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Two patients who injected marihuana intravenously developed a syndrome of hypotension, renal insufficiency, thrombocytopenia, and rhabdomyolysis. These clinical abnormalities appear to be reversible without residua.
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CT fluoroscopy (CTF) facilitates guidance of percutaneous biopsies and other interventional procedures. We wished to demonstrate the usefulness of CTF for the puncture of an unenhanced isodense liver lesion during continuous injection of intravenous contrast medium. We performed CTF-guided puncture of a 2-cm lesion in the liver of a patient suffering from lung cancer. CTF enables puncture of liver foci even if they are unenhanced and isodense with the surrounding parenchyma.
The possible complications in two women who had injected themselves intravenously with thermometer mercury with suicidal intent are discussed with reference to the few comparable cases. A manifest pulmonary hypertension due to multiple mercury emboli in the lesser circulation in one patient who developed a dyspnoea on exertion could be excluded by cardiac catheterization. Signs of acute and chronic mercury poisoning could not be demonstrated in our patients, in contrast to some cases reported in the literature. So far, specific therapy has therefore been dispensed with.
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Weekly s.c. (24, 12, and 6 mg/kg b.w.) or a single i.v. (100 or 50 mg/kg b.w.) injections of N-diethylnitrosamine (DEN) to gerbils (meriones unguiculatus) resulted in tumours of the respiratory tract and liver. Carcinomata of the nasal olfactory region or respiratory-olfactory mucosal junction were most common; papillomata of the tracheobronchial system and adenomata or carcinomata of the lungs appeared in significantly lower incidences. The neoplasms of the liver were of cholangiocellular and in a few cases of hepatocellular origin.
51Cr-or 111In-labelled murine lymphoma cells were injected IV in control and poly I:C-treated mice. The organ distribution (lung, spleen, liver) of radioactivity was measured 2 h after injection. The results showed that if cell injection was performed 1 day after poly I:C treatment, the modifications of organ distribution did not fit with the expectations from a reinforcement of the NK function in vivo. In NK-suppressed mice, poly I:C affected the distribution of radioactivity in spleen and liver in the same manner as in normal mice, suggesting that the action does not entirely depend on the NK system. Additionally to that, poly I:C injections affected coagulability of the plasma from treated mice, by prolonging the coagulation time. It is concluded that poly I:C exerts a complex action on circulation and fixation of lymphoma cells.
Rats were injected intracerebroventricularly (i.c.v.) or i.v. with [14C]homocarnosine (250 nmol). Distribution of the dipeptide in brain structures, transport from the brain to the blood, distribution in peripheral organs, and excretion in the urine were studied by measuring radioactivity in tissue, plasma, and urine samples by liquid scintillation counting 15-120 min after injection. After i.c.v. injection, [14C]homocarnosine was taken up into all parts of the brain investigated (highest uptake in structures close to the site of injection), it was transported to the blood, and radioactive substances were found in low concentration in muscle, spleen, and liver, in high concentration in the kidneys, and very high concentration in the urine. Investigations using high pressure liquid chromatography (HPLC) showed that no degradation took place in the brain, all radioactivity was found in the homocarnosine fraction. In the plasma 86% of the radioactivity was found in the GABA fraction presumed to be formed by cleavage of the peptide.
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In this study we compared the efficacy of orally disintegrating tablets (ODT) and IV ondansetron for preventing spinal morphine-induced pruritus and postoperative nausea and vomiting (PONV) in healthy young male patients. Patients who received bupivacaine with 0.20 mg morphine for spinal anesthesia were randomly assigned to the ODT group (ODT ondansetron 8 mg, n = 50), the IV group (4 mg ondansetron IV, n = 50), or the placebo group (n = 50). Each individual was assessed for pruritus, postoperative nausea and vomiting, and pain at 0, 2, 6, 12, 18, and 24 h after surgery using three distinct visual analog scales. The frequencies of postoperative nausea and vomiting and frequencies of requirement for rescue antiemetic and antipruritic were recorded. There were no significant differences among the three groups with respect to incidence or severity of PONV or postoperative pain visual analog scale scores. The incidences of pruritus in the ODT (56%) and IV (66%) groups were significantly different from that in the placebo group (86%) (P < 0.02 for both). Only the ODT group had significantly lower mean pruritus visual analog scale scores at 0, 2, 6, and 12 h postsurgery than the placebo group (P < 0.023 for all). The frequency of requirement for rescue antipruritic was significantly less in the ODT group than the placebo group (P = 0.013). Both ODT ondansetron 8 mg and IV ondansetron 4 mg are more effective than placebo for preventing spinal morphine-induced pruritus, but neither form of this agent reduces spinal morphine-induced postoperative nausea and vomiting in this patient group.
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Explore the source record for details and available documents.