PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “LUNG DISEASES, FUNGAL”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 199 records · Page 11Linked to original sources
PubMed1997

[Clinical features of eight cases of opportunistic fungal pneumonias].

We evaluated eight cases of pulmonary mycosis in immuno compromised hosts. The underlying diseases were lung cancer with chemotherapy in one case, post bone marrow transplantation (post BMT) in two cases, acquired immunodeficiency syndrome (AIDS) in one case and bronchial asthma with massive steroid therapy in four cases. The causative fungi were Candida sp. in three cases, Aspergillus sp. in four cases, Tricosporon sp. in one case. Prognosis was guarded despite antifungal treatment. Five cases deteriorated and died of fungal infection. In five cases, who died of deterioration, 31.6 days was required from appearance of abnormal infiltration in the chest X-ray to determination of the causative fungi (including two cases who were diagnosed by autopsy) on the average. In three successfully treated cases, the average duration from the appearance of abnormal infiltration in the chest X-ray for the determination of the causative fungi was 8.3 days. On the contrary, the average duration between the appearance of abnormal infiltration in the chest X-ray and the initiation of antifungal treatment was 2.6 days who died of deterioration and 8.3 days who survived. We conclude that early identification of causative fungi and not quick institution of antifungal treatment was mandatory in the treatment of opportunistic fungal pneumonia.

AIDS-Related Opportunistic Infections↗
PubMed1973

Needle lung biopsy, bronchial brushing and mediastinoscopy in management of chest diseases.

Ways to know when not to operate and having guidelines for the extent and direction of intrathoracic operations are recurring needs of thoracic surgeons. History, chest film, pulmonary function tests and bronchoscopy have been useful, but inadequate, solutions to these problems in the past. Needle lung biopsy, bronchial brushing and mediastinoscopy have been used to supplement these conventional diagnostic methods. The result has been that patients with acid-fast and fungal disease, sarcoidosis, and endobronchial inflammatory disorders have been identified for appropriate medical treatment without thoracotomy. In addition, patients with lung cancer in whom the quality of life or survival cannot be aided by surgical operation have been spared thoracotomy. Where co-existing major, systemic illness increases the risk of operation, these additional diagnostic methods have been used to either eliminate the need for thoracotomy or to limit the operation performed to the minimal procedure permitting a satisfactory surgical result. Needle lung biopsy, bronchial brushing and mediastinoscopy are safe and they do not add to the cost or length of stay in hospital.

Adult↗
PubMedDate not supplied

CT findings in pleural aspergillosis.

Two patients who underwent pulmonary resections for lung cancer developed delayed pleural abnormalities. In each instance CT confirmed the presence of pleural thickening, nodularity, and intrapleural masses proven to represent intrapleural aspergillomas.

Aspergillosis↗
PubMed1992

[Thoracic actinomycosis versus bronchial cancer].

We report on 4 thoracic actinomycoses; in three of these four cases a bronchial carcinoma was suspected, and in case No. 2 this carcinoma had been considered to be in a very advanced and inoperable stage. A man of 51 years of age was in a generally run-down condition. He also noticed that his sputum was tinged with blood. The x-ray film showed a large space-occupying growth at the right lung hilus. Repeated perbronchial biopsies of the focus did not yield any diagnosis. Actinomycosis was identified histologically only in the tissue samples obtained via thoracotomy. After a three-month penicillin course the hilar shadow receded. A 61-year old male patient was transferred to our Pneumological Hospital, being strongly suspected of suffering from an extensive bronchial carcinoma, and having multiple intrathoracic space-occupying growths as well as pleural effusions, a pericardial effusion, and an infiltration of the left thoracic wall with fistula formation; however, histological examination of skin biopsies revealed that he was suffering from actinomycosis. Antibiotic therapy cured him completely in a six-month course. In a man of 32 years of age who had been indulging for many years in a severe abuse of nicotin, we suspected a central bronchial carcinoma on the basis of his x-ray, but histology of the tissue taken from the space-occupying growth via diagnostic thoracotomy revealed that this patient, too, suffered from actinomycosis. Complete recession occurred after several months of antibiotic treatment. A woman of 82 years had been an inpatient for several months in another hospital because of relapsing pleuropneumonias on the right side. She was transferred to us as an outpatient after a renewed relapse. We conducted a transcutaneous fine-needle biopsy of the right indurating pleural effusion. A few actinomyces filaments were seen on histological examination of the purulent exudate. Hence, actinomycosis was confirmed. After antibiotic therapy the finding receded completely.

Actinomycosis↗
PubMed1993

Thoracoplasty in the context of current surgical practice.

Although widely employed for well over a century as a procedure for reducing the capacity of the thoracic cavity, thoracoplasty in current practice has become a rarity. A retrospective analysis of 37 patients (29 men, 8 women) who underwent the procedure under the care of one thoracic surgeon in a 16-year period provides the basis for this presentation. Ages ranged from 23 to 82 years with a mean age of 58 +/- 12.8. The mean follow-up was 8.5 years. Nineteen patients underwent the procedure for complications after lung resection for lung cancer. There were four perioperative deaths in this group (21.1%) and 6 long-term survivors (31.6%). Eighteen patients without lung cancer underwent thoracoplasty as a planned treatment or for complications. There were no perioperative deaths, two late deaths, and 16 long-term survivors (88.9%) in the group. In the entire series, the overall perioperative mortality rate was 10.8% with no major long-term morbidity. Although proper timing and proper patient selection are essential in the use of thoracoplasty as a procedure to cope with the septic complications of lung cancer resection, it is overall a safe and successful procedure that has a relatively low mortality and that leads to considerable improvement in quality of life.

Adult↗
PubMed1990

[Semi-invasive aspergillosis with involvement of the thoracic wall cured by itraconazole].

Pulmonary aspergillosis invading the thoracic wall is rare and of sombre prognosis. We report the case of a 49-year old man who developed a pulmonary aspergilloma some time after lung resection and radiotherapy for bronchial adenocarcinoma. Surgical excision of the aspergilloma was followed by sternal, then costal aspergillosis. Conventional surgery and antifungal therapy failed, and the lesion stubbornly followed a chronic course until itraconazole therapy was instituted, resulting in a complete cure which still persists nearly 4 years after withdrawal of any chemotherapy.

Antifungal Agents↗
PubMed1989

Diagnosis and treatment of pulmonary disorders of patients with the acquired immunodeficiency syndrome (AIDS).

It is apparent that the lung is frequently involved by a number of opportunistic pathogens and neoplasms in AIDS patients. What is even more disconcerting is the fact that often several infections or infection and neoplasm can coexist [236]. At this time, although effective therapy is at hand for most of the disorders mentioned, the patient's underlying immunodeficiency prevents any long-term survival and also usually leads to relapse when treatment is discontinued. Perhaps the use of newer antiviral compounds such as azidothymidine [237] or immunomodulating agents will help to reconstitute the waning immunocompetence and allow more durable responses in these currently fatal complications.

Acquired Immunodeficiency Syndrome↗