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PubMed2006

Testicular neoplasms. Evaluation of the experience during 25 years in a military hospital.

INTRODUCTION: Testicular tumors are frequent in young adults, coinciding with incorporation to military service. The present study evaluates the tumor characteristics, time course and results obtained with the treatments used in our center for this type of neoplasms. MATERIAL AND METHODS: A retrospective longitudinal study was conducted in a cohort of 98 patients with an average age of 28.6 years, subjected to orchiectomy for testicular tumors in our center between 1979 and 2004. Data were collected relating to patient age, tumor characteristics, the outcome of treatment, and the course of the disease. RESULTS: The right testicle was affected in 61% (with significant differences versus the left side). The most common histological type corresponded to non-seminomatous germ cell tumors (NSGCTs) (65.3%), followed by pure seminomas (27.6%) and non-germinal cell tumors (NGCs) (7.1%). NSGCT was diagnosed at a significantly younger average age (23.2 years) than the other two tumor types. Stage I was the most frequent presentation (58%). Seminomas presented in stage I significantly more often (80%) than the others tumors. The data collected over the 25-year study period showed no significant variations in tumor characteristics. The log-rank test showed a significant difference in terms of patient survival according to the tumor cell line (p = 0.000) and stage (p = 0.000), except between stages I and II, where no significant differences were observed in terms of survival. CONCLUSIONS: Non-seminomatous germ cell tumors (NSGCTs) are the most frequent testicular tumors in young adults. Most neoplasms are diagnosed in early stages, the prognosis being better in the case of seminomas and tumor stages I and II.

Adult↗
PubMed1994

Paraneoplastic temporal lobe epilepsy with testicular neoplasm and atypical amnesia.

We report a patient who, at age 38, presented with temporal lobe seizures and an atypical memory disorder 3 years before the discovery of a testicular tumor. Detailed neuropsychological testing revealed a relatively isolated amnestic syndrome. The amnesia was atypical as the patient could retain information for hour-long periods, only to lose it later. Serologic studies revealed the presence of a circulating autoantibody that demonstrated an unusual affinity for the nucleolus of cerebral cortical neurons. Western blot analysis of cortical neurons revealed that this antibody reacted with proteins different from other previously identified paraneoplastic neurologic antigens (Hu, Yo, Ri). We believe this to be a case of paraneoplastic limbic encephalitis secondary to the testicular tumor. This patient presents unique characteristics with respect to the mode of presentation, features of the amnesia, and the presence of a circulating antibody with an unusual reactivity pattern.

Amnesia↗
PubMed1982

[Differential diagnosis of testicular neoplasms. Tumorous and clinically tumor-like diseases of the scrotum].

The observation of a case of inguinal omental hernia with marked peritoneal carcinosis treated by operation for suspected testicular tumor leads us to discuss systematically the differential diagnosis of tumors and tumor-like conditions of the scrotal region. In order to analyse the frequency and importance 420 cases of ours were reconsidered. Of these 30 had been admitted to our hospital because of suspicion of tumors of the testis. The diagnosis on admission and after morphological analysis by the pathologist are compared.

Aged↗