THE EFFECT OF PYRIDINIUM ALDOXIMES AND ATROPINE ON THE INCORPORATION OF DF32P IN RAT LIVER CELL FRACTIONS.
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Nerve agents, highly toxic organophosphorus cholinesterase inhibitors, inhibit acetylcholinesterase and cause an accumulation of acetylcholine. Clinical effects depend on the route and amount of exposure and include miosis, bronchoconstriction, excessive secretions, vomiting, seizures, and cessation of respiratory and cardiac activity. Eye effects include miosis, engorgement of ocular vessels, pain, and decrease in light sensitivity. Therapy consists of atropine, a cholinesterase reactivator (pralidoxime), and ventilation as needed.
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The substance responsible for the poisoning effect of ciguatera poison from fish is an anticholinesterase. In rats, mice, and rabbits ciguatera poison causes death by asphyxiation. Protopam chloride with atropine is an effective antidote.
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