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Results for “Neoplastic Cells, Circulating”

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At least 181 records · Page 10Linked to original sources
PubMed2002

Use of veno-venous bypass for resection of malignant pheochromocytoma with vena caval thrombus.

Surgical management of malignant pheochromocytoma with tumor-induced venous obstruction involving the entrance to the right atrium is challenging. The risk of marked hypotension and hemodynamic instability following clamping of the vena cava is increased as a consequence of the sudden decrease in circulating catecholamines. The use of cardiac bypass, however is burdened with additional operating time and coagulopathy. The present report illustrates that veno-venous bypass is a valuable tool during resection of phenochromocytoma with a large vena caval tumor thrombus.

Adrenal Gland Neoplasms↗
PubMed1990

Mapping of cavernous vessels in the liver in an autopsy case of hepatocellular carcinoma in comparison with imaging figures.

Cavernous vessels in the liver have been rarely described in the liver with hepatocellular carcinoma. We report the morphology and distribution of cavernous vessels in an autopsy liver of hepatocellular carcinoma, using a whole liver slice. In this case, antemortem angiography disclosed obstruction of portal veins at the hepatic hilus and portal trunk as well as many hepatopetal collaterals, mainly at the hepatic hilus. Tumor thrombi were diffusely distributed in the liver from the portal trunk to peripheral portal branches at autopsy. The cavernous vessels, which were positive for Factor VIII-related antigen, were also distributed throughout the liver from the hepatic hilus to the subcapsular regions, especially around the occluded portal veins by hepatocellular carcinoma, suggesting that these vessels were collaterals that developed as the result of portal obstruction. This study suggests that these vessels might be present from the hepatic hilus to the subcapsular regions, even if antemortem imaging techniques disclose collateral vessels only at the hepatic hilus.

Autopsy↗
PubMed2006

Photoacoustic detection of metastatic melanoma cells in the human circulatory system.

Detection of disseminating tumor cells among patients suffering from various types and stages of cancer can function as an early warning system, alerting the physician of the metastatic spread or recurrence of the disease. Early detection of such cells can result in preventative treatment of the disease, while late stage detection can serve as an indicator of the effectiveness of chemotherapeutics. The prognostic value of exposing disseminating tumor cells poses an urgent need for an efficient, accurate screening method for metastatic cells. We propose a system for the detection of metastatic circulating tumor cells based on the thermoelastic properties of melanoma. The method employs photoacoustic excitation coupled with a detection system capable of determining the presence of disseminating cells within the circulatory system in vitro. Detection trials consisting of tissue phantoms and a human melanoma cell line resulted in a detection threshold of the order of ten individual cells, thus validating the effectiveness of the proposed mechanism. Results imply the potential to assay simple blood draws, from healthy and metastatic patients, for the presence of cancerous melanoma providing an unprecedented method for routine cancer screening.

Acoustics↗
PubMed2003

[Portal collateral circulation and pancreatic carcinoma: bypass the obstacle].

Portal thrombosis with collateral circulation complicating carcinoma of the head of the pancreas is a contraindication for surgical management of this type of neoplasm. We report a case of a female patient whose portal collateral circulation was first treated by an endoportal transhepatic prosthesis. Three months later, curative surgical resection of pancreatic adenocarcinoma was performed. This case illustrates an interesting two-phase surgical management of pancreatic adenocarcinoma with portal thrombosis, possible when there is not other surgical contraindication.

Adenocarcinoma↗
PubMed2000

A physical-based model for the simulation of neoplastic growth and metastasis.

BACKGROUND AND OBJECTIVES: It is possible to formulate models capable of reproducing the main details of the physical processes involved in the evolution of biological systems. The complexity of the problem requires to begin with a simple and universal model for the description of the cellular growth, to be adapted successively to the local conditions found in clinically observed neoplastic growths. METHODS: A model based on the Local Interaction Simulation Approach (LISA) has been formulated for the simulation of growth, diffusion, and metastasis of neoplasms. The vascularization is described by a blood vessel located on one edge of the specimen in which a constant and homogeneous flow is assumed. A nutrient density is defined to mimic the blood flow within the tissue. RESULTS: Photograms taken at proper times may identify the main characteristics of the tumor evolution and describe its volume variations in a transversal section. Furthermore, it is possible to monitor constantly the volume of the neoplasm and of the necrotic tissue as a function of time, as well as the portion of cells that have migrated in the blood vessel. CONCLUSIONS: In spite of strong simplifying assumptions, the model presents good qualitative agreement with clinical data, which may be further improved by more detailed information about cancer cells properties or local vascular system patterns.

Animals↗