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At least 199 records · Page 11Linked to original sources
PubMed2001

Pure sesame oil vs isotonic sodium chloride solution as treatment for dry nasal mucosa.

OBJECTIVE: To evaluate whether there was any difference in efficacy when nasal mucosa dryness was treated with pure sesame oil (Nozoil) compared with isotonic sodium chloride solution (ISCS). DESIGN: In a randomized, crossover study, 79 subjects with nasal mucosa dryness were enrolled. Half the subjects received pure sesame oil for 14 days followed by ISCS for 14 days, and the other half received ISCS for 14 days followed by pure sesame oil for 14 days. During the test period from March 13 to May 30, 2000, the outdoor absolute humidity was low. Nasal mucosa dryness, stuffiness, and crusts were scored every evening with a visual analog scale. SETTING: The County Hospital, Skellefteå, Sweden. RESULTS: Nasal mucosa dryness improved significantly when pure sesame oil was used compared with ISCS (P<.001). The improvement in nasal stuffiness was also better with pure sesame oil (P<.001) as was improvement in nasal crusts (P<.001). Eight of 10 subjects reported that their nasal symptoms had improved with pure sesame oil compared with 3 of 10 for ISCS (P<.001). Adverse events were few and temporary. CONCLUSION: When nasal mucosa dryness due to a dry winter climate was treated, pure sesame oil was shown statistically to be significantly more effective than ISCS.

Administration, Intranasal↗
PubMed1977

Scanning and transmission electron microscopy of the nasal mucosa.

We attempted to study the nasal mucosa of children (both normal and diseased) under light microscopy followed by both scanning and transmission electron microscopy. Combined methods of microscopy are valuable tools in establishing the diagnosis and lead to a better understanding of disease and its management. For this reason we found it necessary to study the ultrastructural details of the cells of the nasal mucosa. Through scanning electron microscopy we studied the functional aspects and the nature of the surface of these cells. Ultrastructural details of these cells were studied with the aid of transmission electron microscopy.

Adolescent↗
PubMed2002

[Animal experimental study of effects of long-term triamcinolone acetonide acetate nasal spray on the nasal mucosa].

OBJECTIVE: To explore the effects of triamcinolone acetonide acetate nasal spray on the animal's nasal mucosa. METHOD: Animals were divided into three groups: group one for high dosage; group two for low dosage; group three for control. Animals were given the high dosage of triamcinolone acetonide acetate nasal spray (880 micrograms), low dosage of triamcinolone acetonide acetate nasal (220 micrograms), 0.9% saline solution spray for each nasal cavity for two months. Before and after drug spraying, the examination of nasal mucosa and the blood routine were made, and the middle and inferior turbinate were removed for light and electron microscopic examination. RESULT: No differences of blood routine and nasal mucosa can be seen among the three groups, and the light and electron microscopic examination also. CONCLUSION: No harmful effects of triamcinolone acetonide acetate nasal spray on the nasal mucosa for long time using can be seen on the animal's experiment.

Administration, Intranasal↗
PubMed1983

Substance-P-containing nerve fibers in the nasal mucosa.

Nerve fibers displaying SP immunoreactivity were detected in the nasal mucosa of several mammals. The fibers were seen around small blood vessels, seromucous glands, and beneath and sometimes within the surface epithelium. In the pterygopalatine ganglion and the trigeminal ganglion, known to innervate the nasal mucosa, SP-positive nerve cell bodies were seen. Sympathetic denervation with 6-hydroxydopamine (6-OHDA) or bilateral cervical sympathectomy did not visibly affect the distribution of SP fibers in the nasal mucosa in mice or rats. The findings are compatible with the view that the bulk of SP fibers to the nasal mucosa derive from the trigeminal ganglion with a possible contribution from the pterygopalatine ganglion.

Acetylcholinesterase↗
PubMed1999

[Influence of intranasal medication on the structure of the nasal mucosa].

OBJECTIVE: To study the pathological changes and reversibility of the nasal mucosa after drug administration. METHODS: Gentamicin and insulin were dropped into the nasal cavity of rabbits for 3, 5, 7 days to two weeks, after one and two weeks, the nasal mucosa was taken and observed under optical and electron microscopes. RESULTS: It was found that after 3-7 days of drugs administration, damages of the nasal mucosa gradually appeared, and became most serious after one week when the epithelia in some regions detached from basement membr theane. After stopping drug application, the ciliated epithelia restored quickly and completely, goblet cells reproduced and inflammatory reaction disappeared. CONCLUSION: The damages induced by drugs on nasal mucosa are reversible. The intranasal route of drug administration is feasible and promising.

Administration, Intranasal↗
PubMed2000

Effect of hydrogen peroxide on guinea pig nasal mucosa vasculature.

The effect of hydrogen peroxide (H2O2) on guinea pig nasal mucosa vasculature was studied by in vitro assay. H2O2 elicited relaxation of guinea pig nasal mucosa strips precontracted with phenylephrine in a concentration-dependent manner. The relaxant response to H2O2 was abolished in the presence of catalase. Preincubation of the strips with N(G)-nitro-L-arginine methyl ester or methylene blue significantly attenuated the relaxant responses elicited by H2O2. Fluorescence caused by DAF-2 DA, a fluorescence indicator for nitric oxide, was observed along the nasal mucosa vasculature in response to H2O2. These results suggest that H2O2 induced relaxation of the guinea pig nasal mucosa vasculature and that this relaxation is mediated by the NO/cGMP pathway.

Animals↗
PubMedDate not supplied

Impaired norepinephrine-mediated contraction of isolated nasal mucosa in guinea pigs with allergic rhinitis.

BACKGROUND: One of the causes of nasal obstruction associated with allergic rhinitis probably is caused by the dilatation of plexus cavernosum in nasal mucosa. In this study, the change in vascular responsiveness of nasal mucosa was investigated in the septal mucosae isolated from guinea pigs with allergic rhinitis. METHODS: An allergic rhinitis model was prepared in guinea pigs by repeated challenge with aerosolized dinitrophenylated-ovalbumin antigen. Twenty-four hours after the last antigen challenge, the changes in the isometrical tension of isolated nasal septal mucosa were measured. RESULTS: In isolated nasal mucosal tissues, both norepinephrine (NE) and leukotriene D4 caused concentration-dependent contractile and relaxant responses, respectively. The NE-induced contractile response was significantly attenuated in nasal mucosae of the repeatedly antigen challenged guinea pigs. The mucosal relaxation induced by leukotriene D4 was slightly attenuated in this animal model of allergic rhinitis. CONCLUSION: This study shows an attenuation of NE-induced contraction of isolated nasal mucosa in the antigen-exposed guinea pigs. The impaired contractile response mediated by sympathetic alpha-adrenoceptors of nasal blood vessels might be involved in the development of nasal obstruction in allergic rhinitis.

Adrenergic alpha-Agonists↗
PubMed1993

[Serum level of soluble ICAM-1 in subjects with nasal allergy and ICAM-1 mRNA expression in nasal mucosa].

Intercellular adhesion molecule-1 (ICAM-1) has been reported to be instrumental in airway eosinophils and airway hyperreactivity. In nasal mucosa, ICAM-1 molecule is observed on the endothelium, around the nasal gland and just below the epithelium. In this study, we investigated the gene expression of ICAM-1 in nasal mucosa and the serum level of soluble ICAM-1. In subjects with nasal allergy sensitized with house dust, a pair of house dust antigen discs were placed on the inferior nasal mucosa on one side, while control discs free of antigen were placed on the other side. After six hours, the inferior nasal mucosa were bilaterally obtained separately. By Southern blot analysis following a reverse-transcription polymerase chain reaction, we detected ICAM-1 messenger RNA (mRNA) in the nasal mucosa. Although the expression of ICAM-1 mRNA was already observed in the nasal mucosa without antigen challenge, it increased six hours after the challenge. The serum level of immunoreactive soluble ICAM-1 in the subjects with nasal allergy and normal subjects was evaluated by sandwich enzyme-linked immunosorbent assay. The serum level of soluble ICAM-1 in the subjects with nasal allergy was 380.7 +/- 105.2 ng/ml. It was significantly higher than that of the normal control, which was 278.6 +/- 64.6 ng/ml. These results suggested that the increased expression of ICAM-1 may contribute to the pathogenesis of nasal allergy by facilitating the infiltration of inflammatory cells such as eosinophils and their functional activities.

Adolescent↗
PubMed1993

Interleukin-5 preferentially recruits eosinophils from vessels in nasal mucosa.

Interleukin-5 (IL-5), initially described as possessing eosinophil differentiating and proliferating activity, has now been shown to exert its effects on mature eosinophils. To investigate the ability of recombinant human IL-5 (rhIL-5) to cause the migration of eosinophils in the nasal mucosa in vivo, we compared the eosinophil counts in nasal mucosa without and after the nasal application of rhIL-5. In addition, the percentages of eosinophils in leukocytes within the vascular lumens in the nasal mucosa were counted to determine whether IL-5 recruited eosinophils from the vessels. The total number of eosinophils in both the epithelium and lamina propria, as well as the percentage of eosinophils in leukocytes within the lumens of vessels in the nasal mucosa after the application of IL-5, were higher than those in control nasal mucosa. Conversely, neither the number of neutrophils in the nasal mucosa nor the percentages of neutrophils in vessels differed between the two groups of nasal mucosa. The results strongly suggest that IL-5 preferentially recruits eosinophils from vessels into the lamina propria.

Adult↗
PubMed1995

Corrosion casting study on the vasculature of nasal mucosa in the human fetus.

BACKGROUND: The vasculature of the nasal mucosa in the human fetus so far has not been investigated morphologically by modern techniques. METHODS: Nasal blood vessels were studied in 18-21-week-old human fetuses by corrosion casting and scanning electron microscopy. RESULTS: The general vascular architecture was similar to that described for adult humans, with (1) a dense network of subepithelial capillaries, (2) a mucosal layer of larger vessels, predominantly veins, and (3) large arteries located near the perichondrium. Specific vessel types characteristic of the nasal mucosa and important for its functions in adults, such as cavernous veins or cushion veins, were, however, absent in the fetuses, although probable precursor forms of cushion veins could be observed. The arteriovenous anastomoses had the form of short bridges, and no tortuous or glomerular anastomoses present in the mature nasal mucosa were found. CONCLUSIONS: The underdevelopment of some vascular areas is postulated to reflect the functional immaturity of the respiratory system in the fetus.

Arteries↗
PubMed1994

Enzymatic equipment of the nasal mucosa in the developing human nasal cavity.

The activities of some enzymes were described in the developing human nasal cavity in relatively early stages. In cryostat sections of the 8-14-week-old fetuses processed by standard Lojda methods, activities of the following enzymes were found in the respiratory and olfactory regions: ALP, ACP, ATP, TPP, alpha-GPDH, G6PDH, SDH and ANE. The positive reaction for DPP IV failed to be proved in this localization, it was not detected even in the capillary bed of the nasal cavity.

Fetus↗
PubMedDate not supplied

Enzyme-ultracytochemical study of adenylate and guanylate cyclases in normal and pathologic human nasal mucosa.

The ultracytochemical localization of adenylate cyclase (AC) and guanylate cyclase B (GC-B) and C (GC-C) activity was studied after stimulation with pituitary adenylate cyclase activating peptide, C-type natriuretic peptide and guanylin, respectively, in normal human respiratory nasal mucosa and mucosa of nasal polyps. To demonstrate these enzymatic activities, we employed enzyme-ultracytochemical methods for electron microscopy. Both normal and pathologic nasal mucosa contained AC, GC-B and GC-C activity. In the upper portion of respiratory epithelium, the enzymes were detected on ciliary and microvillar membranes. In ciliary membranes, GC-B was the predominant form expressed. In goblet cells and in glands of the lamina propria, enzymatic activities were localized mainly on plasma membranes and on membranes lining secretory granules. The results did not reveal any evident differences between the enzymatic activities in normal and pathological nasal mucosa and suggest complementary activities for these enzymes and their stimulators in the regulation of mucociliary transport and glandular secretion.

Adenylyl Cyclases↗
PubMed1979

Ultrastructural findings of the nasal mucosa of "ozaena" in atrophic rhinitis.

Alterations in the nasal mucous layer of atrophic rhinitis "Ozaena" patients have been investigated. The vast majority (99%) of these patients were women. Morphological findings in healthy nasal mucosa demonstrated the different functional stages of the glandular tissue cells with the healthy epithelium. On the other hand, nasal mucosal material taken from the patients displayed prominent epithelial deterioration, decrease in and loss of cilia, increase in goblet cells with squamous epithelial metaplasia. A decrease in secretory granules and membrane deterioration in the apical region of the secretory cells was also clearly visible. It is possible to postulate that the ultrastructural changes seen in the secretory and storage cycles of glandular tissue of the nasal mucosa from patients seem to arise as a reaction to the superficial epithelial deterioration of the nasal mucosa together with the resulting deterioration of physiological conditions.

Epithelium↗
PubMed1992

The effect of recombinant human interleukin-5 on eosinophil accumulation and degranulation in human nasal mucosa.

Recombinant human interleukin-5 (rhIL-5) was administered repeatedly onto the nasal mucosa of individuals with Japanese cedar pollinosis outside the pollen season. The numbers of eosinophils and epithelial cells and the amount of eosinophil cationic protein (ECP), secretory IgA (S-IgA), and IgA in the nasal lavage fluid increased significantly after the application of rhIL-5. Responsiveness to histamine was also enhanced after the application. When S-IgA was administered onto the nasal mucosa after application of rhIL-5, the amount of ECP in the nasal lavage fluid was significantly more increased. The above findings together with the facts that IL-5 promotes production of IgA, that IgA receptors are present on eosinophils, and that rhIL-5 does not increase release of ECP from eosinophils isolated from the peripheral blood suggest that a series of possible reactions consisting of (1) IL-5--induced production of IgA from the immune-mediating cells, (2) binding of secretory components released from either serous glandular cells or epithelial cells of the nasal mucosa with IgA, (3) release of ECP from eosinophils induced by S-IgA and/or IgA, (4) epithelial damage to the nasal mucosa, and (5) development of nasal hyperreactivity to histamine.

Adult↗