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At least 181 records · Page 10Linked to original sources
PubMed1991

[Neoplasms following kidney transplantation].

The incidence, predisposing factors, localization, evolution and outcome of neoplasms following kidney transplantation were studied in two groups of patients--120 and 146 patients for an observation period from 1 to 16 years. In patients with adequate renal function who received immunosuppressive treatment for more than one year (accordingly 78 and 88 patients) neoplasms developed in 4 and 10 patients with mean duration of immunosuppressive treatment 4.9 and 6.1 years respectively. The neoplasms were: 3 skin cancers, 2 lung cancers, 2 Kaposi sarcomas, 1 lymphosarcoma, 1 breast cancer, 1 prostate cancer, 1 renal cancer, 1 rectal cancer and 2 polyps of the colon. The case fatality rate was 3.6 per cent. The importance of precision of the immunosuppressive treatment for reducing the incidence of these complications is pointed out.

Age Factors↗
PubMed1988

[Action of doxorubicin and a doxorubicin-heparin complex on the growth and metastasis of experimental tumors and the hemostatic system indices].

The electrophoretic and spectral analyses have been used to show the possibility to form a complex consisting of doxorubicin and adriamycin with heparin, the molar ratio being 6:1 and pH 4.8-7.4. Doxorubicin and adriamycin had procoagulant properties but the doxorubicin-heparin complex showed an anticoagulant activity. In experiments on rats with the Pliss lymphosarcoma and sarcoma 45 the doxorubicin-heparin complex depressed more efficiently the tumour growth and metastasis spreading. The combination of doxorubicin and the doxorubicin heparin complex with the trypsin-heparin complex which imitate the hyperfunction of anticoagulative system markedly increased the antitumour effects.

Animals↗
PubMed1988

[Results of radiotherapy treatment of nasopharyngeal tumors depending upon the pathologico-anatomic diagnosis].

Malignant nasopharyngeal tumors are rare, so that there are only few communications about treatment results in dependence on histological findings. The histological classification of malignant tumors, especially in case of malignant lymphomas, has changed considerably during the last few years. All histological preparations available from 157 patients treated by radiotherapy between 1960 and 1985 have been reassessed. Above all it was attempted to classify the formerly current diagnoses "retothelial sarcoma" and "lymphosarcoma" according to today's criteria and to assign to a histological type those tumors which could not be exactly classified hitherto. This proceeding has increased especially the group of malignant non Hodgkin's lymphomas from seven to 29 patients. The therapy results achieved after irradiation are presented in dependence on histological data and compared to the results communicated in literature. A certain stagnation is found for the last few years showing that an optimum of present therapy possibilities has been reached at the individual therapy centers.

Adolescent↗
PubMed1984

Enhancement of the radiation effect by fibrinolysin and quantitative pattern of the change of tumor radiosensitivity.

Radiomodifying action of fibrinolysin was studied during radiation treatment in experimental transplanted tumors. It has been established that the application of fibrinolysin prior to radiation increases the inhibition of the growth rate of Pliss lymphosarcoma and Sarcoma 45, as evidenced by the decrease of the tumor volume, the increase of the dose change factor and the animals survival.

Animals↗
PubMedDate not supplied

Pathogenesis of reticuloendotheliosis virus infection in ducks.

A new isolate of reticuloendotheliosis virus (REV) from ducks, RU-1, was used to experimentally infect white pekin ducks. Embryonal or neonatal infection usually resulted in persistent viremias, no REV antibody development, and inability to mount antibody responses against bovine serum albumin (BSA) or sheep red blood cells (SRBC). In contrast, infection at 21 days of age resulted in transient viremias, which terminated coincident with REV antibody development. These ducks remained persistently infected, however, based on virus isolations from peripheral blood lymphocytes. Ducks infected at that age were immunologically competent against BSA and SRBC unless they had been embryonally bursectomized, in which case they behaved virologically and immunologically like those infected at an early age. Bursectomy by itself did not prevent responses against the antigens. Total mortality during 4- or 6-month experimental periods ranged from 80 to 100% in REV-infected groups, regardless of age at infection, route of exposure, or whether the ducks were intact or bursectomized. Most deaths were from non-neoplastic conditions (stunting, bacterial infections), but 17 of 69 (25%) infected ducks developed a variety of neoplasms, including lymphosarcomas, histiocytic sarcomas, and spindle-cell sarcomas.

Animals↗
PubMed1984

[Intensification of tumor acidification in artificial hyperglycemia using inorganic phosphate].

Using pH glass microelectrodes with maximum diameters of 100-200 micron (sensitivity 55-60 mV/pH unit at 37 degrees C; drift 0,001-0,002 pH unit/hr) pH has been measured in transplanted tumors (Guerin carcinoma, Pliss lymphosarcoma, Krocker sarcoma) and in muscle under artificial hyperglycaemia. We showed the ability of inorganic phosphate to amplify the process of acidification of the tumor tissue under these conditions. Using inorganic phosphate it was possible to reach pH values of 4,6-5,0 in different experimental tumors.

Animals↗
PubMed1977

Human studies following animal models of tumorigenesis by oncornaviruses.

Similarities have been observed for some time between oncornavirus-induced malignancies in laboratory animals and leukemias and solid tumors in man. Particles similar to type C oncornaviruses have been detected by electron microscopy both in cells or plasma from leukemia patients and in solid-tumor human malignancies such as Hodgkin's lymphoma, lymphosarcomas, and sarcomas. Likewise, particles resembling type B oncornaviruses in shape and appearance have been found in human breast cancer. In neither case has the infectious nature of the particles been confirmed. However, DNA synthesized in vitro by the enzyme of murine mammary tumor virus was found to hybridize with polysomal RNA obtained from human mammary adenocarcinomas. The presence of RNA complementary to RNA from the Rauscher strain of murine leukemia virus has been observed in other human malignancies unrelated to breast cancer. It has also been found that cells of patients with myelogenous leukemia possess an oncornaviral-type reverse transcriptase that is distinguishable from other cell DNA polymerases and serologically related to the reverse transcriptase of primate oncornaviruses.

Animals↗
PubMed1977

A new substance effective against transplantable tumors in vivo: L-cystine-bis-(N,N-beta-chloroethyl)-hydrazide.

It is shown that L-cystine-bis-(N,N-beta-chloroethyl)-hydrazide-hydro-bromide possesses strong (50-100%) inhibitory effect in vivo against myeloma P-8, carcinosarcoma Walker, lymphosarcoma Pliss, sarcoma Yoshida, sarcoma Jensen and sarcoma 180 in doses 5-12 mg/kg/day. No suppression of the growth of Ehrlich ascites tumor was observed. The acute toxicity (LD50) of this substance on mice and rats is 71 mg/kg and 47 mg/kg respectively.

Alkylation↗