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Pre-operative planning and intra-operative guidance in modern neurosurgery: a review of 300 cases.

Operative neurosurgery has recently entered an exciting era of image guided surgery or neuronavigation and application of this novel technology is beginning to have a significant impact in many ways in a variety of intracranial procedures. In order to fully assess the advantages of image guided techniques over conventional planning and surgery in selected cases, detailed prospective evaluation has been carried out during the advanced development of an optically tracked neuronavigation system. Over a 2-year period, 300 operative neurosurgical procedures have been performed with the assistance of interactive image guidance, as well as the development of new software applications and hardware tools. A broad range of intracranial neurosurgical procedures were seen to benefit from image guidance, including 163 craniotomies, 53 interactive stereotactic biopsies, 7 tracked neuroendoscopies and 37 complex skull base procedures. The most common pathological diagnoses were cerebral glioma in 98 cases, meningioma in 64 and metastasis in 23. Detailed analysis of a battery of postoperative questions revealed benefits in operative planning, appreciation of anatomy, lesion location, safety of surgery and greatly enhanced surgical confidence. The authors believe that image guided surgical technology, with new developments such as those described, has a significant role to play in contemporary neurosurgery and its widespread adoption in practice will be realised in the near future.

Adolescent↗

[Neuroendoscopic removal of a colloid cyst of the third ventricle].

The removal of the benign and only slightly symptomatic but by virtue of their localization potentially fatal lesions is a challenge for the neurosurgeons. Such cases demand a therapy without any postoperative morbidity. The neuroendoscopy meets these requirements and proves to be effective in more and more fields of the art. This article reports a case when colloid cyst was resected entirely by use of a neuroendoscope, firstly in Hungary.

Adolescent↗

[Neuronavigation in third ventricle tumors].

The authors present the results of neuronavigation as a help to open neurosurgery for the tumors of the third ventricle. From January, 1995 to August, 1999, six image-guided surgical procedures were performed to remove third ventricle lesions : 4 colloïd cysts, 1 ependymoma, and 1 craniopharyngioma. The operative approach was transcortical in 5 cases, and transcallosal in 1 case. The use of neuronavigation allows a decrease of the surgical trauma during the surgical approach. The procedure secures the neurosurgeon in the choice and execution of his pathway to the target. It becomes however less accurate after opening the ventricle, because of the brainshift induced by the loss of cerebrospinal fluid becomes important. Nevertheless, neuronavigation is useful in the surgery of the third ventricle, especially if it is used with neuroendoscopy.

Adult↗

[A case of the development of cavum vergae after head trauma].

We report a case of the development of cavum septi pellucidi and cavum Vergae after head trauma in a 29-year-old female patient. After the accident, cavum septi pellucidi and cavum Vergae gradually expanded. Using magnetic resonance imaging, we followed up the patient for 33 months after the head trauma. Preoperatively, metrizamide CT cisternography was performed in order to investigate CSF flow between the cavum septi pellucidi/cavum Vergae and the subarachnoid space. Using neuroendoscopy, we succeeded in opening the wall of the cavum septi pellucidi via anterior horn of the right lateral ventricle. Cystography was performed during the operation. The volume of the cavum septi pellucidi/cavum Vergae decreased remarkably. In this case, our CSF flow studies revealed that CSF flowed into the posterior part of the cavum Vergae from the third ventricle and did not flow backward to the third ventricle. Therefore, we considered that the development of cavum septi pellucidi/cavum Vergae was related to a one-way valve mechanism between the posterior part of the cavum Vergae and the third ventricle.

Adult↗

[Neuroendoscopic treatment for Rathke's cleft cyst: transventricular approach to suprasellar cystic lesion].

We report a case of a Rathke's cleft cyst, which was successfully treated by neuroendoscopy. The endoscopic procedure for the intra-suprasellar cystic lesion used the transventricular approach, similar to that of third ventriculostomy. A 66-year-old woman suffered from headache, nausea and constriction of the visual field. Magnetic resonance imaging (MRI) on admission showed an intra-suprasellar cystic lesion. Biopsy of the cyst wall and fenestration of the floor of the third ventricle was performed using an endoscopic transventricular approach. The cyst content was totally aspirated, using a suction system which was connected to the operation channel of the endoscope. The histological diagnosis was Rathke's cleft cyst. No post-operative complication was observed. The endoscopic transventricular approach is safe and most suitable in terms of minimum invasiveness for the intrasuprasellar cystic lesion. We consider that neuroendoscopic transventricular approach will become the common surgical method of choice for treating a suprasellar cystic mass lesion.

Aged↗

[Hypoglossal neurilemmoma: current experience in diagnosis and treatment].

OBJECTIVE: To improve the diagnosis and treatment of hypoglossal neurilemmoma (HGN). METHODS: The data of 10 patients with HGN were retrospectively reviewed, 5 of 10 patients (early group) had been reported previously. A comparison of treatment strategy between early and latter group was made. RESULTS: Typical hemiatrophy of the tongue presented in all 10 patients, hypoglossal canal could be showed in the bone window of CT, which, however, might not confirm the existence of tumor if it is very small. MRI was the optical choice for diagnosis. Among the early 5 cases with HGN which were all of dumbbell type, the intracranial part and the extracranial part of the tumor in 2 cases were removed by stages, 3 cases were operated via the far-lateral approach, of which 1 was via trans-condylar approach and 2 were via trans-supracondylar approach; the 5 tumors were removed subtotally except 1 totally; CSF leakage and intra-cranial infection after operation occurred in 1 case; the rating of Karnofsky Prognosis Scale was good in 4 cases and dead in 1 case. However, among the latter 5 cases, 4 cases including 2 of dumbbell type, 1 of intra-cranial type and 1 of intracanal type were operated via the modified far-lateral approach, of which 1 was via trans-condylar approach and 3 were via trans-supracondylar approach; and the tumor of extracranial type in the last case was resected twice via transcervical approach, being removed subtotally in the first operation followed by total removal with the aid of neuronavigation and neuroendoscopy in the second operation when it failed to react to the treatment of gamma knife; the 5 tumors were removed totally except 1 subtotally.; all postoperative courses were uneventful.; follow up was performed successfully in 4 cases, the rating of Karnofsky Prognosis Scale was excellent in 3 cases and fair in 1 case. The outcomes of the latter 5 cases resected via modified approach were better than those of the early 5 cases. CONCLUSION: HGN is extremely rare and it is difficult to treat it. To achieve a good operative outcome, it is very important to design the approach individually based on its location and size and operate mini-invasively and resect tumor totally as possible as can in the primary stage.

Adult↗

[Endoscopic method in etiological diagnosis of spontaneous intracerebral hemorrhage. Case report].

The etiology of cerebral hemorrhage is not always easy to diagnose and modern neuroimaging methods may be deceptive. The authors report on a 48-year-old previously healthy male admitted to hospital with a first-time severe generalized epileptic seizure. The patient presented with aphasia, confusion, headaches, nausea, right hemianopia and early papilledema. CT revealed an intracerebral hematoma in the left occipital lobe but MRI and MRA failed to provide any further insight into the etiology of the hemorrhage. Due to persisting intracranial hypertension, the patient underwent neuroendoscopic removal of the hematoma. After blood clots were evacuated, pathologic vascularity was found. Tissue samples were collected from the walls of the hematoma cavity. Neoplastic cells adjacent to the blood vessels were identified in one of the samples. The patient was reoperated and a glioma-like tumor was removed. The diagnosis of cerebral intratumoral hemorrhage is difficult especially when there are no previous clinical signs of a tumor. Neuroendoscopy may speed up the diagnostic process which usually extends past resorption of the haematoma and the technique may be an alternative to stereotactic surgery.

Brain Neoplasms↗

[Minimally invasive surgery of the pituitary and the sellar region].

INTRODUCTION: New minimal invasive neurosurgical approaches for the treatment of diseases in the sellar and perisellar regions (superciliary and paraseptal approach, perioperative ACTH measurements, application of endoscopes and neuronavigation) were introduced by the author. The modified surgical techniques were applied by the author successfully in the treatment of more than 1000 cases, of which the data of 746 patients were analysed and the results are presented. METHODS AND RESULTS: The results of the clinical studies concerning superciliary and paraseptal approaches were as follows: length of the operations and, loss of blood were decreased, the patients needed shorter anesthesia and the treatment cost became lower. The approaches were performed without hair cutting with excellent cosmetic results leading to easier resocialisation of the patients. In the group of the patients operated on through the superciliary approach postoperative vasospasm developed in significantly lower rate, the number of days spent in the intensive care unit decreased and the rate of patients on discharge in good clinical condition were higher. The study on perioperative plasma ACTH simultaneous measurements with rapid and standard methods revealed first in the literature that, during anaesthesia in patients with ACTH producing adenoma the plasma ACTH level changed individually. There was no difference between arterial and venous plasma ACTH concentration in the same patient and the ACTH concentration in the bleedings from the peripituitary bony structures are individually variable, representing the network of the venous outflow of the pituitary. The decrease in the plasma ACTH concentrations in the peripheral venous samples two hours after operation and next morning proved the radical removal of the adenoma. The differences between concentrations in the left and right sides indicate the intrapituitary lateralization of the adenoma. The study on the usefulness of neuroendoscopy and neuronavigation in the author's hand revealed the advantages and disadvantages of these new neurosurgical instruments. CONCLUSIONS: With the advent of the minimal invasive methods in surgery of the pituitary and the sellar region the mortality end the morbidity of the operations decreased.

Adenoma↗

Complex technical methodologies and their applications in the surgery of intracranial meningiomas.

As neurosurgery moves into the twenty-first century, improved visualization/localization techniques, neuromonitoring, and advanced instrumentation will become standards of care for all intracranial procedures. This article has focused on current available technologies that can be used to facilitate operations on intracranial meningiomas. Preoperative anatomic localization with MR imaging, CT, MR angiography, and angiography are standard techniques. Preoperative functional assessments with MR imaging, magnetic source imaging, PET, and functional MR imaging are crucial to recognize and preserve eloquent adjacent cortex. Pathologic correlations with preoperative imaging (i.e., MR imaging) may help to predict the histopathology. Perioperative rehearsal of the operation can be performed. Intraoperative anatomic localization is important to minimize the craniotomy, dural opening, and passage through normal neural structures. An impressive array of new technologies are currently available, including real-time ultrasonography, frame-based stereotaxy (CT, MR imaging PET), frameless stereotaxy (acoustic localization, neuronavigators, real-time visualization), robotics, neuroendoscopy, and intraoperative dye administration. Increased understanding of the function and individual variability of the human cortex underscores the importance of intraoperative functional localization by electrocorticography and optical imaging. Continuous intraoperative neuromonitoring of sensory (SSEPs, BAERs, visual evoked potentials) and motor evoked potentials is now standard during many intracranial procedures. Complex adjunctive instrumentation, such as the ultrasonic aspirator and the laser, are part of the contemporary armamentarium for meningioma surgery. As we have stated in a previous article, "Developmental trends imply realization of three major directions of technical neurosurgery: (1) precise preoperative simulation, (2) minimization or avoidance of transcranial operative corridors, [and] (3) increased refinement of technical adjuvants--both physical and molecular." The end point of these technical advances is to improve precision and safety and will enhance the outcome in each surgical procedure so that one day we will be able to operate on patients with intracranial lesions with minimal morbidity.

Brain↗

Minimally invasive brain surgery.

Minimally invasive brain surgery refers to technological advances refining surgical access that have enabled neurosurgeons to reduce the morbidity and improve the accuracy and quality of neurosurgical procedures. These advances include computer-assisted stereotaxis, intraoperative ultrasound, brain mapping and neuroendoscopy. Computer-assisted stereotaxis includes not only smaller and accurate craniotomies but precision radiotherapy with radiosurgery and interstitial brachytherapy.

Brain Diseases↗

[Focus on peroperative ultrasonography].

Based on a personal experience of more than 70 intraoperative ultrasound examinations performed in the last 3 years, the authors discuss the present status of this technique in its various indications: insertion of ventricular catheters, intracranial surgery, neuroendoscopy, and spinal surgery. The material and techniques currently used are presented. Because of its simplicity, non-invasive character, and relative low-cost, intra-operative ultrasound is a technique easily incorporated in general neurosurgical practice, providing an alternative to stereotactic procedures in some cases.

Cerebrospinal Fluid Shunts↗

[Analysis of the current status of neuroanesthesia in Spain using a national survey].

OBJECTIVES: Advances in complementary diagnostic explorations, surgical support technology and the complexity of neurophysiological monitoring require anesthesiologists to acquire specific knowledge for dealing with neurosurgery. We aimed to study the implantation of new anesthetic-surgical techniques in the field of neurosurgery, and the state of neuroanesthesia as a subspecialty in Spain. MATERIAL AND METHODS: A 20-item postal questionnaire sent to anesthesiology department heads of Spanish hospitals with neurosurgery teams. RESULTS: We received responses from 62% of the hospitals surveyed. Of these, 69% performed stereotaxic surgery, 30% functional cerebral surgery (for Parkinson's disease and epilepsy) and 21% offered neuroendoscopy. In 38% of the hospitals cerebral metabolism was monitored (hemoglobin oxygen saturation in the jugular or regional cerebral oxygen saturation) and/or cerebral electrophysiology (electroencephalogram, evoked potentials) and in 23.8% flows and pressures were measured (transcranial precordial and/or tracheoesophageal Doppler). Anesthesiologists specializing in neurosurgery are present in 62% of the hospitals. Interventionist neuroradiology is performed in 57%. It was noteworthy that 14.3% do not regularly have an anesthesiologist present during such high risk procedures. CONCLUSIONS: Although most centers continue performing "classical" neurosurgery with standard monitoring, a substantial proportion of hospitals (38%) show evidence of advancing in anesthetic techniques for neurosurgery in Spain. Anesthesia for neurosurgery as a subspecialty is available in 62% of the responding hospitals.

Anesthesia↗

[A new technic in the management of hydrocephalus: neuro-endoscopy].

Conventional valve shunting for treatment of hydrocephalus has a high rate of long-term complication. After a brief historical review of neurosurgical endoscopy the authors present the different indications and methods of neuroendoscopy. Between 1995 and 1997 twenty-two pediatric patients underwent endoscopic surgery at National Institute of Neurosurgery. Twelve of them had third ventriculo-cistemostomy, and cystic wall fenestration was performed in ten children. All but one patient benefited from this minimally invasive endoscopic technic. Minor transient complications were seen in three cases, and only one patient had long-term pupillary dilatation due to the surgical procedure.

Child↗

[Endoscopic brain surgery of intracranial cysts: report of 2 cases].

Two cases are presented of intracranial cystic lesions, which were treated by the neuroendoscopic method. In the two cases the patients' radiological and clinical conditions improved. Neuroendoscopy is a very effective and safe method to treat intracranial cystic lesions.

Adult↗

Experimental application of pulsed Ho:YAG laser-induced liquid jet as a novel rigid neuroendoscopic dissection device.

BACKGROUND AND OBJECTIVES: Although water jet technology has been considered as a feasible neuroendoscopic dissection methodology because of its ability to perform selective tissue dissection without thermal damage, problems associated with continuous use of water and the ensuing fountain-effect-with catapulting of the tissue-could make water jets unsuitable for endoscopic use, in terms of safety and ease of handling. Therefore, the authors experimented with minimization of water usage during the application of a pulsed holmium:yttrium-aluminum-garnet (Ho:YAG) laser-induced liquid jet (LILJ), while assuring the dissection quality and the controllability of a conventional water jet dissection device. We have developed the LILJ generator for use as a rigid neuroendoscope, discerned its mechanical behavior, and evaluated its dissection ability using the cadaveric rabbit ventricular wall. STUDY DESIGN/MATERIALS AND METHODS: The LILJ generator is incorporated into the tip of a stainless steel tube (length: 22 cm; internal diameter: 1.0 mm; external diameter: 1.4 mm), so that the device can be inserted into a commercial, rigid neuroendoscope. Briefly, the LILJ is generated by irradiating an internally supplied water column within the stainless steel tube using the pulsed Ho:YAG laser (wave length: 2.1 microm, pulse duration time: 350 microseconds) and is then ejected through the metal nozzle (internal diameter: 100 microm). The Ho:YAG laser pulse energy is conveyed through optical quartz fiber (core diameter: 400 microm), while cold water (5 degrees C) is internally supplied at a rate of 40 ml/hour. The relationship between laser energy (range: 40-433 mJ/pulse), standoff distance (defined as the distance between the tip of the optical fiber and the nozzle end; range: 10-30 mm), and the velocity, shape, pressure, and average volume of the ejected jet were analyzed by means of high-speed camera, PVDF needle hydrophone, and digital scale. The quality of the dissection plane, the preservation of blood vessels, and the penetration depth were evaluated using five fresh cadaveric rabbit ventricular walls, under neuroendoscopic vision. RESULTS: Jet velocity (7.0-19.6 m/second) and pressure (0.07-0.28 MPa) could be controlled by varying the laser energy, which determined the penetration depth in the cadaveric rabbit ventricular wall (0.07-1.30 mm/shot). The latter could be cut into desirable shapes-without thermal effects-under clear neuroendoscopic vision. The average volume of a single ejected jet could be confined to 0.42-1.52 microl/shot, and there was no accompanying generation of shock waves. Histological specimens revealed a sharp dissection plane and demonstrated that blood vessels of diameter over 100 microm could be preserved, without thermal damage. CONCLUSIONS: The present pulsed LILJ system holds promise as a safe and reliable dissection device for deployment in a rigid neuroendoscope.

Animals↗

Laser-assisted endoscopic third ventriculostomy for obstructive hydrocephalus: technique and results in a series of 40 consecutive cases.

BACKGROUND AND OBJECTIVES: To report a case series of endoscopic third ventriculostomy (ETV) using laser in 40 consecutive patients with obstructive hydrocephalus. STUDY DESIGN/MATERIALS AND METHODS: Under stereotactic and endoscopic guidance, multiple perforations in the ventricular floor using a 1.32 microm neodymium-yttrium/aluminum/garnet (Nd-YAG) or a 0.805 microm diode laser unit and removal of intervening coagulated tissue ensued with a 4-6 mm opening between third ventricle and basilar cisterns. RESULTS: The procedure could be completed in all cases. A transient complication occurred in five cases. In 39 patients (mean follow-up 28 months), 31 (79%) had a favorable outcome. Failure occurred in six patients, requiring permanent shunting leading to complete recovery, and two patients remained in a poor clinical status despite ETV. CONCLUSIONS: Laser-assisted ETV is a safe and efficient procedure for the treatment of obstructive hydrocephalus. Laser is advantageous in cases of distorted anatomy and may reduce technical failures.

Adolescent↗

Endoscopic third ventriculostomy in the treatment of hydrocephalus in pediatric patients.

Advances in surgical instrumentation and technique have lead to an extensive use of endoscopic third ventriculostomy in the management of pediatric hydrocephalus. The aim of this work was to point out the leading aspects related to this technique. After a review of the history, which is now almost one century last, the analysis of the endoscopic ventricular anatomy is aimed to detail normal findings and possible anatomic variations which might influence the correct conclusion of the procedure. The overview of modern endoscopic instrumentation helps to understand the technical improvements that have contributed to significantly reduce the operative invasiveness. Indications are analysed from a pathogenetic standpoint with the intent to better understand the results reported in the literature. A further part of the paper is dedicated to the neuroradiological and clinical means of outcome evaluation, which are still a matter of debate. Finally a review of transient and permanent surgical complications is performed looking at their occurrence in different hydrocephalus etiologies.

Child↗

Percutaneous endoscopic cervical discectomy for discogenic cervical headache due to soft disc herniation.

A discogenic cervical headache is a subtype of cervicogenic headache (CEH) that arises from a degenerative cervical disc abnormality. The purpose of this study was to evaluate the clinical outcome of percutaneous endoscopic cervical discectomy (PECD) for patients with chronic cervical headache due to soft cervical disc herniation. Seventeen patients underwent PECD for intractable headache. The inclusion criteria were soft disc herniation without segmental instability, proven by both local anesthesia and provocative discography for headache unresponsive to conservative treatment. The mean follow-up period was 37.6 months. Fifteen of the 17 patients (88.2%) showed successful outcomes based on the Macnab criteria. Pain scores on a visual analog scale (VAS) improved from a preoperative mean of 8.35 +/- 0.79 to 2.12 +/- 1.17, postoperatively (P < 0.01). The mean disc height decreased from 6.81 +/- 1.08 to 5.98 +/- 1.07 mm (P < 0.01). There was no newly developed segmental instability or spontaneous fusion on follow-up radiography. In conclusion, PECD appears to be effective for chronic severe discogenic cervical headache under strict inclusion criteria.

Adult↗