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At least 199 records · Page 11Linked to original sources
PubMed1995

Community perception of mosquitos and mosquito control in some areas of urban Delhi and rural Alwar, Rajasthan.

There is little information regarding community perception of mosquitos and and their control in India. A qualitative study based on In depth discussions with the people in Urban Delhi, and rural Alwar was carried out in August-September, 1995. In the Ghazipur and Munirka areas of Delhi, 63 respondent groups with 171 head counts, and 59 respondent groups and 305 persons in Alwar were met. Community responses to uniform set of questions on mosquito types, seasonality, biting, breeding places, ongoing control activities, and methods of personal protection were recorded. Most people in the areas surveyed viewed mosquitos primarily as a biting nuisance, and secondarily as agents of disease and debilitators of health. In general the knowledge regarding mosquitos was deficient. An overwhelming tendency to attribute mosquitogenic conditions to the unsavoury features of one's physical environment was observed in both areas. The methods of personal protection and attitudes to organised control are discussed.

Animals↗
PubMed2006

Novel acetylcholinesterase target site for malaria mosquito control.

Current anticholinesterase pesticides were developed during World War II and are toxic to mammals because they target a catalytic serine residue of acetylcholinesterases (AChEs) in insects and in mammals. A sequence analysis of AChEs from 73 species and a three-dimensional model of a malaria-carrying mosquito (Anopheles gambiae) AChE (AgAChE) reported here show that C286 and R339 of AgAChE are conserved at the opening of the active site of AChEs in 17 invertebrate and four insect species, respectively. Both residues are absent in the active site of AChEs of human, monkey, dog, cat, cattle, rabbit, rat, and mouse. The 17 invertebrates include house mosquito, Japanese encephalitis mosquito, African malaria mosquito, German cockroach, Florida lancelet, rice leaf beetle, African bollworm, beet armyworm, codling moth, diamondback moth, domestic silkworm, honey bee, oat or wheat aphid, the greenbug, melon or cotton aphid, green peach aphid, and English grain aphid. The four insects are house mosquito, Japanese encephalitis mosquito, African malaria mosquito, and German cockroach. The discovery of the two invertebrate-specific residues enables the development of effective and safer pesticides that target the residues present only in mosquito AChEs rather than the ubiquitous serine residue, thus potentially offering an effective control of mosquito-borne malaria. Anti-AgAChE pesticides can be designed to interact with R339 and subsequently covalently bond to C286. Such pesticides would be toxic to mosquitoes but not to mammals.

Acetylcholinesterase↗