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At least 181 records · Page 10Linked to original sources

[Clinical studies of the therapeutic effect of Flucinom in prostatic cancer].

Experience is recorded in the treatment of prostate cancer with Flucinom in 42 patients at mean age 64 years. This is a new synthetic patent medicine, a nonsteroid antiandrogen, product of the firm Schering (USA). It acts as concurrent inhibitor of the androgen acceptors in the cytoplasm of the glandular epithelium in prostate cells and averts the entry of the androgenic acceptor complex in the nucleus. Treatment was conducted with Flucinom tablets of 250 mg, 3 times daily 1 tablet. Patients in different stages of the disease were treated. The results were recorded for each patient individually at mean duration of the follow-up period 16 months. Twenty-eight patients received only Flucinom medication, in 14 drug treatment was combined with pulpectomy. The effect of treatment was as follows: regression--26 patients (61.9 per cent, stabilization--10 patients (23.8 per cent) and progression--6 patients (14.3 per cent). The results were superior when drug treatment was associated with pulpectomy. Treatment was well tolerated, including in patients with accompanying cardiovascular diseases and initial renal failure. Side reactions were seldom observed and were mild. It is recommended that Flucinom treatment of prostate cancer should gain acceptance, especially in patients with preserved potency.

Androgen Antagonists↗

[Predictive value of tactile sense in electronic endodontometry].

A statistical study has been conducted in order to study the benefit afforded by tactile sense in endodontometry. The study is based on 154 electronic measures (Dentometer, Endoradar, MEO2) and 90 tactiles ones, all radiographically controlled. Results show that: 1. The rate of good electronic measures is, as a whole, the same as tactile ones. 2. The risk of wrong measures is twofold in the case of narrow root canal, necrosis or molar treatment. 3. The risk lessens in the case of a pulpectomy when the electronic measure is associated with a tactile one: 48.38% success instead of 25%, in tactile sense: 48.8 success instead of 56.25%. Evidently, the study bring up to date the tactile perception in endodontometry in the case of pulpectomy.

Dental Pulp Cavity↗

Histologic evaluation of the effect of formocresol and glutaraldehyde on the periapical tissues after endodontic treatment.

The root canals of twelve pairs of human incisors without hard tissue or periodontal disease were treated with either formocresol or glutaraldehyde. The periapical reactions were compared histologically after periods varying between 6 and 8 weeks. A formocresol dressing always resulted in irritation of the periapical tissues, whereas little or no irritation was found after treatment with glutaraldehyde. It can be concluded that, after a vital pulpectomy, treatment of root canals with glutaraldehyde is faster than, as efficient as, and less irritating than treatment with formocresol.

Adult↗

Management of the primary dentition in vitamin D-resistant rickets.

Vitamin D-resistant rickets (familial hypophosphatemia) is a systemic disease secondary to defective renal-tubular reabsorption of phosphate. The major oral manifestations are spontaneous abscesses in a caries-free dentition. Pulpotomies or extractions were frequently described in the dental literature as the therapies of choice. This article presents a new prophylactic approach utilizing zinc oxide--eugenol pulpectomies and full crown coverage in an attempt to retain the primary dentition and prevent abscess formation.

Abscess↗

Success rate of root canal treatment in primary molars.

OBJECTIVES: The purpose of the present retrospective large-scale study is to evaluate rate of success of root canal treatments in primary infected molars using Endoflas F.S as a filling material. METHODS: The study material consisted of 382 records of root canal treated primary molars of which 174 teeth with high quality radiographs and sufficient data comprised the 'study group'. The technique for root canal treatment in one visit is described. Treatment was considered success if clinically the tooth was asymptomatic and radiographs showed decrease or no change in pre-existing pathologic radiolucent defects. RESULTS: In the total pulpectomy group there was a statistically significant difference between mandibular teeth presented with a periapical lesion prior to the treatment compared to maxillary teeth. This difference was not significant in the study group. Decrease in post treatment radicular radiographic defects was statistically significant more in the maxilla compared to the mandible. The success rate of teeth restored with a permanent restoration (stainless steel crown or amalgam filling) was statistically significant higher than those teeth left with a temporary filling. There was no statistically significant difference between success rate and the extent of root canal filling material. Rate of success was not statistically different depending on pre-existing radiolucent area prior to RCT. CONCLUSIONS: Endoflas F.S. can be used as an alternative root canal filling material for primary teeth. One condition for success is the prevention of microleakage. A permanent restoration should be placed as soon as possible after clinical signs and symptoms of inflammation are eliminated.

Adolescent↗

Histology and lysosomal cytochemistry of the postsurgically inflamed dental pulp after topical application of steroids. I. Histological study.

The purpose of this study was to histologically investigate steroid effects on the dental pulp. Three steroid preparations, hydrocortisone, betamethasone and triamcinolone, were locally applied to the exposed pulp tissue in rat incisor after pulpectomy. After 24 h, the effects on the tissues were assessed by light microscopy. The results showed that topical application of corticosteroids as an intracanal medicament reduced inflammatory changes in the pulp as compared with controls. Furthermore, triamcinolone and betamethasone demonstrated more potent anti-inflammatory effects than did hydrocortisone.

Administration, Topical↗

Safety of dental treatment in patients with previously diagnosed acute myocardial infarction or unstable angina pectoris.

OBJECTIVE: The purpose of this study was to assess the safety of invasive dental treatments, such as tooth extraction and pulpectomy under local anesthesia, in patients with unstable angina pectoris and within 6 months after onset in patients who had experienced acute myocardial infarction. STUDY DESIGN: Cardiovascular complications during and after dental treatment and preoperative risk factors were explored in 63 patients who had experienced unstable angina pectoris or acute myocardial infarction. RESULTS: A total of 79 dental treatments were performed with no intraoperative complications. Chest pain occurred in 8 patients within 1 week after dental treatment. Risk factors for postoperative complications were identified as a history of chest pain within 2 weeks before the dental treatment and failure to clear the Master Test Single stress test. CONCLUSIONS: Many patients who had experienced unstable angina pectoris or acute myocardial infarction tolerated dental treatment when appropriate stress control measures were used. However, approximately 10% of the patients experienced postoperative problems. Acceptability of dental treatment should be determined on the basis of the comprehensive assessment of each patient.

Adult↗

Quantitative analysis of substance P, neurokinin A and calcitonin gene-related peptide in gingival crevicular fluid associated with painful human teeth.

The aim of this study was to investigate the presence of substance P (SP), neurokinin A (NKA) and calcitonin gene-related peptide (CGRP) in the gingival crevicular fluid of teeth diagnosed with pain of pulpal origin compared with clinically healthy teeth, and to detect any changes in the levels of these neuropeptides in gingival crevicular fluid after removal of the pulp from the painful teeth. Gingival crevicular fluid was collected at baseline from one interproximal site at a painful and a non-painful contralateral tooth from 54 adult patients. Sampling was repeated after 1 wk in a subset of 21 subjects. Samples were analysed for SP, NKA, and CGRP using radioimmunoassay. The mean levels of SP and NKA were significantly higher in gingival crevicular fluid from painful teeth compared with non-painful teeth. The level of SP in the GCF of painful teeth fell significantly 1 wk after pulpectomy. In contralateral teeth, there were no significant differences in the levels of SP and NKA after 1 wk. It is concluded that SP and NKA are present in significantly greater amounts in the GCF of painful teeth compared with healthy teeth.

Adolescent↗

Multiple fractures of primary molars caused by injuries to the chin: report of two cases.

Two cases of multiple fractures of the primary molars caused by injuries to the chin are presented. Clinical and radiographic examinations revealed a vertical fracture line in the maxillary and mandibular primary molars. Pulpotomy or pulpectomy treatment was performed on the affected teeth, which were then restored with preformed stainless steel crowns.

Accidental Falls↗

The effect of amoxycillin versus penicillin V in the treatment of acutely abscessed primary teeth.

A clinical study was carried out to compare the efficacy of a short course, high dose amoxycillin versus a conventional penicillin regimen in the treatment of acute abscessed primary teeth. In a blind way children were assigned to either group A (amoxycillin) or group B (penicillin). The efficacy of the antibiotics was assessed using the clinical parameters of pain, swelling, tenderness, mobility and lymphadenitis. The results showed a general trend of less swelling in patients in group A as compared with patients in group B. This was significant at days 1 and 7 for the operators assessment (Mann Whitney U test; z = 2.48 and z = 2.12). More teeth in group A were considered suitable for first stage pulpectomy by day 7 (c2 test; P 0.037 pounds). A short course, high dose amoxycillin regimen proved as efficacious as a conventional penicillin regimen.

Amoxicillin↗

A survey of the incidence of single-visit endodontics.

This survey was conducted to obtain answers to some basic questions regarding the timing of root canal obturation. A questionnaire was sent via e-mail to 738 randomly chosen United States endodontists listed in the 1998 to 1999 membership roster of the American Association of Endodontists. One hundred fifty-six replies were received. In pulpectomy cases, root canal obturation at the first visit was carried out by 55.8% of the responding endodontists; in infected root canal cases, the percentage was 34.4%. Of the responding endodontists, 34.2% indicated that their patients had experienced some trouble after root canal obturation at the first visit.

Bacterial Infections↗

The calcifying potential of the pulpless open apex in untreated teeth of dogs.

Pulpectomies were performed on 22 immature premolars (44 root canals) from 3 young dogs. The root canals remained unfilled and the access cavities were sealed with amalgam. After observation periods of 7, 15 and 45 days, the apical and periapical regions of the teeth were evaluated histopathologically. Hard tissue formation was found in 32 open apices. The apical calcification occurred only in specimens with intracanal vital tissue. The severity of periapical inflammatory response had no relationship to the presence or absence of apical hard tissue formation. No apical bridging was seen in specimens where epithelial proliferation had occurred.

Animals↗

Follow-up study of permanent incisors with complicated crown fractures after acute trauma.

Complicated fractures occur in 3.5% of acute traumatized incisors. A pulp exposure results in almost all cases in endodontic treatment. The present investigation evaluated the prognosis for the different types of endodontic treatments following complicated crown fractures. Only incisors with an observation period of more than 23 months are included; the material comprises 301 incisors. Pulp capping was successful in 90.5% of the cases. There was a clear tendency for a positive correlation between the stage of the root development and the success rate of the endodontic treatment. In cases with pulpotomy ZnO/eugenol cement or calcium hydroxide was used as amputation material. The pulp reactions following the different treatments are discussed. If calcium hydroxide was used 90% was successful, while in cases with ZnO/eugenol cement as amputation material 8.9% developed necrosis of the pulp and 34.4% showed an undesirable reaction with formation of hard tissue barrier or obliteration. The healing frequency was 83.9% for teeth treated with pulpectomy but there was a clear correlation between the standard of the root filling and the success rate. For all three treatment groups there was a correlation between damage to the supportive tissue and treatment success.

Adolescent↗

Socio-economic burden of permanent incisor replantation on children and parents.

This study describes the socio-economic burden and attitudes of children and their parents following replantation of avulsed incisors. Records of 80 patients with 99 avulsion injuries treated in a teaching hospital clinic from 1988 to 1999 were reviewed. Mean age at time of injury was 10.6 years (range = 6.6-17.7 years). Complete records for a minimum of 1 year were obtained for 43 patients with 60 replanted incisors. Mean treatment procedures provided during the first year included 5.5 diagnostic periapical radiographs, 1.9 occlusal radiographs, 1.3 pulpectomies, and 2.7 pulp medicament applications. The mean estimated treatment cost and direct time (dentist) for first-year post-trauma management was 1465 dollars CAD and 7.2 h, respectively. Treatment costs were significantly higher during the first year post-trauma for patients who had their incisors extracted (P = 0.04), but there was no significant difference in direct treatment time between the two groups (P = 0.19). Twenty-one patient-parent pairs were surveyed for a number of qualitative factors. Ninety per cent of patients and 86% of parents reported that school and work time was lost. Even after having gone through the painful experience of replantation, the demands of recall, and in some cases, extraction, the majority of patients (67%) and parents (81%) stated that they would have still made the same (replantation) decision. Patient and parent responses were not statistically different (P = 0.453). Almost half the parents stated they would be willing to pay over 2000 dollars CAD to save an incisor. Patients rated retention of an incisor as significantly more important than infraocclusion. This is the first study to quantify the treatment burden of replantation of avulsion injuries exclusively in the pediatric population. This study describes the socio-economic burden and responsibilities of patient/parent and dentist and their role in informed consent.

Absenteeism↗

Immunohistochemical examination on the localization of macrophages and plasma cells in induced rat periapical lesions.

To investigate the role of plasma cells and macrophages in the development of periapical lesions, we immunohistochemically examined the distribution of these inflammatory cells in experimental induced rat periapical lesions after pulpectomy. The number of ED1-positive mononuclear cells increased rapidly, reached a plateau which remained stable between days 10 and 60, and subsequently decreased. Immunoglobulin (Ig)-bearing plasma cells appeared after 60 days, and, of these, IgG-bearing plasma cells were predominant after 90 days. The radiographic and histopathological findings indicated the development of bone destruction at 10 days which continued until 60 days; tissue repair began to take place after 90 days. The results suggested that macrophages had a close relation to bone destruction and that plasma cells might participate in tissue repair rather than the development of periapical lesions.

Alveolar Bone Loss↗

Clinical investigation of traumatic injuries in Yeditepe University, Turkey during the last 3 years.

The aim of this study was to evaluate etiology, types of traumatic dental injuries, treatment and to determine the incidence of complications according to dental injuries in patients who referred to Yeditepe University, Faculty of Dentistry, Istanbul, Turkey. The study was based on the clinical data of the 161 traumatized teeth in 92 patients. WHO classification slightly modified by Andreasen & Andreasen for dental trauma was used. The causes and localization of trauma, traumatized teeth classification, treatment and complications were evaluated both primary and permanent teeth. The distribution of complications according to diagnosis and treatment of the injured teeth were evaluated. Of 35 (38%) girls and 56 (72%) boys with a mean age 7.6 +/- 3.5 (ranging 1-14.2) participated to study and the mean followed up was 1.72 +/- 1.28 years (ranging 0.10-3.8 years). From the 161 affected teeth, 69 (42.9%) were in primary teeth and 92 (57.1%) in permanent teeth. The highest frequency of trauma occurred in the 6-12 year age group. Overall boys significantly outnumbered girls by approximately 1:1.6. The most common type of injury in the primary and permanent teeth was seen as luxation (38%) and enamel fracture (20%) of the maxillary central incisors, respectively. Falls were the major sources of trauma both the primary (90%) and the permanent teeth (84%). In the primary dentition, the most common type of soft tissue injury is contusion (62.5%) and in the permanent dentition, it is laceration (49%). The most of the treatment choice was determined as examination only and extraction in primary teeth (58 and 24.6%, respectively) while it was applied as restoration and pulpectomy in permanent teeth (31.5 and 18.5%, respectively). Complications were recorded on 37 teeth (23%) with a most common type of necrosis (10.5%) and dental abscess (7.4%). Necrosis was more frequent in luxation whereas dental abscess were in crown fracture with pulpal involvement in both dentitions. The study showed that boys were more prone to dental traumas than girls. Falls were more frequent trauma type with a high complication risk. It reveals that the time of the immediate treatment showed the important predisposing factors that increase the success of treatment and decrease the risk of complication. The correct diagnosis of dental injuries is more important for eliminating the occurrence of complications.

Abscess↗

Exposed human pulp caused by trauma and/or caries in primary dentition: a histological evaluation.

The aim of this study was to compare the pulpal reactions after exposure due to trauma and/or caries and to suggest the appropriate treatment options for the management of pulp, in the light of the histological findings in the primary teeth. Fifteen primary maxillary incisors with pulpal exposure were examined with light microscope in a blind study. After the histological evaluation, teeth were divided into three groups for the etiological factors due to the exposure according to the patient's files: trauma group, caries group and caries and trauma group. The inflammatory infiltration was diminished from the pulp chamber towards the apical third of the root canal in all of the examined teeth. Teeth in the trauma group presented fewer inflammatory cells in the root canal in comparison with other groups. It was concluded that the teeth with traumatic pulp exposure were considered as more likely to respond positively to pulpotomy technique. Pulpectomy or extraction seemed to be indicated for the decayed or decayed and traumatically injured teeth.

Child, Preschool↗

Endodontic treatment of primary teeth.

Endodontic treatment of primary teeth is undertaken by indirect pulp capping, direct pulp capping, formocresol pulpotomy and pulpectomy. The same treatment principles apply to both primary and permanent teeth with infected or necrotic pulps. The main differences are the use of formocresol for root canal medication and a resorbably zinc-oxide and eugenol paste for root canal obturation.

Child↗