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Melatonin and climactery.

Melatonin is a hormone synthesized in the pineal gland from tryptophan. It participates in several biological processes in the human being, such as circadian sleep rhythm, mood, reproductive processes and aging. Melatonin serum levels are increased in childhood and diminish importantly in older people. Serum levels are diminished in patients with insomnia and depressive mood. Experimentally, the melatonin inhibits the growth of mammary tumors in animals. With respect to endometrial cancer and Alzheimer's disease, the information is not conclusive. No changes have been found in melatonin levels in climacterical women. So its use has not fundament in postmenopausal women, however it can only be administered for short periods of time for the treatment of some sleep disturbances.

Aged↗
PubMed2002

[Frequency of HPV infection of the uterine cervix among perimenopausal women in Wielkopolska Region].

OBJECTIVES: Human papillomavirus (HPV) is one of the main causes of cervical neoplasia. There is now consistent evidence that Human Papillomavirus (HPV) has a causal role in the etiology of cervical cancer and that sexual habits and reproductive/hormonal factors are associated with the risk of invasive cervical cancer. In our investigation we estimated the frequency of HPV infection in uterine cervix in women gathered in perimenopausal and postmenopausal groups. MATERIALS AND METHODS: We screened 90 women in western Poland to obtain cytological smears, and tested all smears for 33 types of HPV with a polymerase chain reaction-based system. All women were classified according to age into three groups. RESULTS: HPV infections peaked in the group of 45 to 49 year old (48.5% using universal starters) and decreased in 56 year or olders (26.1% using universal starters) with predominantly non-cancer-associated types of HPV and uncharacterized HPV types. CONCLUSIONS: We confirm the decline of HPV infection with age. But note increased prevalence after menopause, which could be related to a second peak of HSILs, an observation that warrants further investigation. At least 80% of HPVs involved in cervical carcinogenesis in this population have been characterized. Polyvalent vaccines including the main cancer-associated HPV types may be able to prevent most cases of cervical disease in this region.

Adult↗
PubMed1977

The menopause.

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Adult↗
PubMed1987

[Clinico-dynamic analysis of the borderline states of advanced age].

On the basis of clinical follow-up of 579 patients with borderline states related to old age the authors have established the peculiarities of the time-course of these states associated with the age stage (involutional and senile) and nosological structure. The role of endocrine-vegetative and microsocial factors in the manifestation of decompensation states in psychopathic patients is considered. The authors describe different variants of the dynamics in the form of latent compensated psychopathic conditions, transformation of a psychotic nature and "late depsychopathization". The role of psychogenic (microsocial), somatogenic and exogenic-organic factors in the development and time course of the main forms of neuroses is considered. Also discussed is the organization of specialized care for patients with borderline states in advanced age.

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