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PubMed1987

Neuroendocrine and behavioral effects of intrathecal capsaicin in adult female rats.

Neural feedback from the gonads and the reproductive tract has an integral role in normal reproductive function in female rats. To further assess the role of sensory feedback in neuroendocrine control, the effects of an intrathecal injection of the neurotoxin, capsaicin (100-125 micrograms) into the lumbosacral region of the spinal cord on reproductive function was tested in female rats. In addition, the effects of capsaicin on the response to noxious heat and pressure were tested. Intrathecal capsaicin had no effect on estrous cycles, ovarian compensatory hypertrophy or female sexual behavior. However, capsaicin treated animals showed a dramatic reduction in fertility, relative to vehicle treated control rats and this was shown to be due to the reduced capacity of vaginal/cervical stimulation to produce pseudopregnancy. Consistent with a selective loss in the effectiveness of cervical stimulation, immobilization produced by vaginal probing was reduced in capsaicin treated rats, but this response slowly recovered across time in some animals. Similarly, the ability of vaginal probing to induce a lordotic response during estrogen treatment was reduced in the capsaicin treated animals. The capsaicin treated animals showed analgesia to noxious heat, as measured by the tail flick test, but showed a normal foot withdrawal in response to pressure. The analgesic effect of vaginal stimulation on noxious pressure was unaltered in the capsaicin treated rats. Finally, the neurotoxic effect of capsaicin was verified in terms of a quantitative reduction in substance P immunoreactivity in the dorsal horns of the lumbosacral region of the spinal cord of capsaicin treated rats, relative to control animals.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1995

Increased incidence of spina bifida occulta in fluorosis prone areas.

Spina bifida, a congenital deformity of the posterior wall of vertebrae of the spine, is a midline defect of skin, vertebral arches and neural tube, usually in the lumbosacral region. Its incidence is reported to be 0.2 to 0.4 per 1000 live births. Various hypotheses have been put forward as etiological factors for spina bifida including consumption of potato affected by blight and hardness of drinking water but these have not been proven. Two groups of 50 randomly chosen children were established. The study group consisted of children aged 5 to 12 years, weighing 15 to 30 kg, consuming fluoride rich drinking water (4.5 and 8.5 ppm fluoride; WHO permissible limit is 1.5 ppm fluoride), and manifesting either clinical, dental and/or skeletal fluorosis. The control group consisted of age and weight-matched children, consuming less than or equal to 1.5 ppm fluoride in drinking water and not showing any evidence of fluoride toxicity. These children were evaluated for antenatal history, general clinical examination (especially for dimples, tufts of hair, haemangioma on skin throughout the length of spine), other congenital abnormalities, evidence of fluoride toxicity, biochemical estimation for fluoride levels in blood and serum and by skiagrams of the spine to examine for the presence of spina bifida occulta. A total of 22 (44%) of the 50 children in group A, the study group, and 6 (12%) of the 50 children in group B, the control group, revealed spina bifida occulta in the lumbosacral region.(ABSTRACT TRUNCATED AT 250 WORDS)

Case-Control Studies↗
PubMed1992

Galanin-like immunoreactivity in autonomic regions of the rat lumbosacral spinal cord is sexually dimorphic and varies with the estrous cycle.

These investigations show that there is a heterogeneous distribution of galanin-like immunoreactivity (GAL-LI) within laminae VII and X of the rat thoraco-sacral spinal cord. In either sex, GAL-LI fibers sparsely outline the position of male and female preganglionic sympathetic neurons in thoracic spinal segments; whereas in lumbosacral segments, far greater numbers of GAL-LI fibers surround autonomic preganglionic neurons. An unusual feature of the GAL-LI fibers in lumbosacral autonomic regions is their sexually dimorphic distribution with males containing greater numbers of GAL-LI fibers than all females examined. In this regard, although the number of GAL-LI fibers observed in males was consistent from animal to animal, the amount of GAL-LI in females fell into two qualitative categories: an 'average' and a 'heavy' amount. These data indicate that the difference in the amount of GAL-LI in the female rat lumbosacral spinal cord is related to the estrous cycle, such that heavy amounts of GAL-LI are observed during proestrus and estrus, while average amounts of GAL-LI are associated with metestrus and diestrus.

Afferent Pathways↗
PubMed1986

Schmorl's nodes (intravertebral herniations of intervertebral disc tissue) in two historic British populations.

The herniation of the nucleus pulposus into the vertebral body produces ectopic deposit of disc material which are known as Schmorl's nodes. This prolapsed disc tissue leaves characteristic deformations on the surface of the vertebral body and hence the incidence of this lesion can be studied in skeletal remains. This report describes the occurrence of Schmorl's nodes in TV8-SV1 in two historic adult British populations, one from Aberdeen and the other from London. In the Aberdeen group, both males and females showed a high incidence rate and severity of Schmorl's nodes. In the London group, the males had a similarly high affliction whereas the females were nearly free of the condition. The lesion had no significant predilection for any one particular vertebral surface. However, in males in both localities, the frequency of Schmorl's nodes was significantly higher in the thoracic region than in the lumbosacral region. In contrast, both groups of females showed similar node frequency in these two zones. The majority of Schmorl's nodes were localised in the central and central-posterior regions of the vertebral surface. When nodes occurred on successive vertebral surfaces, they often formed sequences showing similar shape and position. The aetiology of Schmorl's nodes is unclear. Various hypothetical causal factors were appraised in relation to the findings of this study. It was suggested that anomalies in vascular and/or notochordal regression may be related to the development of the lesion.

England↗
PubMed1977

The transitional vertebra of the lumbosacral spine: its radiological classification, incidence, prevalence, and clinical significance.

This report presents interim results from a series of studies of the lumbosacral region of the spine. A new classification of the lumbosacral transitional vertebra (LSTV) is proposed. An LSTV was found with similar frequency in patients and in population samples. The radiological findings were related to the presence of symptoms and to evidence of urological problems. Whilst Brocher (1973), Rubin (1971), and others have considered an LSTV to be of importance because it should lead to unfavourable weight bearing in the lower spine, the present extensive material shows that there is no relation between an LSTV and low backache. There may be a genetic factor involved in the various types of LSTV.

Back Pain↗
PubMedDate not supplied

Magnetic resonance imaging of articular process joint geometry and intervertebral disk degeneration in the caudal lumbar spine (L5-S1) of dogs with clinical signs of cauda equina compression.

The geometry of the lumbosacral region has been suspected to play a role in the development of degenerative lumbosacral stenosis in the dog. In this study, 50 dogs (21 German Shepherd dogs and 29 dogs of other breeds) with clinical signs of cauda equina compression were studied by magnetic resonance (MR) imaging. The orientation of the articular process joints in the L5-S1 region and the angle difference between two adjacent motion segments were calculated. Intervertebral disc degeneration of the same region was identified and classified in four stages. A positive association between MR-imaging stage and articular process joint angle difference in the transverse plane was found in the two groups of animals. German Shepherd dogs and dogs of other breeds had different geometry of the lumbosacral region with different articular process joint angles in the transverse plane and statistically different stages of disc degeneration.

Animals↗
PubMed1999

A study of motoneuron groups and motor columns of the human spinal cord.

Eight normal human spinal cords were studied for motoneuron (Mn) groups and columns. Spinal segments (C1 to Coc.) were identified and embedded in paraffin wax. Serial cross sections were cut at 25 microm and stained by cresyl violet. Cross-sectional profiles of the spinal cord were traced for each segmental level and the outlines of the various Mn groups superimposed. These charts (maps) were used to examine intra and intersegmental changes in the relative positions of the columns. An attempt was made to provide topographical picture of Mn groups of individual segments. In the cervical region neuronal groups were more numerous but smaller and less distinct, while in the lumbosacral region they were fewer, larger and at many levels better circumscribed. The average number of Mn groups at any segmental level was 3-4 and never exceeded 5. C4, C5, C6, C7, L4, L5 and S1 contained numerous Mn groups. Maximum intrasegmental changes were noted at C3, C4, C7, T1, and S2, while at C5, C6, all thoracic, L1 L2 and L3, the pattern was constant throughout the segment. Eleven motor columns were traced in the human spinal cord. Column 1 belonged to the medial division and columns 2-11 to the lateral division of the ventral grey horn. Columns 1 and 2 were the most extensive as they were traceable from the lower medulla to S3 segment. Columns 3-8 were confined to cervical segments (including T1), while columns 9-11 were traced in lumbosacral segments. In general, motor columns followed a definite mode for their appearance and disappearance. Many of them showed rotation from a dorsal to a ventromedial direction.

Adult↗
PubMed1978

Lumbosacral intradural periradicular ossification. Case report.

Intrathecal ossification causing progressive myelopathy or radiculopathy does not occur frequently. The majority of the reported lesions have been in the thoracic spine and seldom in the sacral canal. This report presents the occurrence of disabling low backache and sciatica from intradural periradicular ossification in the lumbosacral region in a previously healthy man.

Adult↗
PubMed1989

Different gradients for neurotransmitter metabolites and protein in horse cerebrospinal fluid.

The serotonin metabolite, 5-hydroxyindoleacetic acid (5-HIAA) and the dopamine metabolite, homovanillic acid (HVA) in the cerebrospinal fluid (CSF) of seven clinically normal horses were evaluated with reverse phase high pressure liquid chromatography and electrochemical detection. Comparisons of the neurotransmitter metabolite concentrations were made on CSF collected simultaneously from the atlanto-occipital and lumbosacral regions. There were significantly higher amounts of 5-HIAA and HVA in atlanto-occipital CSF than in lumbosacral CSF. Mean 5-HIAA concentrations in atlanto-occipital and lumbosacral CSF were 206.1 +/- 37.0 nmol/L and 68.5 +/- 12.6 nmol/L, respectively. The mean HVA concentration in atlanto-occipital CSF was 254.4 +/- 50.4 nmol/L. No HVA was detected in lumbosacral CSF. In contrast, significantly greater protein concentrations were present in lumbosacral CSF than in atlanto-occipital CSF. Lumbosacral and atlanto-occipital CSF contained 32.1 +/- 3.7 mg protein/dl and 25.0 +/- 1.3 mg protein/dl, respectively. Thus, between the atlanto-occipital and lumbosacral space of the horses, a rostrocaudal gradient existed for neurotransmitter metabolites and a caudorostral gradient existed for protein.

Animals↗
PubMedDate not supplied

45-degree central ray angulation for improved lumbosacral myelography.

Forty-five-degree central ray angulation was utilized during radiography of the lumbosacral region at the time of myelography in 70 patients. The resulting radiographic image allowed for improved assessment of nerve root detail in the region of the fifth lumbar vertebral body and below.

Adult↗
PubMed1993

Magnetic coil stimulation of the human lumbosacral vertebral column: site of stimulation and clinical application.

We describe the technique of magnetic coil (MC) stimulation of the lumbosacral roots and the possible site of stimulation in 22 control subjects, and the clinical usefulness of MC stimulation in 5 patients with low back pain. We observed 2 components in the compound muscle action potential of the soleus muscle following MC stimulation over the lumbosacral region. The second component had the physiological properties of the H reflex. The conduction time from the anterior horn cells of the lumbosacral spinal cord to the site of nerve root stimulation over the lumbosacral vertebral column was indirectly calculated as between 3.9 and 4.1 msec. Assuming a conduction velocity of 50 m/sec this would represent a distance of approximately 20 cm from the spinal motor neurons. Based on our control and patient data we conclude that the MC stimulation may be an useful technique for the diagnosis of lumbosacral radiculoplexopathy.

Adult↗
PubMed2003

The bony malformations of lumbosacral junction and sacrum: case reports and literature review.

The lumbosacral region, with its manifold variations and anomalies, is one of the most important section of the entire spine. From the fusion defects to the segmentation anomalies, a wide variety of malformation exists in this region. Individuals with such anomalies usually have no physical complaints until their spines undergo pathological conditions. Two patients with a variety of lumbosacral vertebra anomalies are described. Each of them had a different malformation, but low back pain was the common complaint of these patients. According to our knowledge, these cases have never been reported before. We analysed their clinical and radiological features and discussed with the literature.

Adult↗
PubMed2002

Single-stage excision of hemivertebrae via the posterior approach alone for congenital spine deformity: follow-up period longer than ten years.

STUDY DESIGN: Evaluation of the long-term results for single fully segmented hemivertebrae were subjected to single-stage excision via posterior approach alone. OBJECTIVES: To describe the long-term results of this procedure. SUMMARY OF BACKGROUND DATA: In the case of congenital spinal deformity caused by a single, full hemivertebra, excision of the hemivertebra is ideal for obtaining a good correction percentage even in short segments. Recently, single-stage excision of a hemivertebra using a combined anterior and posterior approach has been reported. METHODS: Five patients with a hemivertebra underwent surgery. The hemivertebra involved the thoracolumbar region in three cases and the lumbosacral region in two cases. After removal of a lamina of the hemivertebra, the body of the hemivertebra was visualized easily because the spinal cord had deviated to the concave side of the curve. The vertebral body, along with its cranial and caudal discs, was curetted with this approach. Thereafter, bone chips were grafted into the defect created by vertebrectomy. The results of this surgical procedure, especially those observed during long-term follow-up evaluation, were investigated. RESULTS: For patients with a thoracolumbar hemivertebra, scoliosis improved from 49 degrees +/- 6 degrees to 22.3 degrees +/- 3.5 degrees, for a 54.3% correction. The correction ratio for kyphosis was 67.4%. Over an average 12.8-year follow up period, loss of scoliotic curvature correction was only 3.7 degrees. In contrast, the hemivertebral correction ratio for patients with a lumbosacral hemivertebra remained 32.5% because of difficulty using internal fixation associated with patient age. At the most recent follow-up assessment, one patient exhibited deterioration of coronal spinal balance. CONCLUSION: The described procedure was less invasive because it avoided an anterior approach, yet it yielded satisfactory long-term results for thoracolumbar hemivertebrae.

Adolescent↗
PubMed1993

Lumbosacral dysfunctions in elite cross-country skiers.

While the incidence of injury in cross-country skiing remains relatively low, overuse problems affecting the lumbosacral region may be on the rise, particularly among elite athletes. In this study, a certified "Part A" (Canadian Physiotherapy Association) manual therapist performed lumbosacral physical assessments on 18 elite cross-country skiers and 15 normal subjects. Results indicated sacroiliac (SI) joint dysfunction occurred significantly more often in the skier population (p < 0.007). Incidences of SI joint asymmetry and lumbar spine dysfunction did not differ between groups. The predominant use of asymmetrical ski-skating techniques may play an influential role in the pathogenesis of SI joint dysfunction in elite cross-country skiers.

Adolescent↗
PubMed1995

Congenital dermal sinus associated with an abscessed intramedullary epidermoid cyst in a child: case report and review of the literature.

A 16-month-old male infant presented with paraparesis and a high thoracic skin dimple. After myelography the child underwent complete surgical removal of the dermal sinus and of an abscessed tumor located within the cervicothoracic cord. Histological study showed that the lesion was an intramedullary epidermoid cyst. Only four descriptions have previously been published of dermal sinuses associated with intramedullary epidermoids, three of them complicated by intramedullary abscesses. This appears to be the first report in the current literature of the association of a dermal sinus and an infected intramedullary epidermoid occurring out of the confines of the lumbosacral region.

Epidermal Cyst↗
PubMed1993

[Kinetic studies of the lumbar vertebrae and the lumbosacral transition in the German shepherd dog. 2. Our personal investigations].

The range and type of ventrodorsal motion between two adjacent vertebra (L3-S1) was analyzed on isolated vertebral columns of 13 German Shepherd Dogs. All except one were neurologically normal dogs. The movement from maximal flexion to maximal extension was divided into 5 degree steps. For each step, the center of motion was determined on laterolateral radiographs. It could be shown that mobility between two adjacent vertebra within the lumbar spine increases towards the lumbosacral region with the highest mobility in this joint. In the cranial portion of the lumbar spine, rotation and ventrodorsal (parallel) displacement between two adjacent vertebra was seen. Rotation dominated in the lumbosacral joint in 11 dogs, whereas parallel displacement was mainly seen in 2 dogs. Further studies on pathologic and surgically modified vertebral columns are necessary to clarify the significance of these findings in the pathogenesis of lumbosacral instability and cauda equina compression in the German Shepherd Dog.

Animals↗