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Role of visual attention in cognitive control of oculomotor readiness in students with reading disabilities.

This study investigated eye movement and comprehension therapy in Grade 6 children with reading disabilities (RD). Both order of therapy and type of therapy were examined. Furthermore, the implications of visual attention in ameliorating reading disability are discussed. Thirty-one students with RD were identified using standardized reading comprehension tests. Eye movements were analyzed objectively using an infra-red recording device. Reading scores of participating children were 0.5 to 1 SD below the national mean. Testing took place before the start of therapy (T1) and was repeated after 12 weeks (T2) and 24 weeks (T3) of therapy. One group of students had eye movement therapy first, followed by comprehension therapy; in the other group, the order was reversed. Data were evaluated using a repeated measures MANOVA and post hoc tests. At T1, mean reading grade was 2 years below grade level, and eye movement scores were at about Grade 2 level. Mean growth in reading comprehension for the total sample was 2.6 years (p < .01) at T3; equally significant improvement was measured in eye movements (p < .01). Learning rate in reading comprehension improved from 60% (T1) to 400% (T3). Although within-group differences were statistically significant, between-group differences were not significant for comprehension or eye movements. Order of therapy (comprehension first or eye movements first) was not significant. Improvements in within-group scores for comprehension and eye movements were consistently significant at T2 and T3. Eye movement therapy improved eye movements and also resulted in significant gains in reading comprehension. Comprehension therapy likewise produced improvement both in eye movement efficiency and in reading comprehension. The results support the notion of a cognitive link among visual attention, oculomotor readiness, and reading comprehension.

Attention↗

Stimulus- and response-conflict-induced cognitive control in the flanker task.

Recently, several studies have been conducted to investigate the top-down adjustments made after incongruent trials during conflict tasks. In the present study, we investigated conflict monitoring with different types of conflict. In a modified version of the flanker task, a distinction was made between stimulus-stimulus conflict and stimulus-response conflict. Six colors were mapped to three responses in order to exclude all sequences in which a relevant or an irrelevant stimulus- or response-related feature was repeated from trial n-1 to trial n. An analysis of the effect of the congruency of the previous trial demonstrated that conflict adaptation was present. The stimulus congruency effect was reduced after both a stimulus-incongruent trial and a response-incongruent trial. The response congruency effect did not vary as a function of previous congruency. These findings are discussed in relation to the distinction between conflict detection and conflict regulation.

Adult↗

Predicting cognitive control from preschool to late adolescence and young adulthood.

In this longitudinal study, the proportion of time preschoolers directed their attention away from rewarding stimuli during a delay-of-gratification task was positively associated with efficiency (greater speed without reduced accuracy) at responding to targets in a go/no-go task more than 10 years later. The overall findings suggest that preschoolers' ability to effectively direct their attention away from tempting aspects of the rewards in a delay-of-gratification task may be a developmental precursor for the ability to perform inhibitory tasks such as the go/no-go task years later. Because performance on the go/no-go task has previously been characterized as involving activation of fronto-striatal regions, the present findings also suggest that performance in the delay-of-gratification task may serve as an early marker of individual differences in the functional integrity of this circuitry.

Adolescent↗

Attentional rubbernecking: cognitive control and personality in emotion-induced blindness.

Emotional stimuli often attract attention, but at what cost to the processing of other stimuli? Given the potential costs, to what degree can people override emotion-based attentional biases? In Experiment 1, participants searched for a single target within a rapid serial visual presentation of pictures; an irrelevant, emotionally negative or neutral picture preceded the target by either two or eight items. At the shorter lag, negative pictures spontaneously induced greater deficits in target processing than neutral pictures did. Thus, attentional biases to emotional information induced a temporary inability to process stimuli that people actively sought. Experiment 2 revealed that participants could reduce this effect through attentional strategy, but that the extent of this reduction was related to their level of the personality trait harm avoidance. Participants lower in harm avoidance were able to reduce emotion-induced blindness under conditions designed to facilitate the ignoring of the emotional stimuli. Those higher in harm avoidance were unable to do so.

Adult↗

Visually guided reaching: bilateral posterior parietal lesions cause a switch from fast visuomotor to slow cognitive control.

The visually guided reaching of two patients with bilateral optic ataxia was explored in two experiments. In Experiment 1 simple delayed pointing was compared with immediate pointing. In the immediate pointing task both variable and constant errors increased with target eccentricity. In contrast to the performance of control subjects and contrary to their own beliefs, the patients both showed improved accuracy in the delay condition. This improvement was manifest as a reduction in both pointing variability and in the constant angular error towards the point of fixation. Both angular errors and their improvement with the delay were proportional to target eccentricity. Experiment 2 used a task in which the target was pre-viewed 5s prior to its re-exposure for pointing ('delayed real pointing'). On some trials a conflict was introduced between the present and previous visual information by changing the target's location during the delay. In contrast to control subjects, who ignored the pre-viewed location and aimed directly at the current target, both patients with optic ataxia initiated their movements towards the previously viewed target location. Evidently they relied on off-line information in preference to on-line visual information. In addition, the patients often failed to detect the changes in target location. One of the patients sometimes even guessed incorrectly that the target had changed its location, and her movement trajectory was then more affected by her false belief than by the target's actual location. These findings confirm that posterior parietal lesions severely disrupt direct visuomotor transformations, and suggest that the residual performance is mediated indirectly by expectations or beliefs about target position.

Acoustic Stimulation↗

Selection for cognitive control: a functional magnetic resonance imaging study on the selection of task-relevant information.

The complex environment we live in makes it necessary to distinguish relevant from irrelevant information constantly and reliably. The aim of the present study was to investigate the neural substrate underlying the selection of task-relevant information. We devised a new paradigm in which participants had to switch between two different tasks that were instructed by task cues. The task cues had a relevant and an irrelevant cue dimension. In congruent trials, both cue dimensions indicated the same task; in incongruent trials, they indicated different tasks; and in neutral trials, only the relevant dimension indicated a task. By comparing trials in which both cue dimensions were informative (congruent and incongruent trials) with trials in which only the relevant dimension was informative (neutral trials), we were able to show that the lateral prefrontal cortex and a region in the intraparietal sulcus are involved in the selection of task-relevant information. Furthermore, the present paradigm allows the influence of the selected task and stimulus dimension to be investigated. No significant influence was found in the prefrontal cortex, indicating that this region serves a very abstract role in the selection of task-relevant information.

Behavior↗

Cognitive control can modulate intersensory facilitation: speeding up visual antisaccades with an auditory distractor.

Although saccadic reaction times to a visual stimulus are facilitated if an auditory accompanying stimulus is presented at the same location, this intersensory facilitation effect (IFE) has not been explored for antisaccades (saccades directed opposite to a visual target). In this study participants were asked to make an antisaccade opposite to a point of light presented right or left of fixation while accompanied by an auditory stimulus either at the same or at the opposite location with different stimulus onset asynchronies. Antisaccade reaction times for unimodal auditory and bimodal stimuli were shorter than for unimodal visual stimulation, in line with prosaccade studies. The auditory accompanying stimulus afforded antisaccade reaction times approximately as fast as prosaccades in the direction of a visual target, especially when it was presented 40 ms before the spatially congruent visual target. Moreover, predictiveness of the target position facilitated performance only when the auditory stimulus was presented at the opposite location and 40 ms before the visual target (interstimulus contingency effect). We conclude that intersensory facilitation is a mandatory, bottom-up process, but in the particular case of a response conflict due to a visual target, IFE can be shown to be modulated by the predictability of the target location.

Acoustic Stimulation↗

Using advance information in dynamic cognitive control: an ERP study of task-switching.

Ensuring that behavior remains appropriate over time requires dynamic, flexible control. We used the task-switching procedure to investigate the mechanisms whereby advance information is used to control behavior under conditions of frequently changing task-rules. The color of target stimuli signaled which task-set (or behavioral 'rule') was required on each trial. We provided different forms of advance information in two conditions and found a double dissociation in their effects: visual precues ('precueing') facilitated task-switching, whereas a fixed task-sequence ('predictability') facilitated task-repetition. In addition, precueing was associated with a late parietal positive ERP which preceded target onset, whereas predictability produced an increase in the target-locked centro-parietal P3b ERP. We suggest that these results indicate the activity of two distinct mechanisms. The first, driven by a task-cue and indexed by the late parietal positivity, may drive efficient task-performance on precued switch trials but occurs too late on non-precued switch trials to index an anticipatory task-set reconfiguration process. The second may constitute active consolidation or maintenance of a particular task-set which occurs at least one trial ahead, when task-repetitions are predictable, and results in facilitation of target stimulus evaluation.

Adult↗

Effect of bilingualism on cognitive control in the Simon task: evidence from MEG.

The present study used magneto-encephalography (MEG) to determine the neural correlates of the bilingual advantage previously reported for behavioral measures in conflict tasks. Bilingual Cantonese-English, bilingual French-English, and monolingual English speakers, performed the Simon task in the MEG. Reaction times were faster for congruent than for incongruent trials, and the Cantonese group was faster than the other two groups, which did not differ from each other. Analyses of the MEG data using synthetic aperture magnetometry (SAM) and partial last squares (PLS) showed that the same pattern of activity, involving signal changes in left and medial prefrontal areas, characterized all three groups. Correlations between activated regions and reaction times, however, showed that the two bilingual groups demonstrated faster reaction times with greater activity in superior and middle temporal, cingulate, and superior and inferior frontal regions, largely in the left hemisphere. The monolinguals demonstrated faster reaction times with activation in middle frontal regions. The interpretation is that the management of two language systems led to systematic changes in frontal executive functions.

Adult↗

Pharmacologic challenges in Alzheimer disease and normal controls: cognitive modeling in humans.

Alzheimer disease (AD) is a progressive disorder characterized by cognitive and behavioral dysfunction, central to which are deficits in the cholinergic and other neurotransmitter systems. These results in the essential symptoms of dementia, including impairment of memory, judgment, and abstract thinking. The pharmacologic relationships among the various neurotransmitters (e.g., cholinergic, serotonergic, nicotinic, and dopaminergic) are highly complex and are still being investigated. Information on the pharmacologic basis of cognitive and behavioral dysfunction in AD has applications to drug therapy. One method of obtaining this information is by pharmacomodeling, using individual or combined drugs. Joint cholinergic antagonism with both muscarinic and nicotinic blockade combines to produce short-term memory impairment, which approximates to mild AD in normal elderly people. This effect is better than that achieved with either agent alone. Mixed cholinergic and serotonergic antagonism has an effect on the cognitive function of AD patients and on depression-related behavior. Dopaminergic dysfunction is linked with the development of hallucinatory and psychotic symptoms and may also be involved in dysfunction of verbal fluency. Combination pharmacomodeling allows the various behavioral and cognitive deficits in AD to be studied and allows models for drug trials to be developed.

Aged↗

Existential concerns of terminally ill cancer patients receiving specialized palliative care in Japan.

BACKGROUND: Although alleviation of existential distress is important for terminally ill cancer patients, the concept of existential distress has not been fully understood. The aim of this study was to categorize existential concerns of Japanese terminally ill cancer patients and explore care strategies based on the categorizations. METHODS: A multicenter cross-sectional study in 88 terminally ill cancer patients receiving specialized inpatient palliative care was performed. The nurses explored patient existential concerns by asking several key questions, and recorded the answers that they considered typically described the patients' concerns. All statements recorded by the nurses were analyzed using content analysis methods. RESULTS: A total of 89 statements were subjected to analysis. The categories and their prevalence were: relationship-related concerns (22%; isolation, concerns about family preparation, conflicts in relationship), loss of control (16%; physical control, cognitive control, control over future), burden on others (4.5%), loss of continuity (10%; loss of role, loss of enjoyable activity, loss of being oneself), uncompleted life task (6.8%), hope/hopelessness (17%), and acceptance/preparation (25%). CONCLUSIONS: Existential concerns of Japanese terminally ill cancer patients were categorized as relationship-related concerns, loss of control, burden on others, loss of continuity, uncompleted life task, hope/hopelessness, and acceptance/preparation. These themes seemed to encompass universal human suffering beyond cultural differences, and this conceptualization may contribute to the development of effective therapeutic interventions to alleviate existential distress.

Adult↗

Attributions, beliefs about control, and adjustment to breast cancer.

Attributions for cancer and beliefs about control over cancer were examined for their association with adjustment to breast cancer. Although 95% of the respondents made attributions for their cancer, no particular attribution (e.g., stress, diet) was associated with better adjustment. Analyses of attributions of responsibility for the cancer to the self, environment, another person, or chance yielded only a negative relation between adjustment and blaming another person. In contrast, both the belief that one could now control one's cancer and the belief that others (e.g. the physician) could now control the cancer were significantly associated with good adjustment. Of the different types of control, cognitive control was most strongly associated with adjustment, behavior control was less strongly associated with adjustment, and information control and retrospective control were unassociated with adjustment. The theoretical and practical implications of these results are discussed.

Adaptation, Psychological↗

Issues of control in patients with cancer pain.

The enhancement of patient control is frequently cited in nursing literature as an important area of nursing intervention. In this article, the concept of control, from the perspective of the patient with cancer pain, the primary family caregiver, and the home-care nurse, is discussed. Lewis identified five types of control: processual control, contingency control, cognitive control, behavioral control, and existential control. Lewis's typology of control was used as an organizing analytical framework, in this study, for interpreting the interview responses of each member of the triad. Similarities and differences in the perspectives of each member are discussed and examples of interventions that may be used to increase control in the management of pain are presented.

Community Health Nursing↗

Cognition and control in schizophrenia: a computational model of dopamine and prefrontal function.

Behavioral deficits suffered by patients with schizophrenia in a wide array of cognitive domains can be conceptualized as failures of cognitive control, due to an impaired ability to internally represent, maintain, and update context information. A theory is described that postulates a single neurobiological mechanism for these disturbances, involving dysfunctional interactions between the dopamine neurotransmitter system and the prefrontal cortex. Specifically, it is hypothesized that in schizophrenia, there is increased noise in the activity of the dopamine system, leading to abnormal "gating" of information into prefrontal cortex. The theory is implemented as an explicit connectionist computational model that incorporates the roles of both dopamine and prefrontal cortex in cognitive control. A simulation is presented of behavioral performance in a version of the Continuous Performance Test specifically adapted to measure critical aspects of cognitive control function. Schizophrenia patients exhibit clear behavioral deficits on this task that reflect impairments in both the maintenance and updating of context information. The simulation results suggest that the model can successfully account for these impairments in terms of abnormal dopamine activity. This theory provides a potential point of contact between research on the neurobiological and psychological aspects of schizophrenia, by illustrating how a particular physiological disturbance might lead to precise and quantifiable consequences for behavior.

Cognition Disorders↗