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Prophylaxis for deep vein thrombosis and pulmonary embolism in the surgical patient.

This article reviews the pathophysiology for the development of deep vein thrombosis and pulmonary embolism in the surgical patient. Patients are stratified into risk groups based on predisposing criteria for the development of thrombosis. Seven modalities of prophylaxis are reviewed with respect to appropriate application. Five major types of surgery are described assessing incidence and prophylaxis of choice. The final section deals with the special consideration of patients with thrombotic disease undergoing surgery.

Humans↗

Nuclear medicine in the diagnosis of deep venous thrombosis and pulmonary embolism.

Nuclear medicine techniques offer a variety of approaches to the diagnosis of deep venous thrombosis and pulmonary embolism. Several radionuclide methods are available to visualize venous structures, and many radiolabeled agents have been developed for direct visualization of blood clots, including platelets and monoclonal antibodies. Although still available on a limited basis, radiolabeled fibrinogen uptake studies have been replaced largely by newer methods. Ventilation-perfusion lung scanning remains the mainstay of nuclear medicine detection of pulmonary embolism as it has for the past two decades.

Humans↗

Deep venous thrombosis and pulmonary embolism.

All surgical patients are at risk for the development of deep venous thrombosis and subsequent pulmonary embolism or postphlebitic syndrome. The evolution of ultrasonographic imaging has increased the awareness of prevention, diagnosis, and treatment of deep venous thrombosis. Duplex imaging and Doppler color flow imaging have made the diagnosis of deep venous thrombosis relatively simple, painless, inexpensive, and definitive. These procedures have gained acceptance by both patients and physicians. Several risk factors have been identified that increase the chance of the development of deep venous thrombosis. These factors include a history of deep venous thrombosis, presence of a malignant process, increasing age, cigarette smoking, obesity, prolonged bed rest, and general anesthesia. The greater the number of risk factors, the more aggressive prophylaxis should be. Means of prophylaxis have improved, and surgeons now generally agree that some form of prophylaxis is required. Heparin and intermittent compression devices appear to be equally effective in preventing deep venous thrombosis. The addition of venous monitoring in high-risk patients permits immediate identification of the presence of deep venous thrombosis. During the last decade, the treatment of patients with deep venous thrombosis has changed little. Heparin followed by warfarin remains the treatment of choice. A small group of patients receive fibrinolytic therapy for deep venous thrombosis. Although the incidence of postoperative deep venous thrombosis has decreased during the last decade, it remains a significant complication.

Humans↗