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The second EURADOS intercomparison of national network systems used to provide early warning of a nuclear accident.

In 1999 and 2002, the EURADOS Working Group on Environmental Monitoring organised two European intercomparison exercises of national network systems used to provide early warning in case of a nuclear accident. In total, 12 European countries, represented by more than 40 scientists, participated in these two intercomparisons with more than 35 different dose rate detectors. In addition, an in situ gamma spectrometry intercomparison was performed by a group of European scientists during the 2002 exercise. Results of these spectrometry measurements will be reported elsewhere. This report summarises the results of the second intercomparison, performed in 2002, at the environmental dosimetry facilities of the Physikalisch-Technische Bundesanstalt (PTB) in Germany. The unique combination of the ultra-low background Underground Laboratory (UDO) and two free-field sites (a floating platform on a lake showing an almost pure cosmic radiation field and a free-field gamma ray irradiation facility) provide the particular opportunity to precisely quantify the inherent background of the detectors and to calibrate them almost free of any background and traceable to PTB's primary standards. In addition, the intercomparison comprised investigations on the energy and dose rate dependence of the detectors' response to gamma radiation as well as on the response to cosmic radiation. Finally, the sensitivity of the detector systems to small dose rate variations, similar to that caused by a passing overhead radioactive plume, was studied under realistic free-field conditions. Following the Council Directive 96/29/EURATOM, the participants of the 2002 intercomparison were asked to report their results in terms of the operational quantity ambient dose equivalent, H(*)(10). Although the verification of the individual calibrations showed smaller discrepancies than those in the 1999 intercomparison, in a few cases, these discrepancies would be still unacceptably high in the case of a real emergency situation as demonstrated by the plume results. This shows the clear need for further efforts towards a European harmonisation in environmental dosimetry. For this purpose, a further intercomparison shall be held at the PTB in 2006, especially with the participation of new members of the European Union.

Air Pollution, Radioactive↗

[Current status of the problem of radiation protection in space flight].

This review of radiation protection in space flight considers specific features of radiation effects (the composition of radiation, space-time changes of fluxes of charged particles, nonuniform radiation fields in spacecraft modules, formation of secondary radiations, etc) and the major sources of radiation hazards in space (Earth radiation belts, solar and galactic cosmic radiations). The paper presents estimates of the equivalent dose of protons and electrons of the Earth radiation belts at various orbits, as well as radiation characteristics of certain proton solar flares and galactic cosmic radiation. The paper also discusses the present-day criteria of radiation safety used in calculations of the shielding of manned spacecraft. The paper gives the standards of allowable radiation levels used in the USSR.

Cosmic Radiation↗

Cancer risk in space due to radiation assessed by determining cell lethality and mutation frequencies of prokaryotes and a plasmid during the Second International Microgravity Laboratory (IML-2) Space Shuttle experiment.

We participated in a space experiment conducted during the 2nd International Microgravity Laboratory Mission (IML-2) project. The aim of our study was to investigate the effects of space radiation, i.e., high-LET (linear energy transfer) cosmic radiation, on living organisms in the 'Realtime Radiation Monitoring Device (RRMD)'. The biological samples, dried E. coli DNA repair-deficient mutant cells and shuttle vector plasmid pZl89 DNA, were prepared and placed in a biospecimen box sandwiched between 'Harzlas' plastic radiation detectors. This box was then loaded into the RRMD sensor unit in the Space Shuttle 'Columbia' and an identical box was left in the NASA John F. Kennedy Space Center (KSC) as a control. 'Columbia' (flight No. STS-65) was launched from KSC in Florida, USA on July 8, 1994. The mission duration was 14.75 days and after 'Columbia' returned to earth, we studied (i) the lethal and mutagenic effects of high-LET cosmic radiation on E. coli mutants and (ii) the relationship between high-LET cosmic radiation and the mutation frequency of pZ189 DNA. There were virtually no differences between the cell viabilities of the space and control samples of Escherichia coli KMBL3835 (wild-type), KY383 (lexA-), KY385 (recA-) and KY386 (uvrA-), nor between the mutation frequency ratios of the space and control E. coli mutant samples. Furthermore, the survival and mutation frequency of the supF gene of pZ189 DNA space samples did not differ from those of the control samples. We concluded there was no cancer risk during this Space Shuttle flight.

Cosmic Radiation↗

Childhood leukemia incidence and exposure to indoor radon, terrestrial and cosmic gamma radiation.

This study was undertaken to evaluate the ecological association between terrestrial and cosmic gamma radiation, indoor radon, and acute leukemia incidence among children under 15 y of age. From 1990 to 2001, 5,330 cases of acute leukemia were registered by the French National Registry of Childhood Leukemia and Lymphoma. Exposure to terrestrial gamma radiation was based on measurements, using thermoluminescent dosimeters, at about 1,000 sites covering all the "Départements." In addition, 8,737 indoor terrestrial gamma dose rate measurements covering 62% of the "Départements" and 13,240 indoor radon concentration measurements covering all the "Départements" were made during a national campaign. Cosmic ray doses were estimated in each of the 36,363 "Communes" of France. There was no evidence of an ecological association between terrestrial gamma dose (range: 0.22-0.90 mSv y) or total gamma dose (range: 0.49-1.28 mSv y) and childhood acute leukemia incidence, for acute myeloid leukemia (AML) or for acute lymphoblastic leukemia (ALL), in univariate or multivariate regression analyses including indoor radon. A significant positive association between indoor radon (range: 22-262 Bq m) and AML incidence among children was observed and remained significant in multivariate regression analyses including either terrestrial gamma dose [SIR per 100 Bq m = 1.29 (1.09-1.53)] or total gamma dose [SIR per 100 Bq m = 1.29 (1.09-1.53)]. The study showed no ecological association between terrestrial gamma radiation and childhood leukemia for the range of variation in gamma dose rates observed in France. The moderate ecological association between childhood AML incidence and indoor radon does not appear to be confounded by terrestrial gamma dose.

Air Pollution, Indoor↗

The effects of cosmic particle radiation on pocket mice aboard Apollo XVII: I. Project BIOCORE (M212), a biological cosmic ray experiment: procedures, summary, and conclusions.

The primary objective of the experiment was to determine whether a specific portion of the high Z-high energy (HZE)* galactic cosmic ray particle spectrum, especially particles with Z greater than or equal to 6, can produce microscopically visible injury of brain and eye tissues. Pocket mice (Perognathus longimembris), obtained from the California desert, were selected as the biological target. Five of these mice were flown on Apollo XVII. Not only the brain and eyes but also many other tissues of these animals were studied for evidence of cosmic ray particle damage. The lack of prior experimental evidence as to the character of the potential injury induced by HZE particles required reliance on the physical characteristics of particle radiation in ascertaining the probable nature of the injruy. These characteristics and the key aspects of the experiment are summarized in this paper. Subsequent articles in this special supplement give details of the biological, engineering, and dosimetric aspects of BIOCORE together with the results.

Animals↗

[Detection of drug transport using X-ray techniques].

The purpose of the paper was to show X-ray techniques used to discover drugs transported inside the body (body packers), on the body surface, in the garments or luggage, in goods and vehicles. The analysis was based on the X-ray findings of 141 body packers caught in Hamburg between 1989 and 2004 as well as individual cases from personal collections. The use of X-rays for border and security checks is described, different technical concepts are demonstrated and examples are given, e. g. transmission (fluoroscopic) and backscatter imaging of humans, luggage, goods, and vehicles as well as X-ray spectroscopy. The results showed that body packers produce characteristic findings in native X-ray photographs, which are even more pronounced in CT scans and after application of contrast media. Backscatter imaging allows the investigation of the body surface and the clothing. Transmission and backscatter imaging is suitable for checking humans, goods, passenger cars, trucks and containers. With the help of X-ray spectroscopy suspicious substances can be identified without opening the packaging material. According to present findings, the radiation dose applied seems low compared with exposure to environmental radiation and cosmic radiation during flights. The pictures obtained with the backscatter technique show the person checked in the nude, which raises the question of privacy versus the right of the state to carry out inspections and controls.

Aircraft↗

Overview of aircraft radiation exposure and recent ER-2 measurements.

The intensity of the different particles making up atmospheric cosmic radiation, their energy distribution, and their potential biological effect on aircraft occupants vary with altitude, geomagnetic latitude, and time in the sun's magnetic activity cycle. Dose rates from cosmic radiation at commercial aviation altitudes are such that crews working on present-day jet aircraft are an occupationally exposed group with a relatively high average effective dose. Crews of future high speed commercial aircraft flying at higher altitudes would be even more exposed. Present calculations of such exposures are uncertain because knowledge of important components of the radiation field comes primarily from theoretical predictions. To help reduce these uncertainties for high-altitude flight, the National Aeronautics and Space Administration (NASA) and the Department of Energy (DOE) started the Atmospheric Ionizing Radiation (AIR) project. The measurement part of the AIR project is an international collaboration of 12 laboratories placing 14 instruments on multiple flights of a NASA ER-2 aircraft. This paper describes the basic features of cosmic radiation in the atmosphere as they relate to exposure of aircraft occupants and then describes the AIR ER-2 measurements and presents some preliminary results from a series of flights in June 1997.

Aircraft↗

Dose rate, dose-equivalent rate, and quality factor in SLS-1.

A tissue-equivalent proportional counter (TEPC) sensitive to the lineal energy range of 0.26-300 keV micrometer-1 was flown on STS-40 (39 degrees x 278 km x 296 km) inside the Spacelab. This instrument was previously flown on STS-31 but was modified to provide a finer resolution at lower lineal energies to better map the South Atlantic Anomaly (SAA) protons. The instrument was turned on 6 June 1991, and operated for 7470 min (124.5 h). The flight duration was characterized by a very large number of X-ray solar flares and enhanced magnetic field fluctuations; however, no significant dose from the solar particles was measured at the location of this instrument. The flight data can be separated into trapped and galactic cosmic radiation parts. The dose rate, dose-equivalent rate and quality factor for trapped radiation were 4.21 +/- 0.03 mrad day-1, 7.72 +/- 0.05 mrem day-1, and 1.83 +/- 0.1, respectively. The dose rate, dose-equivalent rate, and quality factor for galactic cosmic radiation were 5.34 +/- 0.03 mrad day-1, 14.63 +/- 0.06 mrem day-1, and 2.74 +/- 0.1, respectively. The overall quality factor for the flight was 2.38. The dose from the GCR is higher than from SAA protons because of the high inclination and low altitude of this flight. The AP8MAX model of the trapped radiation gives a dose rate of 2.43 mrad day-1 and a quality factor of 1.77. The CREME solar maximum model of galactic cosmic radiation gives a dose rate of 2.54 mrad day-1 and a quality factor of 2.91. Thus the AP8MAX model underestimates the dose by a factor of 1.8 whereas the CREME model leads to an underestimation of the dose by a factor of 2. A comparison of the LET spectra using the AP8MAX model and galactic cosmic radiation transport codes shows only a qualitative agreement.

Computer Simulation↗

Incidence of cancer among Nordic airline pilots over five decades: occupational cohort study.

OBJECTIVE: To assess the incidence of cancer among male airline pilots in the Nordic countries, with special reference to risk related to cosmic radiation. DESIGN: Retrospective cohort study, with follow up of cancer incidence through the national cancer registries. SETTING: Denmark, Finland, Iceland, Norway, and Sweden. PARTICIPANTS: 10 032 male airline pilots, with an average follow up of 17 years. MAIN OUTCOME MEASURES: Standardised incidence ratios, with expected numbers based on national cancer incidence rates; dose-response analysis using Poisson regression. RESULTS: 466 cases of cancer were diagnosed compared with 456 expected. The only significantly increased standardised incidence ratios were for skin cancer: melanoma 2.3 (95% confidence interval 1.7 to 3.0), non-melanoma 2.1 (1.7 to 2.8), basal cell carcinoma 2.5 (1.9 to 3.2). The relative risk of skin cancers increased with the estimated radiation dose. The relative risk of prostate cancer increased with increasing number of flight hours in long distance aircraft. CONCLUSIONS: This study does not indicate a marked increase in cancer risk attributable to cosmic radiation, although some influence of cosmic radiation on skin cancer cannot be entirely excluded. The suggestion of an association between number of long distance flights (possibly related to circadian hormonal disturbances) and prostate cancer needs to be confirmed.

Adult↗

Recent radiobiological findings from spaceflight and ground-based studies--an overview.

With respect to radiation standards for manned space flight, we wish to address ourselves to the following topics that we consider pertinent for a realistic assessment of the risk to man when exposed to ionizing radiation under space flight conditions: 1) prediction and measurement of the spectra of the physical traits of cosmic radiation as a function of orbital parameters and the mass shielding of the spacecraft; 2) synergistic or antagonistic modification of radiation effects by dynamic flight conditions and by the space environment; 3) production of biological damage becoming manifest only long after exposure, especially to the heavy ions; and 4) demonstration of possibly specific radiobiological mechanisms for the densely ionizing heavy-ion component of the cosmic radiation. Some recent work referring to these topics will be presented and discussed with emphasis on the high LET component of the cosmic radiation.

Animals↗

Radiation exposure of aircrews.

Information is provided about the radiation to which aircrews are exposed and possible health consequences. Recommended radiation exposure limits are given. Crewmembers on commercial aircraft are exposed to higher doses of ionizing radiation than normally received by members of the general population in most parts of the world. The principal ionizing radiation is galactic cosmic radiation. On infrequent occasions, radiation from the sun leads to an increase in the ionizing radiation at aircraft flight altitudes. Radioactive cargo is another possible source of exposure to ionizing radiation. Crewmembers are exposed to nonionizing radiation in the form of electric and magnetic fields generated by the aircraft s electronic and electrical systems. Other potential sources of nonionizing radiation exposure are microwave radiation from the aircraft's weather radar, laser radiation, and ultraviolet radiation.

Aerospace Medicine↗

Risk of breast cancer in female flight attendants: a population-based study (Iceland).

OBJECTIVES: To study whether increased cancer risk, particularly of cancer types previously related to radiation, was found among cabin attendants, using employment time as a surrogate of exposure to cosmic radiation. METHODS: A cohort of 1690 cabin attendants, 158 men and 1532 women from the Icelandic Cabin Crew Association and two airline companies in Iceland, was established. Cancer sites were ascertained between 1955 and 1997 by follow-up in a cancer registry. The personal identification number of each subject was used in record linkage to population-based registers containing vital and emigration status, reproductive factors and histologically verified cancer diagnosis. Standardized incidence rates (SIR) of different cancer sites in relation to employment time and year of hiring were calculated, as well as predictive values of breast cancer risk for evaluating possible confounding due to reproductive factors. RESULTS: The total number of person-years was 27,148. Among the women, 64 cancers were observed whereas 51.63 were expected (SIR 1.2, 95% CI 1.0-1.6), and significantly increased risk for malignant melanoma (SIR 3.0, 95% CI 1.2-6.2) was found. Significantly increased risks of overall cancers (SIR 1.3, 95% CI 1.0-1.8) and breast cancer (SIR 1.6, 95% CI 1.0-2.4) were observed among the female cabin attendants when 15 years lag time was applied. Those hired in 1971 or later had the heaviest exposure to cosmic radiation at a young age and had significantly increased risk of overall cancer (SIR 2.8, 95% CI 1.4-4.9) and breast cancer (SIR 4.1, 95% CI 1.7-8.5). Predictive values calculated on the basis of reproductive factors among the cabin attendants and the population, and risk of breast cancer were 1.0 for parous vs. nulliparous, 1.0 for number of children, and 1.1 for age at birth of first child. CONCLUSION: The increased risk of breast cancer and malignant melanoma among cabin attendants seems to be occupationally related. The part played by occupational exposures, i.e. cosmic radiation, disturbance of the circadian rhythm, and electromagnetic fields or combination of these factors in the etiology of breast cancer among the cabin crew, is still a puzzle as confounding due to parity appears to be ruled out. The relationship between the sunbathing habits of the cabin crew and the increased risk of malignant melanoma needs to be clarified. There is also an urgent need to elucidate the importance of these findings for today's aviation.

Adult↗

Preliminary studies to develop a personal dosemeter for use by aircraft crew.

This paper describes preliminary work to develop a cosmic-radiation dosemeter for use by military aircraft crew. The dosemeter is based on a combination of CR-39 etched-track detectors and TLD-700 thermoluminescent detectors. It is intended that the CR-39 be used to assess the neutron dose, while the TLD-700 is used to assess the photon and charged particle dose. The sensitivity of CR-39 to the neutron component of cosmic radiation was estimated by irradiating samples of the plastic at the CERN-CEC High Energy Reference Field Facility. This facility produced a radiation field with a neutron spectrum resembling that of the neutron component of cosmic radiation at typical airflight altitudes. The response of the CR-39 was linear over the range of doses studied (0.2-6.0 mSv) and there was no significant fading in the 6-month period after irradiation. The TLD-700 component of the dosemeter was calibrated using 137Cs gamma rays. The response of the TLD-700 was linear over the range of doses studied (0.01-5.0 mSv) with no significant fading in the 6-month period after irradiation. It was concluded that a combination of CR-39 and TLD-700 detectors would provide an effective cosmic-radiation dosemeter for use by military aircraft crew.

Aviation↗

Study on external exposure doses received by the Cuban population from environmental radiation sources.

The results are described of the study carried out with the aim of assessing doses received by the Cuban population due to the external exposure to environmental radiation sources. Contributions of cosmic radiation's ionising and indirectly ionising components to these doses, as well as the fraction resulting from terrestrial radiation, were also assessed as part of this study. Measurements made enabled us to estimate representative effective average doses received by the Cuban population from external exposure to cosmic and terrestrial radiation. Both outdoor and indoor permanency were taken into account for this estimate as well as the distribution of the Cuban population by altitude. The average representative dose due to cosmic radiation was estimated to be 298 +/- 17 microSv per year, while the dose received by terrestrial radiation represented 180 +/- 14 microSv per year, for a total annual dose of 78 +/- 20 microSv. These values are within the range of those reported throughout the world by other authors.

Cuba↗

In-flight radiation exposure during pregnancy.

During high-altitude flight, the cosmic radiation dose rate in an airliner is greater than it is at ground level. For a casual traveler, the impact on pregnancy from cosmic radiation exposure during flight is trivial. Pregnant frequent flyers, pilots, and flight attendants can, however, receive exposures that exceed current recommended values if they do not appropriately modify their work schedules. In addition to the galactic cosmic-ray background that is the source of this radiation, severe disturbances on the sun may cause eruptions that significantly raise radiation levels at airliner altitudes for brief periods, possibly having an impact even on casual travelers. This article will help obstetrician-gynecologists provide advice to their pregnant patients about in-flight radiation risks. That advice should be influenced by an understanding of recommended radiation exposure limits and a perspective on how those limits relate to the potential for real harm. Resources provided by the U.S. Federal Aviation Administration and others to help pregnant women and their physicians make informed decisions about the acceptability of this type of exposure are described.

Abnormalities, Radiation-Induced↗

The effects of cosmic particle radiation on pocket mice aboard Apollo XVII: III. Dosimeter design, construction, and implantation.

To detect the passage of cosmic ray particles through the heads of the pocket mice during the Apollo XVII flight, a "monitor" (dosimeter) composed of plastics was prepared and implanted under the scalp. The monitor was mounted on a platform, the undersurface of which fitted the contour of the skull. Numerous tests were run to assure that the presence of the monitor assembly beneath the scalp would be compatible with the well-being of the mice and that the capacity of the monitor to detect the traversal of cosmic ray particles would be preserved over the several weeks during which it would remain under the scalp.

Animals↗

Present and future radiation dosimetry for Russian cosmonauts.

This report describes the features of the cosmic-radiation monitoring system defined by the parameters of cosmic radiation and by the conditions of operation of dosimeters in space. The objectives of the operative and personal monitoring on board Russian spacecraft have been defined and substantiated. Accordingly, the operating characteristics of the dosimeters used during the flights of Russian manned spacecraft are given. The feasibility of perfecting the radiation monitoring facilities to be used in future manned space missions is discussed. The methods used by the Radiation Safety Service during manned space missions are described.

Aerospace Medicine↗