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Blood loss during transurethral prostatic resection with continuous bladder irrigation.

A total of 120 men with benign prostatic hypertrophy were assigned randomly into three groups. Transurethral prostatic resections were performed in all patients. In Group I the operation was performed with continuous flow bladder irrigation, in Group II with suprapubic flow irrigation (without suction pump) and in Group III without continuous flow irrigation. Blood loss was determined by a colorimetric method. There were no statistically significant changes in blood loss between the groups of patients.

Blood Loss, Surgical↗

Impact of short perioperative courses of cefotaxime on aerobic bacterial flora in patients undergoing transurethral prostatic resection.

The influence of short-term prophylactic courses of cefotaxime on the microbial environment was studied. The distribution of bacterial species and their antibiotic resistance was recorded in isolates collected over a six-year period, during which time cefotaxime was used for perioperative prophylaxis in patients undergoing transurethral prostatic resection. In three consecutive studies covering the six-year observation period, the species distribution and antibiotic resistance patterns remained essentially unchanged for both cefotaxime and ampicillin. Examination of the faecal coliform flora in 23 patients given cefotaxime revealed no marked qualitative or quantitative change in the flora. It is concluded that short-term prophylactic courses of cefotaxime do not promote the emergence of resistance in the aerobic bacterial flora.

Aged↗

Severe mannitol-induced hyponatremia complicating transurethral prostatic resection.

A case is presented in which the absorption of mannitol irrigation solution across prostatic veins resulted in severe hyponatremia in a patient undergoing transurethral prostatic resection. Since hyposmolality of the extracellular fluid was not seen because of the presence of mannitol the patient was asymptomatic despite a rapid decrease in the serum sodium concentration to 99 mEq./l. The importance of distinguishing dilutional hyponatremia from hyponatremia with normal or elevated osmolality is discussed.

Aged↗

A clinical outcomes and cost analysis comparing photoselective vaporization of the prostate to alternative minimally invasive therapies and transurethral prostate resection for the treatment of benign prostatic hyperplasia.

PURPOSE: We critically evaluated the clinical outcomes and cost characteristics of alternative procedural treatment options for symptomatic benign prostatic hyperplasia. MATERIALS AND METHODS: An outcomes and cost analysis was performed for benign prostatic hyperplasia treatments, including photoselective vaporization, microwave thermotherapy, transurethral needle ablation, interstitial laser coagulation and transurethral resection. Clinical outcomes were measured by the percent improvement in American Urological Association/International Prostate Symptom Score, the maximum uroflowmetry rate and quality of life score. An economic simulation model was constructed to estimate the expected cost of benign prostatic hyperplasia procedural therapies from a payer perspective. The model included costs of initial treatment, followup care, adverse events and re-treatment. Sensitivity and threshold analyses tested the impact of changing model inputs on base case results. RESULTS: Ablative therapies showed better improvement in symptom score, flow rate and quality of life score compared to thermotherapy procedures. Photoselective vaporization resulted in the largest beneficial changes in American Urological Association/International Prostate Symptom Score, the maximum uroflowmetry rate and the quality of life score at all time points evaluated, followed by transurethral resection and then interstitial laser coagulation. The estimated cost was lower for photoselective vaporization than for any other procedural option at any interval studied. Sensitivity analyses indicated that the results of baseline analyses were robust to reasonable changes in clinical and economic inputs to the model. CONCLUSIONS: Compared to alternative treatment options photoselective vaporization of the prostate is a clinically efficacious and cost-effective treatment for symptomatic benign prostatic hyperplasia.

Cost-Benefit Analysis↗

Lower urinary tract symptoms. A comparison of micturition symptoms in patients scheduled for transurethral prostatic resection and outpatients of both sexes referred for non-urological complaints.

The presence of ten different micturition symptoms was investigated by means of a patient-administered questionnaire in 355 males and females over 50 years of age referred for non-urological complaints, and compared to those of 131 patients selected for transurethral prostatic resection (TURP) due to symptomatic benign prostatic hypertrophy. Each symptom was evaluated further by a subsequent "bother" question and the questionnaire also contained a global "bother" question. Each of the symptoms was significantly more frequent and pronounced in the TURP group than in the control group. Moderate or severe symptoms were found in 25% of males and 18% of females in the control group as compared to 92% in the TURP group. In the control group most symptoms increased with age regardless of sex, and this was most pronounced for weak stream and hesitancy. Males in the control group had a significantly higher total symptom score than females (5.3 vs 4.3; p < 0.05). This difference was, however, mainly due to higher scores in weak stream, hesitancy and post-micturition dribbling in males. Females tended to have more urgency. The symptom scores and the associated "bother" scores were highly correlated, indicating that each symptom carried the same potential to bother the patient. The single global "bother" question gave an adequate reflection of the combined "bother" scores, and seems sufficient in the evaluation of the individual patient's concern.

Aged↗

Sexual life following 'minimal' and 'total' transurethral prostatic resection.

81 otherwise healthy men with an average age of 67 years and verified prostatic hypertrophy were randomized into two groups for either 'minimal' or 'total' transurethral prostatic resection (TUR-P). Interviews on sexual life were made preoperatively and 6 and 12 months postoperatively. 58 men (72%) were prior to the operation sexually active. 18 (31%), mainly men of advanced age, discontinued sexual activity following TUR-P. 40 (69%) remained active. 19 had retrograde ejaculation. No significant difference was found between 'minimal' and 'total' TUR-P concerning the effect on sexual activity and the occurrence of retrograde ejaculation.

Aged↗

The effect of transurethral prostatic resection on the incidence of osseous prostatic metastasis.

Of 169 patients with a minimum of 4 years follow-up treated definitively with irradiation for adenocarcinoma of the prostate, 100 had transurethral prostatic resection (TURP) before treatment. In comparing that group with the group who did not have TURP, osseous metastases developed in 28% versus 22%, respectively. Further stratification by tumor grade and stage failed to show TURP-dependent tumor dissemination, whereas the incidence of bony metastasis increased progressively with decreasing tumor differentiation and advancing tumor stage.

Aged↗

Acute renal failure directly caused by hemolysis associated with transurethral resection of the prostate.

Transurethral resection of the prostate (TURP) for the treatment of benign prostatic hyperplasia may lead to TURP syndrome, and in some cases, acute renal failure can develop. Hemolysis does happen during TURP. Whether hemolysis itself leads to acute renal failure merits discussion. We report a patient with chronic renal insufficiency who developed oliguric acute renal failure immediately as a major complication after TURP. The renal function of this patient recovered after six hemodialysis sessions, and the patient continued to do well in the subsequent follow-up period.

Acute Kidney Injury↗

Hyponatraemia after transurethral resection of the prostate.

Transurethral resection (TUR) syndrome is a complication of transurethral resection of the prostate characterized by bradycardia, hypotension and postoperative confusional state, which is generally attributed to hyponatraemia occurring during or immediately after operation. In a prospective study of 100 consecutive patients undergoing transurethral resection of the prostate, changes in serum sodium were estimated before and after operation and correlated with various parameters including weight of prostate resected, volume of irrigant fluid and resection time. Seven patients showed a significant drop (greater than 10 mmol/litre) in serum sodium: two of these had the clinical features of TUR syndrome and one of them died. The pathogenesis and management of this syndrome are discussed.

Aged↗

Care of the patient undergoing transurethral resection of the prostate.

Transurethral resection of the prostate (TURP) for benign prostatic hypertrophy is a common surgical procedure in the United States. Left untreated, benign prostatic hypertrophy can lead to detrimental consequences such as renal failure from urinary obstruction. Although TURP is a common procedure, it is not without risk. Complications can occur, and the perianesthesia nurse must be familiar with them and their treatment. Complications related to the surgical procedure and the anesthesia technique must be assessed and treated quickly to prevent morbidity and mortality in these patients. The perianesthesia nurse is instrumental in managing and preventing complications associated with transurethral resection of the prostate.

Aged↗

[Technique of bladder catheterization after transurethral prostatic resection].

The obstacle that represents the bladder neck posterior lip after a prostate transuretral resection is, sometimes, the cause of sugtrigonal perforations when a bladder catheterization is performed after the surgery. We explain an easy procedure that allows a safe catheterization, reducing the risk of complications added to those of the surgery.

Humans↗

[Continuous breath alcohol analysis. Monitoring of irrigation absorption syndrome in transurethral prostate resection].

The absorption of large volumes of irrigation fluid is a major problem in transurethral prostatic surgery (TUR-P). Various indicators have been tested to monitor fluid absorption with regard to continuous registration and sufficient accuracy. The volumetric fluid balance is not suitable as a routine method because of its inaccuracy. Easily accessible parameters are unspecific because of surgical bleeding (haematocrit [Hct]), or are interfered with by physiological counter-regulatory actions (serum sodium [Na] concentration). In 1986 Hulten et al. suggested adding 2% ethanol to the irrigation fluid as a marker and investigated it intermittently in the expired air with an alcohol-test appliance. In a prospective clinical study of 17 patients undergoing TUR-P under spinal anaesthesia, expiratory concentrations of alcohol that was added to the irrigation fluid (2% ethanol in Purisole, Fresenius, Bad Homburg) were monitored. Gas was continuously sampled from the nasopharynx through a nasal cannula and the ethanol concentration was measured using a modified diverting anaesthetic gas monitor (Normac, Datex, Helsinki) that allows continuous as well as early detection of the absorbed irrigation fluid with reliable accuracy for clinical use. In addition, at intervals of 10 minutes we measured blood alcohol, end-tidal alcohol (Alcotest 7110, Dräger, Lübeck), haematocrit, serum Na concentration, and blood gases. Sixty-eight measurements were obtained from the 17 patients. As shown in other studies, serum Na (r2 = 0.68) and Hct (r2 = 0.39) correlated poorly with the irrigation fluid as determined by serum alcohol levels. In contrast, the expiratory alcohol measurements with the Alcotest 7110 (r2 = 0.93) and Normac devices (r2 = 0.85) were closely related. Continuous monitoring of the expiratory alcohol concentration with a Normac monitor closely reflects blood alcohol concentration, and may hence serve as a useful semiquantitative monitor of irrigation fluid absorption during TUR-P.

Absorption↗