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Functional connectivity of disparity-tuned neurons in the visual cortex.

Different mechanisms have been proposed concerning how disparity-tuned neurons might be connected to produce the signals for depth perception. Here we present neurophysiological evidence providing insight on this issue. We have recorded simultaneously from pairs of disparity-tuned neurons in the cat's striate cortex. The purpose was to determine the relationships between disparity tuning and functional connectivity revealed through neural cross-correlograms. Monosynaptic connections tend to be stronger between pairs of cells with similar disparity tuning. Pairs of complex cells tend to have either similar tuning or nearly opposite tuning with an absence of quadrature relations. Pairs with at least one simple cell do have some nearly quadrature relationships when they are recorded from the same electrode. Coarse-to-fine connections (i.e., the presynaptic cell has lower disparity frequency and larger disparity range) tend to be stronger but less frequent than those of a fine-to-coarse nature. Our results are consistent with a system that produces weighted averaging across cells that are tuned to similar disparities but different disparity scales to reduce false matches.

Action Potentials↗

Role of primate visual area V4 in the processing of 3-D shape characteristics defined by disparity.

We studied the responses of V4 neurons in awake, fixating monkeys to a diverse set of stereoscopic stimuli, including zero-order disparity (frontoparallel) stimuli, surfaces oriented in depth, and convex and concave shapes presented at various mean disparities. The responses of many V4 cells were significantly modulated across each of these stimulus subsets. In general, V4 cells were broadly tuned for zero-order disparity, and at any given disparity value, about four-fifths of the cells responded significantly above background. The response modulation by flat surfaces oriented in depth was significant for about one-quarter of cells, and the responses of about one-third of the cells were significantly modulated by convex or concave surfaces at various mean disparities. However, we encountered no cells that unambiguously distinguished a given three-dimensional (3-D) shape independent of mean disparity. Thus 3-D shapes defined by disparity are unlikely to be represented explicitly at the level of individual V4 cells. Nonetheless, V4 cells likely play an important role in the processing of 3-D shape characteristics defined by disparity as a part of a distributed network.

Analysis of Variance↗

Measurements of objective and subjective fixation disparity with and without a central fusion stimulus.

BACKGROUND: Fixation disparity is the condition in which the images of a binocularly fixated object are not imaged on exactly corresponding retinal points, but are still within Panum's fusional areas. Measurements of objective and subjective fixation disparity have indicated that subjective fixation disparity does not indicate the true eye position. However, the effect of the foveal fusional lock (FFL) on the relationship between objective and subjective fixation disparity is still not clear. MATERIAL/METHODS: This relationship was investigated in five subjects. The objective measurements were made using scleral search coils, and at the same time the Sheedy distance disparometer indicated the subjective fixation disparity. Measurements were obtained both with and without an FFL. RESULTS: It was found that without an FFL there was a significant difference (p<0.05) between subjective and objective fixation disparity, whereas when an FFL was added, the difference was no longer significant. Additionally, the absolute sizes of both SFD and OFD were found to be significantly smaller with the FFL. CONCLUSIONS: These results indicate that the presence of an FFL makes subjective fixation disparity a more accurate indicator of the objective eye position. An instrument with an FFL should therefore be used clinically. The difference between objective and subjective fixation disparity presumably indicates a change in correspondence.

Adult↗

[Psychometric function of stereo disparity in normal persons].

UNLABELLED: The accuracy and efficiency of threshold estimation depend on a priori knowledge of the shape of the psychometric function. Such knowledge is available for contrast detection and visual acuity, but not for disparity detection. METHODS: We studied the psychometric function for disparity detection in 26 visually normal, untrained observers by measuring detection rates over a wide range of disparities. In a two-alternative forced-choice (2AFC) task the subject had to decide whether the right or left of two vertical bars, differing in depth, was closer to them. An S-shaped Weibull function was fitted to each subjects's data using the maximum-likelihood procedure. RESULTS: In 21 of the 26 subjects the psychometric function rose with increasing disparities up to a level of about 100%. Five of the 26 subjects only reached hit rates clearly below 100% (66% to 82%), even at disparities well above the threshold. The mean slpe of the S-shaped psychometric function of disparity detection was much lower (1.2 Weibull units) than that known for visual acuity and contrast detection (about 3.0 Weibull units). The slope differed widely among subjects, but was not related to stereo acuity. CONCLUSION: For accurate and efficient estimation of stereo acuity, the shallow slope of the psychometric function requires more than 100 single trials around the threshold if a 2AFC procedure is used. In addition, several disparities well above the threshold must be presented in order to detect subjects who do not reach a hit rate of 100% at any disparity. Otherwise, stereo acuity would be underestimated in these subjects.

Adult↗

Effect of quality improvement on racial disparities in diabetes care.

BACKGROUND: Racial disparities in care are well documented; information regarding solutions is limited. We evaluated whether generic quality improvement efforts were associated with changes in racial disparities in diabetes care. METHODS: Using insurance claims and electronic medical record data, we identified 5101 whites and 1987 blacks with diabetes mellitus receiving care within a multispecialty group practice from 1997 to 2001. We assessed rates of annual low-density lipoprotein cholesterol level testing, low-density lipoprotein cholesterol level control (<130 mg/dL [<3.37 mmol/L]), statin therapy, annual glycosylated hemoglobin level testing, glycosylated hemoglobin level control (<7.0%), and annual dilated eye examinations. We used logistic regression models with generalized estimating equations to adjust for race, year, race x year interactions, age, and sex. RESULTS: Rates of annual low-density lipoprotein cholesterol level testing increased from 39% to 64%, while the white-black disparity decreased from 14% to 4%; rates of low-density lipoprotein cholesterol level control increased from 15% to 43%, while the white-black disparity decreased from 9% to 6% (P<.001 for both race x year interactions). Statin therapy rates increased from 20% to 37%; however, black patients remained less likely than white patients to receive therapy. The 1997 rates of annual glycosylated hemoglobin level testing (76%) and annual eye examinations (74%) were high, and there was no white-black disparity over time. Rates of glycosylated hemoglobin level control remained low (31%), and the white-black disparity remained constant at 10%. CONCLUSIONS: Racial disparities were diminished in some aspects of diabetes care following variably successful quality improvement, but differences in the use of statins and glycemic level control persisted. Reducing disparities may require a focus on minority health.

Black People↗

Inequality in quality: addressing socioeconomic, racial, and ethnic disparities in health care.

Socioeconomic and racial/ethnic disparities in health care quality have been extensively documented. Recently, the elimination of disparities in health care has become the focus of a national initiative. Yet, there is little effort to monitor and address disparities in health care through organizational quality improvement. After reviewing literature on disparities in health care, we discuss the limitations in existing quality assessment for identifying and addressing these disparities. We propose 5 principles to address these disparities through modifications in quality performance measures: disparities represent a significant quality problem; current data collection efforts are inadequate to identify and address disparities; clinical performance measures should be stratified by race/ethnicity and socioeconomic position for public reporting; population-wide monitoring should incorporate adjustment for race/ethnicity and socioeconomic position; and strategies to adjust payment for race/ethnicity and socioeconomic position should be considered to reflect the known effects of both on morbidity. JAMA. 2000;283:2579-2584

Empirical Research↗

CD4+ T cell-mediated rejection of major histocompatibility complex class I-disparate grafts: a role for alloantibody.

Experimental studies of the T cell requirement for rejection of class I major histocompatibility complex (MHC)-disparate grafts have generated controversy over both the autonomy of CD8+ T cells and the mechanism whereby CD4+ T cells are able to independently mediate rejection. In this study of rejection of RT1Aa class I MHC-disparate rat cardiac and skin allografts by high-responder PVG RT1u recipients, we show that elimination of CD8+ T cells [by anti-CD8 monoclonal antibody (mAb) administration in vivo] fails to prolong graft survival, whereas partial depletion of CD4+ T cells (by anti-CD4 mAb treatment) markedly delays rejection of class I-disparate heart grafts, and marginally prolongs survival of skin grafts. Anti-CD4-treated PVG-RT1u athymic nude rats reconstituted with CD8+ T cells failed to reject class I-disparate skin grafts for several weeks and eventual rejection correlated with re-emergence of a small number of donor derived CD4+ T cells. Conversely, anti-CD8-treated nude rats reconstituted with CD4+ T cells alone rapidly rejected class I-disparate skin grafts. Passive transfer of anti-class I immune serum to anti-CD4-treated euthymic recipients promptly restored their ability to specifically reject a class I-disparate heart graft. Similarly, passive transfer of immune serum to PVG-RT1u nude rats bearing skin allografts caused destruction of class I-disparate but not third-party grafts. These results demonstrate that CD4+ T cells are both necessary and sufficient to cause rejection of class I-disparate heart and skin grafts in this model and that CD4+ T cell-dependent alloantibody plays a decisive role in effecting rejection.

Animals↗

The effect of disparity change on binocular visual evoked potential parameters elicited by convergent dynamic random-dot stereogram stimuli in humans.

Binocular visual evoked potentials (VEP) were recorded from the left and right occipital cortices of right-handed subjects in response to six different levels of convergent disparity using the stimulus of dynamic random-dot stereogram (DRDS). The VEP obtained consisted of a negative (N1) and a positive peak (P1) within intervals of 200-400 ms and 400-600 ms, respectively. The latency of the N1 wave decreased with disparity and the amplitude of the same wave displayed a concave-down curve. The tuning-curve of N1 showed that the cortical focus, which produced this wave, was sensitive to mid-disparities. The fact that the tuning-curve of the right hemisphere was sharper than that of the left implied that the right hemisphere was more disparity-selective. In contrast to N1, the change of the latency and the amplitude of the P1 with disparity consisted of concave-up curves. The inverse correlation between the amplitudes of N1 and P1 with disparity made me think that the activation of the neuron population, which gave rise to N1 wave, changed the synchronization level of the cortical focus responsible for the P1 wave. If we keep in mind that the perception of depth is the result of the disparity detection, then we may conclude that N1 is related to disparity detection and P1 is the electrophysiological correlate of a depth percept.

Adult↗

Cell responses to vertical and horizontal retinal disparities in the monkey visual cortex.

Because of the horizontal separation of both ocular globes, the projection angles are slightly different. These differences are commonly termed retinal disparities. Vertical and horizontal retinal disparities occur constantly in normal life. We have investigated the responses of single cells in cortical areas V1 and V2 of behaving Macaca mulatta monkeys to retinal disparities by using dynamic random dot stereograms. Our findings show that cortical visual cells are sensitive to both vertical and horizontal disparities. To calculate the distance between two objects in a three-dimensional space from horizontal disparities, it is necessary to know the fixation distance. It has been suggested that the horizontal gradient of vertical disparity contains information to estimate the fixation distance and therefore to scale horizontal disparities. We suggest that these cells sensitive to horizontal and vertical disparities represent a neural mechanism that provides information to the visual system in order to achieve a correct eye alignment and depth perception.

Animals↗

Diagnostic methods for differentiation of Entamoeba histolytica and Entamoeba dispar in carriers: performance and clinical implications in a non-endemic setting.

Unpreserved faecal samples, suspected to contain Entamoeba histolytica/Entamoeba dispar cysts or trophozoites on the basis of microscopic examination, and serum samples from 416 patients were collected in a prospective study to determine whether stool antigen assays and detection of antibodies in serum are reliable methods to distinguish between carriers of E. histolytica and E. dispar in comparison to the reference test: real-time PCR. In 283 patients (68%) DNA of E. histolytica or E. dispar was amplified by real-time PCR: 6 patients with amoebic colitis (2%), 19 carriers of E. histolytica (6.7%), and 258 carriers of E. dispar (91.2%). In 133 patients (31%) no DNA of E. histolytica or E. dispar could be amplified in the stool samples. This patient group was used as control for the evaluation of diagnostic tests. Using real-time PCR as a reference test, the sensitivity and specificity of (1) the Entamoeba test for the diagnosis of E. histolytica/E. dispar carrier were 59% and 98%, (2) E. histolytica II for the diagnosis of E. histolytica carrier was 71% and 100%, and (3) serology for the diagnosis of E. histolytica infection was 83.3% and 95.2%, respectively. Applied to carriers that did not originate from an endemic country the sensitivity of serology for E. histolytica infection was 90% and specificity was 98.8%. In comparison to real-time PCR the performances of Entamoeba test and E. histolytica II lacked sensitivity for a reliable diagnosis of E. histolytica/E. dispar infection in a non-endemic setting. In carriers of E. histolytica/E. dispar from non-endemic countries the high specificity of serology can be used to establish the diagnosis of E. histolytica infection if antibodies are present.

Adolescent↗

Effects of Different Types of Disparity Cues on the Response of Axis-orientation Selective Cells in the Monkey Parietal Cortex.

Purpose: To specify the cues for the discrimination of orientation in depth in axis orientation selective (AOS) neurons.Method: We analyzed the responses of AOS neurons in the monkey caudal intraparietal sulcus (cIPS) region using binocular disparity stimuli generated by stereoscopic 3 D computer graphics.Result: Most AOS neurons (20/27) were sensitive to binocular disparity and showed tuning to the orientation of a slit in the sagittal plane with orientation disparity cues. For 12 neurons we also used an array of discs or dots instead of slits to eliminate orientation disparity. Half of the neurons (6/12) responded better to the slits than to the discs or dots, suggesting that they were sensitive to orientation disparity. Five neurons (5/12) responded equally well to the discs or dots suggesting that they were more sensitive to the gradient of horizontal disparity than to the orientation disparity.Conclusion: Both orientation disparity and disparity gradient were likely to be integrated in the cIPS area to represent axis orientation of an object in space.

Journal Article↗

Effects of interaural intensity and time disparity on transient evoked otoacoustic emissions.

Monaural and binaural 11/s, 65 dB pe SPL clicks with interaural time and intensity disparities known to affect central auditory processing were used to study contralateral suppression of transient evoked otoacoustic emissions (TEOAEs) in 10 subjects (20 ears). Psychophysical assessment of sound lateralization induced by the same stimuli was also conducted. TEOAEs were recorded to monaural (ipsilateral to the OAE recording probe) and to binaural clicks when clicks to the contralateral ear were synchronous and symmetrical in intensity, or, in the binaural intensity disparity conditions, synchronous but 10 dB higher or 10 dB lower in the ear contralateral to the OAE recording probe. When interaural time disparities were studied, the clicks to the contralateral ear were of the same intensity throughout, but 400 micros earlier or 400 micros later than to the ear with the probe. The TEOAE components at 13-15.8 ms showed suppression, relative to monaural responses, under all binaural conditions. This contralateral suppression did not correlate with the psychophysical findings. Suppression effects were more pronounced with binaural disparity than with binaurally symmetrical clicks. Thus, although contralateral click intensity was the same with time disparities, suppression was paradoxically enhanced compared to the binaurally symmetrical stimulation. To explain these results we propose that two factors are involved in TEOAE suppression with binaural clicks: (1) contralateral intensity and (2) interaural disparity (time or intensity). The latency of the suppressions observed, the effect of interaural disparity on these suppressions, coupled with the anatomical origin of the crossed efferent fibers and the disparity sensitivity of the superior olivary complex (SOC), all suggest SOC involvement in these TEOAE suppressions.

Acoustic Stimulation↗

Socioeconomic and racial/ethnic disparities in unintended pregnancy among postpartum women in California.

OBJECTIVE: We examined social disparities in unintended pregnancy among postpartum women to better understand 1) the role of socioeconomic factors in racial/ethnic disparities and 2) factors that might explain both socioeconomic and racial/ethnic disparities in the risk for unintended pregnancy among women who give birth. METHODS: We used 1999 and 2000 data from a statewide-representative mail and telephone survey of postpartum women in California (N = 7044). We examined associations between unintended pregnancy and race/ethnicity (African American, Asian or Pacific Islander, U.S.-born Latina, foreign-born Latina, European or Middle Eastern), three socioeconomic factors (poverty status, maternal education, paternal education), and several potential explanatory factors. RESULTS: Overall, racial/ethnic disparities in unintended pregnancy were reduced by the three socioeconomic factors individually and collectively (e.g., reducing higher unadjusted odds for African Americans from 3.4 to 1.9); additional adjustment for marital status age, parity, insurance, language, abuse, sense of control, and interaction between marital status and race/ethnicity (each independently associated with unintended pregnancy) reduced the socioeconomic disparities (e.g., reducing odds for the poorest women from 4.1 to 2.3). Although reduced, significant racial/ethnic and socioeconomic disparities remained after adjustment, but generally only among married women. Results for Latinas appeared to vary by nativity, with foreign-born Latinas being at lower odds and U.S.-born Latinas being at higher odds of unintended pregnancy. CONCLUSIONS: Racial/ethnic disparities in unintended pregnancy are partly explained by the socioeconomic factors we measured. Several additional factors were identified that suggest possible directions for policies and programs to help reduce social disparities in unintended pregnancy among childbearing women.

Adolescent↗

Reducing disparity in behavioral health services: a report from the American College of Mental Health Administration.

UNLABELLED: The 2003 AMCHA Summit was an initial step. It served to provide a broad outline of the socio-political context and key issues involved in reducing disparities, and it provided some momentum for change. However, much more work remains to be done. The summit clearly demonstrated that the reduction of disparities requires a multi-level approach and multi-disciplinary leaders. As a neutral convener, AMCHA is in a unique position to help advance the debate and lead the field. The membership includes researchers, administrators, clinicians, and policy makers from all levels of the behavioral health system. As noted, a change agenda needs to include efforts at national, state, and local levels involving consumers, providers, purchasers, oversight organizations, and researchers. ACMHA is committed to advancing the field and helping the national effort to reduce disparities. Examples of potential projects include the following: Training: Much has been done to develop effective cultural-competency training modules and to guide states in its implementation. No one should reinvent the wheel at this time. Funding should be targeted to provide incentives to states for dissemination of existing training curricula and the documentation of effectiveness to all providers and administrators. DATA: Nationally, the field will benefit from data standards for the collection of and reporting on system disparities. This will facilitate interstate comparisons and provide baseline data for change efforts. Conducting surveys of providers, health plans, and public behavioral health systems on the availability and current uses of data by race and ethnicity is one example of a useful first step in this process of setting data standards. RESEARCH: Further research on the nature and causes of disparity is needed. There should be systematic research on factors influencing access, treatment, and outcomes for people of different cultures. Initially, because of the difficulties in deciding on standardized outcome measures, the encounter and claims data will provide the most useful information for analysis. Later, as standardized outcome measures are more widely utilized and the data collected, it may be possible to look for racial and ethnic differences in outcomes. The research agenda needs to be developed with a focus on services and health systems research data. Demonstrations: Demonstration efforts are urgently needed, similar to Connecticut's initiative, that integrate data on disparities with provider reporting, performance contracting, and system-wide interventions. These best practices need to be shared with the field. Coordination: The Summit showed that many are eager to learn from others in this area. As we move from further research to demonstration initiatives, AMCHA can play a role in coordinating these projects, particularly at the state and perhaps local levels. State efforts can benefit from best-practice presentations from other states and by an improved understanding of the nature and scope of the change required at a programmatic and local level. Local efforts need to clearly incorporate the views and perspectives of members of the community and consumers. The 2003 ACMHA Summit provided a foundation and a framework for work to proceed at all levels of the behavioral health delivery system. To accomplish meaningful change, we challenge SAMHSA, and the other federal agencies to provide the leadership to (1) develop common and core-performance measures focused on the reduction of disparities, (2) coordinate the research agenda, and (3) facilitate the use of new information technologies to collect and review these data. This is completely consistent with the vision of federal "leadership by example" that has been outlined by the Institute of Medicine (2003b) for the implementation of the "Crossing the Quality Chasm" report. We need to facilitate the efforts of the states and the federal government to identify and reduce disparities and provide a forum for states to share the results of their efforts, to benchmark their performance, and seek technical assistance. Over the next several years, we also expect that states will expand their efforts to implement evidence-based practices. However, we urge these states to implement existing evidence-based practices cautiously, especially with culturally diverse populations, due to the limited representation of ethnically diverse subjects in the research evidence on current practices. We strongly recommend collecting data on practice-based evidence-where effective interventions are routinely identified from existing practice and shared with the field, particularly those practices that seem effective with minority populations.

California↗

Receptive fields of disparity-selective neurons in macaque striate cortex.

To identify neuronal mechanisms underlying stereopsis, we characterized interactions between inputs from the two eyes in disparity-selective neurons in macaque V1. All disparity-selective cells showed suppressive interactions between the right and left eyes, and some showed facilitatory interactions. Disparity selectivity was narrower than the receptive-field width and was constant across the receptive field. Such position-invariant disparity selectivity is also found in anesthetized cat V1. Complex cells have been suggested to inherit their disparity selectivity from simple cells with receptive fields mismatched between the two eyes. However, we found no such antecedent disparity-tuned simple cells. We did find disparity-selective cells with some simple-cell characteristics, but surprisingly, they also showed position-invariant disparity selectivity rather than simple linear binocular interactions.

Animals↗

Gene conversion disparity: factors influencing its direction and extent, with tests of assumptions and predictions in its evolutionary effects.

The evolutionarily important characteristics of gene conversion disparity extent and direction are surveyed in fungi. Temperature and background genotype can have small or large effects, sometimes even changing the direction of disparity. Disparity results from Sordaria and Ascobolus were very similar, with between-strain, between-data set and between-locus differences being larger than those between species or genera. In general, different loci in an organism show similar disparity properties when comparable types of mutation are considered, but may not do so in pooled results containing different proportions of different mutation types. Frameshifts typically have strong disparities, usually with negative signs for single base additions and positive signs for single base deletions. Base substitutions tend to have moderate disparities, favoring wild type more often than mutant in most data sets. Large deletions usually have significant disparity, either positive or negative. For comparable molecular types of mutation, spontaneous and induced mutations had roughly similar disparity properties.--Experimental tests and theoretical considerations generally failed to support a number of assumptions and predictions made in previous treatments of gene conversion in evolution. In general, a mutation's conversion properties depend much more on its molecular type in relation to wild type than on any evolved conversion advantages or disadvantages.

Alleles↗

Eliminating racial and ethnic disparities in health care: what is the role of academic medicine?

Research has shown that minority Americans have poorer health outcomes (compared to whites) from preventable and treatable conditions such as cardiovascular disease, diabetes, asthma, and cancer. In addition to racial and ethnic disparities in health, there is also evidence of racial and ethnic disparities in health care. The Institute of Medicine Report Unequal Treatment remains the preeminent study of the issue of racial and ethnic disparities in health care in the United States. Unequal Treatment provided a series of general and specific recommendations to address such disparities in health care, focusing on a broad set of stakeholders including academic medicine. Academic medicine has several important roles in society, including providing primary and specialty medical services, caring for the poor and uninsured, engaging in research, and educating health professionals. Academic medicine should also provide national leadership by identifying innovations and creating solutions to the challenges our health care system faces in its attempt to deliver high-quality care to all patients. Several of the recommendations of Unequal Treatment speak directly to the mission and roles of academic medicine. For instance, patient care can be improved by collecting and reporting data on patients' race/ethnicity; education can minimize disparities by integrating cross-cultural education into health professions training; and research can help improve health outcomes by better identifying sources of disparities and promising interventions. These recommendations have clear and direct implications for academic medicine. Academic medicine must make the elimination of health care disparities a critical part of its mission, and provide national leadership by identifying quality improvement innovations and creating disparities solutions.

Academic Medical Centers↗

Racial/ethnic disparities in breast and gynecologic cancer treatment and outcomes.

PURPOSE OF REVIEW: To review recent research in racial/ethnic disparities in breast and gynecologic cancers, focusing on disparities occurring postdiagnosis. RECENT FINDINGS: Mortality statistics show that of the cancers under study, breast cancer has the greatest impact, and of racial/ethnic groups, African Americans suffer the greatest disparities, with highest mortality rates for breast, uterine and cervical cancers, and second highest for ovarian cancer. Recent studies demonstrated that black breast cancer patients suffer more underuse of appropriate adjuvant therapy, and greater delays in diagnosis and institution of treatments, and blacks and Hispanics suffered greater postsurgical pain and symptomatology. Data indicate that the biology of some breast cancers in blacks is unique and more aggressive. One study demonstrated that more black breast cancer patients died of nonbreast cancer causes and that excessive comorbidity in blacks explained substantial amounts of survival disparity. Research is beginning to identify important disparities in nonblack minority racial/ethnic groups, including Hispanics and South Asian Americans. SUMMARY: Research is continuing to identify and explain an important group of disparities - African American disparities in breast cancer outcomes. Disparities in other minority racial/ethnic groups, and in ovarian, uterine and cervical cancers, are at an emerging stage. Continuing efforts at all fronts are needed.

Black or African American↗