A simple field test for the determination of cyclohexanone and methylcyclohexanone vapours in air.
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The beta-hydroxysulfoxide moiety, after oxidation to sulfone, acts as a masked carbonyl group in a cyclic system, opening an easy access to differently substituted enantiomerically pure cyclic ketones by means of aluminium-mediated conjugate additions, stereoselective reductions and elimination by retrocondensation in basic medium.
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A gas chromatographic method for the determination of the mixture of organic solvents in air has been developed. The optimum conditions of the separation of the mixture were obtained in the column packed with 10% UCON HB 2000 coated on Chromosorb W AW DMCS 80-100 mesh. The components of the mixture are collected on activated charcoal and desorbed with CS2. A quantitative analysis is made using methyl isobutyl ketone as an internal standard. The lowest detectable limit under proposed air sampling and analysis conditions is 0.1 TLV (threshold limit value) for each component of the mixture.
Studies were conducted of the teratologic effects of ketamine hydrochloride in rats. Ketamine treatment had no significant effect on the number of animals per litter. The histological examination of heart, liver, and kidney showed focal nuclear hypochromatosis and interfibrillary edema; diffuse hemopoietic cell infiltration, and parenchymal cell degeneration; proximal convoluted tubule degeneration. The degenerative effect is also dependent upon the dose and the duration of treatment.