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Results for “Physical exercise”

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PubMed1991

The interrelationship between physical exercise, muscle strength and body adiposity in a healthy elderly population.

OBJECTIVE: To determine the relationship between habitual physical exercise and body adiposity in a healthy elderly population. RESEARCH DESIGN AND METHODS: Physical exercise was measured by a questionnaire previously adapted for use with the healthy elderly. The level of exercise was converted into calories expended over the previous 14 days and was divided into tertiles. Body adiposity was measured at six sites by anthropometry, and overall percent body fat was measured by bioelectric impedence. PARTICIPANTS AND SETTING: Two hundred and thirteen healthy ambulatory subjects over the age of 60 (116 females and 97 males) were recruited from a large retirement community in Southern Arizona. The mean age of the subjects was 70.0 years. RESULTS: Percent body fat was similar in men with different levels of physical activity (27.9% for lowest tertile of activity, 28.1% for middle tertile of activity, and 28.5% for highest tertile of activity). The corresponding values of percent fat in women was 38.0%, 36.0%, and 37%, respectively. There was a statistically significant increase in muscle strength measured in five muscle groups with a hand-held dynamometer with increasing levels of activity. CONCLUSIONS: These data indicate that level of physical exercise, over the range of 0 to 1,528 Kcal/day, does not predict body adiposity in the healthy elderly population. To decrease body fat without a change in dietary habits would require a more intensive exercise regimen than currently being undertaken by most healthy elderly people.

Aged↗

PubMed1976

Enzyme activities in hepatic venous blood under strenuous physical exercise.

In order to study the influence of physical exercise on liver function, experiments were performed in healthy volunteers subjected to controlled major physical effort. Blood samples obtained by catheterization of hepatic vein during exercise were analyzed for activities of LD (thermostabile and thermolabile isoenzymes), AlAT, SDH, ICD, AP and CPK, and these activities were compared with corresponding values in arterial blood samples taken simultaneously. Hepatic blood flow and oxygen saturation of hepatic venous blood were measured. Physical exercise resulted both in diminished hepatic blood flow and a fall in hepatic venous oxygen saturation. These changes were accompanied by release of liver specific enzymes, indicating that exhausting exercise may induce an "increased hepatocyte membrane permeability" in man.

Adult↗

PubMed1990

Effects of spontaneous physical exercise on experimental cancer anorexia and cachexia.

The aim of this study was to evaluate whether spontaneous physical exercise can modify cancer anorexia and cachexia in tumour-bearing rats. Two transplantable experimental tumours were evaluated. Tumour-bearing Wistar Furth rats fed ad libitum and with free access to a running wheel had a delayed onset of anorexia compared with their non-exercised tumour-bearing controls, retained normal behaviour and were able to run the same daily distance as non-tumour controls until the onset of cachexia. Exercise resulted in a decreased carcass wet weight and lipid stores but in an increased carcass dry weight in the tumour-bearing animals. Despite increased food intake, physical exercise resulted in a reduced final tumour weight without any change in water content. Skeletal and cardiac muscle tissue did not show any difference in water content but there was an increased RNA/protein quotient in the exercising tumour-bearing animals. Thus the deleterious alterations induced by the malignancy on tumour host metabolism are not inevitable but can be modified by spontaneous physical exercise.

Animals↗

PubMed1981

The characteristics of physical exercise programs in rehabilitation: a means of analysis.

The relatively few number of articles available concerning the utility of physical exercise or physical sports activities within rehabilitation, according to a recent literature search, may reflect a general scarcity of such articles and/or programs. According to the 115 references located however, exercise appears potentially useful as a rehabilitation tool, in spite of various programmatic and methodological complications. It is apparent that all forms of exercise training are not suitable for all rehabilitation clients. However, based on the rehabilitation-related characteristics of the 15 different activities represented herein, there are certain forms of physical exercise which (1) are more congruent with normalization principles, (2) are more easily adapted to all disabilities, including the elderly, and (3) employ brief, high-intensity training principles, and therefore seem to be well suited for rehabilitation programming, in general. The anecdotal and empirical reports represented in this literature analysis should provide a base for continued investigation of the rehabilitative impact and relative efficiency of physical fitness/sports activities upon impaired individuals.

Humans↗

PubMed2000

[Physical exercise impairs the acute stage of adaptation to moderate altitude].

UNLABELLED: A recent study has reported the impairment of high altitude adaptation capacity by physical exercise in a decompression chamber. The aim of our protocol was to evaluate if physical exercise at moderate altitude in the Alps would show a similar effect. 8 alpinists were examined in a randomised cross-over trial at 171 m and at 3000 m altitude under sedentary and under exercise condition (50% maximal workload on the bicycle ergometer four times 30 minutes during the first 6 hours of an 8 hour observation period at each altitude). At the beginning and at the end of each observation period AMS scores and arterial oxygen saturation SaO2 were measured. The differences of the AMS scores and the differences of SaO2 at both test conditions were compared at both altitudes. RESULTS: In comparison to sedentary condition, the differences between initial and final AMS scores at 3000 m altitude were significantly higher (-0.38 +/- 0.52 vs. -1.25 +/- 0.46, diff 0.88, 95% CI 0.58 to 1.17, p < 0.01), as well as the difference between initial and final SaO2 (-0.25 +/- 0.71% vs. 2.25 +/- 1.04%, diff. -2.5%, 95% CI for the diff. -3.59 to -1.41, p < 0.01). AMS score and SaO2 did not change after exercise at 171 m altitude. CONCLUSION: Physical exercise impairs the acute stage of adaptation to moderate altitude. This is mainly due to the exercise-induced exaggeration of arterial hypoxaemia.

Acute Disease↗

PubMed1984

Effects of mild physical exercise on serum lipoproteins and metabolites of arachidonic acid: a controlled randomised trial in middle aged men.

To study the effects of physical exercise on biochemical risk factors for ischaemic heart disease 31 healthy middle aged men undertook regular physical exercise for two months and 29 served as controls in a randomised trial. In the men taking regular exercise serum cholesterol concentrations increased 26% more in the high density lipoprotein subfraction two (HDL2) and decreased 31% more in the subfraction three (HDL3) and 9% more in the low density lipoprotein fraction than in the control group. A tendency towards increased plasma 6-keto-prostaglandin F1 alpha concentration and decreased serum thromboxane B2 concentration was found during the period of regular exercise, but prostaglandin E2 concentrations remained unchanged. The increase in plasma 6-keto-prostaglandin F1 alpha concentration was associated with an increase in serum HDL2 cholesterol concentration in the group taking regular exercise. Our data suggest that mild regular physical exercise favourably influences cholesterol distribution in serum lipoproteins in healthy middle aged men and may have beneficial effects on circulating metabolites of arachidonic acid.

6-Ketoprostaglandin F1 alpha↗

PubMed1989

Relationships between physical exercise and cognitive abilities in older adults.

We investigated relationships between physical exercise and the cognitive abilities of older adults. We hypothesized that the performance of vigorous exercisers would be superior to that of sedentary individuals on measures of reasoning, working memory, and reaction time. We gave a series of cognitive tasks to 62 older men and women who exercised vigorously and 62 sedentary men and women. Multivariate and univariate analyses of variance, with age and education as covariates, indicated that the performance of the exercisers was significantly better on measures of reasoning, working memory, and reaction time. Between-group differences persisted when vocabulary, on which the performance of exercisers was superior, was used as a third covariate. Subsequent analyses showed that neither self-rated health, medical conditions, nor medications contributed to the differences between exercise groups. Results suggest that the possible contribution of physical exercise to individual differences in cognition among older adults should be further investigated.

Adult↗

PubMedDate not supplied

A review of research on physical exercise with people with severe and profound developmental disabilities.

During the last two decades, a significant amount of research has examined physical exercise with people with severe and profound developmental disabilities. The research has followed three main objectives: 1) finding strategies for allowing the people to engage in physical exercise fairly independent; 2) improving the people's physical fitness; and 3) reducing the people's deviant behavior. This paper reviews the studies related to the aforementioned objectives and comments on the main findings and on the practicality and acceptability of physical exercise.

Persons with Disabilities↗

PubMedDate not supplied

[Effect of physical exercise on myoglobin and tropomyosin levels in skeletal muscles and myoglobin level in rat blood].

Single intensive physical exercise caused phase alterations in content of myoglobin and tropomyosin in rat skeletal muscles. Within the first 2-4 hrs of rest concentration of myoglobin and tropomyosin was decreased in muscles by 40-50% (catabolic, urgent step of adaptation). Within the later period of rest (72-120 hrs) content of myoglobin and tropomyosin was increased by 25-30% (anabolic, later step of adaptation) as compared with the control level. Similar phase alterations of these proteins in skeletal muscles were detected in trained animals but they were less distinct. Training of the animals led to elevation in content of the proteins in musculus quadriceps. The content of myoglobin increased from 1.2 +/- 0.1 mg/kg up to 2.6 +/- 0.1 mg/kg and that of tropomyosin from 4.9 +/- 0.1 mg/kg up to 5.5 +/- 0.1 mg/kg as a result of an increase in protein biosynthesis. Incorporation of 14C-leucine into myoglobin was increased 1.7-fold. Concentration of myoglobin in blood of untrained rats was increased 3-fold immediately after physical exercises and--9-fold within 72 hrs of the rest. Content of muscular proteins in blood reflected the response of muscle system to physical exercises and may serve as a criterion in evaluation of various steps of adaptation to physical loading.

Animals↗

PubMed1988

The influence of physical exercise on peritoneal macrophage functions: histochemical and phagocytic studies.

Peritoneal murine macrophages were assayed for their enzyme content and phagocytic activity after physical exercise. An endurance training as well as a single exhaustive exercise bout caused increased enzyme and phagocytic activities. However, a homogeneous activation could not be observed. The exhaustively exercised animals delivered macrophages with the highest levels of activation. Therefore, physical exercise has to be listed among the stimuli with macrophage-activating function. The inconsistency between an activating effect of physical exercise on macrophages and the observation that high-performance athletes suffer more frequently from harmless infectious diseases is discussed.

Animals↗

PubMed1982

TSH, T3, rT3 and fT4 in maximal and submaximal physical exercise.

The response of various thyroid hormone parameters to maximal physical exercise (MPE) was investigated in 14 medium and long distance runners and 13 divers. The effects of submaximal long time physical exercise (SMPE) was examined in seven divers. The TSH-level decreases significantly during MPE and slightly rises again after the end of the exercise. In SMPE, however, TSH continuously rises until 15 min after the end of the exercise. The T3 level rises significantly in MPE and falls below the initial value 15 min after the exercise finishes, during SMPE it remains practically unchanged and slightly decreases after the finish. In MPE, the rT3 level does not change and slightly decreases after termination, while the fT4 level continuously decreases from the beginning till 15 min after the exercise period. The latter two parameters do not show any change in SMPE. As possible reasons for the changes of TSH levels a decrease (MPE) or an increase (SMPE) of pituitary secretion might play a role. Furthermore, in MPE the rise in T3 level might be related to hemoconcentration, and the decrease in fT4 level to an elevated cellular utilization.

Adult↗

PubMed1988

Adult inpatient alcoholics: physical exercise as a treatment intervention.

This study examined the usefulness of physical exercise as a treatment intervention to decrease depression and anxiety in adult inpatient alcoholics while increasing aerobic capacity and self-concept. The State-Trait Anxiety Inventory, the Tennessee Self-Concept Scale, the Self-Rating Depression Scale and the Astrand-Rhyming bicycle-ergometer were administered to a treatment and a control group on admission to and again at discharge from a 28-day inpatient treatment program. Control group data were gathered prior to initiating the exercise program. The exercise program consisted of walking or jogging 3 days a week and was designed to meet the American College of Sports Medicine's minimum requirements for a graded exercise program. Results indicated that there were significant differences on posttest scores between the control and exercise groups on state anxiety, trait anxiety and depression, but not on self-concept or aerobic capacity. The usefulness of physical exercise as a treatment intervention as well as the implication for research are discussed.

Adult↗

PubMed1978

Effect of chronic physical exercise on cholesterol biosynthesis in meal-fed rats.

Chronic physical exercise (in a rotating drum) influenced liver cholesterologenesis (from acetate-l-14C) in vivo in meal-fed rats (for 2 hours daily) in close temporary correlation with the time of realimentation. If always performed just prior to feeding physical exercise blocks the development of adaptive hyperchloesterologenesis as a metabolic response to infrequent feeding. If it is performed 3 and a half hours after realimentation, the stimulating effect of infrequent feeding on liver cholesterologenesis is not modified.

Animals↗

PubMed1982

Effect of induced erythrocythemia on hypoxia tolerance during physical exercise.

The effect of induced erythrocythemia on hypoxia tolerance during physical exercise was determined for five male mountain climbers. Treadmill testing was performed under four conditions: 1) prereinfusion, normoxia (Pre-N); 2) prereinfusion, hypoxia (Pre-H); 3) postreinfusion, normoxia (Post-N); and 4) postreinfusion, hypoxia (Post-H). An altitude of 3,566.2 m was simulated by having subjects breath a gas mixture of 13.5% O2-86.5% N2 at normal barometric pressure. Tests were administered immediately before and 24 h after autologous transfusion of 750 ml of red blood cells. Hematocrit increased from 43.3% at prereinfusion to 54.8% at postreinfusion. Hemoglobin concentration increased from 13.80 g X 100 ml-1 at prereinfusion to 17.63 g X 100 ml-1 at postreinfusion. Maximal O2 uptake (VO2 max, 1 X min-1) increased (P less than 0.05) by 12.8% (3.28 to 3.70) from Pre-N to Post-N and 13.0% (2.62 to 2.96) from Pre-H to Post-H. Treadmill performance time (s) increased (P less than 0.05) by 15.8% (793 to 918) from Pre-N to Post-N and 8.9% (687 to 748) from Pre-H to Post-H. VO2 max decreased by 20.1% from Pre-N to Pre-H and by 9.8% from Pre-N to Post-H. Treadmill time decreased by 13.4% from Pre-N to Pre-H and 5.7% from Pre-N to Post-H. The calculated change in hypoxia tolerance following reinfusion indicated that physiological altitude was improved by 463.6 m. It was concluded that induced erythrocythemia increased hypoxia tolerance during physical exercise.

Adult↗

PubMed2000

Influence of physical exercise on polyamine synthesis in the rat skeletal muscle.

BACKGROUND: Physical exercise and testosterone administration result in a series of adaptive anabolic phenomena in the skeletal muscle. The role of polyamines in these processes has been poorly explored. DESIGN: We measured the activities of polyamine-synthesising enzymes, ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (SAMDC) and polyamine content in skeletal muscle of male rats exposed to endurance or resistance exercise, or a single testosterone treatment. Soleus muscle (consisting mainly of slow-twitching oxidative fibres-STO) and extensor digitorum longus (mainly fast-twitching glycolytic muscle fibres-FTG) were analysed for polyamine content by HPLC, and ODC and SAMDC activity. RESULTS: Both endurance and resistance exercise induced a threefold increase in endogenous testosterone production. Two hours after exercise, ODC was increased in STO fibres, returning to baseline after 24 h; in FTG fibres the increase was less prominent. An increase in SAMDC activity occurred in a more sustained manner, with its peak 8 h after exercise. Polyamines were subsequently accumulated in both skeletal muscle fibres, with a rise in putrescine concentration after 2 h, and a fall corresponding to conversion of putrescine to spermidine and spermine by SAMDC. Single dose of 17alpha-methyltestosterone resulted in a similar increase in polyamine-synthesising enzyme activities and polyamine concentrations in the skeletal muscle. CONCLUSION: Polyamine accumulation in the skeletal muscle after physical exercise is likely to occur secondary to testosterone production. Polyamines are apparently involved in the oxidative, but not in glycolytic processes related to muscle adaptation to exercise.

Adenosylmethionine Decarboxylase↗

PubMed1977

Modifications of serum glycoproteins the days following a prolonged physical exercise and the influence of physical training.

Eight male subjects (mean age 24.1 +/- 2.6 years) performed at intervals of 2 weeks successively a 3 h and two 2 h runs of different running speed. The days following the running there were moderate elevations of C-reactive protein, haptoglobin, alpha-1-acid glycoprotein, coeruloplasmin, transferrin, alpha-1-antitrypsin and plasminogen. There were small or no changes of albumin, alpha-2-macroglobulin and hemopexin. The elevations of the "acute phase reactants" were examined in three male subjects following a 2 h run before and after an endurance training period of 9 weeks. This demonstrated a decreased acute phase response after training as illustrated by the changes of C-reactive protein, haptoglobin and alpha-1-acid glycoprotein in spite of higher posttraining running speeds. Well-trained athletes have elevated levels of the serum protease inhibitors alpha-1-antitrypsin, alpha-2-macroglobulin and C1-inhibitor. These antiproteolytic glycoproteins might limit exercise-induced inflammatory reactions.

Adult↗

PubMedDate not supplied

Physical exercise and quality of life in cancer patients following high dose chemotherapy and autologous bone marrow transplantation.

Preliminary evidence indicates that physical exercise may be an effective strategy for the rehabilitation of cancer patients following high dose chemotherapy (HDC) and bone marrow transplantation (BMT), but the focus of this research has been on physical fitness and medical outcomes. In the present study, we employed a prospective design to examine the relationship between physical exercise and various quality of life (QOL) indices in 25 BMT patients. Participants completed weekly self-administered questionnaires upon being admitted to hospital, and monitored the frequency and duration of their exercise during hospitalization. Statistical analyses indicated that exercise during hospitalization was significantly correlated with almost all QOL indices, including physical well-being, psychological well-being, depression, anxiety and days hospitalized. Moreover, only some of the correlations were attenuated after controlling for relevant demographic and medical variables. It was concluded that physical exercise may be related to QOL in BMT patients, but that experimental research is needed before any definitive conclusions can be drawn.

Adult↗

PubMed1988

Low-fat diet and regular, supervised physical exercise in patients with symptomatic coronary artery disease: reduction of stress-induced myocardial ischemia.

The effects of physical exercise and normalization of serum lipoproteins on stress-induced myocardial ischemia were studied in 18 patients with coronary artery disease, stable angina pectoris, and mild hypercholesterolemia (total serum cholesterol 242 +/- 32 mg/dl). These patients underwent a combined regimen of low-fat/low-cholesterol diet and regular, supervised physical exercise at high intensity for 12 months. At 1 year serum lipoproteins has been lowered to ideal levels (serum cholesterol 202 +/- 31 mg/dl, low-density lipoproteins 130 +/- 30 mg/dl, very low-density lipoproteins 22 +/- 15 mg/dl, serum triglycerides 105 [69 to 304] mg/dl) and physical work capacity was improved by 21% (p less than .01). No significant effect was noted on high-density lipoproteins, probably as a result of the low-fat/high-carbohydrate diet. Stress-induced myocardial ischemia, as assessed by thallium-201 scintigraphy, was decreased by 54% (p less than .05) despite higher myocardial oxygen consumption. Eighteen patients matched for age and severity of coronary artery disease served as a control group and "usual medical care" was rendered by their private physicians. No significant changes with respect to serum lipoproteins, physical work capacity, maximal rate-pressure product, or stress-induced myocardial ischemia were observed in this group. These data indicate that regular physical exercise at high intensity, lowered body weight, and normalization of serum lipoproteins may alleviate compromised myocardial perfusion during stress.

Body Weight↗