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Results for “Models, Anatomic”

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At least 181 records · Page 10Linked to original sources

PubMed1998

The Graz hemisphere splint: a new precise, non-invasive method of replacing the dental arch of 3D-models by plaster models.

Three-dimensional (3-D) anatomical models have proven their great value in the field of cranio-maxillofacial surgery. One major disadvantage is the limited representation of the teeth in milled and stereolithographic models. This is mainly caused by the limited resolution of the CT-scan, especially in the plane perpendicular to that of the scan. A new, precise, non-invasive and standardized method of replacing teeth of 3-D models by plaster models is introduced. The accuracy of tooth replacement is analysed. A plastic human skull is scanned with different interscan distances (scan feed), eight 3-D models are fabricated from this data and the positioning precision of the replaced plaster models in the three main axes is examined. Statistical analysis is carried out with a paired samples t-test. A mean positioning deviation of 0.44 and 0.52 mm in all directions is found using a CT feed of 2 and 3 mm. With 4 and 6 mm, the accuracy decreases showing 0.95 mm and 1.08 mm deviation. No significant difference is found between 2 mm and 3 mm scans, but significant differences between 2, 3 mm and 4, 6 mm are found. For the replacement of model teeth, at least three definitive fixed marks are required. With the aid of a hemisphere, used as a marker, the limited resolution in z-direction is overcome. The hemisphere is visible on several scans as semicircles of varying size. In the 3-D model, it allows precise positioning even on the z-axis enabling the exact replacement of teeth for the first time. A scan feed of 3 mm is sufficient for precise tooth replacement.

Calcium Sulfate↗

PubMed1979

[Pathological-anatomical teaching models in moulages. Manufacturing technic and history].

Wax moulages were used as pathological-anatomical teaching objects in medicine well into this century. On the occasion of the restauration of the moulage collection of the Department of Dermatology, University of Munich, the history of Munich wax artists is reviewed. The historical development of reproductions in wax in previous centuries is described. Several moulages showing various dermatological diseases are pictured. The technical details of moulage manufacture are mentioned.

Germany, West↗

PubMed2003

Myocardial oxygenation in isolated hearts predicted by an anatomically realistic microvascular transport model.

An anatomically realistic model for oxygen transport in cardiac tissue is introduced for analyzing data measured from isolated perfused guinea pig hearts. The model is constructed to match the microvascular anatomy of cardiac tissue based on available morphometric data. Transport in the three-dimensional system (divided into distinct microvascular, interstitial, and parenchymal spaces) is simulated. The model is used to interpret experimental data on mean cardiac tissue myoglobin saturation and to reveal differences in tissue oxygenation between buffer-perfused and red blood cell-perfused isolated hearts. Interpretation of measured mean myoglobin saturation is strongly dependent on the oxygen content of the perfusate (e.g., red blood cell-containing vs. cell-free perfusate). Model calculations match experimental values of mean tissue myoglobin saturation, measured mean myoglobin, and venous oxygen tension and can be used to predict distributions of intracellular oxygen tension. Calculations reveal that approximately 20% of the tissue is hypoxic with an oxygen tension of <0.5 mmHg when the buffer is equilibrated with 95% oxygen to give an arterial oxygen tension of over 600 mmHg. The addition of red blood cells to give a hematocrit of only 5% prevents tissue hypoxia. It is incorrect to assume that the usual buffer-perfused Langendorff heart preparation is adequately oxygenated for flows in the range of < or =10 ml. min-1. ml tissue-1.

Animals↗

PubMed2002

Use of a transpedicular drill guide for pedicle screw insertion in the thoracic spine.

A transpedicular drill guide (TDG) was designed to assist in the safe placement of pedicle screws in the thoracic spine. In a preliminary study, pilot holes were drilled into the pedicles (T1 to T12) of eight anatomical models in order to compare the conventional anatomical technique to the TDG. Visual inspection of the drilled pedicles was performed. Subsequently in a cadaveric study, pilot holes were made using the TDG in the thoracic spine (T1 to T11) of one human cadaver before inserting 4.5 mm diameter screws. CT scan followed by visual inspection of the cadaveric spine was performed to evaluate the position of the screws. With the anatomical models, 19 of 96 (19.8%) holes drilled using the TDG and 64 of 96 (66.7%) holes drilled using the anatomical technique violated the pedicle wall (p<0.001). The TDG reduced the rate of medial perforation. Ninety-nine percent of the pilot holes made with the TDG were within 2 mm from the pedicle wall compared to 79.2% for the anatomical technique. In the cadaveric study, one of the 22 (4.5%) screws violated the medial wall of the right T1 pedicle by less than 1 mm. No screw penetrated the anterior vertebral cortex, nor the lateral, superior or inferior pedicle wall. The TDG is easy to use and can decrease the incidence of misplaced thoracic pedicle screws. The TDG could be used alone as an alternative to navigation systems in certain applications or with fluoroscopy during thoracic pedicle screw placement, especially for training surgeons.

Bone Screws↗

PubMed2006

From grid cells to place cells: a mathematical model.

Anatomical connectivity and recent neurophysiological results imply that grid cells in the medial entorhinal cortex are the principal cortical inputs to place cells in the hippocampus. The authors propose a model in which place fields of hippocampal pyramidal cells are formed by linear summation of appropriately weighted inputs from entorhinal grid cells. Single confined place fields could be formed by summing input from a modest number (10-50) of grid cells with relatively similar grid phases, diverse grid orientations, and a biologically plausible range of grid spacings. When the spatial phase variation in the grid-cell input was higher, multiple, and irregularly spaced firing fields were formed. These observations point to a number of possible constraints in the organization of functional connections between grid cells and place cells.

Animals↗

PubMed2005

Dosimetric comparison of the specific anthropomorphic mannequin (SAM) to 14 anatomical head models using a novel definition for the mobile phone positioning.

This paper presents new definitions for obtaining reproducible results in numerical phone dosimetry. Numerous numerical dosimetric studies have been published about the exposure of mobile phone users which concluded with conflicting results. However, many of these studies lack reproducibility due to shortcomings in the description of the phone positioning. The new approach was tested by two groups applying two different numerical program packages to compare the specific anthropomorphic mannequin (SAM) to 14 anatomically correct head models. A novel definition for the positioning of mobile phones next to anatomically correct head models is given along with other essential parameters to be reported. The definition is solely based on anatomical characteristics of the head. A simple up-to-date phone model was used to determine the peak spatial specific absorption rate (SAR) of mobile phones in SAM and in the anatomically correct head models. The results were validated by measurements. The study clearly shows that SAM gives a conservative estimate of the exposure in anatomically correct head models for head only tissue. Depending on frequency, phone position and head size the numerically calculated 10 g averaged SAR in the pinna can be up to 2.1 times greater than the peak spatial SAR in SAM. Measurements in small structures, such as the pinna, will significantly increase the uncertainty; therefore SAM was designed for SAR assessment in the head only. Whether SAM will provide a conservative value for the pinna depends on the pinna SAR limit of the safety standard considered.

Adolescent↗

PubMed2005

Use of anatomical and kinetic models in the evaluation of human food additive safety.

Toxicological testing in animals is relied upon as a surrogate for clinical testing of most food additives. Both animal and human clinical test results are generally available for direct additives when high levels of exposure are expected. Limited animal studies or in vitro test results may be the only sources of toxicological data available when low levels of exposure (microg/person/day) are expected and where no effects of the additive on the food itself are desired. Safety assessment of such materials for humans requires mathematical extrapolation from any effects observed in test animals to arrive at acceptable daily intakes (ADIs) for humans. Models of anatomy may be used to estimate tissue and organ weights where that information is missing and necessary for evaluation of a data set. The effect of growth on target tissue exposure during critical phases of organ development can be more accurately assessed when models of growth and known physiological changes are combined with pharmacokinetic results for test species. Kinetic models, when combined with limited chemical property, kinetic, and distribution data, can often be used to predict steady-state plasma and tissue levels of a test material over the range of doses employed in chronic studies to aid in interpretation of effects that are often nonlinear with respect to delivered dose. A better understanding of the reasons for nonlinearity of effects in animals improves our confidence in extrapolation to humans.

Animals↗

PubMed1991

Computer simulations of activation in an anatomically based model of the human ventricular conduction system.

Simulations of the electrical activity during excitation were performed in an anatomically based model of the human ventricular conduction system. Each of the 33,000 elements of this model represented a unit bundle of Purkinje or atrioventricular nodal tissue. The Ebihara-Johnson model for sodium defined the active membrane characteristics. Using a combination of new and existing modeling techniques, simulations of excitation were completed in approximately 5 min CPU time on an IBM 3090 at the Cornell National Supercomputer Facility. Activation times at sites in the model were compared to experimental measurements for the excitation of the ventricular myocardium on the endocardial surface. These "literature-based" times were estimated from a number of reported human heart mapping studies. Initially, the times fit poorly. The major factor for the discrepancy was the conduction velocities of the elements, which were a result of the physical and electrical parameters derived from a review of histologic and electrical properties studies. In addition, there was a latency between activation of the system in the left ventricle of the model and that in the right ventricle when compared to the experimental work. When the times were scaled to adjust for the conduction velocity and ventricular latency effects, the match between the simulation and literature-based times was much improved. Quantitative comparison between normalized times resulted in correlation coefficients CCF = 0.76 for the right ventricle and CCF = 0.64 for the left ventricle.

Atrial Function↗

PubMed1993

[Three-dimensional computerized modelling of anatomical structures by computerized tomography imaging].

The authors built an automatic CT-driven device by which 3D models of biologic structures can be obtained. Original bidimensional densitometric data are recorded on tape and transferred to a mechanical computer-driven arm capable of cutting polystyrene slices reproducing the original biologic structures by means of an original software. The aim of our research was to assess the feasibility of such a device from a practical point of view and to analyze and solve related problems, in order to use the experience thus gained to develop more complex systems. We deliberately set up a device both technologically advanced and simple to be used even by non-specifically trained operators. The system capabilities open new perspectives in many application fields, such as surgery (stereotactic procedures, the making of personalized prostheses, plastic surgery, procedures planning and simulation), treatment (stereotactic radiotherapy), diagnostics (stereotactic biopsy) and educational use.

Humans↗

PubMed1998

Validation of a lower limb model with in vivo femoral forces telemetered from two subjects.

A mathematical model of the human pelvis-leg system in the sagittal plane, with an anatomical model of the knee, was developed to calculate forces transmitted by the structural elements of the system. The model was used to study the influence of activity of hip flexors and extensors on the forces in the femur during isometric exercises and during level walking. Kinematic and kinetic data together with simultaneous electromyography (EMG) and in vivo axial forces transmitted along the prostheses from two patients implanted with instrumented massive proximal femoral prostheses were obtained. Comparison of the levels of the calculated axial forces in the model femur to the simultaneous telemetered forces showed good agreement for isometric tests. Interaction between the muscles and the bones during isometric tests was examined and bi-articular muscles were shown to play a major role in modulating forces in bones. The study supports the hypothesis that muscles balance the external limb moments, not only at joints but also along the limbs, decreasing the bending moments but increasing the axial compressive forces in bones. It is thus suggested that appropriate simulation of muscle force is necessary in in vitro laboratory experiments and in theoretical studies of load transmission in bones. The sagittal plane model underestimates the value of the maximum axial force in the femur during walking by about 30% but suggests that 70% was due to the action of the extensors or flexors. The results encourage further development of a three-dimensional model with anatomical models of the joints to include coronal and transverse planes for the study of adductors and abductors.

Evaluation Studies as Topic↗

PubMed2002

Recent development on computer aided tissue engineering--a review.

The utilization of computer-aided technologies in tissue engineering has evolved in the development of a new field of computer-aided tissue engineering (CATE). This article reviews recent development and application of enabling computer technology, imaging technology, computer-aided design and computer-aided manufacturing (CAD and CAM), and rapid prototyping (RP) technology in tissue engineering, particularly, in computer-aided tissue anatomical modeling, three-dimensional (3-D) anatomy visualization and 3-D reconstruction, CAD-based anatomical modeling, computer-aided tissue classification, computer-aided tissue implantation and prototype modeling assisted surgical planning and reconstruction.

Animals↗

PubMed2005

Modeling wave propagation in realistic heart geometries using the phase-field method.

We present a novel algorithm for modeling electrical wave propagation in anatomical models of the heart. The algorithm uses a phase-field approach that represents the boundaries between the heart muscle and the surrounding medium as a spatially diffuse interface of finite thickness. The chief advantage of this method is to automatically handle the boundary conditions of the voltage in complex geometries without the need to track the location of these boundaries explicitly. The algorithm is shown to converge accurately in nontrivial test geometries with no-flux (zero normal current) boundary conditions as the width of the diffuse interface becomes small compared to the width of the cardiac action potential wavefront. Moreover, the method is illustrated for anatomically realistic models of isolated rabbit and canine ventricles as well as human atria.

Action Potentials↗

PubMed1980

A technique for kinematic modeling of anatomical joints.

This paper describes a general technique for fitting a spatial kinematic model to an in-vivo anatomical joint under typical physiological loading conditions. The method employs a nonlinear least squares algorithm to minimize the aggregate deviation between postulated model motion and experimentally measured anatomical joint motion over multiple joint positions. Estimation of the parameters of a universal joint with skew-oblique revolutes to best reproduce wrist motion was used as an example. Experimental motion data from the right wrists of five subjects were analyzed. The technique performed very well and produced repeatable results consistent with previous biomechanical wrist findings.

Biomechanical Phenomena↗

PubMed2006

Rapid prototyping as a tool for diagnosis and treatment planning for maxillary canine impaction.

Treating an impacted maxillary canine requires identifying its exact position; this can pose a challenge to both orthodontists and oral surgeons. The purpose of this article is to present a new method for diagnosis and treatment planning of maxillary canine impaction by using computed tomography combined with rapid prototyping. Computed tomography image files of a patient with tooth 13 impaction were edited to produce, by means of rapid prototyping, an anatomic model of the maxillary teeth and a single attachment model that was later used to fabricate a metal attachment to be bonded to the impacted tooth. The dental model was used in the diagnosis and orthodontic treatment planning, and to communicate with the patient and his parents. The model showed the exact anatomical relationship between the impacted tooth and the other teeth; it was the main aid in intraoperative navigation during surgery to expose the tooth. The metal attachment built from the prototype was bonded to tooth 13 during surgery. Prototyping could become a new tool for fabricating brackets and other precision accessories for specific needs. Dental models made with rapid prototyping could become the diagnostic procedure of choice for evaluating impacted maxillary canines.

Adolescent↗

PubMed1991

Knowledge-based system for the three-dimensional reconstruction of blood vessels from two angiographic projections.

A knowledge-based system for the three-dimensional reconstruction of blood vessels from wide-angle coronary and stereoscopic cerebral angiographic projections is developed. For the reconstruction of the coronary vessels, the left coronary artery (LCA) is automatically labelled on standard RAO and LAO projections, using anatomical models of the LCA. The labelling system succeeds in giving the most important coronary arteries a correct anatomical label. These labelling results enable us to find corresponding segments in both images. In the case of the reconstruction of the cerebral vessels however, such an anatomical model is clearly unavailable. To find corresponding segments, small-angle projections must be relied on, resulting in very similar images. Owing to the small angular separation between both projections, the three-dimensional reconstruction will be less accurate. Once the corresponding segments in both projections are obtained, the three-dimensional artery trajectory is reconstructed with dynamic programming techniques. The three-dimensional reconstructed coronary vessels are also used for an automatic quantification of stenotic lesions.

Blood Vessels↗

PubMed1992

The computer synthesis of expressive faces.

This paper presents a methodology for the computer synthesis of realistic faces capable of expressive articulations. A sophisticated three-dimensional model of the human face is developed that incorporates a physical model of facial tissue with an anatomical model of facial muscles. The tissue and muscle models are generic, in that their structures are independent of specific facial geometries. To synthesize specific faces, these models are automatically mapped onto geometrically accurate polygonal facial representations constructed by photogrammetry of stereo facial images or by non-uniform meshing of detailed facial topographies acquired by using range sensors. The methodology offers superior realism by utilizing physical modelling to emulate complex tissue deformations in response to coordinated facial muscle activity. To provide realistic muscle actions to the face model, a performance driven animation technique is developed which estimates the dynamic contractions of a performer's facial muscles from video imagery.

Computer Graphics↗

PubMed1995

Three-dimensional anatomical model-based segmentation of MR brain images through Principal Axes Registration.

Model-based segmentation and analysis of brain images depends on anatomical knowledge which may be derived from conventional atlases. Classical anatomical atlases are based on the rigid spatial distribution provided by a single cadaver. Their use to segment internal anatomical brain structures in a high-resolution MR brain image does not provide any knowledge about the subject variability, and therefore they are not very efficient in analysis. We present a method to develop three-dimensional computerized composite models of brain structures to build a computerized anatomical atlas. The composite models are developed using the real MR brain images of human subjects which are registered through the Principal Axes Transformation. The composite models provide probabilistic spatial distributions, which represent the variability of brain structures and can be easily updated for additional subjects. We demonstrate the use of such a composite model of ventricular structure to help segmentation of the ventricles and Cerebrospinal Fluid (CSF) of MR brain images. In this paper, a composite model of ventricles using a set of 22 human subjects is developed and used in a model-based segmentation of ventricles, sulci, and white matter lesions. To illustrate the clinical usefulness, automatic volumetric measurements on ventricular size and cortical atrophy for an additional eight alcoholics and 10 normal subjects were made. The volumetric quantitative results indicated regional brain atrophy in chronic alcoholics.

Alcoholism↗

PubMed1998

Induced current densities from low-frequency magnetic fields in a 2 mm resolution, anatomically realistic model of the body.

This paper presents calculations of current density in a fine-resolution (2 mm) anatomically realistic voxel model of the human body for uniform magnetic fields incident from the front, side and top of the body for frequencies from 50 Hz to 10 MHz. The voxel phantom, NORMAN, has a height of 1.76 m and a mass of 73 kg. There are 8.3 million voxels in the body differentiated into 37 tissue types. Both the impedance method and the scalar potential finite difference method were used to provide mutual corroboration. Results are presented for the current density averaged over 1 cm2 in muscle, heart, brain and retina.

Electromagnetic Fields↗