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PubMed2000

Lord of the Rings: An Octameric Lanthanum Pyrazolonate Cluster Coordination Number Incommensurate Cluster Formation, Part 14. This research was supported by the NSF (CHE-9709621 and INT-9603212) and by NATO (SRG951516). We gratefully acknowledge Dr. Frederick J. Hollander for help in the crystal structure determination. Part 13: T. N. Parac, M. Scherer, K. N. Raymond, Angew. Chem. 2000, 112, 1288-1291; Angew. Chem. Int. Ed. 2000, 39, 1239-1242.

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Journal Article↗
PubMed1989

Indeno[1,2-c]pyrazolone acetic acids as semirigid analogues of the nonsteroidal anti-inflammatory drugs.

A series of 3-substituted indeno[1,2-c]pyrazol-4(1H)-one-2-acetic acids (3a-e) and 3-substituted indeno[1,2-c]pyrazol-4(1H)-one-1-acetic acids (4a-e) were synthesized as semirigid analogues of tolmetin (1). These compounds were evaluated for their anti-inflammatory action by investigating their ability to block arachidonic acid metabolism in vitro as well as the ability to block carrageenan-induced rat foot edema in vivo. No consistent pattern of biological activity was noted.

Animals↗
PubMed1985

Influence of pyrazolones on hepatic glutathione in rats.

Aminophenazone, phenazone, propyphenazone, and paracetamol given to female Wistar rats in a dose of 3 mmol/kg decrease the GSH content in the liver by 24, 18, 58, and 24 per cent, respectively. After the repeated administration (5 days) only aminophenazone depletes the hepatic GSH. The pretreatment with phenobarbital or cobaltous chloride has an influence only on the effect of propyphenazone. Hepatotoxins cause more extensive hepatotoxic alterations than the drugs investigated, however, their influence on the hepatic GSH level is negligible. Therefore it can be concluded that a temporary GSH depletion is not always linked with a hepatotoxic effect.

1-Propanol↗