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[Sarcoidosis gastropathy: diagnosis and contribution of echo-endoscopy].

We report a case of gastric sarcoidosis in a 36-year old woman. The clinical and endoscopic ultrasonography findings initially suggested linitis plastica. Subsequently the discovery of unexpected gastric and then, bronchial granulomas after bronchoscopy and bilateral ocular fixation on gallium scanning, led to the diagnosis of sarcoidosis. Endoscopic ultrasonography showed abnormal hypertrophy of the third hyperechoic layer. These findings usually suggest among the etiologies of giant gastric folds, malignant diseases and particularly linitis plastica.

Adult↗

Descending auditory system/cerebellum/tinnitus.

The cerebellum and the descending auditory system (DAS) are considered clinically significant for influencing the development of the clinical course of tinnitus of the severe disabling type. It is hypothesized that the SPECT of Brain perfusion asymmetries in cerebellum, demonstrated since 1993, reflect clinically the influence of an aberrant auditory stimulus i.e. tinnitus, on the activity and function of the descending auditory system highlighted by the cerebellum and the acousticomotor systems. SPECT of Brain perfusion asymmetries in the cerebellum have been demonstrated in 60-70% of tinnitus patients of the central type. Electrophysiologic support for this finding includes interference in ocular fixation suppression of the vestibulocular (VOR) with rotation and position testing. Abnormalities in cerebellar function are considered to reflect the psychomotor component of tinnitus. Support for the hypothesis is demonstrated with one patient with a predominantly central type tinnitus of the severe disabling type with cerebellar perfusion asymmetries and associated electrophysiologic evidence of interference in the VOR with rotation testing.

Acoustic Stimulation↗

Impact of path parameters on maze solution time.

In order to compare spatial attention and visual processing capabilities of humans and rhesus macaques, we developed a visual maze task both could perform. Maze stimuli were constructed of orthogonal line segments displayed on a monitor. Each was octagonal in outline and contained a central square (the 'start box'). A single ('main') path, containing a random number of turns, extended outward from the start box, and either reached an exit in the maze's perimeter, or a blind ending within the maze. Subjects maintained ocular fixation within the start box, and indicated their judgment whether the path reached an exit or not by depressing one of two keys (humans) or foot pedals (monkeys). Successful maze solution by human subjects required a minimum viewing time. Replacing the maze with a masking stimulus after a variable interval revealed that the percent correct performance increased systematically with greater viewing time, reaching a plateau of approximately 85% correct if mazes were visible for 500 ms or more. A multiple linear regression analysis determined that the response time of both species depended upon several parameters of the main path, including the number of turns, total length, and exist status. Human and nonhuman primates required comparable time to process each turn in the path, whereas monkeys were faster than humans in processing each unit of path length. The data suggest that a covert analysis of the maze proceeds from the center outward along the main path in the absence of saccadic eye movements, and that both monkeys and humans undertake such an analysis during the solution of visual mazes.

Animals↗

Posterior cortical atrophy.

Two patients had a steadily progressive disorder of higher cortical function dominated by the early development of cortical visual deficits. In one, a right visual inattention progressed over a period of 2 years to a complete right homonymous hemianopia and relative left inferior quadrantanopia. In the second case, blind in the left eye for unrelated reasons, a temporal field loss was noted at presentation in the right eye, with the subsequent development of field loss in the inferior nasal quadrant on that side. Features of Balint's syndrome developed in both patients, with sticky fixation, ocular dysmetria and simultanagnosia. Prominent associated features were progressive dysmnesia, dyscalculia, ideomotor apraxia and spatial disorientation. Abstract reasoning, speech function and insight were all well preserved. MRI and CT scans revealed no focal abnormalities. These cases are similar to the 5 recently described by Benson et al. The pathological basis is unknown but may be an atypical form of Alzheimer's disease.

Atrophy↗

[Clinical study of primary pontine hemorrhage].

Forty-three cases of primary pontine hemorrhage were seen in our hospital from 1979 to 1986. We studied the correlations between clinical signs, CT, ABR findings and their outcomes, and then reported surgical results. The case consisted of 30 males and 13 females between 32 to 73 years with an average age of 54.5. Thirty cases were confirmed to have had hypertension prior to the hemorrhage. In ten other cases hypertension was suspected, although their past histories were not obtained. In the remaining three cases, no hypertension was detected. On admission, comatose state, ocular fixation, absence of light reaction, tetraplegia, decerebrate posture, respiratory disturbance, tachycardia and hyperthermia were the signs of unlikely recovery. On the CT, the hematomas of the group of likely recovery patients were less than 25% of the cross section of the pons and lower midbrain in vertical. Greater size of hematomas were seen exclusively among the groups of death and severe disability cases. Acute stage ABR and CT findings showed discrepancy. We suggest, if ABR, CT findings and clinical symptoms were studied more in depth, it is possible to determine a patient's prognosis more precisely. Three cases were treated by Stereotactic Aspiration, three cases by ventricular drainage and the remaining thirty-seven cases conservatively. There was, however, no significant difference in recovery between surgically treated cases and conservatively treated one. We think that surgical indication is doubtful except for limited cases.

Adult↗

Seeing her looking at you: acquaintance and variation in the judgment of gaze depth.

The acquaintance of subject and looker as well as the depth of gaze affected male subjects' judgments of a female assistant's looking behavior. In a situation ruling out visual interaction, eye-contact gazes were located no more accurately than other gazes. Nevertheless, although gaze depths were not accurately discriminated, gazes deviating vertically and horizontally, to the edge of the head and just beyond the head, were located with some accuracy. The pattern of errors was toward the head and away from the body. Acquaintance produces a stronger bias away from the body, and may produce other interaction-facilitating biases.

Convergence, Ocular↗

Diffential diagnosis of the caloric nystagmus.

Diagnostic considerations based upon the nystagmogram are limited. Quantitative assessment of horizontal canal sensitivity is available through the use of culmination frequency or culmination slow phase velocity. Qualitative characteristics of nystagmometry have been sought but with no satisfactory results. Three distinctive features of the caloric nystagmus were evaluated and were found to be suggestive or outrightly pathognomonic for retrolabyrinthine or central nervous system abnormalities. These are: (1) Vestibular decruitment. The disproportionate caloric responsiveness when a weak stimulus elicits a more intense nystagmic reaction than a strong stimulus is capable of creating. (2) Hyperactive vestibular responsiveness (3) Ocular fixation reversal phenomenon. Contrary to the normal behaviour, the elimination of fixation decreases the nystagmus intensity instead of facilitating the evoked nystagmus. The assessment of these qualitative features of the caloric nystagmus in addition to the quantitative measurements widens the scope of our diagnostic capabilities.

Adult↗

[Difficulty in manual prehension under visual control (author's transl)].

Visuomotor ataxia causes difficulty in the prehension of objects under visual control which can occur without paralysis of ocular fixation and spatial agnosia. This can involve the total visual field or the right or left half-fields, and can affect both hands or one only. 1) Unilateral visuomotor ataxia is localized to the two right or left homonymous half-fields and can affect both hands or one only. It is direct when the ataxic hand is on the same side as the affected visual half-field, and crossed when the ataxic hand is contralateral to the affected visual half-field. 2) Bilateral visuomotor ataxia involves the total visual field. Each hand may be ataxic only for the contralateral visual field with a crossed bilateral visuomotor ataxia, or in the homolateral field with a direct bilateral visuomotor ataxia. The anatomical and clinical observations reported imply the existence of visuomotor connections, both direct and crossed, the latter crossing the median line through the corpus callosum.

Adult↗

[Photoscreening].

Photoscreening is a photographic method to determine whether a child's eyes focus properly or not. This method can be used from the moment the child is able to fix, which is around six months. Photoscreening allows us to detect a hypoaccommodation and to determine the minimal optical correction to prescribe. It is used to evaluate the postoperative position of the eyes and shows the dominant eye. This eye should be occluded intermittently in order to prevent amblyopia and/or a relapse of the squint.

Accommodation, Ocular↗

Effect of age on the interaction between the AC/A and CA/C ratios.

A number of previous studies have examined the effects of age and the development of presbyopia on either the accommodative convergence to accommodation (AC/A) or convergent accommodation to convergence (CA/C) ratios. However, changes in the interaction of these oculomotor crosslinks with increasing age have received relatively little attention, especially over a wide age distribution. Accordingly, the present study examined both crosslink ratios in 42 subjects ranging from 22 to 65 years of age. A dual haploscope-optometer was used to measure accommodation and vergence. The response AC/A ratio showed a small but significant positive correlation with age in those subjects under 45 years of age, while no significant correlation was observed between the stimulus AC/A ratio and age for all subjects. The CA/C ratio exhibited a significant negative correlation with age for all subjects. Furthermore, a trend was observed for lower CA/C findings to be associated with higher response AC/A ratios. However, the two ratios were inversely but not reciprocally related, with the mean difference between the CA/C ratio and the reciprocal of the response AC/A ratio being significantly different from zero. These age-related changes in the output of the oculomotor crosslinks provide further evidence of the continual oculomotor adaptation that occurs concurrent with the loss of accommodative responsivity.

Accommodation, Ocular↗

Stereotactic radiotherapy in the treatment of ocular melanoma: a noninvasive eye fixation aid and tracking system.

Ocular melanoma is frequently treated using brachytherapy implants (such as 125I and 60Co plaques or 184Ta wire), surgery, or external beam radiotherapy using small 60Co beams, high energy x-rays, or proton therapy. The last technique, though very expensive, provides improved dose distributions and dose localizations in the treatment of tumours adjacent to critical normal tissues. The technique of fractionated stereotactic radiotherapy is now being used at an increasingly large number of centers in the treatment of lesions in the brain, and the head and neck. This article describes the successful extension of the stereotactic technique to the treatment of ocular melanoma: an eye fixation aid is attached to a noninvasive, relocatable Gill-Thomas-Cosman head frame together with a simple eye-movement tracking system.

Dose Fractionation, Radiation↗

Influence of target color and vergence of light on ocular accommodation during binocular fixation.

In an earlier study we reported large discrepancies between ocular refraction and perception of blur for black/white letters. In the present study we report on the influence of target color and vergence of light on the human focusing system. Twenty visually normal volunteers between 14 and 25 years of age participated in this experiment. Targets were brightness-matched red, yellow, green, blue or white 21 minarc letters displayed on the black background of a high resolution RGB monitor, at a 40 cm observation distance. Changes in the vergence of light were effected via increasing amounts of positive and negative power spherical lenses placed binocularly in front of the subject's eyes. Our results showed that: 1) the accommodative level varied as a function of the color of a target, 2) the vergence of light was not an infallible cue for accurate accommodation and 3) the inter-subject variability seen in response to the vergence of light was not linked with the chromaticity of test targets. All subjects showed a decreasing ability to fully relax accommodation with increasing plus power lenses. For minus power lenses, accommodative response profiles were divided into 3 categories, category 1 having accurate accommodation for the test target, category 2 showing a low level lag of accommodation and category 3 being totally unresponsive to increasing divergence of light. While subjects across response categories showed differential endpoints in clinical estimates of positive relative accommodation, other clinical measurements related to refractive error, accommodative amplitude and fusional ability failed to predict the accommodative behavior of our subjects as did measurements of the resting focus of accommodation.

Accommodation, Ocular↗