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PubMed2003

Physical exercise reduces risk of breast cancer in Japanese women.

To evaluate the effects of physical exercise on breast cancer risk, a large-scale case-referent study of 2376 incident breast cancer cases and 18,977 non-cancer referents was conducted using data from the hospital-based epidemiologic research program at Aichi Cancer Center (HERPACC). To adjust appropriately for possible confounders, we examined the effects within subgroups of the study population. The multivariable-adjusted odds ratio (OR) was 0.81 (95% confidence interval (CI): 0.69-0.94) for twice a week or more regular exercise. We observed a decreased risk of breast cancer for women who regularly exercised for health twice a week or more, irrespective of menopausal status, and were able to detect greater risk reductions within particular subgroups, including women who were parous, without a family history or non-drinkers. Among premenopausal women, a particularly strong protective effect of physical exercise was observed (OR=0.57, 95%CI: 0.28-1.15) for those women whose body mass index (BMI) was high (BM > or = 25). In contrast, risk reduction was found (OR=0.71, 95%CI: 0.50-1.01) among postmenopausal women whose BMI was medium (BMI: 22-25). Stratification of history of stomach cancer screening to adjust modifying effects of healthy consciousness allows a more precise assessment of the protective effect of exercise twice a week or more, independent of stomach cancer screening history. This study provides evidence that physical exercise, especially exercise twice a week or more, reduces the risk of breast cancer among Japanese women.

Adult↗

PubMed2003

[The effects of physical exercise on the immune system].

Physical exercise has numerous effects on the human body, including the immune system. After strenuous exercise, athletes pass through a period of impaired immune resistance. During this period, athletes are theoretically more susceptible to upper respiratory tract infections, although a causal relation has never been demonstrated. Moderate exercise seems to have a beneficial effect on the immune function, which could protect against upper respiratory tract infections. Exercise has effects on both the humoral and the cellular immune system. Doping products, except glucocorticoids, only have modest effects on the immune system, although erythropoietin may, in rare cases, cause severe side-effects. Glutamine and vitamin C could, hypothetically, prevent the negative effects of strenuous exercise on the immune function, but further studies are needed to demonstrate and explain these effects.

Antibody Formation↗

PubMed1989

The pattern of breathing and the ventilatory response to breathing through a tube and to physical exercise in sport divers.

Well-trained divers can be expected to differ from healthy controls in their ventilatory response to breathing through a tube and to physical exercise. Therefore, we measured their minute ventilation (VE) at rest and during breathing through a tube combined with two levels of physical exercise (1 or 2 W.kg body weight-1). For breathing through a tube an additional dead space of 600 ml was used. All divers were trained in the breath-hold technique and in the use of the breathing apparatus. Their mean period of training as divers was 9 +/- 6 years. The approximate age of the subjects was 25 years. The pattern of breathing and the oxygen uptake were measured by spirometer, the end-tidal concentration of CO2 was measured and all experiments were carried out above sea level. The ventilation of the divers at rest was comparable to that of the controls. During physical exercise it was smaller whether during breathing through a tube or not. The inadequate increase of VE during exercise in divers was associated with hypercapnia only at a higher physical work intensity (of 2 W.kg-1). This finding is interpreted as a lower chemoregulatory response to the combined stimuli of hypercapnia, hypoxia and physical exercise. In some situations significant bradypnoea and higher tidal volumes were found in the divers.

Adolescent↗

PubMed2006

Short term effects of physical exercise and low calorie diet on left ventricular function in obese subjects: a tissue Doppler study.

BACKGROUND AND AIM: The effects of combined physical exercise and a hypocaloric diet on left ventricular function in obese subjects without heart disease are not well defined and have never been studied with the tissue Doppler technique. The purpose of our study was to describe the modification of left ventricular systolic and diastolic functions after a short period of physical exercise and a hypocaloric diet in obese patients. METHODS AND RESULTS: Fifteen patients (10 females and 5 males) aged 29.7+/-6.1 years with uncomplicated obesity (mean body mass index=41.4+/-5.5 kg/m(2)) were subjected to a low calorie diet and physical exercise. Systolic and diastolic functions were evaluated by Doppler and tissue Doppler echocardiography. After 3 weeks echocardiographic and conventional Doppler measurements were unchanged, while Sa increased (0.109+/-0.019 vs 0.118+/-0.016 m/s) and Ea decreased (0.162+/-0.029 vs 0.147+/-0.022 m/s, P=0.044) resulting in a decrease in Ea/Aa (1.66+/-0.53 vs 1.40+/-0.28, P=0.033) and an increase in E/Ea (5.65+/-1.00 vs 6.35+/-1.21, P=0.038). CONCLUSION: Physical exercise and a hypocaloric diet in obese healthy subjects result in an improvement of a TDI index of systolic function and a slight reduction in early diastolic velocity of mitral annulus.

Adult↗

PubMedDate not supplied

Blood glucose and insulin concentration in rats subjected to physical exercise in acute poisoning with parathion-methyl.

Unexercised rats or those subjected to single physical exercise were given parathion-methyl (10 mg/kg p.o. - 0.5 DL50) or oil (vehicle). Blood glucose and serum insulin concentration were assayed 1 h after the treatment. Physical exercise depressed the serum insulin concentration without changes in blood glucose level. In acute poisoning with parathion-methyl hyperglycemia occurred concurrently with hypoinsulinemia. Physical exercise abolished the pesticide-induced hypoinsulinemia, but not hyperglycemia.

Animals↗

PubMedDate not supplied

[Physical exercise and food habits: a study of adolescents in Cádiz].

BACKGROUND: A increased number of eating disorders among teen-agers are currently being reported. Physical exercise, especially when done individually, is one of the methods chosen for losing weight. We are basing this study on the hypothesis of a larger number of eating habit disorders (EHD's) in subjects who do physical exercise alone. This study describes and compares eating habits among teen-agers that do individual exercise as opposed to athletes who work out in groups or on teams. METHOD: Cross-section study of 532 teen-agers ages 14-18 who are enrolled in school and who do physical exercise, having been selected at random by means of a two-stage, stratified sampling process. The subjects were divided into two groups according whether they did individual physical exercise alone (Number: 216) or in groups (Number: 316). The eating habits of both groups were analyzed based on a questionnaire filled out by the subjects themselves. RESULTS: In the group preferring individual sports, females were predominant (degree of males 0.44). Of these females, their being on diets in order to lose weight was 3.12 times more frequent, compulsive eating episodes being 3.73 times more frequent. As regards behaviors which might be considered to be compensatory, there is a clear concentration thereof among those who do sports individually, hence 43% stated to voluntarily undergo periods of fasting (4.96 times more than those who exercise in groups), 46% stating to have brought on vomiting at one time or another for "dieting" purposes (3.76 more) and up to 26% have used laxatives with the intention of losing weight (2.56 times more than among athletes who play on teams). CONCLUSION: The existence of EHD's seems to be associated with teen-agers who play individual sports as opposed to those who play on teams.

Adolescent↗

PubMedDate not supplied

Lack of effect of physical exercise on pharmacokinetics of acetaminophen tablets in healthy subjects.

The study was designed to evaluate the effect of physical exercise on the pharmacokinetics of acetaminophen. Ten healthy volunteers were drawn to the investigation. Each person was subjected to the pharmacokinetic study twice, i.e. at rest and on an exercise day. On the exercise day the subjects were performing 3 hours long physical exercise which consisted of a walk on a treadmill at 3 mph for 20 minutes of each half an hour. Acetaminophen was given orally at a single dose of 1.0 g prior to the exercise. Blood for pharmacokinetic assay was sampled within 24 hours following the drug administration. Acetaminophen concentrations were determined by the FPIA method. The total concentrations versus time curve were described by the one-compartment open model for extravascular administration. It was revealed, that the standard submaximal physical exercise does not affect the pharmacokinetics of acetaminophen statistically significantly.

Acetaminophen↗

PubMedDate not supplied

Effect of physical exercise upon nystagmus and locomotor dysequilibrium after labyrinthectomy in experimental primates.

Spontaneous nystagmus and locomotor equilibrium function were repeatedly tested before and after unilateral labyrinthectomy in 12 squirrel monkeys in order to study the effect of physical exercise on the vestibulo-oculomotor and vestibulo-locomotor compensation. Post-operatively, 6 of the monkeys received forced physical exercise in the rotating cage, while the other 6 did not. The provocation of post-operative spontaneous nystagmus was less in the exercise group. The statistical studies showed a certain contribution of physical exercise toward the oculomotor balance compensation and maintenance, probably at the level of the brain stem. Statistical comparison of the locomotor equilibrium performance did not depict a significant difference between the exercise and non-exercise groups; however, there was a possibility that the present testing maneuver which involves physically advanced tasks might have concealed the effect of the physical exercise.

Animals↗

PubMed2005

Physical exercise does not favour adverse reactions to allergen immunotherapy by the sublingual route.

It is generally recommended in consensus documents on allergen immunotherapy to avoid any kind of physical exercise in the 24 hours following the administration of the allergen extract but such recommendation is not supported by scientific evidence. We evaluated the risk of developing adverse reactions in a group of patients submitted to sublingual immunotherapy by performing a controlled exercise test. Eleven patients were included in the study, 8 treated with grass pollen and 3 with Parietaria pollen extract by Staloral300 (Stallergénes, Antony, France), with the build-up phase in 11 days suggested by the manufacturer and a top dose of 300 IR. At the first maintenance dose, in all patients were measured heart rate, blood pressure, FEV1, and tryptase in blood. Then the maintenance dose was assumed and the physical exercise performed by cycloergometer maintaining a heart rate around 100 b/min and measuring again tryptase, blood pressure and FEV1. The results showed that no patient had adverse reaction following physical exercise, neither showed significant changes in FEV1, blood pressure, or tryptase level, which was 5.57 +/- 4.54 mcg/l before and 5.81 +/- 4.34 mcg/l after exercise. This suggests that there is no reason to advise against physical exercise, and particularly sporting activity, in patients treated with sublingual immunotherapy thus avoiding to interfere with the subject's lifestyle and consequently with his quality of life.

Abdominal Pain↗

PubMed2001

Circulating insulin-like growth factor I mediates the protective effects of physical exercise against brain insults of different etiology and anatomy.

Physical exercise ameliorates age-related neuronal loss and is currently recommended as a therapeutical aid in several neurodegenerative diseases. However, evidence is still lacking to firmly establish whether exercise constitutes a practical neuroprotective strategy. We now show that exercise provides a remarkable protection against brain insults of different etiology and anatomy. Laboratory rodents were submitted to treadmill running (1 km/d) either before or after neurotoxin insult of the hippocampus (domoic acid) or the brainstem (3-acetylpyridine) or along progression of inherited neurodegeneration affecting the cerebellum (Purkinje cell degeneration). In all cases, animals show recovery of behavioral performance compared with sedentary ones, i.e., intact spatial memory in hippocampal-injured mice, and normal or near to normal motor coordination in brainstem- and cerebellum-damaged animals. Furthermore, exercise blocked neuronal impairment or loss in all types of injuries. Because circulating insulin-like growth factor I (IGF-I), a potent neurotrophic hormone, mediates many of the effects of exercise on the brain, we determined whether neuroprotection by exercise is mediated by IGF-I. Indeed, subcutaneous administration of a blocking anti-IGF-I antibody to exercising animals to inhibit exercise-induced brain uptake of IGF-I abrogates the protective effects of exercise in all types of lesions; antibody-treated animals showed sedentary-like brain damage. These results indicate that exercise prevents and protects from brain damage through increased uptake of circulating IGF-I by the brain. The practice of physical exercise is thus strongly recommended as a preventive measure against neuronal demise. These findings also support the use of IGF-I as a therapeutical aid in brain diseases coursing with either acute or progressive neuronal death.

Animals↗

PubMed2002

Effect of physical exercise on lipid metabolism in the elderly.

PURPOSE: To assess the effect of regular physical exercise on plasma lipids and apoproteins in an elderly group. MATERIAL AND METHODS: Sixty-three old people of both sexes, aged between 65 and 94, were randomly distributed between a test group (n = 31) and a control group (n = 32). The test group followed a program of physical exercise for eight months, with intensity of 60% to 80% of heart rate reserve, consisting of three weekly sessions, on alternate days, of 60 minutes each. Before the beginning of the program and eight months afterwards, blood samples were collected to assess total cholesterol, triglycerides, HDL-C, HDL2-C. HDL3-C, apo A1, apo B-100 and apo (a). The ratios total cholesterol/HDL-C, LDL-C/HDL-C, HDL2-C/HDL3-C and apo A1/apo B-100 were also calculated. RESULTS: In the test group total cholesterol, triglycerides, LDL-C, apo B-100, total cholesterol/HDL-C and LDL-C/HDL-C decreased significantly; HDL-C, HDL2-C, apo A1, HDL2-C/HDL3-C and apo A1/apo B-100 increased significantly; HDL3-C and apo (a) did not change. The control group did not present any significant alterations in any of the parameters assessed. CONCLUSIONS: Regular physical exercise decreases vascular risk and may help to reduce cardiovascular events in the elderly.

Age Factors↗

PubMed2005

Neck/shoulder disorders in a general population. Natural course and influence of physical exercise: a 5-year follow-up.

STUDY DESIGN: A 5-year follow-up study was conducted of men and women seeking care for new incidents of neck/shoulder disorders (NSD). OBJECTIVES: To study the natural course of pain and disability caused by NSD during a 5-year follow-up and to investigate the possible influence of regular physical exercise on recovery. SUMMARY OF BACKGROUND DATA: NSD are a major health problem, but their natural course is not very well studied. Several studies have investigated the role of physical exercise on NSD, with inconsistent results. METHODS: At baseline, a total of 439 subjects seeking care for NSD completed a questionnaire, and were interviewed about personal, medical, and occupational history, as well as physical exercise during leisure time. Over 5 years, 4 follow-up assessments were made by postal questionnaire. At all measuring points, pain intensity ratings and disability scores were compared between men and women, and between 3 exercise categories. RESULTS: The highest improvements in pain and disability, both in men and in women, were seen after 3 months. After that, only minor improvements were seen. In some cases, there was deterioration. However, after 5 years, both men and women had significant improvements, men more than women. Only the women were analyzed concerning physical exercise and were pooled into 3 categories according to intensity of exercise. There were no differences in changes in pain intensity and disability scores from baseline between the groups. CONCLUSIONS: A gender difference was seen in the change of pain and disability, with men having higher improvement than women over 5 years. Self-reported physical exercise of any intensity was not associated with higher recovery in women.

Adult↗

PubMed1976

Cardiac output during physical exercises following real and simulated space flight.

During moderate physical work (after 5 min) the cardiac stroke volume in the cosmonauts who made 2--8-day flights in the Soyuz spacecraft was lower and the pulse rate was higher than the pre-flight level. By the end of the 49-day bed-rest experiment the stroke volume during physical exercises (after 5 min) was lower than at the 5th min of the pre-test period in both the supine and sitting positions. The cosmonauts performed physical exercises in the sitting position. Therefore, it can be assumed that the major factor changing cardiac output may be the effect of the earth's gravity against the background of decreased orthostatic tolerance. Results of simulated experiments give evidence that in both cases one of the major factors responsible for changes in the cardiac output was a decline in the contractile capacity of the myocardium.

Bed Rest↗

PubMed1998

Evaluation of clotting and fibrinolytic activation after protracted physical exercise.

The behavior of hemostatic system activation during protracted physical exercise is well known, but the duration of its modification is not yet defined. In order to evaluate the time of hemostatic system activation after prolonged strenuous endurance physical exercise (typical marathon race: 42.195 km, v=15.35 km/h; mean length of time run 2.45+/-0.15 hours) 12 well-trained long-distance male runners (mean age: 35+/-7, range 25-47 years) were investigated. Blood samples were drawn in the morning on the day before the performance, immediately after the race, and 24 hours and 48 hours after the end of run. With respect of baseline, immediately after the race, a significant decrease of fibrinogen (-25%) and significant increases of prothrombin fragment 1+2 (+633%) and thrombin-antithrombin complex (+848%) were observed. A significant acceleration of euglobulin lysis time (-41%), and rises of plasma levels of tissue plasminogen activator antigen (+361%), plasminogen activator inhibitor type 1 antigen (+235%), d-dimer (+215%), and plasma fibrinogen degradation products (+1200%) were also found. Only a slight, yet not significant, decrease in plasminogen activator inhibitor type 1 activity was observed. One day after the end of marathon different parameters were still unchanged. Forty-eight hours after the competition all parameters investigated returned to baseline values. These results indicate a persistence of clotting as well as fibrinolysis activation up to 24 hours after the end of the race.

Adult↗

PubMed1989

[Effect of physical exercise on the fate of drugs in the body].

A data from the literature on the effect of physical exercise on the fate of drugs in the body have been collected. An intensive exercise and training produce several important changes in the physiological and metabolic function of the tissues and organs, especially kidneys, liver and circulatory system. Therefore, absorption, metabolism, and elimination of numerous drugs are modified. An intensive physical exercise increases or decreases blood levels of drugs and effect their elimination. It should be stressed that the data on these problems are incomplete and related to various groups of drugs, different modes of application, and various models of exercise testing. It seems, however, that physical exercise should be considered and additional, besides genetic factors, diet or patient's age, factor affecting the fate of drugs in the body.

Exercise↗

PubMed1983

Physical exercise as prophylaxis against involutional vertebral bone loss: a controlled trial.

1. The skeletal effects of physical training were studied in a controlled trial involving 31 healthy women (aged 50-73 years) with previous Colles' fracture of the forearm. The bone mineral content of the lumbar spine and both distal forearms was measured by dual-photon (153Gd) absorptiometry. 2. The participants were allocated to either a physical exercise group or a control group. The former group followed a standardized exercise programme, exercising for 1 h twice weekly during 8 months. 3. Twenty-seven women completed the study. Lumbar spine bone mineral content of the exercise group increased by 3.5%, whereas that of the control group decreased by 2.7%. The rate of bone loss in the control group equalled that of age-matched normal women. 4. The changes in forearm bone mineral content appeared to be independent of the exercise. The bone mineral content of the previously fractured forearm remained nearly unchanged. The bone mineral content of the uninjured forearm decreased on average by 3.5%. 5. The data suggest that physical exercise can inhibit or reverse the involutional bone loss from the lumbar vertebrae in normal women. Physical exercise may prevent spinal osteoporosis.

Aged↗

PubMed1989

Nitrogen metabolism in man under hypokinesia and physical exercise.

Experimental studies of hypokinetic physiology are generally based on the assumption that diminished muscular activity (progressive reduction of number of steps per day) is hostile to animal and human organisms, since the entire animal kingdom has been formed in a high motor activity environment, which left its imprint on the evolution, structure, function and behavior of living organisms. It has been suggested that physical exercise may be used to prevent changes in man's nitrogen metabolism under hypokinesia. Thus, the aim of this study was to evaluate the effect of physical exercise in attenuating nitrogen metabolic changes under hypokinesia of 90 days in twelve healthy men aged 19 to 23 years. They were divided into two groups with six men in each. The control group was subjected to pure hypokinesia, that is, without the use of any preventive measures, and the experimental group was submitted to combined hypokinesia and physical exercise with energy expenditure of about 500 kcal. For the simulation of the hypokinetic effect the men were kept under an average of 500 steps/day. The caloric value of their diet was about 2400 kcal/day and 2600 kcal/day for the control and experimental groups, respectively. Total nitrogen, urea nitrogen, nitrogen ammonium salts, nitrogen of free amino acids, creatine, creatinine, as well as vitamins C, B1 and 4-pyridoxic acid excretion were measured in urine. Hypokinesia induced a negative nitrogen balance, which was most pronounced in the control group. The excretion of the other nitrogeneous compounds, vitamins, creatine, and creatinine was also increased. Physical exercise had only a limited effect on nitrogen metabolism. We concluded that diminished muscular activity induced a marked increased excretion of nitrogen; at the same time it was revealed that physical exercise cannot be used to counteract effectively the development of adverse reactions of nitrogen metabolism under hypokinetic conditions.

Adult↗

PubMed1991

Reduced active protection to the cochlea during physical exercise.

The present investigation was designed to evaluate whether dynamic physical exercise is able to modify stapedius reflex (SR) activity and, as a consequence, to influence the amount of temporary threshold shift (TTS). Experimental subjects were 10 normal-hearing male volunteers, aged 27-34 years (mean 30.8). SR parameters in the time-domain were assessed before, during and after submaximal exercise test, performed for 10 min on an ergometer cycle at 50% of maximum work capacity. The same parameters were also investigated in the absence of exercise, at time-matched intervals. In addition, the combined effect of noise and exercise was studied. The outcome of the investigation indicates that dynamic physical exercise depresses the SR and potentiates noise-induced TTS. The mechanisms underlying the present findings are discussed.

Adult↗