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Results for “SPOROTRICHOSIS”

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PubMed1990

[Leukocyte phagocytic activity in gerbils with experimental sporotrichosis treated with potassium iodide].

One effective treatment against sporotrichosis is the oral administration of potassium iodide (KI). It is not known how it works, and also it is not known if this substance has some effect on the microbicidal activity of polymorphonuclear neutrophils (PMN) and macrophages. In this work the phagocytic activity of gerbils treated with KI was studied. Gerbils cured within 62 days of treatment with KI, their PMN and macrophages showed an increased ability for reducing nitroblue-tetrazolium (NBT); myeloperoxidase activity was decreased in PMN. These results were the expected in any chronic infection and demonstrates that KI effectiveness on the experimental sporotrichosis works by an independent mechanism of phagocytosis.

Animals↗
PubMed1986

Itraconazole therapy in lymphangitic and cutaneous sporotrichosis.

Itraconazole, a new orally absorbable azole derivative, was used for the treatment of 17 patients with cutaneous and lymphangitic sporotrichosis. The drug, administered at a dose of 100 mg/day, proved to be effective in all cases. Lesions disappeared and cultures became negative after 90 to 180 days of therapy. There were no major side effects. Posttherapy evaluations, done in 14 of 17 cases for an average of 115 days, revealed no relapses. Objective evaluation of the treatment by means of a scoring system indicated complete resolution of the pretherapy abnormalities at varying periods; thus, 35.3% (six of 17) of the patients had recovered by 90 days, 45.4% (five of 11) by 120 days, and 83.3% (five of six) by 150 days of therapy. Consequently, therapy with itraconazole is an adequate alternative to iodide treatment in sporotrichosis.

Adolescent↗
PubMed1987

[Lymphangitic sporotrichosis].

A case of cutaneous lymphangitic sporotrichosis in a 63-year-old Sicilian woman is reported. The diagnosis of sporotrichosis was made using a direct smear preparation and confirmed by the findings of histological studies and those obtained via culture ketoconazole therapy led to a significant reduction of the lesions.

Biopsy↗
PubMed1978

[An endemic area of sporotrichosis in Guatemala].

An endemic area of sporotrichosis is described in the Lake of Ayarza District, South Guatemala, where 53 patients have been observed within 3 years. In 45.3% of the cases, the infection appeared after handling fish. The disease was more frequently observed in man (83%) and in patients less than 30 years of age. The most frequent clinical type was the ascending lymphocutaneous sporotrichosis of the limbs. Some cases of ulcerative or verrucous lesions were seen. Almost all the patients cured rapidly either by potassium iodide (46 patients) or spontaneously, or after application of local heat (4 patients). Intradermal tests were performed in healthy population in the endemic area and, for comparison, in Guatemala City. Whole yeast cell antigens of Sporothrix schenckii and Ceratocystis stenoceras were used in these tests. Skin tests to both antigens were more frequently positive in the endemic area; the highest frequency was obtained with the antigen of C. stenoceras. A serological study was performed in 26 patients. The fluorescent antibody staining technique was more sensitive than yeast cell and latex particles agglutinations. C. stenoceras was isolated from bark of some trees, especially Eucalyptus, in the environment, but not S. schenckii.

Agglutination↗
PubMed1987

Sporothrix infection of the lung without cutaneous disease. Primary pulmonary sporotrichosis.

The clinical spectrum of sporotrichosis is expanding and now includes pulmonary infection in absence of skin lesions. Lung involvement, albeit unusual, is a granulomatous pneumonitis which may progress to bilateral, apical, fibrotic, and contracted infiltrates or cavities, thereby mimicking tuberculosis or histoplasmosis. The patients are most often middle-aged men with alcoholism and chronic obstructive pulmonary disease. Our case report is yet another variant of primary pulmonary sporotrichosis that presented as diffuse, bilateral granulomatous pneumonitis without cavitation or predilection for upper lobes.

Dermatomycoses↗
PubMed1986

Articular sporotrichosis.

Sporotrichosis is a fungal disease caused by Sporothrix schenckii, which is seen worldwide. Infection usually involves cutaneous and subcutaneous tissues. Articular involvement is rare. A 29-year-old man with ankle sporotrichosis is reported to demonstrate the differential diagnosis and treatment.

Adult↗
PubMed1979

Auricular sporotrichosis in a brick mason.

A case of cutaneous sporotrichosis involving the auricle of a brick mason is reported. Despite the infrequency of such an infection, sporotrichosis must be considered in the differential diagnosis of perichondritis. The occupational associations with Sporothrix schenckii are reviewed and the relationship with bricks is emphasized.

Adult↗
PubMed1984

Rosacea-like sporotrichosis.

Sporotrichosis is rarely included in the differential diagnosis of rosacea. A patient who clinically appeared to have rosacea, but proved by culture and clinical response to have sporotrichosis of the fixed cutaneous variety, is reported.

Diagnosis, Differential↗
PubMedDate not supplied

[Generalized sporotrichosis. Study of a Mexican case treated with amphotericin B and ketoconazole].

A case of deep sporotrichosis with cutaneous, articular, (...) and osseous lesions was observed in a Mexican patient following a beesting. The disease was associated with a complex pathological background namely diabetes. The pathogenic fungus Sporothrix schenckii was isolated in pure culture. The mycosis was successfully treated by amphotericin B and ketoconazole. Persisting enzymatic impairment was observed due to the sporotrichosis and/or underlying diseases.

Amphotericin B↗
PubMed1983

[Serology of cutaneous sporotrichosis].

Sporothrix schenckii antigens were tested with seventy-nine sera from human cases of sporotrichosis for their value in the serological diagnosis of extracutaneous forms of the disease. 55.7% of the sera reacted in the tube agglutination test; 29.1% of them were positive by counter immunoelectrophoresis and only 7.6% reacted in the simple immunodiffusion test. There was a clear correlation between agglutination titers and the respective reactivity of sera by counter immunoelectrophoresis. By immunoelectrophoresis, 2 different anodic precipitin bands were observed between S. schenckii metabolic antigen and anti-Sporothrix hyperimmune animal sera. Since no false positive reactions were found in sera from patients with other mycoses, and considering the simplicity of the antigen preparation, we agree with previous authors that these methods may be useful for the detection of visceral forms of sporotrichosis.

Agglutination Tests↗
PubMed1984

Epidemiology and ecology of sporotrichosis in Japan.

Some characteristics in epidemiology and ecology of sporotrichosis in Japan are summarized as follows: 1) In some areas of Japan, sporotrichosis shows relatively high incidence. 2) Frequent onset of the infection in the cold season. 3) Preponderance of the infection in females. 4) Preponderance of the infection in children and aged persons. 5) Predilection of lesions on the face of children as well as on the upper extremity in the case of adolescent and adult patients. 6) Familial occurrence. 7) High frequency of demonstration of the parasite in tissue.

Adolescent↗
PubMed1981

Disseminated cutaneous sporotrichosis. Three illustrative cases.

Three cases of disseminated cutaneous sporotrichosis are reported, including a rare presentation of the disease as vesicular dermatitis. The diagnosis was confirmed by culture of a skin biopsy specimen, and all patients responded well to amphotericin B therapy. The sporotrichosis slide latex agglutination titer was used to determine the end point of therapy.

Adult↗
PubMed1994

[Sporotrichosis in a horse].

A 9-year old male Arabian horse was referred to the Department of Large Animal Surgery of the University of Utrecht because of multiple nodules on the inner side of the right hind leg. The nodules seemed to follow a cutaneolymphatic pattern. Histopathology of a nodule showed a granulomatous inflammation with the presence of multinucleated giant cells. In PAS- and Grocott-stained sections, spheroid yeast-like organisms with some budding were found throughout the tissue. A preliminary diagnosis of sporotrichosis was made. A fresh nodule was cultured and the presence of Sporothrix c.f. schenckii was confirmed. Antifungal therapy was started, which stopped the extension of the granulomata. Sporotrichosis is a rare disease in Europe, but it is quite common in the southern part of the U.S.A.

Animals↗
PubMed1994

Cutaneous lymphatic sporotrichosis.

The first case of cutaneous lymphatic sporotrichosis from Nagaland and a case of cutaneous sporotrichosis from Kerala who had acquired infection from Assam are reported. The diagnosis in both cases were established by isolating Sporothrix schenckii from multiple cutaneous lesions. The dimorphic nature of fungus was established in vitro by demonstrating the mycelial phase at 25-30 degrees C and yeast phase at 37 degrees C and pathogenicity to white mice. Both the patients were successfully treated with oral administration of potassium iodide for 3 months.

Adult↗
PubMed1998

Chronic cavitary pulmonary sporotrichosis: efficacy of oral itraconazole.

The small number of patients suffering from pulmonary involvement with Sporothrix schenckii has prevented prospective controlled studies that could determine the optimal therapy for this chronic infection. The clinician's ability to determine the best medical treatment for chronic cavitary pulmonary sporotrichosis is also tempered by the limited use of newer azole antifungal agents in this disorder as well as the relative lack of efficacy reported with older therapies. We present a 50-year-old male with primary pulmonary sporotrichosis whose chronic cavitary disease responded to oral itraconazole.

Administration, Oral↗
PubMed2001

Sporotrichosis in patient with AIDS: report of a case and review.

Although sporotrichosis is not an AIDS-defining infection, reports of sporotrichosis in individuals infected with HIV are increasing. We report an unusual case of this co-infection in a man with progressive deep cutaneous ulcerations with numerous pleomorphic yeast cells of Sporothrix schenckii. In addition a review of the literature on this subject was carried out and commented upon.

Journal Article↗
PubMed2001

Recurrence of sporotrichosis in cats with zoonotic involvement.

The aim of this work is to describe the prevalence of the disease in the same cattery after three years, and to report a case of human sporotrichosis following a cat scratch. In May 1997, four felines presenting a cachexy state and ulcerous lesions on the head, nose and limbs were examined in a veterinary clinic in the town of Rio Grande (RS-Brazil). Exudate and crusts were collected for microbiological diagnosis. The cat's owner returned to the clinic reporting that another eleven felines presented similar lesions. She had ulcerous lesions on her hand and ascending lymphangitis. She was conducted to medical examination where exudate and crusts from the lesions were collected and after the culture Sporothrix schenckii was isolated. After three years the same person sought veterinary assistance for seven more cats with similar lesions to the five previously described. Microbiological tests resulted again in isolation of S. schenckii. Treatment with potassium iodine was effective for the cure of human sporotrichosis, whereas for the felines it showed toxic effect. Only one showed regression of the disease while all the others presented progression of the lesions or even death. The authors call attention to the possible persistence of S. schenckii in cat populations.

Journal Article↗