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PubMed1979

[The radioprotective effect of iodine and its preventive action on renal calcification (author's transl)].

The protective effect of iodine against injurious damage caused by ionizing radiation was studied in 26 rats irradiated with cobalt-60 gamma rays as a single dose of 1000 rads (10 joule/kg). Twelve rats were pretreated 13 times every second day before irradiation. After irradiation they were treated daily during 21 days with 2.5 to 3.0 mg iodine given subcutaneously along with 9 mg Ca2+ (as gluconolactobionate) intramuscularly. In addition, they received 500 micrograms of iodine in their food daily. 67% of the iodine-treated rats remained alive after 30 days in contrast to 36% of the control rats which received Ca2+ only. 10 further rats which received neither iodine nor Ca2+ died within 3 to 5 days after irradiation. Deposition of calcium in the renal parenchyma was observed in 12 out of the 14 control rats, but only in 2 out of the 12 iodine-treated rats. It can be concluded from the results that iodine has a protective effect on ionizing radiation. It is assumed that iodine promotes the energy-conserving mechanism in mitochondria and also prevents the irradiation-induced decrease in calcium efflux.

Animals↗
PubMed1979

The effect of preirradiation application of aspartic acid salts on hemopoietic recovery in X-irradiated mice.

The possibility of radioprotective action of K and Mg aspartate administered in tap water for ten days prior to X-irradiation was investigated in male mice of the strain C 57 Bl/10. In normal animals, thymus weight was found to be increased by 10-day treatment with K and Mg aspartate. The postirradiation regeneration of spleen weight and incorporation of radioactive iron into the spleen and femoral marrow following sublethal irradiation was favorably modified by the treatment used. Pretreatment of mice with K and Mg aspartate delays the onset of early deaths at irradiation with an absolutely lethal X-ray exposure and raises the percentage of surviving animals after nearly lethal exposures.

Animals↗
PubMed1975

Studies on the effect of Fenchlorphos on postirradiation changes of serum proteins and nucleic acids content in rat liver.

The effect of Fenchlorphos on postirradiation changes of serum protein levels and nucleic acid content in rat liver were investigated. It was found that this compound significantly decreases postirradiation changes in serum proteins, properdin level and nucleic acid content in rat liver. An important role of these phenomena in radioprotective action of Fenchlorphos is suggested.

Alpha-Globulins↗
PubMed1975

Cytogenetics analysis of meiotic chromosomes of irradiated mice and their progeny after treatment with streptomycin and dihydrodeoxystreptomycin.

The purpose of this investigation is to find out whether streptomycin and the related compound dihydrodeoxystreptomycin have any mutagenic effect and whether they both are capable of recovering X-ray induced chromosomal translocations in mouse spermatogonia of directly treated animals and their progeny of the first generation. The cytological findings show the absence of any mutagenic effect in animals nonirradiated and treated with streptomycin and dihydrodeoxystreptomycin. The frequency of chromosomal translocation after total irradiation was 9,07%; in animals treated with streptomycin following irradiation 5.13%, and in those irradiated and treated with dihyrodeoxystreptomycin, 3.70%. Male offsprings, originated from parents treated only with antibiotics show no chromosomal translocations. However, offsprings originated from irradiated and treated parents gave birth to the male offspring with chromosomal translocations.

Animals↗