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PubMed1990

Administered dose and tumor dose of bleomycin labeled with cobalt-57 in mice and men.

Tumor concentrations of the chemotherapeutic drug, bleomycin, labeled with cobalt-57 (Co-bleo) were compared in mouse tumor models and in human lung tumors using quantitative single-photon emission computed tomography. Drug concentrations in histologically similar human tumors showed marked variability for the same injected dose (ID). Small cell carcinomas showed concentrations between 1.09 and 8.85 %ID/cc x 10(-3) while non-small cell lung tumors showed a concentration variation between 0.36 and 6.75 %ID/cc x 10(-3). In contrast to the situation in human tumors, uptake in mouse tumors showed only slight variability in animals with the same tumor model. EMT-6 tumors in mice showed at 6 hr significantly higher uptake of Co-bleo (p less than 0.001) and significantly higher tumor-to-lung ratio (p less than 0.001) when compared to murine fibrosarcomas. The EMT-6 tumors in contrast to the fibrosarcomas responded to bleomycin treatment in a dose dependent manner. The results indicate that while in mice the tumor dose closely follows the administered dose, in humans, the tumor dose and the tumor-to-lung ratio in the individual patient cannot be predicted from the administered dose.

Aged↗
PubMed1976

Heterologous sera: a target for in vitro cell-mediated cytotoxicity.

During the course of studies in inbred Strain 2 Guinea pigs on in vitro cell-mediated cytotoxicity to viral induced fibrosarcomas, it was observed that fetal calf serum in the medium in which the target cells were grown was responsible in some instances for much of the cytotoxicity observed. This fetal calf serum-specific cytotoxicity seemed mainly mediated by T cells and appeared to be independent on histocompatibility between target and killer cells.

Animals↗
PubMed1991

Collagenolytic activity of methylcholanthrene-induced rat fibrosarcoma.

It has been found that the methylcholanthrene-induced rat fibrosarcoma contains an enzyme (probably a cathepsin) which digests type I and type III collagens in acid pH. At physiological pH no proteolytic activity against collagen was found. It may be concluded that the tumour collagen is degraded mainly by the action of cathepsin(s).

Animals↗
PubMed1979

[Hematopoiesis and changes in the RES of the spleen pulp in fibrosarcoma-bearing rats].

The transplantable fibrosarcoma of the Rat gives birth to different modifications in the splenic structures, and a strong perturbation is found within the enzymatic activities. The macrophages have an altered acid phosphatase activity. This is in marked contrast to the increase in number of the alkaline phosphatase polymorphonuclear cells, which are originated from myeloid areas in the red pulp. Lymphoïd-reticular cells, possessing one 5'nucleotidase activity, seem to be responsible, possibly, by forming numerous clonal systems during the development of this fibrosarcoma. The role of this separate system is discussed.

5'-Nucleotidase↗
PubMedDate not supplied

Cellular immunity in chicks expressing fibrosarcomatous liver tumor following embryo infection with subgroup A Rous sarcoma virus.

Bryan standard strain of Rous sarcoma virus (BS-RSV) of subgroup A was inoculated into heavy and light breeds of chicken embryos via chorioallantoic membrane (CAM) to ascertain cell-mediated immune response, as measured by a leukocyte migration inhibition (LMI) test. Chicks hatched from eggs with pock-positive CAMs were more likely to develop liver tumors than those hatched from eggs with pock-negative CAMs. Chicks that developed tumors usually had a positive cell-mediated immune response, and those that were negative for liver tumor were negative, based on the LMI test.

Animals↗
PubMed1988

[Effect of combined use of radiation and twice intratumor administration of OK-432 at one week intervals against a murine fibrosarcoma (NFSA)].

Effect of combination use of radiation and multiple administration of OK-432 was studied using a radio-resistant and weakly immunogenic murine fibrosarcoma (NFSa) originated spontaneously in a C3H female mouse. Mice implanted the tumor in the leg were locally irradiated with 40 Gy of gamma rays and locally administered total 8 KE of OK-432. The first group was given 1 KE daily for 8 days, 2 KE every other day in the 2nd group, 4 KE at 1 week interval in the 3rd group and 8 KE immediately after irradiation in the 4th group. The tumor volume at day 19 after irradiation was compared. The tumor growth inhibitory effect was observed in the 3rd group (p less than 0.01) and 4th group (p less than 0.05) compared to the group given radiation alone. This effect was seen at even more smaller dose of OK-432 as 0.5 KE by 2 times administration at 1 week interval. The effect of route of OK-432 administration was studied comparing the tumor volume at day 22. OK-432 was given 2 times at 1 week interval. A significant difference was seen in the group given OK-432 locally compared to the control group given radiation alone (p less than 0.001). There were no significant differences between the groups given OK-432 by the routes of i.p., s.c. i.v. and the control group. TCD50 value was examined giving OK-432 4 KE on the day and 2 KE on day 7 after irradiation. TCD50 value in the group treated with irradiation alone was 83.5 (79.6-87.4) Gy and the group given combination therapy with OK-432 was 60.7 (55.9-65.4) Gy. Two times OK-432 administration at 1 week interval appears to potentiate the radiation response by about 23 Gy.

Animals↗
PubMed1987

[Increased anti-tumor activity of chemotherapeutic agents combined with direct current against murine transplanted tumors].

The antitumor activity of direct current was studied in mice which were transplanted fibrosarcoma (FSa) into the right thigh. Mice were inserted electrodes into tumor and normal tissue surrounding the tumor, and treated with constant current. The direct current therapy (D.C.T.) (0.6 mA, 120 min) alone was effective to regress tumor, but tumor was not eradicated by D.C.T. alone. Cyclophosphamide (CPA, 100 mg/kg) could markedly reduce the FSa tumor size, but all tumor regrew finally. When D.C.T. was combined with CPA (100 mg/kg), the therapeutic response of FSa tumor was enhanced in mice which were inserted cathode into tumor. For example, in mice receiving direct current (0.6 mA, 120 minutes), the cure rate was 70% compared with 30% by the anode in tumor. Using cure rate assay, D.C.T. and about half dose of CPA could give the similar treatment results as the full dose of CPA alone. That is, D.C.T. will be able to reduce the dose of chemotherapeutic agents. Combination of D.C.T. and doxorubicin was not so effective as CPA, but showed the similar results. The experimental results suggest that D.C.T. alters the drug distribution in the tumor and makes the drugs more effective.

Animals↗
PubMed1987

[Synergistic effects of human recombinant TNF and hyperthermia on in vitro cytotoxicity and artificial metastases].

Synergistic effects of hyperthermia on the cytotoxicity of TNF were examined, using L-M cells (mouse tumorigenic fibroblasts) and HEL cells (human embryonic lung cells) as targets. The sensitivity of L-M cells to TNF apparently increased when the culture temperature was raised from 37 degrees C to 38.5 degrees C or 40 degrees C, probably reflecting the increased turnover rate of the TNF-receptor complex. The anti-metastatic effects of a combined regimen of TNF (300U) and whole-body hyperthermia (40 degrees C, 30 min) was also examined in Balb/c mice injected with 1 X 10(6) Meth A F15 cells into a tail vein. No effects of TNF or hyperthermia alone were observed on artificial metastasis, while the combination of TNF and hyperthermia remarkably enhanced the inhibition of metastasis. These studies clearly suggest that combination of TNF with hyperthermia provides a significant synergistic effect against tumor.

Animals↗
PubMedDate not supplied

Cytodiagnosis of bone tumors by fine needle aspiration.

A retrospective study was undertaken of bone lesions examined by preoperative fine needle aspiration (FNA) cytology in our hospital during the ten-year period from 1970 to 1979. The 430 cytologically examined lesions were classified into three groups: inflammatory lesions, tumorlike lesions and tumors. A total of 54 patients had undergone surgery, with most of the lesions in those cases proven to be tumors or tumorlike by histologic study. Correlation between the histologic and FNA cytologic findings showed complete compatibility in 76% of the cases, partial compatibility in 13% and incompatibility in 11%. It is concluded that FNA biopsy is appropriate for identifying bone tumors and tumorlike lesions if sufficient numbers of tumor cells are obtained for morphologic examination. Although aspiration cytodiagnosis can be of considerable value in the recognition of certain bone lesions, it cannot replace formal tissue biopsy in the diagnosis of primary bone neoplasms. The morphology of several common bone tumors is described in detail and their differential diagnosis is discussed.

Biopsy, Needle↗
PubMed1979

Effect of thymectomy on tumor development and on T and B lymphocytes in tumor-bearing rats.

Tumor growth and changes in T and B lymphocyte ratio in spleen, draining lymph node and peripheral blood of thymectomized, irradiated rats, reconstituted with syngeneic bone marrow transplanted at various time intervals with MC-1 fibrosarcoma cells were followed. Control nonthymectomized or "sham" operated rats were transplanted an equal dose of tumor cells. Thymectomy and irradiation reduced the numbers of T lymphocytes in all lymphoid organs, while the enhanced numbers of B cells are probably related to reconstitution with cells of syngeneic bone marrow. The time interval between thymectomy, irradiation and transplantation of tumor cells proved to be a limiting factor for tumor growth and changes in T and B cell ratio. Early transplantation of tumor cells (7 days after irradiation) resulted in an enhanced resistance to tumor development, a reduced tumor growth rate and a progressing decline in the number of T cells. If the interval between thymectomy and tumor cell transplantation lasted 4 weeks, the T cell population became partially regenerated, and tumors grew progressively in correlation with a continuing T lymphocyte depletion. The results are discussed in terms of the role of various T cell subpopulations and the significance of residual, thymectomy- and irradiation-resistant T lymphocyte population, vital for a preservation of T cell immunological functions.

Animals↗
PubMed1985

[Immunogenicity of viable tumor cells--comparison of immunogenicity between xenogenized tumor cells and BCG-tumor cell vaccine].

We compared the immunogenicity of FV-KMT-17 (fibrosarcoma, KMT-17 cells which had been xenogenized by infection with Friend leukemia virus (FV] and BCG + KMT-17 (KMT-17 cells which had been admixed with BCG), both of which can be used as viable tumor cell vaccines. The strength of immunogenicity shown by ETD50 (50% effective tumor dose), the number of immunizing cells required for a 50% suppression of growth of 10(7) KMT-17 cells, was 2.1 X 10(3) in FV-KMT-17 and 36.3 X 10(3) in BCG + KMT-17. The LTD50 (50% lethal tumor dose) which was required to kill 50% of rats immunized with 10(5) FV-KMT-17 was more than 10,000 times as high as the amount of LTD50 in normal rats. The LTD50 in rats immunized with the same number of BCG + KMT-17 was only 3,680 times higher than the amount in normal rats. These results indicate that the immunogenicity of FV-KMT-17 is much stronger than that of BCG + KMT-17. The difference in immunogenicity between the two vaccines was also observed in the tumor -neutralizing activities of spleen cells obtained from rats which had been immunized with them, as measured by Winn assay. Moreover, the antitumor activity of spleen cells from rats immunized with FV-KMT-17 concentrated in the carrageenan-non-sensitive and plastic nonadherent cells, while that of spleen cells from rats immunized with BCG + KMT-17 was observed in both carrageenan-sensitive and plastic adherent cells as well as nonadherent cells.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗

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