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Results for “OSTEORADIONECROSIS”

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At least 181 records · Page 10Linked to original sources

PubMed1978

[Osteoradionecrosis resulting from cobalt-60 therapy for head and neck tumors (author's transl)].

From 1966--1974, 628 patients were irradiated with Cobalt-60 as treatment for tumors of the head and neck. Tumor doses ranged from 6200 R to 8000 R. An osteoradionecrosis was discovered in 17 patients, and was mostly localized in the mandible. Most of the patients developed the necrosis during the first two years following completion of their radiation, although necrosis was also found up to 9 years following therapy. Prophylactic treatment of teeth should be completed before beginning radiation therapy, but such does not exclude the risk of necrosis.

Cobalt Radioisotopes↗

PubMed1995

Osteoradionecrosis of the hyoid induced by combined modality therapy for laryngeal carcinoma.

Contemporary management of laryngeal carcinoma often incorporates multiple modalities of therapy. We report a case of osteoradionecrosis of the hyoid bone in a patient treated with surgery, chemotherapy, and radiation therapy for a supraglottic squamous cell carcinoma. A discussion regarding pathophysiology, radiation dosimetry and treatment options is also presented.

Carcinoma↗

PubMed1995

[Dento-alveolar surgery of the irradiated jaw: is infected osteoradionecrosis a preventable complication?].

In spite of preventive procedures before, during and after radiotherapy, profound caries and periodontal breakdown of healthy teeth occur. In the course of dentoalveolar surgery in the region of irradiated bone, the risk of development of an infected osteoradionecrosis can be reduced by prophylactic antibodies, prevention of extensive detaching of the periosteum careful osteotomy or extraction, complete smoothing of sharp alveolar ridges and epiperiosteal plastic coverage. When extensive dentoalveolar surgery is necessary, the application of prophylactic pre- and postoperative hyperbaric oxygen may reduce the rate of complications even more.

Follow-Up Studies↗

PubMed1995

A modified protocol to treat early osteoradionecrosis of the mandible.

Hyperbaric oxygen (HBO) increases oxygen availability to hypoxic tissues thereby inducing fibroblastic proliferation and capillary formation in bone and soft tissue. From 1981 to 1991 we used a monoplace hyperbaric chamber, and since 1992 a multiplace chamber, for HBO treatments. HBO was given at 2.5-2.8 atm abs for 90-120 min, once per day. We used five to seven preoperative and five to seven postoperative sessions. Altogether, 17 patients with osteoradionecrosis (ORN) of the mandible or maxilla were treated with surgery and HBO. Surgical therapy consisted of decortication of the affected bone that was subsequently covered with a free periosteal transplant from the tibia. The shortest follow-up time is 18 mo. Sixteen patients have remained symptom free after the first treatment period. One case was a failure in the early protocol but was successfully treated using a free microvascular flap. It is concluded that HBO is a promising adjunct to surgery in treating mandibular or maxillary ORN.

Adult↗

PubMed1993

Management of osteoradionecrosis of the mandible.

Osteoradionecrosis (ORN) of the mandible is a severe complication that follows ionizing radiation therapy in patients undergoing treatment for head and neck cancers. The occurrence of ORN usually implies other coexisting problems and should not be thought of as a "bone only" defect. For treatment to be effective, all tissues involved must be addressed.

Humans↗

PubMed1995

[Osteoradionecrosis of the jaws].

9 patients with osteoradionecrosis of the mandible were treated during 1975-1994. All primary tumor had received high dose external radiation or brachytherapy, using iridium-192 sources. In 6 patients the complication was triggered, shortly before or after irradiation, by surgical interventions such as tooth extraction, or by the presence of an infected focus in the mandible. The complications were treated conservatively, including 2 cases by hyperbaric oxygen. The value of prevention is emphasized.

Adult↗

PubMed1963