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PubMed2002

TP53 mutation pattern of esophageal squamous cell carcinomas in a high risk area (Southern Brazil): role of life style factors.

In an attempt to correlate the TP53 mutation pattern of squamous cell carcinomas of the esophagus (ESCC) and life style factors of patients from the high risk area Rio Grande do Sul, Brazil, 135 ESCC were analyzed, after prescreening by p53 immunohistochemistry, by SSCP and DNA sequencing of TP53, exon 5-9. Forty-nine somatic TP53 mutations (and 1 case with p53 polymorphism) were identified as missense (n = 39), frameshift (n = 6), silent (n = 1), amber (n = 1) or intron border mutations (n = 2) that cause splicing aberrations. They were preferentially found in exon 5 (36.7%) and exon 8 (32.7%). Several mutations were located in the mutation hot spot codons 248, 273 and 282, mainly at CpG sites. Transition mutations were observed in 53.1% (among them 50% G > A), transversion mutations in 34.7% (among them 47.1% G > T) and frameshifts in 12.2%, the latter 2 mainly in smokers and alcohol drinkers. Transitions were more prevalent in females than in males (p < 0.05). TP53 mutations, mainly transversions, were more frequently found in heavy smokers (p = 0.03), with the same tendency after chronic alcohol consumption. Comparison with the worldwide IARC database disclosed differences in the TP53 mutation pattern of the Brazilian tumors, with a higher accumulation of TP53 mutations in exon 8 and a higher prevalence of transition mutations. Mutations at the reported hot spot codon 176 were missing. Although difficult because of the documented coexposure to various life style risk factors in most patients of this series, the hypothesis is proposed that besides smoking and alcohol drinking the commonly consumed hot mate tea in this high risk area for ESCC is responsible for this different pattern of TP53 mutations because of chronic hyperthermic irritation and inflammation in the esophagus with an endogenous formation of radicals or carcinogenic factors that lead to a higher prevalence of transition mutations.

Adult↗

PubMed2006

[Doctors' use and assessment of a fee-for-service life-style advice scheme].

BACKGROUND: Fee-for-service life-style advice, a "green prescription" was introduced in Norway in 2003 as an alternative to the prescription of drugs to patients with moderate hypertension or risk of type 2 diabetes. The prescription includes an assessment of diet and/or physical activity, and an individual plan for change with systematic follow up from the GP. Material was provided by the Directorate of Health and Social Affairs, and a special fee of NOK 200 was established. The Research Institute of the Norwegian Medical Association has evaluated GPs' attitudes to and use of this scheme. MATERIAL AND METHODS: A representative sample of 1134 Norwegian GPs, of whom 59% responded. Ten of the respondents were also interviewed comprehensively over the telephone. RESULTS AND INTERPRETATION: Green prescriptions has low legitimacy among Norwegian GPs. Advise on lifestyle to patients with moderate hypertension or risk of type 2 diabetes is already an integral and natural component of GP work and calls for no extra fee or bureaucratic procedures. There is a risk of medicalisation in that non-patients become patients. On the other hand, patients who already are on drugs, but who may be able to reduce or eliminate these if they change their lifestyle, are not included in the scheme. Further development of the concept should to a larger degree include collaboration with the GPs.

Attitude of Health Personnel↗

PubMed2004

Classifying life-style types of phytoseiid mites: diagnostic traits.

Several traits are useful for identifying life-style types of predaceous phytoseiid mites when either 2 (diet generalist-specialist) or 4 (specialist I and II-generalist III and IV) type models [McMurtry J.A. and Croft B.A. 1997. Annu. Rev. Entomol. 42: 291-321] are considered. Traits useful for both models are developmental time and oviposition rates when feeding on several food types. Discriminating for the 2-types model are dorsal shield setae lengths, and intra- and inter-specific predation. Another trait useful for both models is feeding preferences of adult female phytoseiids on eggs versus larvae of Tetranychus urticae Koch. In this paper, we review established and other traits that need more study such as mouthpart types, other morphological features, spider mite webbing effects, distributions relative to prey-foods, plant-host relationships including domatia and sap feeding, density-dependent responses to prey and predator-prey ratios required for biological control. Uses of life-style data in biological control decision-making are discussed.

Animals↗

PubMed1987

Life-style correlates of risk factor change in young adults: an eight-year study of coronary heart disease risk factors in the Framingham offspring.

This paper describes the life-style and behavioral correlates of change in coronary heart disease risk factors measured eight years apart in the young adult offspring of the Framingham Heart Study cohort. Changes in total cholesterol, lipoprotein cholesterols (high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol, very low density lipoprotein (VLDL) cholesterol), and blood pressure were observed longitudinally in 397 men and 497 women who were aged 20-29 years at entry into the study. Stepwise multiple linear regression procedures were used to identify characteristics and their changes that were significantly associated with risk factor changes in each sex. The attribute most strongly and consistently related to lipoprotein and blood pressure changes in both sexes was change in body mass index (p less than or equal to 0.01 or p less than or equal to 0.001). In addition to weight gain, increases in alcohol consumption in men (p less than or equal to 0.001) and beginning oral contraceptive use in women (p less than or equal to 0.01) were associated with increases in blood pressure over the study period. Weight loss, stopping or decreasing cigarette consumption (p less than or equal to 0.01), increasing alcohol intake (p less than or equal to 0.01), and, in women, discontinuing oral contraceptive use (p less than or equal to 0.01) also were independently related to improvements in lipoprotein profiles during follow-up. After adjustment for all life-style correlates of risk factor change, simple self-assessments of physical activity or activity change were negatively associated with changes in VLDL cholesterol (p less than or equal to 0.01) and the total cholesterol/HDL cholesterol ratio (p less than or equal to 0.05) in men and positively associated with changes in HDL cholesterol (p less than or equal to 0.05) in women. Sociodemographic and behavioral characteristics that made a further independent contribution to increases in the total cholesterol/HDL cholesterol ratio in men were blue-collar occupation and trait Type A behavior pattern (p less than or equal to 0.05). Unexplained, but provocative, results of this study included the associations of interim vasectomy with increases in total cholesterol in men (p less than or equal to 0.05) and of number of livebirths with decreases in total cholesterol and HDL cholesterol in women (p less than or equal to 0.01). These findings are among the first to offer prospective evidence which suggests that habits and behaviors during young adulthood have a substantial effect on lipid and lipoprotein profiles in men and women.(ABSTRACT TRUNCATED AT 400 WORDS)

Adult↗

PubMed1984

Life-style and health: some remarks on different viewpoints.

Within the framework of the medical model of health and disease the factor 'life-style' plays a central role in the genesis of important disorders such as myocardial infarction or lung cancer. Two central issues, however, have been left unconsidered by most of the research done by medical epidemiologists: Disease, as a rule, has not one single but several causes; it is multifactorial in its etiology. This means that alongside 'life-style' there are other factors influencing pathogenesis. In this way we can explain, for example, the empirical finding that the classical risk factors only explain a minor amount of the morbidity and mortality due to coronary disease. A number of social and psychological factors influence those types of human behavior, which are known to have an adverse effect on health. The influence of age, sex, social status and parental and peer-group models have been empirically demonstrated. Social epidemiological research could contribute to a clarification and supplementation of the above-mentioned relationships leading to an improvement in our knowledge upon which to found preventive intervention. Social epidemiologists view health-adverse behavior as the consequence of social stress, that the individual attempts to cope with via smoking, drinking, etc. In the individual's social environment there exist numerous models, as well as informal pressures leading to such behavior. We should know more about the acute and chronic strains in the transition to adolescence and in later stages of the life-cycle.(ABSTRACT TRUNCATED AT 250 WORDS)

Coronary Disease↗

PubMed1998

Combined effects of shift work and life-style on the prevalence of insomnia, sleep deprivation and daytime sleepiness.

OBJECTIVES: The combined effects of age, leisure-time physical activity, smoking, alcohol consumption, and different forms of shift work on the prevalence of sleep complaints and daytime sleepiness were studied among workers in industry, transport, and traffic. METHODS: Altogether 3020 subjects were studied using a psychosocial questionnaire. The participants were currently employed men, aged 45-60 years, from a postal and telecommunication agency, the railway company, and 5 industrial companies. On the basis of a factor analysis of an 11-item sleep questionnaire, the sleep complaints were grouped into the categories of insomnia, sleep deprivation, daytime sleepiness, and snoring. The importance of the shift schedule, age, and life-style factors as simultaneous predictors of the complaints was studied in a logistic regression analysis and an analysis of covariance. RESULTS: The prevalence of insomnia, sleep deprivation, and daytime sleepiness depended significantly on the shift system. All sleep complaints were more common in 2- and 3-shift work and in irregular shift work than in day work. The prevalence of daytime sleepiness was 20-37%, depending on the shift system. Leisure-time physical activity and alcohol consumption were the most important life-style factors predicting all sleep complaints, except snoring. The effects of physical activity and alcohol consumption differed for different shift schedules. CONCLUSIONS: Different shift systems, also 2-shift work and permanent night work, seem to increase the frequency of sleep complaints. Especially 3-shift work seems to interact with life-style factors by increasing the adverse effects and decreasing the beneficial effects on sleep and sleepiness.

Adult↗

PubMed1998

[Successful coping with declining objective life style by institutionalized long-term patients. Results of a follow-up analysis of quality of life in long-term care institutions with the Zurich Quality of Life Inventory].

Measurement of quality of life in institutionalized frail patients is difficult considering the high prevalence of dementia. The Zurich quality of life inventory was developed specifically for this purpose and applied to describe longitudinally 103 institutionalized long-term care patients 3-12 months after entry: 11 slow-stream-rehabilitation patients (SSR), 16 severely dependent patients (ASL), 61 moderately dependent patients (ALL), and 15 young severely dependent patients, all of whom were assessed at least twice. The objective conditions of life deteriorated in all 4 groups, significantly in the SSR and ASL, and with high significance in the whole population from 121 +/- 54 to 139 +/- 58 (P < 0.001). Well-being did not change significantly in any of the groups or overall (from 122 +/- 59 to 117 +/- 54, p = 0.90). Deteriorating life conditions were due to a decline in clinical dementia rating, (p < 0.01) and living space diameter (p < 0.001), whereas the remaining subscores of life condition, i.e., number of falls, days of sickness, life style rating, and all subscores of well-being, i.e., number of medicines, valuation of handicap and of suffering, visual self-rating of well-being and caregivers' stress did not change significantly.

Activities of Daily Living↗

PubMed1981

Life stress, life-styles, depression, and illness in adult women.

The relationships between life stress and depression and physical illness were investigated in a sample of 122 normal adult women. Results indicated that life stress was associated with both illness and depression in this sample but that both type of stress and life-style were important moderators of these relationships. Thus, work stresses were associated with illness (not depression), and the relationship between life stress and illness was strongest among work-centered women. Family stresses were associated with depression (not illness), and the relationship between life stress and depression was strongest among housewives. Implications for sex role definitions are discussed.

Adult↗

PubMedDate not supplied

Testing a life-style risk model in an Afro-American population.

This article discusses the results of a research study investigating the possible relationship between life-style risk factors, e.g., weight, dietary patterns, stress, activity and smoking in the development of diseases. The author concludes that there is a need for individuals to improve weight, dietary patterns, reduce stress and increase recreational activity to reduce life-style risk.

Adult↗

PubMed1997

Life-styles of Phytoseiid mites and their roles in biological control.

This review categorizes the diversity of life-styles in the Phytoseiidae, based primarily on food habits and related biological and morphological traits. The life-styles proposed are as follows: Type I, specialized predators of Tetranychus species represented by the Phytoseiulus species; Type II, selective predators of tetranychid mites (most frequently associated with species that produce dense webbing) represented by Galendromus, some Neoseiulus, and a few Typhlodromus species; Type III, generalist predators represented by some Neoseiulus species and most Typhlodromus and Amblyseius species, as well as species in all other genera about which information is available; Type IV, specialized pollen feeders/generalist predators represented by Euseius species. Consideration is given to the relative importance of each of these types in biological control and pest management programs.

Journal Article↗

PubMed1979

Pre-retirement life-style and the degree of planning for retirement.

The purpose of this study was to examine the relationship between the pre-retirement life-style of adult men, and both the degree of planning for the retirement years and the decision to retire early. Adult males (N = 360) between 55 and 64 years of age were interviewed about their present leisure life-style and the amount of retirement planning they were doing or had done. In order to determine which demographic, attitudinal and social participation variables predict retirement related behavior, Multiple Classification Analysis (MCA) was used. It was found that socioeconomic status, health, involvement in expressive type organizations, job satisfaction and degree of leisure orientation were associated with pre-retirement attitudes toward retirement.

Attitude↗

PubMed2006

[The effects of a comprehensive life style modification program on glycemic control and stress response in type 2 diabetes].

PURPOSE: This study was to evaluate the effects of a comprehensive life style modification program on glycemic control and stress response in type 2 diabetes. METHOD: The participants(n=34) with type 2 diabetes were divided into either a usual care(control) or treatment(experimental) group. The experimental group(n=21) received a program that was based on a comprehensive life style modification protocol at a weekly meeting for 16 weeks. They also participated in individually prescribed exercise and diet along with stress management and self monitoring. The participants were followed for 6 months, during which postprandial glucose, HbA1C, and stress response inventory were measured. RESULT: The experimental group showed a significant lower postprandial glucose and stress response compared to those of the control group. However, there was no significant change in the HbA1C value in either group. CONCLUSIONS: These results suggest that a type 2 diabetes comprehensive lifestyle modification program may lead to clinical improvement in glycemic control and reduce the stress response.

Aged↗

PubMed1989

Effects on mood of a life-styles program for the rehabilitation of injured workers.

This study reports an examination into the effects on daily mood of participation in a life-styles program by injured workers. In the current prospective study, 14 participants completed the Memorial University Mood Scale (MUMS) prior to starting the program, at 1 month, 2 months, and at 3 months. They also completed the Memorial University Scale of Happiness (MUNSH) prior to entry and after three months. There were significant improvements on the MUMS subscales of positive mood and vigor as well as overall mood. There were no changes in negative mood. Neither the positive nor the negative dispositional subscales of the MUNSH revealed any change. The results were interpreted as indicating strong psychologic benefits of the life-styles program for injured workers and are also consistent with a recently proposed two-factor state/trait model of well-being.

Adult↗

PubMed1998

Relationship of prison life style to blood pressure, serum lipids and obesity in women prisoners in Japan.

This prospective study of female prison inmates assessed the effects of prison labour life style on the blood pressure (BP), serum lipids, and body mass index of pre- and postmenopausal female prisoners. This study was carried out in the largest women's prison, located in a town in the North East of Japan. The prison serves a reasonably large community. Three hundred and twelve premenopausal female prisoners and 88 postmenopausal female prisoners in a women's prison participated in this study. Weight and height were measured to calculate the body mass index, and systolic and diastolic blood pressure were measured with a sphygmomanometer. Serum samples were collected for serum lipid estimations. Base-line data of two groups were compared by unpaired t-test, and changes in these data from the initial values were tested by paired t-test. From our limited data, both the pre- and postmenopausal female prisoners showed decreases in systolic and diastolic pressure, total cholesterol, triglycerides, LDL-cholesterol, and body mass index. Both also showed increases in HDL-cholesterol. Given that almost all the women in this prison had the same labour life style, the findings of this study suggest that BP, the serum lipids concentration and obesity can be changed effectively by prison labour life, but are less readily changed in postmenopausal than in premenopausal women.

Adult↗

PubMed2006

Design of the New Life(style) study: a randomised controlled trial to optimise maternal weight development during pregnancy. [ISRCTN85313483].

BACKGROUND: Preventing excessive weight gain during pregnancy is potentially important in the prevention of overweight and obesity among women of childbearing age. However, few intervention studies aiming at weight management during pregnancy have been performed and most of these interventions were not as successful as expected. In this paper the design of the New Life(style) study is described as well as the content of the individually tailored intervention program, which focuses on controlling weight development during pregnancy. METHODS: The effectiveness of the New Life(style) intervention program versus usual care by midwives is evaluated in a randomised controlled trial. Women who expect their first child and visit one of the participating midwifery practices are included. The intervention is standardised in a protocol and executed by trained counsellors with the women who are randomised in the intervention group. During 5 sessions--at 18, 22, 30 and 36 weeks of pregnancy and at 8 weeks postpartum--individual weight gain is discussed in relation to weight gain guidelines for pregnant women of the American Institute of Medicine. Counsellors coach the women to maintain or optimise a healthy lifestyle, in a period of drastic physical and mental changes. Data is collected at 15, 25, 35 weeks of pregnancy and at 6, 26, and 52 weeks after delivery. Primary outcome measures are body weight, BMI, and skinfold thickness. Secondary outcome measures include physical activity, nutrition and blood levels of factors that are associated with energy homeostasis. DISCUSSION: Results of the current RCT will improve the knowledge of determinants of weight gain during pregnancy, weight retention after childbirth and of the effectiveness of the intervention program that is described. Caregivers and researchers in the field of health promotion are offered more insight in specific elements of the New Life(style) intervention program.

Counseling↗

PubMed1998

[Changes in life style as a causal therapeutic approach in coronary heart disease].

Life style measures (weight reduction and control, reduction of total fat calories to < 30% of total calories, modification of fat intake to increased monounsaturated vegetable fat, increased intake of dietary fibers, increased physical activity, controlled stress relaxation) are the basis of longterm therapy of coronary heart disease. For transformation to daily life both patient and doctor need motivation, information, patience, and realistic aims. For realization the 10 rules of medical information should be followed. The patient must be informed that the "new lifestyle" is not punishing but means a new quality of life. With respect to the most important metabolic syndrome with hyperinsulinemia due to insulin resistance, weight reduction is the most important measure for preventing complications of atherosclerosis. The patient should use a diary for weight control and blood pressure self-measurement. Secondary prevention of CHD has been shown useful and effective; however, most patients need additionally drug therapy to avoid or retard progression of the coronary heart disease. The targets for cholesterol and blood pressure control are low; the responsibility of the patient remains high. Besides weight reduction, stopping smoking, lowering lipids, controlling hypertension, and aspirin are the most important.

Coronary Disease↗

PubMed1991

Differential effect of diabetes education on self-regulation and life-style behaviors.

OBJECTIVE: To examine the effect of diabetes education on self-regulation and life-style behaviors. RESEARCH DESIGN AND METHODS: Participants in an outpatient diabetes education program completed a protocol measuring several self-care behaviors and glycemic control at entry (n = 165) and 6 (n = 124) and 12 (n = 89) mo after the program. RESULTS: Improvement was noted at 6 mo for most self-care behaviors and glycemic control. At 12 mo, lower glycosylated hemoglobin levels were maintained (P less than 0.001) without increases in perceived hypoglycemia. Improvement was not maintained for those self-care behaviors that require change in life-style, i.e., diet and exercise. However, self-care behaviors that allow patients to self-regulate their glycemic control--self-monitoring of blood glucose and insulin dose self-adjustment--were improved at 12 mo over preprogram levels (P less than 0.001). Frequency of insulin self-adjustment continued to increase during the period between follow-ups. CONCLUSIONS: The findings suggest that diabetes education is effective in promoting self-regulation behaviors, although it has less effect on traditional regimen behaviors such as diet and exercise.

Activities of Daily Living↗

PubMed2004

Effect of diet, life style, and other environmental/chemopreventive factors on colorectal cancer development, and assessment of the risks.

This review presents a comprehensive, evenhanded evaluation of the evidence from experimental, in vitro and human studies associating environmental and therapeutic factors with risk of colorectal cancer. Life styles correlated with the greatest increase in colorectal cancer risk are the ones that typify a diet rich in fat and calories, alcohol drinking and tobacco smoking, and low intake of vegetable, fruits and fibers, referred to as a "western diet," as well as sedentary style (i.e., no- or low-exercise). This kind of life style has also been associated with other chronic diseases (other cancers, obesity, dyslipedemia, diabetes, hypertension cardiovascular, and hypertension). The evidence does not implicated red meat as a risk factor, and fiber has been shown to protect against colorectal adenomas and carcinomas. Calcium, vitamin D, folate, and some antioxidant vitamins and minerals (gamma-tocopherol and selenium) have protective effects, and daily exercise for > or =30 min results in a significant decrease in risk. Estrogen use (hormone replacement therapy) substantially reduces colorectal cancer risk in postmenopausal women. Nonsteroidal anti-inflammatory drugs (e.g., aspirin) in excessive doses is protective, especially in high risk populations, but the side effects of its use and cost incurred due to its continued intake over long periods must be carefully scrutinized before any recommendations are made for the general public.

Adult↗