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PubMed1989

Significance tests for cancer screening trials.

The goal of a cancer screening program is to reduce cancer mortality by detecting tumors at earlier stages of their development. For some types of cancer, screening tests may allow the preclinical detection of benign precursors of a tumor, and thus a screening program could result in reductions in both cancer incidence and mortality. For other types of cancer, a screening program will not reduce cancer incidence, and thus the expected outcome in a randomized cancer screening trial would be equal cancer incidence rates in control and study groups, but reduced cancer mortality in the study group. For the latter situation, we employ a variety of Poisson models for cancer incidence and mortality to derive optimal tests for equality of cancer mortality rates in a cancer screening trial, and we compare the asymptotic relative efficiencies of the test statistics under various alternatives. We demonstrate that testing equality of case mortality rates using Fisher's exact test or its Pearson chi-square approximation is nearly optimal when cancer incidence rates are equal and is fully efficient when cancer incidence rates are unequal. When valid, this comparison of case mortality rates in the study and control groups can be considerably more powerful than the standard comparison of population mortality rates. We illustrate the results using data from a clinical trial of a breast cancer screening program.

Adult↗

PubMed1990

Evaluation of melanoma/skin cancer screening in Massachusetts. Preliminary results.

Although screening for melanoma/skin cancer is theoretically of value, few data are available to evaluate its effectiveness or the value of a visual exam by a dermatologist as a cancer screening tool. From the 2560 persons screened for melanoma/skin cancer in Massachusetts in 1986 and 1987, the authors followed the positive screenees to determine their final diagnosis. The authors obtained information on 85% of these persons, and found nine malignant melanomas, 91 non-melanoma skin cancers, 39 dysplastic nevi, and three congenital nevi. The sensitivity of the visual exam by a dermatologist was 89% to 97% and the predictive value positive was 35% to 75% for skin cancer. The authors conclude that the yield of screening is equivalent to that of other major cancer screening efforts and that the sensitivity and predictive value of the visual examination by the dermatologist is appropriate for a cancer screening tool.

Carcinoma in Situ↗

PubMed1992

Breast cancer screening.

Breast cancer, as the second leading form of cancer death among women, causes significant morbidity and mortality. The primary care physician can help raise the survival rate of women with breast cancer by providing important screening procedures that will lead to early diagnosis and treatment. Screening mammography and regular breast physical examinations are the current screening procedures of choice. Although there is still considerable debate over the age and interval at which women should undergo screening (see Table 1 for recommendations from various organizations), the primary care physician's recommendation is the single most important factor and will certainly lead to a higher screening rate for women in the greater at-risk age groups. Judicious use of these screening procedures should allow primary care physicians to catch more breast cancers at an early, curable stage.

Adult↗

PubMedDate not supplied

Radiologic aspects of breast cancers detected through a breast cancer screening program.

Early detection of breast cancer and reduced mortality in women with this disease is today attributed to the widespread use of mammography. High-quality performance is essential in every step of breast cancer screening programs in order to avoid unnecessary anxiety and surgery in the women concerned. This report presents the radiologic aspects of screening cancers. A total of 8370 asymptomatic women aged between 50-69 years were screened with 2-view mammography, of which only 70 (0.84%) were selected for surgery after a thorough work-up. Cancers were verified histologically in 61 women and 9 showed non-malignant histology, giving a cancer detection rate of 7.3 cancers per thousand screened asymptomatic woman. The benign/malignant ratio in the operated cases is thus approximately 1:7. The cancers detected showed all existing types of mammographic features where 77% (47 cases) showed rather typical findings, such as spiculated densities both with and without microcalcifications and with microcalcifications only. The remaining 23% (14 cases) showed parenchymal distortions, asymmetric and well-defined densities, both with and without calcifications. Our results indicate that surgery can be minimized without impairing the breast cancer detection rate. Radiologists in screening programs should be aware that a large proportion of non-palpable breast cancers present in rather unconventional forms. This point is important in order to maintain a high cancer detection rate and thereby justify the widespread use of mammography as a screening tool for breast cancer in asymptomatic women.

Aged↗

PubMed2006

Uniquely women's issues in colorectal cancer screening.

Colorectal cancer (CRC) is the third most common cause of cancer in women. Screening has been shown to increase detection and decrease morbidity from this disease, but compliance is poor. This paper reviews special considerations for determining screening intervals in women, factors making screening more difficult in women, and studies reviewing preventative strategies in addition to screening that may reduce CRC.

Colorectal Neoplasms↗

PubMed2006

Evolution of breast cancer screening in countries with intermediate and increasing incidence of breast cancer.

BACKGROUND: Few studies have been published regarding the practice of breast cancer screening in Asian countries. AIMS: The present study illustrates how the health policy for breast cancer screening has evolved in Taiwan from selective mammographic screening within a high-risk group, firstly to a programme of physical examination by public health nurses, and finally to a two-stage breast cancer screening programme, with a risk assessment followed by mammography for those at moderate to high risk. DATA SOURCES: Breast cancer screening has evolved from 1995 to 2004 in Taiwan in three stages: (1) selective screening for breast cancer with mammography, ultrasound and physical examination only in first-degree relatives of breast cancer cases (1995-1998); (2) a programme of mass screening (1999-2001) with physical examination by public health nurses; and (3) two-stage breast cancer screening with a risk factor questionnaire and mammography for those deemed at moderate-to-high risk (2002-2004). The questionnaire was based on significant risk factors in a previous epidemiological study, in conjunction with the physical examination programme, a risk score was constructed from the logistic regression coefficients from the previous study, and women with a score above the median in the previous epidemiological study were assigned to mammography. RESULTS: Two-stage mammography screening had the most favourable results compared with the two previous screening regimes. It had a positive predictive value of recall after mammography of 14%, compared with 8% for selective screening and 2% for physical examination. Of screen-detected cancers in the two-stage programme, 71% were either ductal carcinoma in situ or stage T1, compared with 61% for selective screening and 60% for physical examination. The area under the receiver operating characteristic curve was 71% for the two-stage programme. CONCLUSIONS: For a low- to medium-risk country such as Taiwan, two-stage screening has acceptable parameters of recall and cancer detection, and compares well with other screening strategies.

Aged↗

PubMed2006

Gastric cancer screening and subsequent risk of gastric cancer: a large-scale population-based cohort study, with a 13-year follow-up in Japan.

We prospectively investigated the association between gastric cancer screening and subsequent risk of gastric cancer in a large-scale population-based prospective cohort study, with a 13-year follow-up in Japan. Data were analyzed from a population-based cohort of 42,150 (20,326 men and 21,824 women) subjects. Approximately 36% of subjects reported that they had undergone screening photofluorography during the preceding 12 months, and were regarded as the screened group. A total of 179 gastric cancer deaths and 636 incident gastric cancers were identified during the follow-up period. We observed a 2-fold decrease in gastric cancer mortality in screened versus unscreened subjects (RR = 0.52; 95% CI = 0.36-0.74). The extent of the reduction in mortality for gastric cancer was greater than in death from all causes excluding gastric cancer (RR = 0.71; 95% CI = 0.65-0.78). A significant decrease in the incidence of advanced gastric cancer was observed in screened subjects (RR = 0.75; 95% CI = 0.58-0.96), although the overall incidence rate did not differ significantly between the screened and unscreened subjects (RR = 1.06; 95% CI = 0.90-1.25). In age-stratified analyses, a significant reduction in gastric cancer mortality was seen in screened subjects aged 40-49 years at baseline, compared with a lesser reduction in screened subjects aged 50-59 (RR = 0.30, 95% CI = 0.13-0.72; and RR = 0.60, 95% CI = 0.40-0.88, respectively). These findings suggest that gastric cancer screening may be associated with a reduced risk of mortality from gastric cancer.

Adult↗

PubMed2004

The cumulative risk of a false-positive recall in the Norwegian Breast Cancer Screening Program.

BACKGROUND: Biennial breast cancer screening for women ages 50-69 years is recommended by the World Health Organization. It has been claimed that the cumulative risk of a false-positive recall is a significant disadvantage in breast cancer screening programs. The primary objective of this study was to estimate the cumulative risk of a false-positive recall during a screening period of 20 years in women ages 50-51 years who are screened biennially in a population-based screening program. A secondary objective was to estimate the cumulative risk of undergoing fine-needle aspiration cytology, core needle biopsy, and open biopsy with benign morphology in the same group of women. METHODS: The Norwegian Breast Cancer Screening Program invites all women ages 50-69 years who reside in the country to a 2-view mammography biennially. A nationwide data base that covers all of the invited women includes individual information about all screening activity. Results from three screening rounds in four counties were the basis for this study. False-positive recalls due to abnormal mammograms among 83,416 women who participated all the 3 screening rounds were the basis for the estimations. RESULTS: It was calculated that women ages 50-51 years who participate in biennial screening run a cumulative risk of 20.8% for a false-positive recall during a screening period of 2 decades. The cumulative risk of undergoing fine-needle aspiration cytology was estimated at 3.9%, and the risk of undergoing core needle biopsy or open biopsy with benign morphology was 1.5% and 0.9%, respectively. CONCLUSIONS: False-positive recalls are a disadvantage in a breast cancer screening programs, but the cumulative risk seemed to be acceptable in the Norwegian Breast Cancer Screening Program. It is important to communicate the existence and extent of this risk to the target group.

Aged↗

PubMed2005

Measuring sexual orientation and gender expression among middle-aged and older women in a cancer screening study.

BACKGROUND: The Cancer Screening Project for Women is about the experiences of legally unmarried women aged 40 to 75 years. METHODS: Prior to the implementation of a survey of experiences with breast, cervical, and colorectal cancer screenings, we used cognitive-based interviewing to evaluate questions for measuring sexual orientation and gender expression. RESULTS: We conducted interviews with 40 women, 19 who partner with women and 21 who partner with men. Interviews highlighted respondent confusion, clarified the meaning of terms, and improved the comprehension and utility of questions. CONCLUSIONS: Cognitive interview techniques can improve the validity and reliability of data collected by cancer screening programs.

Adult↗

PubMedDate not supplied

The design and implementation of a community breast cancer screening project.

A breast cancer screening program offers a community the opportunity to highlight and address an important health issue. This article has described the important elements of any such screening effort. To be successful, the program will require a multidisciplinary cadre of health care professionals working collaboratively throughout all phases of the planning, screening, and follow-up process. An agency should be identified to lead these professionals and monitor the progress of the screening effort. These screening programs can have direct and indirect benefits in the community. The direct benefits include improved access and delivery of health services, particularly those that meet state-of-the-art quality standards. The indirect benefits involve the promotion of breast cancer screening through education of women and providers about good breast health practices. As our experience in Michigan has shown, efforts featuring a broad coalition of forces can foster debate and discussion throughout the community and ultimately lead to improvements in the delivery of breast cancer screening services.

Breast Neoplasms↗

PubMed2003

Cost-effectiveness of pancreatic cancer screening in familial pancreatic cancer kindreds.

BACKGROUND: Endoscopic screening of families predisposed to pancreatic cancer is increasingly used, but the cost-effectiveness of screening is unknown. METHODS: A decision analysis was used to compare one-time screening for pancreatic dysplasia with EUS to no screening in a hypothetical cohort of 100 members of familial pancreatic cancer kindreds. Abnormal EUS findings are confirmed with ERCP and patients with abnormal findings are candidates for total pancreatectomy. Lifetime medical care costs and life expectancy were modeled, and the main analysis was conducted from the third-party payer perspective. The base-case analysis assumed a 20% prevalence of pancreatic dysplasia and 90% sensitivity of EUS and ERCP. RESULTS: Endoscopic screening was cost-effective, with an incremental cost-effectiveness ratio of $16,885/life-year saved. Screening was more cost-effective as the probability of dysplasia increased and as the sensitivity of EUS and ERCP increased. Screening remained cost-effective if the prevalence of dysplasia was greater than 16% or if the sensitivity of EUS was greater than 84%. Procedure costs had a limited impact on cost-effectiveness. CONCLUSIONS: Endoscopic screening of carefully selected members of familial pancreatic cancer kindreds appears to increase patient life expectancy in a cost-effective manner. Screening should be performed in centers that have experience with endoscopic screening for pancreatic dysplasia. The cost-effectiveness of repeated screening remains to be determined.

Cholangiopancreatography, Endoscopic Retrograde↗

PubMed2002

Skin cancer screening.

BACKGROUND: Skin cancer is the most common malignancy occurring in humans, affecting 1 in 5 Americans at some time during their lives. Early detection of cancerous lesions is important for reducing morbidity and mortality. CASE DESCRIPTION: The patient was a 79-year-old woman who was receiving physical therapy for cervical stenosis. The physical therapist identified a mole with suspicious characteristics, using the ABCD checklist for skin cancer screening. The patient was referred to her primary care physician, and the lesion was removed and identified as basal cell carcinoma. OUTCOMES: Early detection of this lesion allowed for complete excision, with no further treatment of the area warranted. DISCUSSION: Physical therapists can aid in detection of suspect lesions with knowledge of the basic screening techniques for skin cancer, which may help reduce the morbidity and mortality caused by these lesions.

Aged↗

PubMed2002

Use of visual screening methods for cervical cancer screening.

This article has considered recent advances in visual screening methods. Devices that use electro-optical sensors offer great potential in various clinical roles, but considerable additional work is required to develop these devices and it is unlikely that they will come into widespread clinical use in the next 5 years. In contrast numerous studies, demonstrate that simple visual screening methods, such as DVI, have a sensitivity for the detection of women with biopsy-confirmed high-grade SIL (CIN 2,3) and cancer that is equivalent to that of conventional cervical cytology. The primary disadvantage of the simple visual screening methods is poor specificity. These methods classify up to 30% of all women screened as being test positive and as a result new strategies toward managing DVI positive women must be developed before simple visual screening methods can be adopted for routine screening. Enhanced visual methods that use cervicography and speculoscopy may be more specific and improve detection of biopsy-confirmed SIL, but the added time and expense to perform either of these methodologies must be considered and justified. Currently numerous studies are evaluating the best strategies for incorporating visual screening methods into cervical cancer screening programs. In the near future we should be able to determine whether these approaches should be incorporated into routine clinical care.

Acetic Acid↗

PubMed1998

Cancer screening guideline preference surveys: physicians' perceptions of the American Cancer Society.

OBJECTIVE: The primary objective of this study was to assess cancer screening guideline preference by Tennessee internists and family physicians. DESIGN: A one-page, 14-item survey was mailed to 580 internists and family physicians followed by a reminder postcard and a second survey within six weeks of the original mailing. The survey addressed physician practice characteristics, specific preferred cancer screening guidelines used, and self-evaluation of cancer screening and detection practices compared with the practice of coronary artery disease risk and prevention, depression, and obesity/adult-onset diabetes mellitus. SETTING: Internal medicine and family physicians in Tennessee. RESULTS: The overall survey response rate was 57% (N = 300). Of respondents, 83.4% were male and 16.6% were female. Eighty-three percent were board-certified, 30% had subspecialty training, and 62% practiced in a solo practice or a single-specialty group. There were few differences in guideline preference between generalists and subspecialists. Approximately 52% of respondents cited American Cancer Society (ACS) guidelines, 1.7% used US Preventive Services Task Force (USPSTF) guidelines, 34% cited a compilation of various guidelines, and 10% used no guidelines. More physicians rated their treatment of depression (22.9%) or obesity/diabetes mellitus (22.0%) as poor or needing improvement than rated their screening of cancer (16.3%) and coronary artery disease (12.5%) as poor or needing improvement. Survey respondents suggested that the ACS could be most effective in lobbying against tobacco and in providing patient education pamphlets. CONCLUSIONS: Most physicians report using ACS screening guidelines, rate their cancer screening practices as good or very good, and recommend that the ACS lobby against tobacco and provide patient pamphlets. This study reflects physician preference of various cancer screening guidelines. Further research is needed to determine factors influencing physician preferred guideline use as well as actual practices.

American Cancer Society↗

PubMed1991

Ovarian cancer screening.

Ovarian cancer will kill more women this year than cancer of the uterine corpus and cervix combined. Outcome is stage dependent. At stage IV, the five year survival rate is about 4.5%, but at stage I it may be well over 90%. Overall, regardless of stage, about 30% of women with ovarian cancer will be alive five years after its diagnosis. The fact that changes in treatment over the past two decades have done little to alter these depressing figures has led to a reassessment of our approach to this problem. It has been proposed that earlier diagnosis of the condition will lead to improved patient outcome. Because the disease is asymptomatic in its earliest stages in the majority of cases, this has prompted the search for a reliable screening test that could be used to detect the cancer when it is still confined within the capsule of the ovary. This paper discusses these issues, assesses the different techniques available to screen for ovarian cancer, and comments on possible future developments.

Antigens, Neoplasm↗

PubMed1993

The effect of pre-education on patient compliance with full-body examination in a public skin cancer screening.

BACKGROUND: Public skin cancer screening has become increasingly common in recent years. However, currently there is no standardized procedure for these screenings. Full body skin examination as opposed to examination of sun-exposed areas offers several advantages, including the opportunity to diagnose early melanoma in areas normally covered by clothing. Disadvantages of full body skin examination include patient resistance because of inconvenience and concerns about privacy and modesty. The additional time involved in full body skin examination may also be an impediment. OBJECTIVE: In a randomized double-armed study, we studied whether patients were more likely to develop a positive attitude towards full body skin examination if they were advised beforehand, in writing, of the logic underlying the need for a complete examination. METHODS: Patients presenting to a public skin cancer screening were divided into two groups. Group A (N = 111) received a written explanation of the need for full body skin examination and Group B (N = 175) received no information. Patients were then surveyed, after the screening, about their attitudes towards full body skin examination. RESULTS: Those who received pre-education were less likely (P < .05) to be concerned about a genital examination. Those who were concerned about a genital exam were compared with those who were not concerned about a genital exam, the former patients were: 1) younger (P < .05); 2) more concerned about privacy (P < .001); and 3) preferred a physician of the same sex (P < .001). CONCLUSION: Providing patients with information about the need for full body skin examination decreases concern about undergoing a skin genital exam and may minimize resistance to full body skin examination in public skin cancer screenings.

Adult↗

PubMed2005

[Breast cancer screening for women with a strong familial risk].

Screening for breast cancer in high-risk women could be seen through the general criteria for cancer screening. The attributable part of BRCA in breast cancer is estimated to be between 2 and 5%. For these women, breast cancer screening lay between prevention with low risk/benefit efficacy and prophylactic mastectomy with high efficacy but low acceptability. Risk reduction could be achieve with "classic" screening tools (examination, mammography and ultra sound) but should soon benefit from MRI experimental protocols. Later, combined imaging and biology protocols may solve the issue of screening in cancer prone women. A comprehensive program is required, taking in account both the competitive risk of ovarian cancer and the risk reduction observed at the breast level with prophylactic oophorectomy, at least in BRCA1 women. Information, and psychological help is all the more a necessity, since the lack of specificity of screening may induce harm, particularly for these women. Due to methodological flaws, the low power and a short follow-up of the surveys, this statement cannot however aspire to a high stability.

Breast Neoplasms↗

PubMed2000

Recent developments in ovarian cancer screening.

There has been growing interest in the possibility of screening for ovarian cancer. This article addresses papers published following a systematic review of all prospective ovarian cancer screening studies since 1998. In the past year, new markers have been reported and previous strategies have been refined. A randomized controlled trial of ovarian cancer screening has shown a survival benefit in women who developed ovarian cancer in the screened group. Although the results do not justify ovarian cancer screening in the general population, the data support the need for a larger randomized trial powered to assess the impact of screening on mortality.

Biomarkers, Tumor↗