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PubMedDate not supplied

[Surgical treatment of aortic stenosis in small aortic annulus].

The purpose of this work is to demonstrate that the aortic enlargement procedures, first described for patients with small aortic annulus, are reproducible with excellent results. A retrospective revision of 72 cases in which an enlargement procedure was done, with consideration regarding the relationship between valve size and patient body surface area, in order to avoid prosthesis-patient mismatch, was done. We consider the immediate mortality of the group, differentiating the cardiac mortality, concluding with other authors that body surface areas between 1.3 and 1.7 m2 should receive aortic prosthesis larger than #23, which will eventually improve the late outcome of this population. We demonstrate that the aortic annular enlargement procedures can be safely done in our hospital, with a slight increase in mortality during the learning phase, but great benefit afterwards.

Adolescent↗
PubMed1970

[Aortic stenosis].

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Aortic Valve Stenosis↗
PubMed2005

[Severe aortic stenosis successfully treated with percutaneous aortic valve implantation].

Patients with severe calcific aortic stenosis are occasionally not amenable to surgery because of advanced age or severe co-morbidities. Percutaneous aortic valve dilation is used but has only limited time relief. While preclinical evidence on percutaneous aortic valve replacement seems promising, only very limited clinical data are available worldwide. We hereby present the first case of percutaneous aortic valve replacement successfully performed in Italy in a 74-year-old high-risk female. This case emphasizes the technical challenges inherent to this procedure and its promising role in selected very high-risk patients with severe aortic stenosis, notwithstanding the early and long-term risk of adverse events.

Aged↗
PubMed2002

The risk of the development of aortic stenosis in patients with "benign" aortic valve thickening.

BACKGROUND: Aortic valve thickening (AVT) without aortic stenosis (AS) is common and was often considered benign. However, it has recently been found to be associated with increased morbidity and mortality. It is unknown whether patients with AVT are at risk for the development of AS. METHODS: Our echocardiography database from 1987 to 1993 was searched for cases of AVT with at least 1 year of echocardiographic follow-up. The risk of the development of AS was compared in patients with and without AVT. RESULTS: There were 2131 patients with AVT and at least 1 year of echocardiographic follow-up. Aortic stenosis developed in 338 patients (15.9%) (mild, 10.5%; moderate, 2.9%; and severe, 2.5%). Multivariate analysis, including age, left ventricular hypertrophy, and mitral annular calcification, revealed that only mitral annular calcification was independently and significantly associated with progression to AS. CONCLUSIONS: Aortic valve thickening without stenosis is common, and it may progress to significant AS. It is possible that this development of AS may be responsible for some of the increased morbidity and mortality in patients with AVT.

Aged↗
PubMedDate not supplied

Timing of surgery in aortic stenosis.

In adults with valvular stenosis, the importance of prompt aortic valve replacement once symptoms occur is well known. The operative mortality for aortic valve replacement has improved dramatically over the past 4 decades and remains the only effective therapy for severe symptomatic aortic stenosis. Aortic valve replacement in patients with left ventricular dysfunction has a high operative mortality, although those patients who do not undergo surgery at all have an even worse outcome. While issues to consider include the presence or absence of coronary artery disease and expected hemodynamics of the prosthetic valve compared with the native valve, when in doubt, one should err on the side of surgical intervention. Elderly age is not a contraindication to aortic valve replacement for severe symptomatic aortic stenosis, although there is a higher prevalence of comorbid disease and higher operative mortality. Life expectancy is significantly prolonged and quality of life is significantly improved in the elderly who survive surgery. Indications for surgery in asymptomatic patients are controversial. We do not recommend valve replacement in asymptomatic patients at this time due to the known risks of surgery and a prosthetic valve and the lack of evidence for benefit of early surgery. Patients undergoing coronary bypass surgery should be considered for concomitant aortic valve surgery for moderate aortic stenosis that is expected to progress to severe stenosis in less than 5 years.

Adult↗
PubMed1991

Two-dimensional transesophageal echocardiographic determination of aortic valve area in adults with aortic stenosis.

To determine if aortic stenosis severity could be accurately measured by two-dimensional transesophageal echocardiography (TEE), 62 adult subjects (mean age 66 +/- 12 years) with aortic stenosis had their aortic valve area (AVA) determined by direct planimetry using TEE, and with the continuity equation using combined transthoracic Doppler and two-dimensional echocardiography (TTE). Eighteen subjects had AVA calculated by the Gorlin method during catheterization. An excellent correlation (r = 0.93, SEE = 0.17 cm2) was found between AVA determined by TEE (mean 1.24 +/- 0.49 cm2; range 0.40 to 2.26 cm2) and TTE (mean 1.23 +/- 0.46 cm2; range 0.40 to 2.23 cm2). The absolute (0.13 +/- 0.12 cm2) and percent (10.8 +/- 8.9%) differences between AVA determined by TEE versus TTE were small. Excellent correlations between AVA by TEE and TTE were also found in subjects with normal systolic function (r = 0.95, SEE = 0.14 cm2; n = 38) and impaired function (r = 0.91, SEE = 0.21 cm2; n = 24). AVA determined by catheterization correlated better with AVA measured by TEE (r = 0.91, SEE = 0.15 cm2) than AVA measured with TTE (r = 0.84, SEE = 0.19 cm2). These data demonstrate that AVA can be accurately measured by direct planimetry using TEE in subjects with aortic stenosis. TEE may become an important adjunct to transthoracic echocardiography in the assessment of aortic stenosis severity.

Adult↗
PubMed1988

Percutaneous single- and double-balloon aortic valvotomy in adolescents and young adults with congenital aortic stenosis.

Percutaneous balloon aortic valvotomy was attempted in six consecutive adolescents and young adults, (mean age 18 +/- 5 years), with severe congenital aortic valvular stenosis. Peak systolic aortic valve gradient measurement and aortography was performed before and immediately after valvotomy, and a 1-6 months follow-up. The single-balloon technique was used in two patients and the double-balloon technique in four patients. After balloon valvotomy the mean peak systolic aortic valve gradient (PSG) decreased from 122 +/- 53 to 43 +/- 20 mmHg (P less than 0.01). The haemodynamic improvement persisted at follow-up (PSG = 47 +/- 31 mmHg), except in one patient who had previously undergone aortic surgical valvotomy. One balloon valvotomy was unsuccessful, presumably because of the selection of an inappropriately small balloon. Two patients with critical aortic stenosis (PSG greater than 165 mmHg), who exhibited a thick aortic valve on echocardiography with a relatively small aortic root and annulus, had a dramatic reduction in PSG. However, the degree of aortic regurgitation increased significantly in both cases. The theoretical haemodynamic advantage of the double versus the single balloon techniques was confirmed in one patient. We have demonstrated that percutaneous balloon aortic valvotomy using either the single- or double-balloon technique is feasible in young adults with severe congenital aortic stenosis. Further studies are required both to define appropriate patients and the selection of balloon diameter and length.

Adolescent↗
PubMed1979

Acquired supravalvular aortic stenosis.

Severe supravalvular aortic stenosis was discovered at reoperation in 3 children with recurrent stenosis of the left ventricular outflow tract. The lesion consisted of gross thickening of the sinus ridge, most marked at the site of the previous aortotomy. The thickening had shortened the free edge of one or more leaflets and had distorted adjacent commissures. Preoperative angiography had indicated valve stenosis, but little commissural fusion was found at operation and the outflow tract obstruction was relieved by inserting a prosthetic patch in the ascending aorta. Recognition of this iatrogenic pathology is important to avoid supravalvular stenosis after aortic valvotomy and unnecessary valve replacement in children requiring reoperation for recurrent left ventricular outflow tract obstruction.

Adolescent↗
PubMed1988

Alterations in left ventricular geometry, wall stress, and ejection performance after correction of congenital aortic stenosis.

Children with congenital aortic stenosis have "excessive" left ventricular hypertrophy with reduced resting systolic wall stress that allows for supernormal ejection performance. If aortic stenosis is uncorrected, this pattern persists until adulthood. The effect of removing the aortic pressure gradient on left ventricular hypertrophy and wall stress in children with congenital aortic stenosis is unknown. To test the hypothesis that removal of the stimulus for hypertrophy by aortic valve replacement or repair would normalize left ventricular mass and wall stress, we measured left ventricular ejection performance, wall stress, and contractile function in seven patients at cardiac catheterization before and 36 +/- 7 months after surgical correction of congenital aortic stenosis. After aortic valve replacement or repair, the aortic valve gradient fell from 87 +/- 12 to 7 +/- 4 mm Hg, and peak left ventricular pressure fell from 187 +/- 14 to 128 +/- 8 mm Hg. Left ventricular ejection fraction decreased postoperatively from 86 +/- 4% to 74 +/- 4% (p less than 0.001), whereas velocity of circumferential fiber shortening decreased from 2.15 +/- 0.15 to 1.6 +/- 0.11 (p less than 0.002). Left ventricular mass remained unchanged preoperatively (121 +/- 14 g/m2) and postoperatively (121 +/- 16 g/m2), but wall thickness (h) decreased in relation to ventricular radius (r) (h/r = 0.55 +/- 0.05 preoperatively, 0.36 +/- 0.02 postoperatively; p less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)

Aortic Valve↗
PubMed1989

[Percutaneous aortic valvuloplasty: immediate results in calcified aortic stenosis].

Symptomatic calcific aortic stenosis in elderly patients has a poor prognosis and a relatively high surgical risk. Percutaneous aortic valvuloplasty is a new therapeutic procedure that may be applied in this group of patients. We report immediate results obtained with this technique in a cooperative study of 3 hospitals. In 16 of 19 patients we were able to locate a balloon catheter across the aortic valve following a femoral artery puncture. Mean age was 72 years and almost all patients were considered high surgical risk. Peak aortic gradient fell from 89 + 33 to 47 + 21 mmHg while valve area rose from 0.43 + 0.14 to 0.66 + 0.27 cm2; cardiac output remained unchanged. In 5 patients, an aortic valve area above 0.7 cm2 was obtained. Four patients needed blood transfusion, one developed pericardial tamponade and other recovered uneventfully from ventricular fibrillation. One patient died hours after the procedure in a low output state probably related to aortic insufficiency. We feel that aortic valvuloplasty is indicated in patients with severe calcific aortic stenosis and high surgical risk. Moderate improvement can be obtained with risks commensurate with the severity of the illness.

Aged↗
PubMed2006

Aortic valve bypass for the high-risk patient with aortic stenosis.

BACKGROUND: Interest in percutaneous therapy of heart valve disease has focused attention on the high-risk patient with aortic stenosis. Aortic valve bypass (apicoaortic conduit) surgery is the construction of a vascular graft containing a bioprosthetic valve from the apex of the left ventricle to the descending thoracic aorta. We have undertaken a programmatic effort to perform aortic valve bypass surgery as an alternative to conventional aortic valve replacement in selected high-risk patients, and now report our recent experience. METHODS: Between April 2003 and May 2005, 14 patients with aortic stenosis underwent aortic valve bypass surgery at two institutions. All patients selected for aortic valve bypass surgery were deemed to be at very high risk for conventional aortic valve replacement. These patients represented 14 (5.8%) of all 243 patients undergoing isolated aortic valve surgery during the same time period. Mean Society of Thoracic Surgeons predicted risk for operative mortality (11%) was between the 90th and 95th percentile. RESULTS: Twelve of 14 patients had previous cardiac surgery with patent bypass grafts. Average age was 78 years. Mean aortic valve area was 0.68 cm2. All operations were performed through a left thoracotomy on the beating heart (cross-clamp time, 0 minutes). Cardiopulmonary bypass was used for 6 patients (median cardiopulmonary bypass time, 15 minutes). There were 2 perioperative deaths. Median postoperative length of stay was 9 days. Two noncardiac late deaths occurred. Nine of 10 surviving patients are functional class I and are living independently. Early postoperative echocardiography confirms excellent aortic valve bypass function with preservation of ventricular ejection performance. CONCLUSIONS: Treatment of high-risk aortic stenosis patients with aortic valve bypass surgery is promising. Avoidance of sternotomy and cardiopulmonary bypass supports broader application to moderate-risk patients with aortic stenosis and as a control arm for studies of novel interventional therapies.

Aged↗
PubMed1983

Discrete subaortic stenosis associated with congenital valvular aortic stenosis--a diagnostic challenge.

Discrete subaortic stenosis has only rarely been reported in association with congenital valvular aortic stenosis. The valvular lesion may obscure the subaortic stenosis or may be obscured by it. Our experience with seven such cases (10% of our 71 patients with discrete subaortic stenosis) is reported and the diagnostic problems are discussed. In six cases the discrete subaortic stenosis was membranous and in one it was a fibromuscular tunnel. Two patients had associated coarctation of the aorta, two had aortic insufficiency, and one had a ventricular septal defect. An important clinical clue to the diagnosis was an ejection systolic click, which was found in four patients. Four patients were accurately diagnosed at cardiac catheterization. Two patients, in whom cross-sectional echocardiography (2DE) was performed, were accurately diagnosed by it.

Adolescent↗
PubMed1992

Simplified continuity equation: a simple, accurate, and noninvasive method in the evaluation of aortic stenosis.

Traditional evaluation of aortic stenosis usually requires cardiac catheterization for estimation of aortic valve area by the Gorlin formula. However, it is invasive and has been shown to be inaccurate in the presence of aortic regurgitation or low cardiac output. Evaluation of aortic stenosis by Doppler echocardiography using a continuity equation has been proved to have excellent correlation with cardiac catheterization. It requires hand tracing and computer software for calculation of time velocity integral. Recently, a simplified continuity equation was introduced, which uses the peak velocities instead of time velocity integrals. It saves time and obviates the computer assistance. The purpose of this study is to evaluate its accuracy using the standard continuity equation as the reference standard. Seventy patients with pure or combined aortic stenosis were examined. There was an excellent correlation between these two methods (r = 0.979, 95% confidence interval: 0.978-0.980). The aortic valve area derived from the peak velocity method = 0.018 + 0.949 X aortic valve area derived from the time velocity integral. The difference between the two methods was 0.04 +/- 0.08 cm2 (mean +/- SD) with a 95% confidence interval of -0.12 to 0.20 cm2. Furthermore, the correlation still remained good even in the presence of significant aortic regurgitation or impaired left ventricular function. In conclusion, the simplified continuity equation is a safe, time-saving, and accurate method for the evaluation of aortic stenosis.

Adult↗
PubMed2002

Arterial remodeling of the common carotid artery after aortic valve replacement in patients with aortic stenosis.

BACKGROUND AND PURPOSE: Aortic stenosis, causing flow abnormalities, disturbs the normal hemodynamics in the common carotid arteries. The aim of the present study was to investigate the remodeling process of the common carotid arteries after surgical correction of aortic stenosis. METHODS: Eleven subjects with aortic stenosis were studied before and 1 and 6 months after aortic valve replacement. Arterial diameter, intima-media thickness (IMT), and flow velocity were measured by echo-Doppler examination. Shear stress, blood flow, and pulsatility index were calculated. Blood viscosity and hematocrit were measured by standard methods. A control group was also enrolled. RESULTS: Before surgery, compared with controls, patients had lower systolic peak velocity but higher mean and end-diastolic velocity. Arterial diameter, IMT, and blood flow were comparable in the 2 groups. Blood viscosity, hematocrit, wall shear stress, and pulsatility index were markedly lower in patients. After surgery, IMT was reduced (0.741+/-0.152 versus 0.627+/-0.108 mm before and 6 months after surgery, respectively; P<0.0001), and hematocrit and blood viscosity increased, leading to increased wall shear stress (mean wall shear stress, 7.83+/-1.97 versus 9.65+/-3.12 dyne/cm(2) before and 6 months after surgery, respectively; P<0.02). CONCLUSIONS: The present results demonstrate that aortic valve replacement, in subjects with aortic stenosis, leads to reduction of the common carotid artery IMT. Wall shear stress is increased after the intervention and probably mediates the remodeling process.

Aortic Valve↗
PubMed1995

[Characteristics and clinical course of degenerative aortic stenosis in the elderly].

Degenerative aortic stenosis represents the most common form of aortic stenosis. The aim of this study was to evaluate the relationship between symptoms, valvular disease severity and prognosis. We studied the evolution of valvular aortic stenosis in 65 patients (39 males and 26 females, mean age 77.78 +/- 6.2 years) for a period of 7 years. All patients were submitted to accurate anamnestic examination, ECG, color Doppler echocardiography. Sixteen patients (26%) underwent cardiac catheterization. Associated diseases were: hypertension (45%), diabetes (40%), dyslipidemia (29%), chronic obstructive lung disease (6%). In 64% patients, the diagnosis of aortic stenosis was made after symptoms onset, and in 36% was occasional. Mean age at symptoms onset was 70 +/- 17 years: dispnoea was present in 81%, chest pain in 32%, and syncope in 8%. At the beginning of the follow-up, echocardiography showed, aortic stenosis to be mild in 21.73%, moderate in 60.8% and severe in 17.4%. At the end of the follow-up, mild stenosis was present in 9.5%, moderate in 38.7%, and severe in 51.8%. At entry, 56.6% had pure aortic stenosis, 34.78% had steno-insufficiency and 8.7 had an associated mitral valve insufficiency. At the end of the follow-up pure aortic stenosis was present in 17%, steno-insufficiency in 40%, and associated mitral valve insufficiency in 4.3%. Surgery was performed in 21% of the patients (77% valve replacement and 23% valve replacement and aortocoronary bypass). The mortality, at the end of the follow-up, was 31%. Causes of death were: heart failure (61%), arrhythmias (23%), and surgical complications (16%).(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗