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At least 181 records · Page 10Linked to original sources
PubMed2006

AmpliChip CYP450 test: personalized medicine has arrived in psychiatry.

The US FDA has granted market approval for the first pharmacogenetic test using a DNA microarray, the AmpliChip CYP450, which genotypes cytochrome P450 (CYP)2D6 and CYP2C19. The test uses software to predict phenotypes and tests for 27 CYP2D6 alleles, including the deletions and duplications, and three CYP2C19 alleles. Other DNA microarray platforms are being developed for CYP testing, but none have been completely developed or approved by the FDA to date. The differences between an implementation of pharmacogenetic tests centered on the individual and implementation using a public health approach are discussed. In this review, the major obstacles to the wide implementation of pharmacogenetic testing in the clinical environment are summarized.

Alleles↗
PubMed1994

[Asymptomatic sexually transmitted infections among HIV-tested persons].

We have prospectively determined the frequency of asymptomatic sexually transmitted diseases (STD) among patients seeking an HIV-test. In 246 patients, we observed 32 cases (13%) of asymptomatic STD, predominantly infections caused by Chlamydia trachomatis or human Papillomavirus. STD screening is of significance among patients seeking an HIV-test.

Denmark↗
PubMed1963

Personality test interpretation by digital computer.

In this study a set of decision rules was devised for interpreting profile patterns of the Minnesota Multiphasic Personality Inventory (MMPI) of maladjusted and adjusted college students. The procedure used was that of computer programming of the "maladjusted" versus "adjusted" decisions of an expert test interpreter. The interpreter's decision-making processes were tape-recorded while he was thinking aloud during the sorting of the profiles of 126 college students. The programmed decision rules, which were based on the interpreter's protocol and which were improved upon by a process of trial-and-error statistical checking, yielded a greater hit percentage than the decisions of the original interpreter. In its final form, the set of objective configural inventory rules identified correctly large numbers of maladjusted college students in two cross-validation samples.

Biometry↗