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Pathologic anatomy of the dilated cardiomyopathies.

Dilated cardiomyopathies are characterized by systolic pump failure and by dilatation of the ventricular cavity. Thus, they differ from the other 2 main types of cardiomyopathies, namely, hypertrophic cardiomyopathy and restrictive/obliterative cardiomyopathy. The term dilated cardiomyopathy designates a number of heterogeneous syndromes: idiopathic dilated cardiomyopathy, alcoholic cardiomyopathy, postpartal cardiomyopathy, infantile cardiomyopathy with histiocytoid change in cardiac muscle cells, anthracycline cardiomyopathy, Keshan disease, and several ultrastructurally distinct abnormalities, some of which maybe familial. The pathologic features of these syndromes are reviewed in detail.

Antibiotics, Antineoplastic↗

Dysphagia aortica.

A tortuous thoracic aorta is common in the elderly, often displacing the esophagus without causing organic obstruction. The potential for this complication is present, and a case is reported which required surgical relief of this problem.

Aged↗

Endothelial regulation of vascular tone.

Through the release of a variety of relaxing and contracting factors, including nitric oxide and endothelin-1, the endothelium exerts a complex paracrine influence on vascular smooth muscle cells. Dysfunction of these mechanisms for regulating tone may have relevance to various clinical entities, including hypertension, atherosclerosis, renal failure, and diabetes.

Arteriosclerosis↗

Pericallosal artery ectasia with associated stenosis.

We report a rare case of bilateral pericallosal artery ectasia with stenosis in a 49-year-old man complaining of frontal headache. CT showed a serpiginous calcified interhemispheric fissure lesion with contrast enhancement. Imaging of this lesion was pursued with MR and MR angiography; however, conventional cerebral angiography was needed to make a definitive diagnosis.

Calcinosis↗