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At least 199 records · Page 11Linked to original sources
PubMed1989

The effect of noradrenaline on the ability of rat papillary muscle to resist an acute respiratory acidosis.

We have studied the effect of an increase in extracellular calcium and of noradrenaline on the ability of rat right ventricular papillary muscle in vitro to resist an acute fall in extracellular pH (pHe) produced by a rise in superfusate PCO2. We found a steep linear relationship, slope 0.86(SEM 0.06), r = 0.94, between a plot of logarithmic change in tension against pHe for control muscles (superfusate containing 1.8 mmol.litre-1 calcium). An increase in extracellular calcium (3.6 mmol.litre-1) increased absolute tension but did not alter the slope significantly. Increasing concentrations of noradrenaline (6.3 x 10(-8) to 6.3 x 10(-6) M) progressively reduced the slope of the tension/pHe plot from 0.82(0.05) to 0.35(0.07), p less than 0.001. Noradrenaline improved the ability of rat papillary muscle to resist an acute acidosis by a mechanism independent of changes in calcium concentration.

Acidosis, Respiratory↗
PubMed1975

Effects of respiratory acidosis on the arrhythmia threshold during fluroxene and halothane anesthesia.

Hypercarbia was induced in 12 patients anesthetized with either halothane or fluroxene in an inspired concentration of approximately 1.3 MAC (1% halothane and 4-5% fluroxene). The six patients receiving halothane anesthesia responded to hypercarbia with a pronounced tachycardia, an increased arterial pressure and an electrocardiographically monitored threshold level for ventricular arrhythmias at a Paco2 level averaging 98 mmHg. The six patients receiving fluroxene anesthesia responded to hypercarbia with both tachycardia and hypertension, but in spite of an average Paco2 level of 109 mmHg, no ventricular arrhythmias could be provoked. It is therefore suggested that within the non-narcotic level of hypercarbia a threshold level for cardiac arrhythmias does not exist under fluroxene anesthesia.

Acidosis, Respiratory↗