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At least 181 records · Page 10Linked to original sources
PubMed1980

Interrelationships between the retinal pigment epithelium and the neurosensory retina.

The role of the retinal pigment epithelium in regulating transport between the choriocapillariss and sensory retina was studied by examining the diffusion fluorescent across the intact rabbit retinal pigment epithelium and the retinal pigment epithelium damaged by intravenous injection of sodium iodate. Destruction of the tight junctions of the retinal pigment epithelium allowed free diffusion of fluorescein from the choroid into the retina. The electrical characteristics of the cat retinal pigment epithelium which play an important role in governing transport of substances across the retinal pigment epithelium were studied. The apical membrane of the cat retinal pigment epithelium resembled that of the frog in having high sensitivity to apical K+, greater sensitivity to apical Na+, and less sensitivity to apical HCO3-. The apical membrane was sensitive to oubain which produced a rapid fall in the transepithelial potential. Previous studies of the electrical properties of the retinal epithelium in cold blooded preparations are summarized with emphasis on the important interactions between the retinal pigment epithelium and sensory retina and the implications that these studies have with regard to the regulation of photoreceptor function.

Animals↗
PubMed1982

Subjective vs. objective evaluation of gallbladder opacification during oral cholecystography in comparative clinical trials: implications for studies involving visual assessment.

Radiographs and CT images taken during oral cholecystography in dogs were interpreted in an independent, blind fashion by three radiologists on two occasions and visual assessment of gallbladder density compared to the actual CT values. While there was significant intra- and inter-observer variation, the mean scores for the observers' interpretations of both radiographs and prints correlated well with the actual CT values (p less than 0.05). In five out of six comparisons between first and second readings, the observers gave a lower score on the second reading. The considerable variation reflects the problems inherent in subjective evaluation of agents that produce small but measurable differences in radiographic density. Studies involving such subjective data have to be carefully designed in order to obtain meaningful results.

Administration, Oral↗