases are the pathologies that cause more concern among the surveyed and these are the diseases which mostly affect their relatives and relationships. Nevertheless their worry for the AIDS don't show their immediate reality. Frequently, patients don't recognize the health problem that motivated their visit as a real disease.

Cross-Sectional Studies↗

PubMed2002

[Effectiveness of a personalized information system on the quality of family doctors' medical prescription].

OBJECTIVES: To evaluate the effectiveness of a system of personalised prescription information (PPI) to improve prescription habits of family doctors (FD); to examine how useful PPI is in maintaining these habits, and to analyse its influence through factors of the doctor and his/her environment. DESIGN: Cross-sectional, descriptive pilot study to analyse conditioning factors and possible confusion; quasi-experimental intervention study to assess the effectiveness of PPI, with two groups (experimental and control) and 4 determinations (before the PPI and after: short, medium and long-term).Setting. Family doctors in the Murcia Region. SUBJECTS OF STUDY: The prescriptions of all family doctors in the Murcia region which started before PPI and which continued until the end of the study and without absences of over 10% at each measurement.Intervention. The family doctors from the Murcia city area formed the experimental group: they received PPI with specific proposals for improvement. The FDs of Cartagena and Lorca, who did not receive PPI, made up the control group. Statistical analysis. Logistical regression to identify conditioning factors. Z comparison of proportions contrasted with one-tail hypothesis to check the effectiveness of PPI. LIMITATIONS OF THE DESIGN: Non-randomised allocation to groups made comparison difficult: conditioning factors for stratification or adjustment were studied. PRACTICAL APPLICATION: Confirmation of PPI s effectiveness justifies its dissemination. If there is no such confirmation, it will have to be perfected. Isolating the factors conditioning prescription that can be modified helps find ways to improve PPI.

Cross-Sectional Studies↗

PubMed2004

[How suitable is thromboembolism prophylaxis for patients with chronic auricular fibrillation at 3 primary care centers].

OBJECTIVE: To find just how suitable thromboembolism prophylaxis (TEP) is in a group of patients with chronic auricular fibrillation belonging to the primary care environment. DESIGN: Cross-sectional and descriptive multi-centre study. SETTING: The study was performed at 3 urban primary care centres in Madrid. PARTICIPANTS: All the patients recorded up to April 2001 with the diagnosis of chronic auricular fibrillation (n=274) were included. Patients with no clinical history or who had a valve prosthesis were excluded. MAIN MEASUREMENTS: Demographic variables, existence of factors of risk of embolism, presence of counter-indications for oral anti-coagulants, and the kind of thromboembolic prophylaxis taken were collected. RESULTS: A total of 274 patients were evaluated. Average age was 75 (SD, 9) and 52% were women. 82% of patients had at least one factor of risk of thromboembolism. The most commonly used kind of TEP was oral anti-coagulants. 45% of patients did not receive suitable TEP. 13.5% of patients at risk of embolism and who had no kind of TEP were found. CONCLUSIONS: There is a high percentage of patients with chronic auricular fibrillation and a high risk of embolism, who do not receive adequate TEP, in the absence of counter-indications to taking oral anticoagulants. There is great scope for improvement, which is within professionals' possibilities.

Age Distribution↗

PubMed2003

The potential use of constructed wetlands in a recirculating aquaculture system for shrimp culture.

A pilot-scale constructed wetland unit, consisting of free water surface (FWS) and subsurface flow (SF) constructed wetlands arranged in series, was integrated into an outdoor recirculating aquaculture system (RAS) for culturing Pacific white shrimp (Litopenaeus vannamei). This study evaluated the performance of the wetland unit in treating the recirculating wastewater and examined the effect of improvement in water quality of the culture tank on the growth and survival of shrimp postlarvae. During an 80-day culture period, the wetland unit operated at a mean hydraulic loading rate of 0.3 m/day and effectively reduced the influent concentrations of 5-day biochemical oxygen demand (BOD5, 24%), suspended solids (SS, 71%), chlorophyll a (chl-a, 88%), total ammonium (TAN, 57%), nitrite nitrogen (NO2-N, 90%) and nitrate nitrogen (NO3-N, 68%). Phosphate (PO4-P) reduction was the least efficient (5.4%). The concentrations of SS, Chl-a, turbidity and NO3-N in the culture tank water in RAS were significantly (P<or=.05) lower than those in a control aquaculture system (CAS) that simulated static pond culture without wetland treatment. However, no significant difference (P<or=.05) in BOD5, TAN and NO2-N was found between the two systems. At the end of the study, the harvest results showed that shrimp weight and survival rate in the RAS (3.8 +/-1.8 g/shrimp and 90%) significantly (P<or=.01) exceeded those in the CAS (2.3+/-1.5 g/shrimp and 71%). This study concludes that constructed wetlands can improve the water quality and provide a good culture environment, consequently increasing the shrimp growth and survival without water exchange, in a recirculating system.

Animals↗

PubMed2003

Analysis of the exterior colour of agroindustrial buildings: a computer aided approach to landscape integration.

The visual and aesthetic aspects of any object are defined by its colour, form, line and texture, to which might be added compositional reference elements such as scale and, in the case of three dimensional scenes, spatial character. This paper investigates one of these colour and proposes a method for predicting the value of a building's integration into the landscape. Based on psychological aspects, the method uses computers to analyse and measure the pertinent attributes. The designer can analyse visual elements in terms of the properties that define them. For example, colour, the subject of this paper, is defined by its hue, saturation and lightness. Tables are proposed to study the relationship between buildings and their background using computers. This paper offers a tool, based on the digital examination of scenes and on people's integration preferences with respect to agroindustrial buildings, which it is hoped will help project designers select appropriate colour schemes.

Agriculture↗

PubMed2003

A multi-agent intelligent environment for medical knowledge.

AMPLIA is a multi-agent intelligent learning environment designed to support training of diagnostic reasoning and modelling of domains with complex and uncertain knowledge. AMPLIA focuses on the medical area. It is a system that deals with uncertainty under the Bayesian network approach, where learner-modelling tasks will consist of creating a Bayesian network for a problem the system will present. The construction of a network involves qualitative and quantitative aspects. The qualitative part concerns the network topology, that is, causal relations among the domain variables. After it is ready, the quantitative part is specified. It is composed of the distribution of conditional probability of the variables represented. A negotiation process (managed by an intelligent MediatorAgent) will treat the differences of topology and probability distribution between the model the learner built and the one built-in in the system. That negotiation process occurs between the agents that represent the expert knowledge domain (DomainAgent) and the agent that represents the learner knowledge (LearnerAgent).

Artificial Intelligence↗

PubMed1997

Vein grafts: haemodynamic forces on the endothelium--a review.

OBJECTIVE: To review the mechanisms believed to be important in the development of vein graft stenosis, with particular attention placed on the adaptation of saphenous vein endothelium to a new haemodynamic environment. DESIGN AND METHODS: Discussion based on review of published research. RESULTS: The aetiology of vein graft stenosis remains to be established and appears to be multi-factorial. The increasing evidence for an important role of haemodynamic forces is discussed, particularly via the interaction of these force with the endothelium. CONCLUSION: Further understanding of the interaction between haemodynamic forces, blood constituents and the newly implanted vein graft is required. Use of in vitro models is contributing increasing knowledge to this area, but ultimately better non-invasive methods of assessing haemodynamic forces in vivo are required.

Animals↗

PubMedDate not supplied

Pharmacists' attitudes regarding quality of worklife.

OBJECTIVE: To examine the quality of worklife of pharmacists across practice environments. DESIGN: Written survey mailed to a stratified random sample of pharmacists. PARTICIPANTS: 2,014 pharmacist-members of the American Pharmaceutical Association (APhA) residing in the United States. MAIN OUTCOME MEASURES: Work-related attitudes including job satisfaction, career satisfaction, organizational commitment, turnover intention, likelihood of voting for a union, and patient care issues. RESULTS: Usable surveys were returned by 1,199 practicing APhA members (60% response rate). Overall, work-related attitudes were generally positive. However, clear differences were identified in quality-of-worklife perceptions associated with practice setting, area of primary responsibility, and several demographic variables. Some quality-of-worklife concerns were found in all practice settings. While a majority of respondents indicated that they would not vote for a union at their place of employment if given the opportunity, 43% of staff employee pharmacists (who would likely be targeted in any union campaign) indicated that they would definitely or probably vote for a union. CONCLUSION: From the pharmacist's perspective, important quality-of-worklife issues include job and career satisfaction, turnover intention, and patient care concerns. The data provide a point of departure for future dialogue, action, and research aimed at understanding and enhancing the quality of pharmacists' worklife.

Adult↗

PubMed2005

Quantum computing via defect states in two-dimensional antidot lattices.

We propose a new structure suitable for quantum computing in a solid-state environment: designed defect states in antidot lattices superimposed on a two-dimensional electron gas at a semiconductor heterostructure. State manipulation can be obtained with gate control. Model calculations indicate that it is feasible to fabricate structures whose energy level structure is robust against thermal dephasing.

Computer Simulation↗

PubMed2001

Mammography utilization among california women age 40-49 in a managed care environment.

OBJECTIVE: To examine the utilization of screening mammography and the relationship between risk factors and mammography use in women age 40-49 in a managed care environment. DESIGN: Retrospective observational study based on a mailed survey. SETTING: A large HMO in California. PATIENTS/PARTICIPANTS: The study population included respondents age 40-49 who completed a breast health assessment questionnaire mailed to all women age 34-49 and enrolled in a California HMO in early 1997. MAIN RESULTS: About 67.6% of the 20,391 women age 40-49 had at least one mammogram during 1995 and 1996. Logistic regression revealed that women age 40-44 were less likely (odds ratio: 0.83-0.90) than women age 45-49 to obtain mammography. Family history of breast cancer (odds ratio: 1.12-1.16), breast biopsy (odds ratio: 1.14-1.18), and a mammogram in the previous three years (odds ratio: 1.15-1.18) were associated with an increased likelihood of taking a mammogram. However, monthly breast self-exams (odds ratio: 0.996-1.04), having a child at or after age 30 (odds ratio: 0.97-1.02), and having menarche at age 12 or younger (odds ratio: 0.96-1.01) had no significant effect on the screening mammography rates. CONCLUSION: A relatively higher percentage of younger HMO members receive screening mammography than that of general population. However, some higher-risk groups, especially women whose first pregnancies were late in life, do not show a higher rate of using mammography.

Adult↗

PubMed1998

Comparison of the frequency and enjoyability of pleasant events in cocaine abusers vs. non-abusers using a standardized behavioral inventory.

AIMS: To examine whether cocaine abusers differ from non-abusers in their frequency and enjoyability of engaging in various "pleasant events", in order to approximate the density of positive reinforcement experienced in their natural environment. DESIGN: Comparisons of cocaine abusers to normative data and matched controls. SETTING: An outpatient substance abuse treatment center in Burlington, Vermont, USA. PARTICIPANTS: Subjects included 100 individuals enrolled in outpatient treatment for cocaine abuse or dependence and 50 community volunteers without histories of drug abuse or other major psychiatric illness and matched to cocaine-dependent patients on age, sex and SES. MEASUREMENTS: Diagnostic assessments were based upon clinical interviews using the DSM-III-R checklist. The primary focus of this study was the Pleasant Events Schedule (PES), a self-rated behavioral inventory of the frequency and enjoyability of engaging in "pleasant" activities. Cocaine use history, treatment outcome and other relevant variables were also assessed. FINDINGS: Cocaine abusers reliably reported lower frequency of non-social, introverted, passive outdoor and mood-related activities than controls. These differences remained after controlling for demographic and life-style differences between groups, with the exception of mood-related activities. Perceived enjoyability of the activities did not differ across groups. Intravenous cocaine use and prior treatment for cocaine abuse predicted particularly low frequency of pleasant activities. Greater frequency of non-social activities predicted better treatment outcome. CONCLUSIONS: Drug abuse is associated with low density of certain types of non-drug reinforcement. Systematic increases in these activities may improve treatment outcome.

Adult↗

PubMed2002

Effects of paternal drinking, conduct disorder and childhood home environment on the development of alcohol use disorders in a Thai population.

AIMS: To identify influences on the development of alcohol use disorders in a Thai population, particularly parental drinking and childhood environment. DESIGN: Case-control study. SETTING: A university hospital, a regional hospital and a community hospital in southern Thailand. PARTICIPANTS: Ninety-one alcohol-dependents and 77 hazardous/harmful drinkers were recruited as cases and 144 non- or infrequent drinkers as controls. MEASUREMENTS: Data on parental drinking, family demographic characteristics, family activities, parental disciplinary practice, early religious life and conduct disorder were obtained using a structured interview questionnaire. The main outcome measure was the subject's classification as alcohol-dependent, hazardous/harmful drinker or non-/infrequent drinker. FINDINGS: A significant relationship was found between having a drinking father and the occurrence of hazardous/harmful drinking or alcohol dependence in the subjects. Childhood factors (conduct disorder and having been a temple boy, relative probability ratios, RPRs and 95% CI: 6.39, 2.81-14.55 and 2.21, 1.19-4.08, respectively) also significantly predicted alcohol dependence, while perceived poverty and ethnic alienation was reported less frequently by hazardous/harmful drinkers and alcohol-dependents (RPRs and 95% CIs=0.34, 0.19-0.62 and 0.59, 0.38-0.93, respectively) than the controls. The relative probability ratio for the effect of the father's infrequent drinking on the son's alcohol dependence was 2.92 (95% CI=1.42-6.02) and for the father's heavy or dependent drinking 2.84 (95% CI=1.31-6.15). CONCLUSIONS: Being exposed to a light-drinking father increases the risk of a son's alcohol use disorders exhibited either as hazardous-harmful or dependent drinking. However, exposure to a heavy- or dependent-drinking father is associated more uniquely with an increased risk of his son being alcohol-dependent. The extent to which this is seen in other cultures is worthy of exploration.

Adolescent↗

PubMed1997

Increased prevalence of colonic polyps and altered lymphocyte subset pattern in the colonic lamina propria in acromegaly.

OBJECTIVE: The balance of evidence suggests that acromegaly is a risk factor for colonic neoplasia. We have evaluated the prevalence of colonic polyps in acromegalics from Southern Italy and characterized the lymphocyte subsets in the colonic lamina propria in order to analyze differences in the colonic immunological environment. DESIGN: All the patients and controls were submitted to pancolonoscopy. Ten per-endoscopic biopsies of the intestinal mucosa surrounding polyps were carried out to evaluate lymphocyte subsets. PATIENTS: Fifty acromegalics and 318 sex- and age-matched controls entered this study. Colonic lamina propria lymphocyte subsets were studied in 34 patients and 34 controls. RESULTS: Colonic polyps were resected in 23 acromegalics (46%) and 42 controls (13.2%; P < 0.0001); hyperplastic polyps were found in 24% and 6.3%, adenomatous polyps in 22 and 6.9%, (P < 0.01), adenocarcinoma in 2 and 1.2% while synchronous polyps occurred in 18% and 2.5% (P < 0.01), respectively. The number of polyps was significantly correlated with age both in acromegalics (r = 0.422, P < 0.005) and in controls (r = 0.865, P < 0.001). However, polyp prevalence was greater in patients aged below 40 yrs (r.r = 1.9) and in patients with two or more skin tags (r.r = 1.2). A significant decrease of CD20, CD19, CD16, gamma/delta, CD4@leu8- and increase of CD3 and CD4+/leu8+ was found in the lamina propria lymphocyte subsets. CONCLUSIONS: The results of this study confirm that acromegalics are at increased risk of colonic polyps compared to the healthy population. The increased prevalence of premalignant polyps, namely the adenomatous type, suggests that acromegalics should undergo a careful screening and follow-up by pancolonoscopy. An impairment of mucosal immune surveillance seems to exist in acromegaly although a causal effect in the polyp formation cannot be ruled out.

Acromegaly↗

PubMed1999

Visiting elective students at the University of Toronto from the Korea University Medical College.

OBJECTIVES: The main goal of the international elective programme was to provide the Korean students with a cross-cultural educational environment. DESIGN: This programme was carried out on a voluntary basis during the summer vacation, rotating students through various clinical divisions in the teaching hospital. SETTING: The University of Toronto. SUBJECTS: Medical students from the Korea University Medical College. RESULTS: The students found the student-teacher relationship to be much more open and liberal. Due to a different curricular structure, the Canadians have better clinical skills and problem-solving abilities in real clinical settings. The cultural differences perceived by the students during the elective programme led them to believe that educational reform in Korea imperatively requires curricular change, but more importantly, a change in our traditional psychological and behavioural traits which derive from Confucianism. CONCLUSIONS: Extreme politeness, passiveness and blind respect for teachers, which are encouraged by Confucianism, are not effective in higher education. All the elective students, as well as the Canadian preceptors, believe that this programme is an invaluable asset.

Cross-Cultural Comparison↗

PubMed1999

Evaluating problem-based learning in a multilingual student population.

OBJECTIVES: The University of Natal Medical School in South Africa provides training for a student body composed of two groups: one with English as a first language and the other with an African language as a first language and English as the second. A new methodology was developed to evaluate an innovative course using modified problem-based learning techniques in this heterogeneous environment. DESIGN: The learning model proposed required achieving a balance of three components: content, enquiry/learning process and social interaction/group process. A multidimensional system, felt to be consistent with this educational philosophy, was developed using seven different quantitative and qualitative techniques. SETTING: The University of Natal Medical School. SUBJECTS: First-year multilingual medical students. RESULTS: The results revealed that social interaction was highly successful in reducing barriers between the student groups and between students and facilitators. However, the emphasis on group participation may have overshadowed the enquiry process, leading to superficial discussions of problems and feelings of repetitiveness. During the course students and facilitators expressed concern that the innovative assessments used did not assess the course content adequately. While the group presentations and projects were useful exercises for consolidation and group interaction, they did not enable facilitators to identify struggling students. CONCLUSIONS: The outcome of the evaluation stressed the need of achieving an appropriate balance both in the curriculum and assessments of the three components of the learning model, particularly in a setting where student backgrounds and language ability differ. Multidimensional methodology is needed for effective evaluation that promotes critical reflection.

Attitude of Health Personnel↗

PubMed2004

Changes in student approaches to learning with the introduction of computer-supported problem-based learning.

OBJECTIVES: To study changes in student approaches to learning following the introduction of computer-supported, problem-based learning. SETTING: Medical students at the University of Oslo undertake a 12-week period of clinical placement during their 10th term. In this period they continue to undertake problem-based learning (PBL) in the form of distributed problem-based learning (DPBL) in a computer-supported learning environment. DESIGN: A questionnaire focusing on learning styles, PBL, and information and communication technology (ICT) was distributed before and after the DPBL period. SUBJECTS: All students in their 10th term at the University of Oslo (n = 61). RESULTS: The introduction of DPBL did not seem to affect the participants' use of regulating strategies or their mental models of learning. After the DPBL period, group discussion and tutor input were reported to have less influence on students' self-study, while the students perceived themselves as being less active in groups and as expecting less from tutors. There was a relationship between perceived tutor influence and students' familiarity with ICT. The DPBL period seemed to increase students' task-related web accesses and use of experts, and to decrease their task-related use of textbooks and discussions with students outside the group. CONCLUSIONS: Students' general approaches to learning were not affected by the introduction of DPBL. However, there was a decrease in students' expectations concerning activity in the group and the importance of the tutor. These changes were related to students' familiarity with the use of computers. Web-based resources and experts became more important resources to the students during the DPBL period.

Adult↗

PubMed2001

Differential binding of X- and Y-chromosome-bearing human spermatozoa to zona pellucida in vitro.

The sex of human offspring has been associated with the day in the mother's menstrual cycle on which insemination occurs, with male zygotes being formed earlier in the fertile period than female zygotes. Using an in vitro environment designed to mimic the in vivo milieu, we tested the hypothesis that Y-chromosome-bearing spermatozoa survive functionally longer than X-chromosome-bearing spermatozoa, and that this differential functional survival is a contributing factor to the in vivo phenomenon. Donor semen was processed by swim-up and incubated at 37 degrees C in culture medium for 0, 24 and 48 h, with human zona pellucida (hemizona, HZ) being used to select functional spermatozoa. A second set of in vitro storage conditions, 4 degrees C in test-yolk refrigeration buffer, was used to determine whether changing the incubation conditions alters the process. The sex chromosome of the spermatozoa was determined using fluorescent in situ hybridization (FISH). For spermatozoa incubated at 37 degrees C, the percentage of functional (HZ bound) Y-bearing spermatozoa was significantly increased (P < 0.05) at 48 h (55.4 + 2.9%) but not at 0 h (50.5 + 0.7%) or 24 h (52.8 + 3.1%) compared to swim-up spermatozoa (50.6 + 0.3%). No difference in the percentage of functional Y-spermatozoa was observed at any time-point with storage at 4 degrees C in refrigeration buffer. Thus, we demonstrated that significantly more Y-bearing spermatozoa were capable of zona binding than X-bearing spermatozoa at 48 h at 37 degrees C incubation, with an observed Y : X ratio of 1.15 for these zona-bound spermatozoa compared to 1.02 for post-swim-up spermatozoa. We conclude that a differential functional survival appears to exist between X-bearing and Y-bearing spermatozoa, with the latter exhibiting a longer functional survival under in vitro conditions.

Cell Nucleus↗