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Results for “Lymphocyte Count”

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At least 181 records · Page 10Linked to original sources

PubMed1998

Lack of direct correlation between CD4 T-lymphocyte counts and induration sizes of the tuberculin skin test in human immunodeficiency virus type 1 seropositive patients.

SETTING: The study was conducted in Bobo-Dioulasso, Burkina Faso, where Mycobacterium tuberculosis infection and human immunodeficiency virus type 1 (HIV-1) infection are prevalent. OBJECTIVE: To identify proportions of representative (test) populations who are reactive to the tuberculin skin test, and to study the relationship between CD4 T-lymphocyte counts and the induration size of the tuberculin skin test in these groups. DESIGN: A group of 435 healthy students was tuberculin skin tested in order to evaluate the intensity of skin testing in a 'normal' population. The study group consisted of 195 subjects with or without tuberculosis, and with or without HIV-1 infection, who received a tuberculin skin test and a CD4 T lymphocyte count on the same day. RESULTS: In total, 90% of the control (nontuberculous, HIV negative) subjects, 32% of the HIV-1 seropositive subjects, 76.5% of the tuberculous patients and 57% of the tuberculous HIV-1 seropositive patients were tuberculin positive. There was no direct correlation between the induration size of reactions to the tuberculin skin test and CD4 T-lymphocyte count in these study groups using linear regression analysis. CONCLUSION: In vivo skin testing using tuberculin yields clinically significant information on the degree of immunodeficiency which is different from that of CD4 T-lymphocyte counts. The tuberculin skin test should therefore be used as an independent marker of the weakened immunological status of HIV-1 seropositive subjects.

AIDS-Related Opportunistic Infections↗

PubMed2004

Clinical impact of early absolute lymphocyte count after allogeneic stem cell transplantation.

The role of repopulating lymphocytes after allogeneic stem cell transplantation (SCT) includes the prevention of serious infections and attacking residual tumour cells in the early post-transplant phase. Therefore, the current study analysed the role of the absolute lymphocyte count (ALC) on day 21 after SCT in predicting transplant outcomes of 82 patients in terms of the risk of opportunistic infections and recurrence of original disease. The median dose of CD34+, CD3+ and mononuclear cells (MNC) infused was 6.41 x 10(6)/kg, 1.96 x 10(8)/kg and 6.81 x 10(8)/kg respectively. The high ALC group (high ALC on day 21; > or =0.35 x 10(9)/l) was associated with the use of peripheral blood stem cells, matched sibling donors and higher cell doses of MNC, CD3+ and CD4+ cells. The high ALC group also exhibited a better overall survival (56.3% vs. 17.7%) and disease-free survival (50.1% vs. 15.9%) after 3 years and lower incidences of relapse (33.6% vs. 67.1%) and fungal infections (3.0% vs. 19.5%) after 1 year. The incidence of cytomegalovirus antigenaemia was lower in the high ALC group (47.7% vs. 73.7%). Accordingly, identifying the ALC on day 21 would appear to be a useful and simple measurement to predict those patients with a high risk of opportunistic infections and relapse after allogeneic SCT.

Adolescent↗

PubMed1980

Peripheral lymphocyte count in untreated non-Hodgkin's lymphoma patients and their lymphographic findings.

The relation between grades of foaminess in lumbar, iliac and inguinal nodes on bipedal lymphograms, and peripheral lymphocyte counts was assessed in patients with untreated non-Hodgkin's lymphoma. The lymphocyte counts were widely distributed in and around the normal range in patients with normal lymphographic findings, but in patients with increased grades of foaminess they were depressed to a marked degree. The decrease in peripheral lymphocyte counts in patients revealing no pathological grades of foaminess may be caused by the occult abdominal non-Hodgkin's lymphoma or may suggest the impending extension of the disease in these nodal chains.

Humans↗

PubMed1995

Protracted cutaneous disorders in association with low CD4+ lymphocyte counts.

We report two patients with skin disorders usually associated with severe immunosuppression, who had low CD4+ lymphocyte counts but normal immunoglobulin levels. The patients were HIV negative, and had CD4+ lymphocyte counts just above 300/mm3, but they presented with cutaneous manifestations of profound immunodeficiency. Idiopathic CD4+ lymphocyte deficiency is a recently described syndrome which may present with dermatological disease. We discuss the symptom complex of our patients in relationship to the diagnosis of idiopathic CD4+ lymphocyte deficiency.

Adult↗

PubMed2003

Rapid declines in total lymphocyte counts and hemoglobin concentration prior to AIDS among HIV-1-infected men.

OBJECTIVE: To describe temporal patterns in total lymphocyte count (TLC) and hemoglobin (Hgb) concentration during HIV infection and relate these patterns to changes in other markers and to clinical disease. DESIGN: Prospective cohort study. METHODS: Longitudinal trajectories of total lymphocyte count and hemoglobin from men in the Multicenter AIDS Cohort Study were studied by applying, to each individual, a segmented regression model to capture changes in marker trajectories at an inflection point. The estimated slope of these markers before and after the inflection point were examined to determine whether those with AIDS onset could be distinguished from those remaining free of AIDS through the use of receiver operating characteristic (ROC) curves. RESULTS: Prior to the estimated inflection points, TLC and Hgb marker slopes were distributed around zero in all men; afterwards, those who developed AIDS showed rapid declines in both markers. A TLC decline greater than 10% and Hgb decline greater than 2.2% was present in over 77% of HIV-positive men who developed AIDS but only 23% of HIV-positive men who did not. Among those who developed AIDS, rapid declines in TLC and Hgb began as CD4+ cell counts fell from 350 to 200 x 106 cells/l and preceded clinical AIDS by a median of about 1.6 years. CONCLUSIONS: Both TLC and Hgb showed a period of stability, which was followed by a rapid decline beginning shortly before the onset of AIDS. These results suggest that TLC and Hgb might be useful for monitoring disease progression in resource-limited settings.

Acquired Immunodeficiency Syndrome↗

PubMed1971