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Results for “LUPUS ERYTHEMATOSUS, DISCOID”

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PubMed1982

Antibodies to single-stranded DNA in patients with discoid lupus erythematosus.

Sera from 31 patients with discoid lupus erythematosus were examined for the presence of antibodies to single-stranded and native DNA. None of these sera had antibodies to native DNA. When rabbit anti-human IgM was used, 6 of 28 patients had elevated binding, whereas only 1 of 29 patients had abnormal binding when antiIgG was used. The IgM nature of this response was confirmed when we demonstrated the binding activity in heavy fractions from gel filtration. We concluded that at least one-fifth of patients with discoid lupus erythematosus have IgM antibodies to single-stranded DNA.

Antibodies↗
PubMed2004

[Discoid lupus erythematosus involving the eyelids: 4 cases].

BACKGROUND: Discoid lupus erythematosus is a chronic skin disease frequently involving the face, scalp and ears. Palpebral lesions are rare. We report 4 cases of this uncommon localization. In one case, palpebral lesions were the sole manifestation of the discoid lupus erythematosus. CASE REPORTS: Four patients aged between 26 and 45 Years had lesions of the lower eyelid as erythematous, infiltrated and scaly plaques. One patient, without diagnosis despite 2 skin biopsies of lesion, presented with a 2-Year history of blepharitis in the absence of any other cutaneous abnormality. In one case, chronic blepharitis has been present for 4 Years and associated with inflammatory arthralgia. Alopecia occurred 4 Years after the onset of blepharitis and led to the diagnosis of discoid lupus erythematosus. In 2 cases, blepharitis was associated with typical cutaneous lesions of discoid lupus erythematosus. Antimalaria drugs were very effective in 3 cases. In one patient the antimalaria drug failed, but thalidomide was effective. DISCUSSION: The location of lesions on the eyelids in the absence of any other cutaneous abnormality is rare and can easily lead to the misdiagnosis of discoid lupus erythematosus. Most Authors mention a predilection of the lesions to the inferior portion of the eyelid, more specifically to the external third. The involvement of the eyelids with permanent scarring and severe eye impairment is explained by the long duration of the disease without diagnostic and appropriate treatment. Clinical examination is highly consistent with discoid lupus erythematosus: the lesions typically present as well-circumscribed, erythematous plaques with telangiectasia and scales and atrophy in long-standing disease. Antimalaria drugs are remarkably effective.

Adult↗
PubMedDate not supplied

Linear childhood discoid lupus erythematosus following the lines of Blaschko: a case report with review of the linear manifestations of lupus erythematosus.

Seventeen cases of childhood discoid lupus erythematosus (DLE) have been previously reported in the literature. We describe the first reported case of childhood linear DLE following the lines of Blaschko. The clinical and histologic characteristics of childhood DLE are discussed and a review of the linear manifestations of childhood LE is presented.

Biopsy↗
PubMed2001

Epidermal grafting for depigmentation due to discoid lupus erythematosus.

BACKGROUND: Longstanding lesions of discoid lupus erythematosus (DLE) may heal with thin, depigmented scar(s). The depigmentation may fail to respond to medical therapies. OBJECTIVE: To evaluate the efficacy of suction blister epidermal grafting in longstanding, quiescent, depigmented scar(s) of DLE. METHODS: The suction blisters were raised on the lateral aspect of the upper third of the thigh in 4 patients (3 males, 1 female) with depigmented scars of DLE on the face. The roofs of the blisters were transferred to the dermabraded recipient area. Both donor and recipient sites were dressed with nonadherent tulle. RESULTS: The dressings were removed after 7 days. The graft take was complete. The pigmentation achieved was more than 100% of the grafted area due to peripheral spread of the pigmentation and more than 75% of the depigmented area. The color match was good. There was no loss of pigment or recurrence/relapse of the disease during the follow-up of 6 months to 1 year. CONCLUSIONS: Our preliminary results suggest that leukodermic scars of healed inactive DLE lesions can be successfully treated with epidermal grafting.

Adult↗
PubMed2005

Association between discoid lupus erythematosus and cigarette smoking.

BACKGROUND: Discoid lupus erythematosus (DLE) is a chronic cutaneous disease affecting photoexposed areas and has also been associated with cigarette smoking. OBJECTIVE: To evaluate the association between smoking and DLE. METHODS: A case-control study was performed involving 57 cases diagnosed with DLE and 215 healthy controls. RESULTS: A higher smoking prevalence was noted in DLE cases (84.2%) than controls (33.5%), and the odds ratio adjusted for gender, age and ultraviolet index in the city of origin was 14.4 (95% confidence interval 6.2-33.8; multiple logistic regression, p < 0.01). The cumulative smoking exposure was not related to premature DLE development. At the beginning of the disease, smokers had more extensive involvement than nonsmokers; compromise of the upper arms was statistically related to smoking. CONCLUSION: Cigarette smoking was statistically associated with DLE development. Other studies are needed in order to evaluate the effects of smoking cessation on the course of disease.

Adolescent↗
PubMed1988

Malignant fibrous histiocytoma arising from discoid lupus erythematosus.

While the association of discoid lupus erythematosus (DLE) and subsequent squamous cell carcinoma is well known, there are no reports in the English-language literature concerning the association of DLE and soft-tissue sarcoma. We describe a patient with DLE and malignant fibrous histiocytoma.

Histiocytoma, Benign Fibrous↗
PubMedDate not supplied

Childhood discoid lupus erythematosus: a report of two cases.

Discoid lupus erythematosus (DLE) is an uncommon disease in childhood. We present two patients initially diagnosed as impetigo and photosensitive eczema with impetigo, respectively, who failed to respond to topical and systemic antistaphylococcal agents and in whom a diagnosis of discoid lupus erythematosus subsequently became apparent.

Child↗
PubMedDate not supplied

Topical 0.1% tacrolimus for the treatment of discoid lupus erythematosus and pemphigus erythematosus in dogs.

Topical 0.1% tacrolimus was used for treatment of localized lesions associated with 10 cases of discoid lupus erythematosus (DLE) and two cases of pemphigus erythematosus (PE) either as a sole therapy (n=2) or as an adjunctive treatment (n=10). Eight of 10 dogs with DLE and both dogs with PE were improved following 8 weeks of topical application. In six of the eight dogs that improved, other medications were discontinued. No adverse effects in clinical or laboratory parameters were noted throughout the study.

Administration, Topical↗
PubMed1984

Neonatal lupus erythematosus in four successive siblings born to a mother with discoid lupus erythematosus.

A young woman with inactive discoid lupus erythematosus (LE) gave birth in three successive pregnancies to four male infants who showed cutaneous, and in one case cardiac, signs of neonatal LE. The mother had Ro and La antibodies although the anti-nuclear factor (ANF) was not consistently detectable. Three of the infants received phototherapy for neonatal jaundice. Maternal discoid LE may give rise to neonatal LE, and successive siblings can be affected.

Adult↗
PubMedDate not supplied

Systemic and discoid lupus erythematosus: analysis of pulmonary function.

To determine the prevalence of pulmonary dysfunction in lupus erythematosus, 24 patients with systemic lupus erythematosus (SLE) and 5 patients with discoid lupus erythematosus (DLE) were studied. Diffusing capacity for carbon monoxide was abnormal in 17 (71 percent) SLE patients. A restrictive ventilatory defect was present in 6 (25 percent) and arterial hypoxemia in 4 of 23 (17 percent). The mean ratio of forced expiratory volume in one second to forced vital capacity (FVC) was 83 percent. To test for the presence of small airways disease, maximum expiratory flow rate at 50 percent of FVC was measured on air and on an 80 percent helium-20 percent oxygen mixture. Ten patients (5 smokers and 5 nonsmokers) with SLE were nonresponders to helium suggesting small airways disease. Pulmonary dysfunction was present in 90 percent (9/10) of SLE patients with a previous history of pleuritis and/or pneumonitis, and in 71 percent (10/14) without respiratory symptoms or history of lung disease and with a normal chest radiograph. Pulmonary function tests were normal in DLE patients except for an abnormal response to helium and/or mild arterial hypoxemia in two patients, all of whom were smokers. These data indicate that there is a high prevalence of pulmonary function abnormalities in SLE including patients without clinically evident pleuropulmonary disease.

Female↗
PubMed1977

Conversion of discoid lupus erythematosus to mixed connective tissue disease.

The progression from discoid lupus erythematosus (DLE) to severe systemic lupus erythematosus (SLE) is rare. Two patients with DLE for five and 10 years eventually developed systemic involvement with clinical features of mixed connective tissue disease (MCTD). Both patients had high titer serum antibody to ribonucleoprotein (RNP) and epidermal nuclear staining on direct immunofluorescence of normal skin. Neither patient had renal disease but one patient developed pulmonary involvement. This observation suggests that patients with DLE and the Raynaud phenomenon may have a connective tissue disease subset characterized by anti-RNP, the immunologic marker for MCTC.

Adult↗
PubMed1977

Antibodies to UV DNA and photosensitivity.

Antibodies to ultraviolet light denatured DNA (UV DNA) have been measured in the sera of patients with systemic lupus erythematosus, discoid lupus erythematosus, and light sensitive skin lesions. Antibodies were found in significant levels in the patients with SLE but not in the other groups. It appears that although UV denaturation of dermal DNA occurs in vivo this is not sufficient to induce antibodies to UV DNA in patients with a normal DNA repair mechanism. This may not be the case in patients with SLE in whom a break in tolerance to Native (N-) DNA has already occurred and where antibody to N-DNA will cross react with UV DNA.

Antibody Formation↗
PubMed1999

Report of an association between discoid lupus erythematosus and smoking.

Smoking has been shown to be associated with many medical disorders, including many involving the skin. While preliminary studies suggest a modest association between smoking and systemic lupus erythematosus, epidemiologic data on discoid lupus erythematosus (DLE) and smoking are lacking. To study this relationship, we examined current smoking habits in two unique patient populations with DLE. One group was compared with matched dermatology patients while the second group was compared with the corresponding statewide population. For both groups, the current smoking prevalence was much higher than that of the comparison population. For the control-matched group of DLE patients, smoking prevalence was found to be significantly greater than that of controls (odds ratio 12.2; p = 0.001). We therefore propose that smoking is a risk factor for development of DLE.

Adult↗
PubMed1992

Incidence of alopecia areata in lupus erythematosus.

BACKGROUND: A small percentage of patients with alopecia areata have connective diseases such as systemic lupus erythematosus, discoid lupus erythematosus, rheumatoid arthritis, and scleroderma. Lupus erythematosus is associated with a number of different types of alopecia, but the incidence of alopecia areata in lupus erythematosus has not been examined. OBSERVATIONS: Of our cohort of 39 patients with lupus erythematosus, alopecia areata developed in 10% (four patients), in contrast to 0.42% of general dermatologic patients. Biopsy specimens of alopecia areata lesions in each of our patients showed continuous granular deposition of IgG at the dermoepidermal junction, a finding usually found in only a minority of alopecia areata cases. Intralesional injections of corticosteroids were effective treatment. CONCLUSIONS: The incidence of alopecia areata in patients with lupus erythematosus is increased. Recognition of this form of alopecia allows for specific therapy with intralesional corticosteroids.

Adult↗
PubMed1992

Investigation of antibodies to extractable nuclear antigens in dogs.

Determination of antibodies to specific nuclear antigens, termed extractable nuclear antigen (ENA), was investigated in healthy dogs and in dogs with autoimmune, inflammatory, and neoplastic diseases. Using a counterimmunoelectrophoresis method, the dogs' sera were tested for antibodies against the nuclear antigens single-stranded DNA, Sm, Ro, La, ribonucleoprotein, Scl, and proliferating cell nuclear antigen. Antibodies to the Ro antigen were found in 1 dog with discoid lupus erythematosus, in 1 dog with pemphigus erythematosus, and in 1 dog with facial pyoderma and chronic superficial keratitis. In 15 dogs, antibodies were detected to ENA, but the precipitin lines were too weak to identify the specific ENA. These antibodies were found in some dogs with systemic lupus erythematosus, discoid lupus erythematosus, pemphigus erythematosus, dermatomyositis, vitiligo, lymphoma; in the dog with facial pyoderma and chronic superficial keratitis; and in 1 healthy dog. The highest percentage of dogs with antibodies to ENA in a large series (greater than 8) of this study was in dogs with systemic lupus erythematosus (4 of 13; 31%).

Animals↗
PubMed1988

Circulating immune complex concentrations in selected cases of skin disease in dogs.

Serum samples from 25 clinically normal dogs and 137 base-line serum samples from dogs with skin disease were assayed blindly for presence of circulating immune complexes (CIC). The method used was a solid-phase C1q-binding enzyme-linked immunosorbent assay. This assay detected only IgG-containing CIC that were capable of binding C1q. Statistical analysis revealed that dogs with systemic lupus erythematosus, discoid lupus erythematosus, generalized demodicosis, and recurrent staphylococcal pyoderma had significantly higher mean CIC concentrations than did normal dogs. Dogs with other skin diseases had mean CIC concentrations indistinguishable from those of normal dogs. Presence of CIC in dogs with these dermatopathies may have pathogenetic significance or may be the result of the disease process. Further studies are necessary to define the antigens contained in the immune complexes and the importance of CIC in skin disease of dogs.

Analysis of Variance↗